Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ELOVL fatty acid elongase 6 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | Fatty acid elongase | ELOVL fatty acid elongase 6 | 265 aa | 259 aa | 34.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hexokinase 2 | 0.086 | 1 | 0.5 |
Echinococcus granulosus | hexokinase | 0.086 | 1 | 0.5 |
Trypanosoma brucei | hexokinase, putative | 0.086 | 1 | 1 |
Loa Loa (eye worm) | hexokinase type II | 0.086 | 1 | 1 |
Onchocerca volvulus | 0.086 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.2758 | 0.2758 |
Brugia malayi | Hexokinase family protein | 0.0539 | 0.6043 | 0.6043 |
Treponema pallidum | hexokinase (hxk) | 0.086 | 1 | 0.5 |
Trypanosoma brucei | hexokinase | 0.086 | 1 | 1 |
Onchocerca volvulus | 0.0539 | 0.6043 | 0.4804 | |
Loa Loa (eye worm) | hexokinase | 0.086 | 1 | 1 |
Onchocerca volvulus | 0.086 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.2758 | 0.2758 |
Loa Loa (eye worm) | hexokinase | 0.0266 | 0.2667 | 0.2667 |
Echinococcus multilocularis | hexokinase type 2 | 0.086 | 1 | 0.5 |
Onchocerca volvulus | 0.086 | 1 | 1 | |
Brugia malayi | Hexokinase family protein | 0.0266 | 0.2667 | 0.2667 |
Brugia malayi | Hexokinase family protein | 0.086 | 1 | 1 |
Echinococcus granulosus | hexokinase type 2 | 0.086 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0237 | 0.2313 | 0.2313 |
Trypanosoma cruzi | hexokinase, putative | 0.086 | 1 | 1 |
Entamoeba histolytica | hexokinase 1 | 0.086 | 1 | 0.5 |
Schistosoma mansoni | hexokinase | 0.086 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.086 | 1 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.086 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.2249 | 0.2249 |
Trypanosoma brucei | hexokinase | 0.086 | 1 | 1 |
Echinococcus granulosus | hexokinase | 0.086 | 1 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0539 | 0.6043 | 0.6043 |
Trypanosoma cruzi | hexokinase, putative | 0.086 | 1 | 1 |
Plasmodium falciparum | hexokinase | 0.086 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0586 | 0.6624 | 0.6624 |
Echinococcus granulosus | hexokinase | 0.086 | 1 | 0.5 |
Plasmodium vivax | hexokinase, putative | 0.086 | 1 | 1 |
Brugia malayi | hexokinase type II | 0.0273 | 0.2758 | 0.2758 |
Leishmania major | hexokinase, putative | 0.086 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0237 | 0.2313 | 0.2313 |
Loa Loa (eye worm) | hexokinase | 0.086 | 1 | 1 |
Onchocerca volvulus | Hexokinase homolog | 0.0539 | 0.6043 | 0.4804 |
Toxoplasma gondii | hexokinase | 0.086 | 1 | 1 |
Echinococcus multilocularis | hexokinase | 0.086 | 1 | 0.5 |
Leishmania major | hexokinase, putative | 0.086 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 10000 nM | Inhibition of human ELOVL6 expressed in Pichia pastoris SND1168 | ChEMBL. | 19522500 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.