Detailed information for compound 1736518

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 404.91 | Formula: C20H21ClN2O3S
  • H donors: 1 H acceptors: 3 LogP: 3.85 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NC(=O)N1[C@@H]2CC[C@H]1C[C@H](C2)S(=O)(=O)c1ccccc1
  • InChi: 1S/C20H21ClN2O3S/c21-14-6-8-15(9-7-14)22-20(24)23-16-10-11-17(23)13-19(12-16)27(25,26)18-4-2-1-3-5-18/h1-9,16-17,19H,10-13H2,(H,22,24)/t16-,17+,19+
  • InChiKey: LDGUADLRFWCPDN-DZFIZOCASA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ELOVL fatty acid elongase 6 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Trypanosoma cruzi fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Plasmodium yoelii unnamed protein product, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania donovani fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative Get druggable targets OG5_127859 All targets in OG5_127859
Cryptosporidium hominis fatty-acyl elongase Get druggable targets OG5_127859 All targets in OG5_127859
Trypanosoma brucei gambiense fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania major fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania mexicana fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Neospora caninum GNS1/SUR4 family domain-containing protein, putative Get druggable targets OG5_127859 All targets in OG5_127859
Plasmodium berghei long chain fatty acid elongation enzyme, putative Get druggable targets OG5_127859 All targets in OG5_127859
Brugia malayi Fatty acid elongation protein 3 Get druggable targets OG5_127859 All targets in OG5_127859
Trypanosoma cruzi fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania braziliensis fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Candida albicans one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1) Get druggable targets OG5_127859 All targets in OG5_127859
Trypanosoma congolense fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania mexicana fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Trypanosoma cruzi fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Trypanosoma cruzi fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Loa Loa (eye worm) GNS1/SUR4 family protein Get druggable targets OG5_127859 All targets in OG5_127859
Trypanosoma brucei Fatty acid elongase Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania major fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania infantum fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Brugia malayi GNS1/SUR4 family protein Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania infantum fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Toxoplasma gondii GNS1/SUR4 family protein Get druggable targets OG5_127859 All targets in OG5_127859
Candida albicans one of three potential fatty acid elongase genes similar to S. cerevisiae FEN1 (YCR034W), SUR4 (YLR372W) and ELO1 (YJL196C ELO1) Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania donovani fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Cryptosporidium parvum 7 pass integral membrane proteinwith FLHWFHH motif shared with fatty-acyl elongase Get druggable targets OG5_127859 All targets in OG5_127859
Neospora caninum GNS1/SUR4 domain containing protein, related Get druggable targets OG5_127859 All targets in OG5_127859
Loa Loa (eye worm) fatty acid elongation protein 3 Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania donovani fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative Get druggable targets OG5_127859 All targets in OG5_127859
Plasmodium falciparum long chain fatty acid elongation enzyme, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania braziliensis fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania mexicana fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania major fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Plasmodium yoelii 30 kDa glycoprotein Get druggable targets OG5_127859 All targets in OG5_127859
Plasmodium vivax GNS1/SUR4 domain containing protein Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania braziliensis fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
Leishmania infantum fatty acid elongase, putative Get druggable targets OG5_127859 All targets in OG5_127859
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei Fatty acid elongase ELOVL fatty acid elongase 6 265 aa 259 aa 34.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei histone deacetylase 1 0.0346 0.1373 1
Onchocerca volvulus 0.0057 0.019 0.0285
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0026 0.019
Brugia malayi Cytochrome P450 family protein 0.0014 0.0017 0.0026
Brugia malayi Animal haem peroxidase family protein 0.1637 0.6653 1
Echinococcus multilocularis musashi 0.0054 0.018 0.018
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0027 0.004
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0028 0.0201
Echinococcus multilocularis histone deacetylase 3 0.0346 0.1373 0.1373
Plasmodium falciparum long chain fatty acid elongation enzyme, putative 0.005 0.0163 0.1189
Echinococcus granulosus neuropeptide s receptor 0.0939 0.3799 0.571
Onchocerca volvulus 0.0016 0.0026 0.0039
Onchocerca volvulus 0.0016 0.0026 0.0039
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0093 0.0606
Entamoeba histolytica cysteine protease, putative 0.0016 0.0026 0.0163
Echinococcus multilocularis protein jagged 1 0.0324 0.1285 0.1285
Echinococcus granulosus L aminoadipate semialdehyde 0.0163 0.0627 0.0942
Echinococcus multilocularis peroxidasin 0.1637 0.6653 0.6653
Schistosoma mansoni inositol monophosphatase 0.0037 0.0108 0.0162
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0027 0.004
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0115 0.0173
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0034 0.0222
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.018 0.027
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0093 0.0678
Echinococcus multilocularis sex peptide receptor 0.0017 0.0027 0.0027
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0034 0.0136
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.015 0.0225
Loa Loa (eye worm) latrophilin receptor protein 2 0.0063 0.0215 0.0323
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0147 0.1067
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0053
Toxoplasma gondii histone deacetylase HDAC2 0.0346 0.1373 1
Schistosoma mansoni amine GPCR 0.0017 0.0027 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0027 0.004
Brugia malayi N-terminal motif family protein 0.0177 0.0682 0.1024
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) notch protein 0.0324 0.1285 0.1932
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0027 0.0027
Echinococcus granulosus peroxidasin 0.1637 0.6653 1
Schistosoma mansoni ap endonuclease 0.0018 0.0034 0.0051
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0027 0.004
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Schistosoma mansoni neuropeptide receptor 0.0017 0.0027 0.004
Brugia malayi histone deacetylase 11 0.0124 0.0466 0.07
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0147 0.1033
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0027 0.0027
Trypanosoma brucei trypanothione reductase 0.0047 0.015 0.1091
Echinococcus granulosus g protein coupled receptor 0.0017 0.0027 0.004
