Detailed information for compound 1736544

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 639.035 | Formula: C11H17BN5Na4O12P3S
  • H donors: 6 H acceptors: 11 LogP: -4.42 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 3
  • SMILES: CSc1nc(N)c2c(n1)n(cn2)[C@@H]1O[C@@H]([C@@H]([C@H]1O)O)COP(=O)(OP(=O)(OP(=O)([O-])[O-])[O-])[BH3-].[Na+].[Na+].[Na+].[Na+]
  • InChi: 1S/C11H20BN5O12P3S.4Na/c1-33-11-15-8(13)5-9(16-11)17(3-14-5)10-7(19)6(18)4(27-10)2-26-30(12,20)28-32(24,25)29-31(21,22)23;;;;/h3-4,6-7,10,18-19H,2H2,1,12H3,(H,24,25)(H2,13,15,16)(H2,21,22,23);;;;/q-1;4*+1/p-3/t4-,6+,7-,10-,30?;;;;/m1..../s1
  • InChiKey: WBNGHUVHRVWRPJ-OZYHUUIHSA-K  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2Y, G-protein coupled, 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus pyroglutamylated rfamide peptide receptor purinergic receptor P2Y, G-protein coupled, 1 373 aa 393 aa 17.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi glutathione reductase 0.0086 0.0255 0.0399
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0065 0.0096
Echinococcus granulosus transient receptor potential gamma protein 0.0427 0.1644 0.1633
Entamoeba histolytica hypothetical protein 0.008 0.0229 0.311
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0343 0.1301 0.1289
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0043 0.0095
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0144 0.1205
Echinococcus multilocularis snurportin 1 0.0307 0.1156 0.1144
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0218 0.0792 0.6813
Trypanosoma cruzi hexokinase, putative 0.0185 0.0659 0.2879
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0022 0.0009
Schistosoma mansoni hypothetical protein 0.0168 0.0589 0.0577
Loa Loa (eye worm) hypothetical protein 0.0056 0.0135 0.0208
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0065 0.052
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0277 0.1033 0.4514
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0245 0.0983
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0065 0.0283
Echinococcus multilocularis SAM and MBT domain containing protein 0.0056 0.0135 0.0122
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0056 0.0134 0.0121
Echinococcus multilocularis short transient receptor potential channel 6 0.0282 0.1055 0.1043
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0082 0.024 0.1049
Loa Loa (eye worm) hypothetical protein 0.0029 0.0022 0.0028
Schistosoma mansoni cpg binding protein 0.0158 0.0547 0.0535
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0168 0.0589 0.0577
Schistosoma mansoni hypothetical protein 0.0307 0.1156 0.1144
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0092 0.0281 0.0269
Echinococcus multilocularis transient receptor potential ion channel A 0.0413 0.1586 0.1575
Trichomonas vaginalis glucosylceramidase, putative 0.0739 0.2913 0.6489
Loa Loa (eye worm) hypothetical protein 0.0059 0.0145 0.0224
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.0281 0.2395
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0277 0.1033 0.4514
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.003 0.0026 0.0057
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0092 0.0281 1
Schistosoma mansoni nuclear hormone receptor 0.0056 0.0134 0.0121
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0065 0.052
Brugia malayi Carboxylesterase family protein 0.0264 0.098 0.1557
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.003 0.0026 0.0186
Brugia malayi tailless protein 0.0027 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.008 0.0229 0.0217
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0064 0.0166 0.0153
Entamoeba histolytica hypothetical protein 0.008 0.0229 0.311
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0056 0.0134 0.0207
Brugia malayi hypothetical protein 0.003 0.0026 0.0034
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0168 0.0589 0.0577
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0056 0.0134 0.0445
Treponema pallidum hexokinase (hxk) 0.0185 0.0659 1
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0264 0.098 0.0968
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0585 0.2288 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.0281 0.2509
Schistosoma mansoni ap endonuclease 0.0079 0.0228 0.0215
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0005 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.1126 0.449 1
Leishmania major hexokinase, putative 0.0185 0.0659 0.2879
Brugia malayi Hexokinase family protein 0.0057 0.0138 0.0213
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0026 0.0115
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0343 0.1301 0.1289
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0096
Echinococcus multilocularis hexokinase 0.0185 0.0659 0.0646
