Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0125 | 0.619 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0768 | 0.0699 |
Schistosoma mansoni | glycogen phosphorylase | 0.0054 | 0.2173 | 0.2114 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0125 | 0.619 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0125 | 0.619 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0125 | 0.619 | 0.6161 |
Echinococcus granulosus | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Schistosoma mansoni | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0768 | 0.0699 |
Echinococcus granulosus | tar DNA binding protein | 0.0069 | 0.3001 | 0.2949 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1559 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.215 | 0.3474 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2222 | 0.2164 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0125 | 0.619 | 0.5 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0768 | 0.1241 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0768 | 0.0699 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0074 | 0.012 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1559 | 0.1495 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0768 | 0.1241 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.324 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1559 | 0.2518 |
Loa Loa (eye worm) | TAR-binding protein | 0.0069 | 0.3001 | 0.4848 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.324 | 0.319 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2222 | 0.2164 |
Echinococcus multilocularis | geminin | 0.0192 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0768 | 0.0699 |
Echinococcus granulosus | lamin | 0.0029 | 0.0768 | 0.0699 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.324 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 0.324 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1189 | 0.1921 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0768 | 0.0699 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2222 | 0.2164 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0768 | 0.1241 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1189 | 0.1123 |
Echinococcus granulosus | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.215 | 0.3474 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1559 | 0.1495 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2222 | 0.2164 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.215 | 0.3474 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0069 | 0.3001 | 0.4848 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0768 | 0.1241 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0125 | 0.619 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 0.324 | 0.319 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0125 | 0.619 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0125 | 0.619 | 0.6161 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.1189 | 0.1921 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0768 | 0.1241 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.2222 | 0.359 |
Entamoeba histolytica | glycogenphosphorylase, putative | 0.0054 | 0.2173 | 0.1327 |
Brugia malayi | RNA binding protein | 0.0069 | 0.3001 | 0.4848 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0074 | 0.012 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0073 | 0.324 | 0.319 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0074 | 0.012 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0125 | 0.619 | 1 |
Schistosoma mansoni | lamin | 0.0029 | 0.0768 | 0.0699 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 0.324 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0074 | 0.012 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.2222 | 0.2164 |
Schistosoma mansoni | lamin | 0.0029 | 0.0768 | 0.0699 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.215 | 0.3474 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.2222 | 0.359 |
Loa Loa (eye worm) | RNA binding protein | 0.0069 | 0.3001 | 0.4848 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0738 | 0.1192 |
Brugia malayi | carbohydrate phosphorylase | 0.0125 | 0.619 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0054 | 0.2173 | 0.1327 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 0.324 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0054 | 0.2173 | 0.1327 |
Echinococcus multilocularis | tar DNA binding protein | 0.0069 | 0.3001 | 0.2949 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 0.324 | 0.319 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0125 | 0.619 | 0.6161 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1559 | 0.1495 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0125 | 0.619 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0069 | 0.3001 | 0.4848 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0069 | 0.3001 | 0.4848 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.2222 | 0.2164 |
Schistosoma mansoni | tar DNA-binding protein | 0.0069 | 0.3001 | 0.2949 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0768 | 0.0699 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.2222 | 0.2164 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 0.324 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.19 ug ml-1 | Cytotoxicity against human SW620 cells after 3 days by MTT assay | ChEMBL. | 19456120 |
IC50 (functional) | = 6.8 ug ml-1 | Cytotoxicity against human HepG2 cells after 3 days by MTT assay | ChEMBL. | 19456120 |
IC50 (functional) | > 10 ug ml-1 | Cytotoxicity against human BT474 cells after 3 days by MTT assay | ChEMBL. | 19456120 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19456120 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.