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0034 0.0249
Brugia malayi CXXC zinc finger family protein 0.0057 0.019 0.0285
Schistosoma mansoni adenoreceptor 0.0017 0.0027 0.004
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0026 0.0039
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0034 0.0222
Brugia malayi AKH receptor 0.0017 0.0027 0.004
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.004
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.015 0.1059
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0025 0.0154
Schistosoma mansoni neuropeptide receptor 0.0017 0.0027 0.004
Brugia malayi larval opioid receptor 0.0017 0.0027 0.004
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0025 0.0181
Loa Loa (eye worm) hypothetical protein 0.009 0.0328 0.0492
Trichomonas vaginalis set domain proteins, putative 0.0235 0.0918 0.6674
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0027 0.004
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0108 0.076
Schistosoma mansoni pyruvate kinase 0.0017 0.0028 0.0042
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0027 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0216 0.157
Schistosoma mansoni hypothetical protein 0.0167 0.0641 0.0964
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0093 0.014
Brugia malayi neuropeptide F receptor 0.0017 0.0027 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) animal heme peroxidase 0.1637 0.6653 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0147 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0027 0.004
Trypanosoma cruzi fatty acid elongase, putative 0.005 0.0163 0.1189
Schistosoma mansoni amine GPCR 0.0017 0.0027 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Brugia malayi G protein-coupled receptor 0.0017 0.0027 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0181
Loa Loa (eye worm) hypothetical protein 0.0054 0.018 0.027
Trichomonas vaginalis histone deacetylase, putative 0.0346 0.1373 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0354 0.1405 0.1405
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0007 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0053
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0027 0.004
Echinococcus multilocularis protein jagged 1 0.0324 0.1285 0.1285
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0035 0.0052
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0108 0.0725
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0073 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0023 0.0052 0.0079
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0346 0.1373 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0108 0.076
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0395 0.3013
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0027 0.0027
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0027 0.004
Schistosoma mansoni notch 0.0325 0.1286 0.1932
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0027 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Plasmodium vivax vivapain-2 0.0016 0.0026 0.019
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0527 0.0792
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0026 0.0039
Echinococcus multilocularis pyruvate kinase 0.0017 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Brugia malayi Serotonin receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0527 0.0792
Schistosoma mansoni intermediate filament proteins 0.0054 0.018 0.027
Brugia malayi Dopamine receptor protein 1 0.0017 0.0027 0.004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0034 0.0222
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0025 0.0154
Trypanosoma cruzi histone deacetylase, putative 0.0124 0.0466 0.3392
Schistosoma mansoni histone deacetylase 1 2 3 0.0124 0.0466 0.07
Echinococcus granulosus pyruvate kinase 0.0017 0.0028 0.0042
Onchocerca volvulus 0.0017 0.0027 0.004
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0025 0.0181
Echinococcus multilocularis serotonin receptor 0.0017 0.0027 0.0027
Onchocerca volvulus Neurogenic locus notch homolog 0.0325 0.1286 0.1932
Leishmania major histone deacetylase, putative 0.0124 0.0466 0.3392
Brugia malayi glutathione reductase 0.0047 0.015 0.0225
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0027 0.004
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0193 0.1408
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0027 0.004
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0027 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.02 0.0301
Echinococcus multilocularis histone deacetylase 6 0.0124 0.0466 0.0466
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0027 0.0027
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0181
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0027 0.0027
Echinococcus multilocularis histone deacetylase 7 0.0124 0.0466 0.0466
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0039
Plasmodium falciparum thioredoxin reductase 0.0016 0.0025 0.0181
Schistosoma mansoni hypothetical protein 0.0324 0.1285 0.1932
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0346 0.1373 1
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0052 0.0355
Echinococcus multilocularis cysteine protease 0.0016 0.0026 0.0026
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0038 0.0115 0.0173
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0163
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Echinococcus granulosus death domain containing protein 0.0014 0.0017 0.0025
Echinococcus multilocularis neurogenic locus notch protein 0.0324 0.1285 0.1285
Schistosoma mansoni neuropeptide receptor 0.0017 0.0027 0.004
Brugia malayi Animal haem peroxidase family protein 0.1637 0.6653 1
Brugia malayi Thioredoxin reductase 0.0047 0.015 0.0225
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Plasmodium falciparum glutathione reductase 0.0016 0.0025 0.0181
Echinococcus granulosus microtubule associated protein 2 0.1356 0.5503 0.8271
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0053
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0093 0.0678
Onchocerca volvulus 0.0324 0.1285 0.1932
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0027 0.0027
Onchocerca volvulus 0.0011 0.0004 0.0006
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0027 0.004
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0021 0.0031
Echinococcus multilocularis RUN 0.0059 0.02 0.02
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0025 0.0181
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0108 0.0786
Brugia malayi Blistered cuticle protein 3 0.1637 0.6653 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0034 0.0034
Onchocerca volvulus 0.1637 0.6653 1
Onchocerca volvulus 0.0163 0.0627 0.0942
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0026 0.0039
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0027 0.0027
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0163 0.0627 0.0942
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0026 0.0163
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0017 0.0025
Echinococcus multilocularis histone deacetylase 1 0.0346 0.1373 0.1373
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Toxoplasma gondii integral membrane protein, GNS1/SUR4 family protein, putative 0.005 0.0163 0.1189