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.0095
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0079 0.0228 0.0215
Mycobacterium ulcerans hypothetical protein 0.0308 0.116 1
Brugia malayi hypothetical protein 0.0027 0.0013 0.0013
Brugia malayi Fli-1 protein 0.0213 0.0771 0.1225
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0035 0.0175
Brugia malayi nuclear hormone receptor 0.0027 0.0013 0.0013
Trypanosoma brucei hexokinase 0.0185 0.0659 0.2809
Brugia malayi Isocitrate dehydrogenase 0.0083 0.0245 0.0384
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0205 0.0738 0.1171
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0238 0.0875 0.0863
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0531 0.2068 0.3296
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Loa Loa (eye worm) DR-78 0.0027 0.0013 0.0013
Trypanosoma brucei trypanothione reductase 0.0086 0.0255 0.1027
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0056 0.0134 0.0121
Brugia malayi Carboxylesterase family protein 0.1562 0.6265 1
Trypanosoma brucei hexokinase 0.0185 0.0659 0.2809
Plasmodium falciparum glutathione reductase 0.0086 0.0255 0.325
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0056 0.0134 0.0207
Echinococcus granulosus short transient receptor potential channel 6 0.0282 0.1055 0.1043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0134 0.0207
Loa Loa (eye worm) hypothetical protein 0.0059 0.0145 0.0224
Toxoplasma gondii ABC1 family protein 0.0039 0.0065 0.0412
Loa Loa (eye worm) hypothetical protein 0.0264 0.098 0.1557
Onchocerca volvulus 0.0027 0.0013 0.0029
Brugia malayi nuclear hormone receptor family member nhr-6 0.0027 0.0013 0.0013
Loa Loa (eye worm) transcription factor SMAD2 0.0272 0.1013 0.1611
Echinococcus granulosus carboxylesterase 5A 0.1562 0.6265 0.626
Loa Loa (eye worm) steroid hormone receptor 0.0056 0.0134 0.0207
Onchocerca volvulus 0.0157 0.0545 0.1859
Brugia malayi orphan nuclear receptor NR2E1 0.0027 0.0013 0.0013
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0079 0.0228 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0056 0.0134 0.0207
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0056 0.0134 0.0121
Echinococcus granulosus neuropeptide receptor A26 0.1038 0.4132 0.4125
Brugia malayi nuclear receptor NHR-67 0.0027 0.0013 0.0013
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0264 0.098 0.8439
Schistosoma mansoni gliotactin 0.0264 0.098 0.0968
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0083 0.0245 0.3113
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0056 0.0135 0.0122
Echinococcus granulosus hexokinase type 2 0.0185 0.0659 0.0646
Echinococcus multilocularis geminin 0.2479 1 1
Onchocerca volvulus 0.0264 0.098 0.3352
Loa Loa (eye worm) CXXC zinc finger family protein 0.0149 0.0512 0.0811
Schistosoma mansoni transcription factor LCR-F1 0.008 0.0229 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.0095
Loa Loa (eye worm) hypothetical protein 0.0145 0.0494 0.0781
Plasmodium vivax ataxin-2 like protein, putative 0.0081 0.0233 0.2945
Trichomonas vaginalis mercuric reductase, putative 0.003 0.0026 0.0058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0245 0.0232
Echinococcus multilocularis hexokinase 0.0185 0.0659 0.0646
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0233 0.1018
Loa Loa (eye worm) hypothetical protein 0.0126 0.0419 0.0662
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0245 0.1071
Brugia malayi Carboxylesterase family protein 0.0264 0.098 0.1557
Trichomonas vaginalis helicase, putative 0.0034 0.0043 0.0095
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0005 0.0063
Onchocerca volvulus 0.0264 0.098 0.3352
Mycobacterium tuberculosis Probable reductase 0.0196 0.0703 0.6042
Schistosoma mansoni thyroid hormone receptor 0.0056 0.0134 0.0121
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0844 0.3343 0.3335
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0092 0.0281 0.3516
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0168 0.0589 0.0577
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.1126 0.449 0.7164
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0144 0.0131
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0092 0.0281 0.4035
Brugia malayi F/Y-rich N-terminus family protein 0.0046 0.0091 0.0137
Onchocerca volvulus 0.0039 0.0065 0.0207
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0196 0.0703 0.6042
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0027 0.0013 0.0013
Loa Loa (eye worm) carboxylesterase 0.0264 0.098 0.1557
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0343 0.1301 0.1289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0056 0.0134 0.0207
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0061 0.0152 0.1868
