TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.422 | Formula: C22H22N2O3
H donors: 0 H acceptors: 2 LogP: 4.31 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(CCOc1ccc(c2c1oc1ccccc1c2=O)Cn1cncc1)C
InChi: 1S/C22H22N2O3/c1-15(2)9-12-26-19-8-7-16(13-24-11-10-23-14-24)20-21(25)17-5-3-4-6-18(17)27-22(19)20/h3-8,10-11,14-15H,9,12-13H2,1-2H3
InChiKey: ZWHZNYABNPIRLV-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cytochrome P450, family 11, subfamily B, polypeptide 2	Starlite/ChEMBL	References
Homo sapiens	cytochrome P450, family 11, subfamily B, polypeptide 1	Starlite/ChEMBL	References
Homo sapiens	cytochrome P450, family 17, subfamily A, polypeptide 1	Starlite/ChEMBL	References
Homo sapiens	cytochrome P450, family 19, subfamily A, polypeptide 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Neospora caninum	Os02g0824100 protein, related	Get druggable targets OG5_134469	All targets in OG5_134469
Toxoplasma gondii	cytochrome p450 superfamily protein	Get druggable targets OG5_134469	All targets in OG5_134469

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	cytochrome P450, putative	cytochrome P450, family 19, subfamily A, polypeptide 1	503 aa	425 aa	18.8 %
Brugia malayi	Cytochrome P450 family protein	cytochrome P450, family 17, subfamily A, polypeptide 1	508 aa	468 aa	25.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Brugia malayi	Variant SH3 domain containing protein	0.1427	0.3311	0.3311
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2381	1	1
Schistosoma mansoni	hypothetical protein	0.1427	0.3311	0.3311
Onchocerca volvulus		0.2381	1	1
Schistosoma mansoni	tensin	0.1427	0.3311	0.3311
Onchocerca volvulus		0.2381	1	1
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1427	0.3311	0.3311
Trichomonas vaginalis	conserved hypothetical protein	0.0954	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.2381	1	1
Leishmania major	protein kinase, putative	0.0954	0	0.5
Echinococcus granulosus	tensin	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine kinase	0.2381	1	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.2381	1	1
Echinococcus granulosus	hypothetical protein	0.1427	0.3311	0.3311
Brugia malayi	Variant SH3 domain containing protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Brugia malayi	SH2 domain containing protein	0.1427	0.3311	0.3311
Echinococcus granulosus	tyrosine kinase	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TK family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.1427	0.3311	0.3311
Leishmania major	protein kinase, putative	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2381	1	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2381	1	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1427	0.3311	0.3311
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Echinococcus multilocularis	NCK adaptor protein	0.1427	0.3311	0.3311
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2381	1	1
Brugia malayi	protein-tyrosine kinase	0.2381	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1427	0.3311	0.3311
Schistosoma mansoni	vav2	0.1427	0.3311	0.3311
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus granulosus	expressed conserved protein	0.1427	0.3311	0.3311
Brugia malayi	RhoGAP domain containing protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0954	0	0.5
Onchocerca volvulus		0.1427	0.3311	0.3311
Plasmodium falciparum	tyrosine kinase-like protein	0.0954	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0954	0	0.5
Loa Loa (eye worm)	STAT protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1427	0.3311	0.3311
Brugia malayi	SRC-1	0.2381	1	1
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Echinococcus granulosus	tyrosine protein kinase shark	0.2381	1	1
Schistosoma mansoni	tensin-related	0.1427	0.3311	0.3311
Onchocerca volvulus		0.2381	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2381	1	1
Giardia lamblia	Kinase, NEK	0.0954	0	0.5
Giardia lamblia	Protein 21.1	0.0954	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2381	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1427	0.3311	0.3311
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Schistosoma mansoni	GTPase activating protein	0.1427	0.3311	0.3311
Echinococcus multilocularis	SH2 motif	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1427	0.3311	0.3311
Echinococcus granulosus	SHC transforming protein 3	0.1427	0.3311	0.3311
Echinococcus multilocularis		0.1427	0.3311	0.3311
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1427	0.3311	0.3311
Brugia malayi	SH2 domain containing protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2381	1	1
Brugia malayi	hypothetical protein	0.2381	1	1
Brugia malayi	SH2 domain containing protein	0.1427	0.3311	0.3311