Toxoplasma gondii histone deacetylase HDAC4 0.0124 0.0466 0.3392
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni pyruvate kinase 0.0033 0.0093 0.014
Brugia malayi Calcitonin receptor-like protein seb-1 0.0198 0.0769 0.1156
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0027 0.004
Schistosoma mansoni hypothetical protein 0.0324 0.1285 0.1932
Echinococcus multilocularis slit 2 protein 0.0324 0.1285 0.1285
Brugia malayi Cytochrome P450 family protein 0.0023 0.0052 0.0079
Loa Loa (eye worm) cytochrome P450 0.0014 0.0017 0.0026
Leishmania major cathepsin L-like protease 0.0063 0.0216 0.157
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0006
Echinococcus granulosus pyruvate kinase 0.0033 0.0093 0.014
Echinococcus multilocularis lamin dm0 0.0054 0.018 0.018
Schistosoma mansoni amine GPCR 0.0017 0.0027 0.004
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0052 0.0079
Brugia malayi hypothetical protein 0.0059 0.02 0.0301
Brugia malayi Cadherin domain containing protein 0.0324 0.1285 0.1932
Trichomonas vaginalis histone deacetylase, putative 0.0346 0.1373 1
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0034 0.0051
Schistosoma mansoni cpg binding protein 0.0057 0.019 0.0285
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0065 0.0098
Schistosoma mansoni lamin 0.0054 0.018 0.027
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Schistosoma mansoni rab6-interacting 0.0059 0.02 0.0301
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0053
Echinococcus granulosus g protein coupled receptor 0.0017 0.0027 0.004
Trypanosoma cruzi fatty acid elongase, putative 0.005 0.0163 0.1189
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.004
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0039
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Giardia lamblia Pyruvate kinase 0.0033 0.0093 0.0505
Echinococcus multilocularis pyruvate kinase 0.0026 0.0065 0.0065
Echinococcus multilocularis pyruvate kinase 0.0017 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0025 0.0181
Echinococcus multilocularis histone deacetylase 6 0.0124 0.0466 0.0466
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0026 0.0039
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0395 0.3013
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0108 0.076
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0053
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0147 0.1067
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0163
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.019
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0053
Echinococcus multilocularis L aminoadipate semialdehyde 0.0163 0.0627 0.0627
Brugia malayi EGF-like domain containing protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0094 0.0141
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Schistosoma mansoni hypothetical protein 0.0324 0.1285 0.1932
Onchocerca volvulus 0.0017 0.0027 0.004
Onchocerca volvulus 0.0017 0.0027 0.004
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0084 0.0084
Brugia malayi Fatty acid elongation protein 3 0.005 0.0163 0.0245
Schistosoma mansoni hypothetical protein 0.0324 0.1285 0.1932
Schistosoma mansoni hypothetical protein 0.0403 0.1606 0.2414
Echinococcus granulosus nuclear factor of activated T cells 5 0.0073 0.0255 0.0384
Echinococcus granulosus protein jagged 1 0.0324 0.1285 0.1932
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0163 0.0627 0.0942
Loa Loa (eye worm) inositol-1 0.0037 0.0108 0.0162
Brugia malayi Animal haem peroxidase family protein 0.1637 0.6653 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0443 0.3401
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0027 0.004
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0027 0.004
Onchocerca volvulus 0.0017 0.0027 0.004
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0321 0.127 0.9247
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0027 0.004
Schistosoma mansoni histone deacetylase 0.0346 0.1373 0.2064
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0034 0.0051
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0027 0.0027
Plasmodium falciparum glutathione reductase 0.0047 0.015 0.1091
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0527 0.0792
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0053
Echinococcus granulosus protein jagged 2 0.0324 0.1285 0.1932
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0027 0.0027
Echinococcus granulosus histone deacetylase 3 0.0346 0.1373 0.2064
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0025 0.0181
Brugia malayi Doublecortin family protein 0.0059 0.02 0.0301
Echinococcus granulosus neuropeptide receptor A26 0.0939 0.3799 0.571
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Brugia malayi EGF-like domain containing protein 0.0324 0.1285 0.1932
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0017 0.0125
Schistosoma mansoni histone deacetylase 4 5 0.0124 0.0466 0.07
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0093 0.014
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0163 0.0627 0.0942
Brugia malayi Serotonin receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0527 0.0792
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0021 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0053
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0027 0.0027
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0027 0.004
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0026 0.0039
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0027 0.004
Loa Loa (eye worm) doublecortin family protein 0.0059 0.02 0.0301
Leishmania major cytochrome p450-like protein 0.0014 0.0017 0.0125
Schistosoma mansoni myosin xvIII 0.0017 0.0027 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0027 0.004
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0035 0.0035
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0027 0.004
Trypanosoma brucei histone deacetylase 3 0.0124 0.0466 0.3392
Schistosoma mansoni inositol monophosphatase 0.0037 0.0108 0.0162
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0147 1
Echinococcus multilocularis cpg binding protein 0.006 0.0203 0.0203
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0004 0.0006
Onchocerca volvulus 0.0059 0.02 0.0301
Onchocerca volvulus 0.0054 0.018 0.027
Brugia malayi EGF-like domain containing protein 0.0324 0.1285 0.1932
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0027 0.0027
Onchocerca volvulus 0.0017 0.0027 0.004
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0017 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0527 0.0792
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.004
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0063 0.0215 0.0323
Brugia malayi notch-like transmembrane receptor 0.0324 0.1285 0.1932
Schistosoma mansoni histone deacetylase hda2 0.0124 0.0466 0.07
Onchocerca volvulus 0.0017 0.0027 0.004
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.0813
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0147 0.1067
Trypanosoma cruzi histone deacetylase, putative 0.0124 0.0466 0.3392
Brugia malayi Muscle positioning protein 4 0.0324 0.1285 0.1932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Trypanosoma cruzi histone deacetylase 1, putative 0.0346 0.1373 1
