Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.1887 | 0.1369 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0103 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0103 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0103 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1887 | 0.1887 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0103 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0103 | 1 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0103 | 1 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0103 | 1 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.41 | 0.41 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0103 | 1 | 0.5 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.2479 | 0.1999 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0103 | 1 | 0.5 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0103 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.2489 | 0.2489 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0103 | 1 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0103 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.41 | 0.3724 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0067 | 0.5483 | 0.5358 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0103 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.41 | 0.3724 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.7029 | 0.7029 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0103 | 1 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0103 | 1 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.004 | 0.2147 | 0.1931 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0025 | 0.0268 | 0.0268 |
Brugia malayi | Bromodomain containing protein | 0.0084 | 0.763 | 0.7478 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1887 | 0.1887 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.41 | 0.41 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0103 | 1 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0103 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.2821 | 0.2821 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.3089 | 0.3089 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0067 | 0.5483 | 0.5358 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.004 | 0.2147 | 0.1931 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0103 | 1 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0071 | 0.5985 | 0.5985 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.