Trypanosoma cruzi	protein kinase, putative	0.0954	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0954	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1427	0.3311	0.3311
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine protein kinase shark	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1427	0.3311	0.3311
Loa Loa (eye worm)	SH2 domain-containing protein	0.1427	0.3311	0.3311
Giardia lamblia	Kinase, NEK	0.0954	0	0.5
Brugia malayi	SH2 domain containing protein	0.1427	0.3311	0.3311
Echinococcus granulosus	growth factor receptor bound protein 2	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2381	1	1
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trypanosoma brucei	protein kinase, putative	0.0954	0	0.5
Brugia malayi	SH2 domain containing protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	SRC-1	0.2381	1	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0954	0	0.5
Echinococcus granulosus	SH2 motif	0.1427	0.3311	0.3311
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2381	1	1
Brugia malayi	Sex muscle abnormal protein 5	0.1427	0.3311	0.3311
Brugia malayi	Protein kinase domain containing protein	0.2381	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0954	0	0.5
Onchocerca volvulus		0.2381	1	1
Echinococcus multilocularis	SH2 motif	0.1427	0.3311	0.3311
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1427	0.3311	0.3311
Echinococcus granulosus	NCK adaptor protein	0.1427	0.3311	0.3311
Echinococcus multilocularis	tensin	0.1427	0.3311	0.3311
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1427	0.3311	0.3311
Schistosoma mansoni	tyrosine kinase	0.2381	1	1
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Leishmania major	hypothetical protein, conserved	0.0954	0	0.5
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1427	0.3311	0.3311
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Schistosoma mansoni	tyrosine kinase	0.2381	1	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Plasmodium vivax	protein kinase, putative	0.0954	0	0.5
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1427	0.3311	0.3311
Schistosoma mansoni	suppressor of cytokine signaling	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Toxoplasma gondii	STE kinase	0.0954	0	0.5
Echinococcus multilocularis	N chimaerin	0.1427	0.3311	0.3311
Schistosoma mansoni	tensin	0.1427	0.3311	0.3311
Plasmodium falciparum	tyrosine kinase-like protein	0.0954	0	0.5
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0954	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0954	0	0.5
Schistosoma mansoni	tyrosine kinase	0.2381	1	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0954	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus granulosus	SH2 motif	0.1427	0.3311	0.3311
Echinococcus multilocularis	SH2 motif	0.1427	0.3311	0.3311
Trichomonas vaginalis	conserved hypothetical protein	0.0954	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2381	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0954	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2381	1	1
Schistosoma mansoni	shc transforming protein	0.1427	0.3311	0.3311
Echinococcus granulosus	tyrosine protein kinase Srms	0.2381	1	1
Brugia malayi	hypothetical protein	0.1427	0.3311	0.3311
Brugia malayi	Variant SH3 domain containing protein	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2381	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2381	1	1
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1427	0.3311	0.3311
Onchocerca volvulus		0.2381	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1427	0.3311	0.3311
Toxoplasma gondii	protein kinase domain-containing protein	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0954	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2381	1	1
Schistosoma mansoni	growth factor receptor-bound protein	0.1427	0.3311	0.3311
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.1427	0.3311	0.3311
Onchocerca volvulus		0.2381	1	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1427	0.3311	0.3311
Echinococcus granulosus	tyrosine kinase	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Brugia malayi	Tensin	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2381	1	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.1427	0.3311	0.3311
Brugia malayi	SH2 domain containing protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	TK protein kinase	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Schistosoma mansoni	nck2/grb4	0.1427	0.3311	0.3311
Onchocerca volvulus		0.1427	0.3311	0.3311
Echinococcus granulosus	tyrosine protein kinase Blk	0.2381	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0954	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Plasmodium falciparum	protein kinase, putative	0.0954	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Schistosoma mansoni	SH2A	0.1427	0.3311	0.3311