Plasmodium falciparum fatty acid elongation protein, GNS1/SUR4 family, putative 0.005 0.0163 0.1189
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni microtubule-associated protein tau 0.1356 0.5503 0.8271
Echinococcus granulosus neuropeptide receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0346 0.1373 0.2064
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0181
Leishmania major histone deacetylase, putative 0.0124 0.0466 0.3392
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0026 0.0163
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0027 0.004
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.0682 0.1024
Onchocerca volvulus 0.0324 0.1285 0.1932
Entamoeba histolytica histone deacetylase, putative 0.0346 0.1373 1
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0216 0.157
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0075 0.0112
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0147 1
Brugia malayi latrophilin 2 splice variant baaae 0.0136 0.0513 0.0771
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0027 0.004
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0052 0.0282
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0053
Onchocerca volvulus 0.0017 0.0027 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0026 0.0163
Trichomonas vaginalis histone deacetylase, putative 0.0346 0.1373 1
Echinococcus granulosus cpg binding protein 0.006 0.0203 0.0305
Loa Loa (eye worm) hypothetical protein 0.0025 0.0061 0.0092
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0025 0.0181
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0017 0.0025
Onchocerca volvulus Phospholipase A2 homolog 0.009 0.0328 0.0492
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0027 0.0027
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Leishmania major fatty acid elongase, putative 0.005 0.0163 0.1189
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0026 0.0039
Plasmodium falciparum histone deacetylase 1 0.0346 0.1373 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0027 0.004
Echinococcus granulosus neurogenic locus protein delta 0.0324 0.1285 0.1932
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0093 0.0606
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0027 0.0027
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0108 0.076
Echinococcus granulosus fmrfamide receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0026 0.0039
Onchocerca volvulus 0.0017 0.0027 0.004
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0027 0.004
Schistosoma mansoni opsin-like receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.0802 0.1206
Onchocerca volvulus 0.1637 0.6653 1
Leishmania major histone deacetylase, putative 0.0346 0.1373 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0027 0.004
Schistosoma mansoni lipoxygenase 0.0354 0.1405 0.2112
Brugia malayi Animal haem peroxidase family protein 0.1637 0.6653 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0028 0.0042
Schistosoma mansoni lipoxygenase 0.0247 0.097 0.1458
Echinococcus granulosus histone deacetylase 1 0.0346 0.1373 0.2064
Echinococcus granulosus hypothetical protein 0.0017 0.0027 0.004
Echinococcus granulosus delta-like protein 1 0.0324 0.1285 0.1932
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0092 0.06
Brugia malayi G-protein coupled receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0025
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0027 0.004
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0026 0.019
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0077 0.0116
Echinococcus granulosus notch 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0093 0.0651
Onchocerca volvulus Slit protein homolog 0.0324 0.1285 0.1932
Echinococcus multilocularis 0.0014 0.0017 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0084 0.0126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0084 0.0126
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Echinococcus multilocularis neurogenic locus notch protein 0.0324 0.1285 0.1285
Schistosoma mansoni hypothetical protein 0.0059 0.02 0.0301
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0084 0.0084
Plasmodium vivax glutathione reductase, putative 0.0047 0.015 0.1091
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0034 0.0766
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0063 0.0215 0.0323
Schistosoma mansoni septate junction protein 0.0324 0.1285 0.1932
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.015 0.1091
Brugia malayi Cathepsin L-like precursor 0.0011 0.0004 0.0006
Leishmania major cytochrome p450-like protein 0.0014 0.0017 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0181
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0026 0.019
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0027 0.004
Brugia malayi EGF-like domain containing protein 0.0324 0.1285 0.1932
Schistosoma mansoni cytochrome P450 0.0014 0.0017 0.0026
Onchocerca volvulus 0.0016 0.0026 0.0039
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0021 0.0031
Brugia malayi histone deacetylase 1 (HD1) 0.0346 0.1373 0.2064
Loa Loa (eye worm) histone deacetylase 1 0.0346 0.1373 0.2064
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0443 0.3401
Trichomonas vaginalis histone deacetylase, putative 0.0346 0.1373 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0025 0.0037
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0027 0.0027
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0028 0.0201
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0147 0.3036
Loa Loa (eye worm) hypothetical protein 0.0136 0.0513 0.0771
Loa Loa (eye worm) hypothetical protein 0.0053 0.0176 0.0264
Plasmodium vivax histone deacetylase 1, putative 0.0346 0.1373 1
Plasmodium falciparum thioredoxin reductase 0.0047 0.015 0.1091
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0027 0.004
Echinococcus granulosus slit 2 protein 0.0324 0.1285 0.1932
Brugia malayi Inositol-1 0.0037 0.0108 0.0162
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0006
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Brugia malayi Dopamine receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0093 0.014
Onchocerca volvulus Dual oxidase homolog 0.1637 0.6653 1
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0027 0.004
Brugia malayi Calcium binding EGF domain containing protein 0.0324 0.1285 0.1932
Echinococcus granulosus somatostatin receptor 0.0017 0.0027 0.004
Giardia lamblia High cysteine protein 0.0324 0.1285 0.9345
Leishmania major fatty acid elongase, putative 0.005 0.0163 0.1189
Loa Loa (eye worm) animal heme peroxidase 0.1637 0.6653 1
Plasmodium falciparum histone deacetylase, putative 0.0124 0.0466 0.3392
Plasmodium falciparum pyruvate kinase 0.0033 0.0093 0.0678
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0084 0.0126
Echinococcus granulosus histone deacetylase 6 0.0124 0.0466 0.07
Echinococcus multilocularis histone deacetylase 0.0124 0.0466 0.0466
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0025 0.0181
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0027 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Trypanosoma brucei histone deacetylase 4 0.0124 0.0466 0.3392
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0027 0.004
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.0026
Brugia malayi Animal haem peroxidase family protein 0.1637 0.6653 1
Brugia malayi EGF-like domain containing protein 0.0324 0.1285 0.1932
Schistosoma mansoni hypothetical protein 0.0167 0.0641 0.0964
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Plasmodium vivax histone deacetylase 2, putative 0.0124 0.0466 0.3392
Plasmodium falciparum LCCL domain-containing protein 0.0059 0.02 0.146
Entamoeba histolytica hypothetical protein 0.0046 0.0147 0.1042
Schistosoma mansoni slit 0.0324 0.1285 0.1932
Schistosoma mansoni opsin-like receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) histone deacetylase 11 0.0124 0.0466 0.07
Schistosoma mansoni hypothetical protein 0.0063 0.0215 0.0323
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0027 0.004
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0321 0.127 1
Echinococcus multilocularis GPCR, family 2 0.0063 0.0215 0.0215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0063 0.0215 0.0215
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0027 0.004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0181
Schistosoma mansoni polycystin 1-related 0.0059 0.02 0.0301
Onchocerca volvulus 0.0017 0.0027 0.004
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0027 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0163
Echinococcus multilocularis Ankyrin 0.0014 0.0017 0.0017
Plasmodium vivax histone deacetylase, putative 0.0124 0.0466 0.3392
Echinococcus granulosus GPCR family 2 0.0063 0.0215 0.0323
Onchocerca volvulus 0.0017 0.0027 0.004
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0027 0.004
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0027 0.0027
Echinococcus multilocularis neurogenic locus protein delta 0.0324 0.1285 0.1285
Toxoplasma gondii EGF family domain-containing protein 0.0324 0.1285 0.9357
Loa Loa (eye worm) hypothetical protein 0.0033 0.0093 0.014
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0108 0.0786
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Onchocerca volvulus Peroxidasin homolog 0.1637 0.6653 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Plasmodium vivax histone deacetylase, putative 0.0124 0.0466 0.3392
Giardia lamblia Pyruvate kinase 0.0017 0.0028 0.002
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0027 0.004
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0025 0.0062
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0163
Brugia malayi cytochrome P450 0.0014 0.0017 0.0026
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0006
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0147 0.1067
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0017 0.0125
Brugia malayi Pre-SET motif family protein 0.0031 0.0084 0.0126
Schistosoma mansoni laminin gamma-3 chain 0.0324 0.1285 0.1932
Echinococcus granulosus geminin 0.0167 0.0641 0.0964
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0027 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0027 0.004
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0321 0.127 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0026 0.0039
Schistosoma mansoni histamine h1 receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) histone deacetylase 3 0.0346 0.1373 0.2064
Schistosoma mansoni hypothetical protein 0.0136 0.0513 0.0771
Onchocerca volvulus 0.0016 0.0026 0.0039
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0017 0.0025
Leishmania major pyruvate kinase 0.0033 0.0093 0.0678
Schistosoma mansoni lamin 0.0054 0.018 0.027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0163
Schistosoma mansoni hypothetical protein 0.0063 0.0215 0.0323
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0093 0.014
Echinococcus multilocularis somatostatin receptor 0.0017 0.0027 0.0027
Schistosoma mansoni peroxidasin 0.1637 0.6653 1
Echinococcus granulosus RUN 0.0059 0.02 0.0301
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0027 0.0027
Onchocerca volvulus 0.0324 0.1285 0.1932
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.0813
Loa Loa (eye worm) animal heme peroxidase 0.1637 0.6653 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0027 0.004
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0063 0.0215 0.0323
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0027 0.0027
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni pyruvate kinase 0.0033 0.0093 0.014
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0093 0.014
Brugia malayi Cadherin domain containing protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0527 0.0792
Leishmania major cathepsin L-like protease 0.0016 0.0026 0.019
Schistosoma mansoni loxhd1 0.0059 0.02 0.0301
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0443 1
Echinococcus granulosus protein jagged 1 0.0324 0.1285 0.1932
Onchocerca volvulus Histone deacetylase 10 homolog 0.0124 0.0466 0.07
Toxoplasma gondii histone deacetylase HDAC1 0.0124 0.0466 0.3392
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0065 0.0065
Onchocerca volvulus Peroxidase homolog 0.1637 0.6653 1
Leishmania major fatty acid elongase, putative 0.005 0.0163 0.1189
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.02 0.02
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0027 0.004
Schistosoma mansoni netrin receptor unc5 0.0014 0.0017 0.0025
Echinococcus granulosus protein jagged 2 0.0324 0.1285 0.1932
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0115 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0321 0.127 0.9247
Schistosoma mansoni amine GPCR 0.0017 0.0027 0.004
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0052 0.0382
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0093 0.1781
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0027 0.004
Plasmodium vivax multidomain scavenger receptor, putative 0.0059 0.02 0.146
Loa Loa (eye worm) animal heme peroxidase 0.1637 0.6653 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0034 0.0136
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Onchocerca volvulus 0.0059 0.02 0.0301
Onchocerca volvulus 0.0324 0.1285 0.1932
Schistosoma mansoni hypothetical protein 0.0324 0.1285 0.1932
Echinococcus multilocularis neuropeptide s receptor 0.0939 0.3799 0.3799
Brugia malayi Protein kinase domain containing protein 0.0014 0.0017 0.0025
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0027 0.004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0181
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0453 0.0681
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0395 0.3013
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0026 0.0026
Schistosoma mansoni histone deacetylase hda2 0.0124 0.0466 0.07
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Echinococcus granulosus histone deacetylase 6 0.0124 0.0466 0.07
Brugia malayi Histone deacetylase 1 0.0346 0.1373 0.2064
Brugia malayi Calcium binding EGF domain containing protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) intermediate filament protein 0.0054 0.018 0.027
Toxoplasma gondii histone deacetylase HDAC5 0.0124 0.0466 0.3396
Echinococcus multilocularis neuropeptide receptor A26 0.0939 0.3799 0.3799
Onchocerca volvulus 0.0016 0.0026 0.0039