Trichomonas vaginalis	conserved hypothetical protein	0.0954	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Giardia lamblia	Kinase	0.0954	0	0.5
Entamoeba histolytica	protein kinase, putative	0.1427	0.3311	0.3311
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0954	0	0.5
Echinococcus granulosus	c src tyrosine kinase	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Onchocerca volvulus		0.1427	0.3311	0.3311
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	STE family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2381	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Onchocerca volvulus		0.1427	0.3311	0.3311
Echinococcus granulosus	N chimaerin	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2381	1	1
Schistosoma mansoni	tyrosine kinase	0.2381	1	1
Brugia malayi	SH2 domain containing protein	0.2381	1	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1427	0.3311	0.3311
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2381	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Brugia malayi	Protein kinase domain containing protein	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2381	1	1
Brugia malayi	SH2 domain containing protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0954	0	0.5
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0954	0	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0954	0	0.5
Echinococcus multilocularis	signal transduction protein lnk realted	0.1427	0.3311	0.3311
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1427	0.3311	0.3311
Onchocerca volvulus		0.1427	0.3311	0.3311
Schistosoma mansoni	signal transduction protein lnk-related	0.1427	0.3311	0.3311
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2381	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Entamoeba histolytica	SH2 domain containing protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2381	1	1
Schistosoma mansoni	tyrosine kinase	0.2381	1	1
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0954	0	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Onchocerca volvulus		0.1427	0.3311	0.3311
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1427	0.3311	0.3311
Trypanosoma brucei	Pseudokinase, putative	0.0954	0	0.5
Plasmodium falciparum	protein kinase, putative	0.0954	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Schistosoma mansoni	tensin	0.1427	0.3311	0.3311
Echinococcus multilocularis	c src tyrosine kinase	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus multilocularis	tensin	0.1427	0.3311	0.3311
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0954	0	0.5
Schistosoma mansoni	tensin-related	0.1427	0.3311	0.3311
Brugia malayi	Tyrosine-protein kinase abl-1	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1427	0.3311	0.3311
Brugia malayi	Protein kinase domain containing protein	0.2381	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Schistosoma mansoni	growth factor receptor-bound protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	hypothetical protein	0.1427	0.3311	0.3311
Schistosoma mansoni	tyrosine kinase	0.2381	1	1
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1427	0.3311	0.3311
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1427	0.3311	0.3311
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1427	0.3311	0.3311
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5
Echinococcus granulosus	SH2 domain containing protein 7	0.1427	0.3311	0.3311
Brugia malayi	SH2 domain containing protein	0.2381	1	1
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0954	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.1427	0.3311	0.3311
Loa Loa (eye worm)	TK/FER protein kinase	0.2381	1	1
Schistosoma mansoni	adapter molecule crk	0.1427	0.3311	0.3311
Echinococcus multilocularis	SHC transforming protein 3	0.1427	0.3311	0.3311
Toxoplasma gondii	protein kinase	0.0954	0	0.5
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2381	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0954	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 24.4 nM	Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate	ChEMBL.	23363058
IC50 (binding)	= 25.2 nM	Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxycorticosterone as substrate	ChEMBL.	23363058
IC50 (binding)	= 837 nM	Inhibition of human placental CYP19 using [1beta-3H]androstenedione as substrate by 3H2O-method	ChEMBL.	23363058
IC50 (binding)	> 5000 nM	Inhibition of human CYP17 expressed in Escherichia coli co-expressing rat NADPH-P450-reductase using progesterone as substrate	ChEMBL.	23363058

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2333332

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1735873