Trichomonas vaginalis helicase, putative 0.0013 0.0011 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Brugia malayi hypothetical protein 0.0038 0.0115 0.0173
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0017 0.0026
Giardia lamblia Histone deacetylase 0.0346 0.1373 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0034 0.0249
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0093 0.0678
Brugia malayi Cytochrome P450 family protein 0.0023 0.0052 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0037
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0027 0.004
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0025 0.0062
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.0813
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Onchocerca volvulus 0.0054 0.018 0.027
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0014 0.0017 0.0025
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0115 0.0173
Loa Loa (eye worm) histone deacetylase 0.0124 0.0466 0.07
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0027 0.004
Echinococcus granulosus neurogenic locus notch protein 4 0.0324 0.1285 0.1932
Onchocerca volvulus 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Schistosoma mansoni cpg binding protein 0.006 0.0203 0.0305
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0026
Toxoplasma gondii GNS1/SUR4 family protein 0.005 0.0163 0.1189
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0025 0.0181
Echinococcus multilocularis serotonin receptor 0.0017 0.0027 0.0027
Loa Loa (eye worm) blistered cuticle protein 3 0.1637 0.6653 1
Echinococcus granulosus cathepsin l1 0.0016 0.0026 0.0039
Onchocerca volvulus 0.0017 0.0027 0.004
Brugia malayi Pre-SET motif family protein 0.0206 0.0802 0.1206
Onchocerca volvulus 0.0235 0.0918 0.138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0026 0.0039
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Echinococcus granulosus pyruvate kinase 0.0033 0.0093 0.014
Trypanosoma cruzi histone deacetylase, putative 0.0124 0.0466 0.3392
Loa Loa (eye worm) hypothetical protein 0.0059 0.02 0.0301
Echinococcus granulosus lamin 0.0054 0.018 0.027
Trichomonas vaginalis histone deacetylase, putative 0.0346 0.1373 1
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0027 0.0027
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0039
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0034 0.0249
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0527 0.0527
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Onchocerca volvulus Putative cubilin 0.0324 0.1285 0.1932
Brugia malayi RE15519p 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Brugia malayi Dopamine receptor protein 2 0.0017 0.0027 0.004
Echinococcus granulosus lamin dm0 0.0054 0.018 0.027
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0037
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0108 0.0162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0198 0.0769 0.1156
Onchocerca volvulus 0.1637 0.6653 1
Schistosoma mansoni hypothetical protein 0.0063 0.0215 0.0323
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0027 0.004
Brugia malayi putative neuropeptide receptor 0.0017 0.0027 0.004
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0027 0.004
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0027 0.004
Brugia malayi intermediate filament protein 0.0054 0.018 0.027
Brugia malayi histone deacetylase 3 (HD3) 0.0346 0.1373 0.2064
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0034 0.0249
Mycobacterium tuberculosis Probable reductase 0.0107 0.0395 0.3013
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0027 0.004
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0395 0.3013
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0027 0.004
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0028 0.0201
Brugia malayi GnHR receptor homolog 0.0017 0.0027 0.004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0084 0.0612
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Brugia malayi Delta serrate ligand family protein 0.0324 0.1285 0.1932
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0039
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0346 0.1373 1
Trypanosoma brucei histone deacetylase, putative 0.0124 0.0466 0.3392
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0026 0.0163
Schistosoma mansoni amine GPCR 0.0017 0.0027 0.004
Brugia malayi neuropeptide F receptor 0.0017 0.0027 0.004
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0216 0.157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0527 0.0527
Trypanosoma cruzi fatty acid elongase, putative 0.005 0.0163 0.1189
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0026 0.0039
Echinococcus multilocularis microtubule associated protein 2 0.1356 0.5503 0.5503
Onchocerca volvulus 0.0017 0.0027 0.004
Echinococcus granulosus neurogenic locus notch protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.0177 0.0682 0.1024
Onchocerca volvulus Peroxidase homolog 0.1637 0.6653 1
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0052 0.0382
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0021 0.0021
Echinococcus multilocularis neural cadherin 0.0324 0.1285 0.1285
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0108 0.0786
Echinococcus granulosus fibropellin Ia 0.0324 0.1285 0.1932
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0027 0.0027
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0025 0.0062
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0027 0.0027
Brugia malayi cathepsin L-like precursor 0.0011 0.0004 0.0006
Brugia malayi Latrophilin receptor protein 2 0.0063 0.0215 0.0323
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0027 0.004
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0025 0.0181
Loa Loa (eye worm) GNS1/SUR4 family protein 0.005 0.0163 0.0245
Trypanosoma cruzi histone deacetylase, putative 0.0124 0.0466 0.3392
Echinococcus multilocularis lamin 0.0054 0.018 0.018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0163
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0025 0.0181
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0007 0.0011
Schistosoma mansoni rab6-interacting 0.0059 0.02 0.0301
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0181
Trypanosoma brucei histone deacetylase 2 0.0124 0.0466 0.3392
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0027 0.004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0063 0.0215 0.0215
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0181
Echinococcus multilocularis histone deacetylase 6 0.0124 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0027 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0147 0.1067
Echinococcus multilocularis cysteine protease 0.0016 0.0026 0.0026
Loa Loa (eye worm) Notch2 0.0324 0.1285 0.1932
Schistosoma mansoni histone deacetylase 4 5 0.0124 0.0466 0.07
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.1606 0.1606
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0027 0.0027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0034 0.0249
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0443 0.3401
Onchocerca volvulus 0.0016 0.0026 0.0039
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0027 0.004
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0027 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0027 0.0027
Echinococcus granulosus neurogenic locus notch protein 0.0324 0.1285 0.1932
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0052 0.0382
Schistosoma mansoni ap endonuclease 0.0018 0.0034 0.0051
Loa Loa (eye worm) hypothetical protein 0.0014 0.0017 0.0025
Brugia malayi Melatonin receptor type 1A 0.0017 0.0027 0.004
Schistosoma mansoni notch 0.0324 0.1285 0.1932
Toxoplasma gondii thioredoxin reductase 0.0047 0.015 0.1091
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0039
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0027 0.0027
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0027 0.004
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0324 0.1285 0.1932
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0027 0.0027
Echinococcus granulosus neuropeptide receptor 0.0017 0.0027 0.004
Brugia malayi sulfakinin receptor protein 0.0017 0.0027 0.004
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0027 0.0027
Schistosoma mansoni cell polarity protein 0.0324 0.1285 0.1932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Plasmodium vivax vivapain-2 0.0016 0.0026 0.019
Plasmodium vivax GNS1/SUR4 domain containing protein 0.005 0.0163 0.1189
Echinococcus granulosus histone deacetylase 7 0.0124 0.0466 0.07
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0025 0.0181
Echinococcus granulosus Polycystic kidney disease protein 0.0059 0.02 0.0301
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0021 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0084 0.0126
Loa Loa (eye worm) ctsf protein 0.0016 0.0026 0.0039
Onchocerca volvulus Peroxidasin homolog 0.1637 0.6653 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0161 0.117
Brugia malayi Death domain containing protein 0.0014 0.0017 0.0025
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0034 0.0051
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0052 0.0079
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0093 0.0678
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0027 0.004
Toxoplasma gondii histone deacetylase HDAC3 0.0346 0.1373 1
Onchocerca volvulus 0.0031 0.0084 0.0126
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0027 0.004
Toxoplasma gondii cathepsin CPL 0.0016 0.0026 0.019
Brugia malayi hypothetical protein 0.1637 0.6653 1
Trypanosoma cruzi histone deacetylase 1, putative 0.0346 0.1373 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0147 0.1033
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.015 0.0225
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0126
Schistosoma mansoni biogenic amine receptor 0.0017 0.0027 0.004
Trypanosoma cruzi histone deacetylase, putative 0.0124 0.0466 0.3392
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0027 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0163
Brugia malayi hypothetical protein 0.0059 0.02 0.0301
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0027 0.004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0354 0.1405 0.2112
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0027 0.004
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.018 0.027
Schistosoma mansoni biogenic amine receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.019 0.0285
Toxoplasma gondii histone lysine methyltransferase SET1 0.0108 0.0401 0.2919
Brugia malayi Uncoordinated protein 44 0.0014 0.0017 0.0025
Brugia malayi hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni notch 0.0324 0.1285 0.1932
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0034 0.0249
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0034 0.0766
Toxoplasma gondii exonuclease III APE 0.0018 0.0034 0.0249
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0025 0.0181
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0027 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0011 0.0053
Onchocerca volvulus 0.0017 0.0027 0.004
Onchocerca volvulus Phospholipase A2 homolog 0.009 0.0328 0.0492
Echinococcus granulosus pyruvate kinase 0.0017 0.0028 0.0042
Echinococcus granulosus dnaJ subfamily B 0.0403 0.1606 0.2414
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0017 0.0025
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0093 0.014
Echinococcus granulosus orexin receptor type 2 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0027 0.004
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.015 0.1091
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Loa Loa (eye worm) fatty acid elongation protein 3 0.005 0.0163 0.0245
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0034 0.0069
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0027 0.004
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0027 0.0027
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0011 0.0053
Leishmania major cytochrome p450-like protein 0.0023 0.0052 0.0382
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0027 0.0027
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.004
Plasmodium falciparum histone deacetylase 2 0.0124 0.0466 0.3392
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0108 0.0786
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0181
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0084 0.0126
Brugia malayi Cathepsin L-like precursor 0.0016 0.0026 0.0039
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0147 0.1033
Loa Loa (eye worm) hypothetical protein 0.0025 0.0061 0.0092
Echinococcus multilocularis pyruvate kinase 0.0017 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Echinococcus granulosus lipoxygenase domain containing protein 0.0059 0.02 0.0301
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Echinococcus granulosus histone deacetylase 8 0.0124 0.0466 0.07
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Onchocerca volvulus 0.0324 0.1285 0.1932
Brugia malayi GNS1/SUR4 family protein 0.005 0.0163 0.0245
Echinococcus multilocularis neurogenic locus protein delta 0.0324 0.1285 0.1285
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0093 0.014
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0093 0.014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0027 0.004
Schistosoma mansoni notch 0.0324 0.1285 0.1932
Brugia malayi G-protein coupled receptor 0.0017 0.0027 0.004
Trypanosoma cruzi fatty acid elongase, putative 0.005 0.0163 0.1189
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0093 0.0651
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0027 0.0027
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0026 0.019
Echinococcus granulosus histone deacetylase 6 0.0124 0.0466 0.07
Echinococcus granulosus neural cadherin 0.0324 0.1285 0.1932
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Schistosoma mansoni neuropeptide receptor 0.0017 0.0027 0.004
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0065 0.0098
Schistosoma mansoni hypothetical protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0026 0.0163
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0025 0.0181
Brugia malayi Histone deacetylase family protein 0.0124 0.0466 0.07
Schistosoma mansoni hypothetical protein 0.0324 0.1285 0.1932
Schistosoma mansoni biogenic amine receptor 0.0017 0.0027 0.004
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0093 0.0678
Echinococcus granulosus Ankyrin 0.0014 0.0017 0.0026
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0027 0.0027
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0108 0.0108
Loa Loa (eye worm) hypothetical protein 0.009 0.0328 0.0492
Echinococcus multilocularis notch 0.0324 0.1285 0.1285
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0324 0.1285 0.1932
Schistosoma mansoni cpg binding protein 0.006 0.0203 0.0305
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0027 0.004
Schistosoma mansoni notch 0.0324 0.1285 0.1932
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0124 0.0466 0.07
Echinococcus multilocularis geminin 0.0167 0.0641 0.0641
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0017 0.0017
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0027 0.004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0216 0.157
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) glutathione reductase 0.0047 0.015 0.0225
Loa Loa (eye worm) fibroinase 0.0016 0.0026 0.0039
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0216 0.157
Loa Loa (eye worm) hypothetical protein 0.0198 0.0769 0.1156
Onchocerca volvulus 0.0017 0.0027 0.004
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0027 0.0027
Onchocerca volvulus Chorion peroxidase homolog 0.1637 0.6653 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Entamoeba histolytica hypothetical protein 0.0038 0.0115 0.0813
Echinococcus multilocularis histone deacetylase 8 0.0124 0.0466 0.0466
Loa Loa (eye worm) cysteine protease 0.0016 0.0026 0.0039
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0026 0.0026
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.015 0.015
Echinococcus granulosus allatostatin A receptor 0.0017 0.0027 0.004
Echinococcus granulosus intermediate filament protein 0.0054 0.018 0.027
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0027 0.004
Trichomonas vaginalis histone deacetylase, putative 0.0346 0.1373 1
Echinococcus multilocularis fat cadherin tumor suppressor 0.0324 0.1285 0.1285
Brugia malayi EGF-like domain containing protein 0.0324 0.1285 0.1932
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0017 0.0017
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0017 0.0026
Chlamydia trachomatis pyruvate kinase 0.0033 0.0093 0.5603
Echinococcus granulosus g protein coupled receptor 0.0017 0.0027 0.004
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0108 0.0786
Echinococcus multilocularis fibropellin Ia 0.0324 0.1285 0.1285
Schistosoma mansoni notch 0.0324 0.1285 0.1932
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0321 0.127 0.9247
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0026 0.0026
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0063 0.0215 0.0323
Schistosoma mansoni peroxidasin 0.1637 0.6653 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0026 0.0163
Echinococcus multilocularis lipoxygenase domain containing protein 0.0059 0.02 0.02
Brugia malayi Calcium binding EGF domain containing protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0395 0.3013
Loa Loa (eye worm) hypothetical protein 0.0059 0.02 0.0301
Leishmania major histone deacetylase, putative 0.0346 0.1373 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0059 0.02 0.02
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0395 0.8858
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Brugia malayi EGF-like domain containing protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Brugia malayi Histone deacetylase family protein 0.0124 0.0466 0.07
Echinococcus multilocularis protein jagged 2 0.0324 0.1285 0.1285
Schistosoma mansoni histone deacetylase 0.0346 0.1373 0.2064
Leishmania major cathepsin L-like protease 0.0063 0.0216 0.157
Brugia malayi ORL1-like opioid receptor 0.0017 0.0027 0.004
Schistosoma mansoni opsin-like receptor 0.0017 0.0027 0.004
Echinococcus granulosus cathepsin l1 0.0011 0.0004 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0034 0.0051
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0052 0.0079
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0026 0.0039
Echinococcus granulosus sex peptide receptor 0.0017 0.0027 0.004
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0092 0.1764
Leishmania major cathepsin L-like protease 0.0063 0.0216 0.157
Echinococcus multilocularis neurogenic locus notch protein 4 0.0324 0.1285 0.1285
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0035 0.0052
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0027 0.004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.0053
Echinococcus granulosus histone deacetylase 0.0124 0.0466 0.07
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0108 0.6829
Onchocerca volvulus 0.0016 0.0026 0.0039
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0027 0.004
Echinococcus multilocularis pyruvate kinase 0.0033 0.0093 0.0093
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0321 0.127 0.9247
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0017 0.0025
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0052 0.0079
Schistosoma mansoni hypothetical protein 0.0063 0.0215 0.0323
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0011 0.0004 0.0006
Brugia malayi Peroxidasin 0.1637 0.6653 1
Onchocerca volvulus 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) histone deacetylase 7A 0.0124 0.0466 0.07
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Trypanosoma brucei Fatty acid elongase 0.005 0.0163 0.1189
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0025 0.0181
Plasmodium vivax SET domain protein, putative 0.0031 0.0084 0.0612
Brugia malayi Cytochrome P450 family protein 0.0033 0.0094 0.0141
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0026 0.019
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932
Echinococcus multilocularis pyruvate kinase 0.0033 0.0093 0.0093
Brugia malayi GCC2 and GCC3 family protein 0.0324 0.1285 0.1932
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Brugia malayi Phospholipase A2 family protein 0.009 0.0328 0.0492
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0025 0.0062
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0027 0.004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0527 0.0792
Leishmania major pyruvate kinase 0.0033 0.0093 0.0678
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0147 0.1067
Leishmania major trypanothione reductase 0.0047 0.015 0.1091
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0027 0.0027
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0093 0.0678
Loa Loa (eye worm) hypothetical protein 0.1637 0.6653 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0198 0.0769 0.1156
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0027 0.0027
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0011 0.0053
Onchocerca volvulus 0.0017 0.0027 0.004
Echinococcus granulosus serotonin receptor 0.0017 0.0027 0.004
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0077 0.0116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.004
Loa Loa (eye worm) hypothetical protein 0.0324 0.1285 0.1932

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 970 nM Inhibition of human ELOVL6 expressed in Pichia pastoris SND1168 ChEMBL. 19522500

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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