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.003 0.0026 0.0115
Echinococcus granulosus para nitrobenzyl esterase 0.0264 0.098 0.0968
Brugia malayi steroid hormone receptor 0.0056 0.0134 0.0207
Mycobacterium tuberculosis Conserved hypothetical protein 0.0308 0.116 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0316 0.1193 0.1182
Schistosoma mansoni transient receptor potential channel 0.0427 0.1644 0.1633
Toxoplasma gondii thioredoxin reductase 0.0086 0.0255 0.2251
Echinococcus multilocularis neuroligin 0.0264 0.098 0.0968
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0056 0.0134 0.0121
Loa Loa (eye worm) hypothetical protein 0.0168 0.0589 0.0934
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.0095
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.003 0.0026 0.0057
Schistosoma mansoni transient receptor potential channel 0.0282 0.1055 0.1043
Schistosoma mansoni coup transcription factor 0.0056 0.0134 0.0121
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.003 0.0026 0.0013
Schistosoma mansoni hypothetical protein 0.2479 1 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0205 0.0738 0.1643
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.008 0.0229 0.0217
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0065 0.0096
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0096
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0205 0.0738 0.0726
Mycobacterium tuberculosis Conserved protein 0.0039 0.0065 0.052
Brugia malayi ecdysteroid receptor 0.0056 0.0134 0.0207
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0037 0.0056 0.0043
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0083 0.0245 0.1071
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0196 0.0703 0.6042
Brugia malayi Hexokinase family protein 0.0185 0.0659 0.1045
Brugia malayi Carboxylesterase family protein 0.1562 0.6265 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0531 0.2068 0.3296
Trypanosoma cruzi hexokinase, putative 0.0185 0.0659 0.2879
Echinococcus multilocularis dnaJ subfamily B 0.1715 0.689 0.6886
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0343 0.1301 0.1289
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0046 0.0093 0.008
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0065 0.052
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0205 0.0738 1
Trichomonas vaginalis glucosylceramidase, putative 0.1126 0.449 1
Loa Loa (eye worm) acetylcholinesterase 1 0.1562 0.6265 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0056 0.0134 0.0121
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0343 0.1301 0.207
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0205 0.0738 0.1643
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Brugia malayi nuclear receptor NHR-88 0.0056 0.0134 0.0207
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0205 0.0738 0.1171
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0277 0.1033 0.446
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0134 0.0121
Schistosoma mansoni acetylcholinesterase 0.0264 0.098 0.0968
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.1156 0.1838
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0207
Plasmodium falciparum thioredoxin reductase 0.0086 0.0255 0.325
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0264 0.098 0.1557
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0182 0.0644 0.8731
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0026 0.0115
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0264 0.098 0.0968
Schistosoma mansoni hypothetical protein 0.0168 0.0589 0.0577
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.003 0.0026 0.0186
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0205 0.0738 0.0726
Echinococcus multilocularis muscleblind protein 0.0459 0.1775 0.1764
Brugia malayi nuclear receptor NHR-88 0.0027 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0207
Mycobacterium tuberculosis Conserved protein 0.0039 0.0065 0.052
Brugia malayi isocitrate dehydrogenase 0.0083 0.0245 0.0384
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0343 0.1301 0.1289
Loa Loa (eye worm) hypothetical protein 0.0264 0.098 0.1557
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0065 0.052
Echinococcus multilocularis FTZ F1 alpha 0.0056 0.0134 0.0121
Loa Loa (eye worm) carboxylesterase 0.1562 0.6265 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0043 0.0095
Echinococcus multilocularis histone acetyltransferase MYST2 0.0064 0.0166 0.0153
Echinococcus multilocularis tumor protein p63 0.0403 0.1545 0.1534
Toxoplasma gondii NADPH-glutathione reductase 0.003 0.0026 0.0039
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0144 0.0131
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0083 0.0245 0.1071
Brugia malayi mbt repeat family protein 0.0056 0.0135 0.0208
Brugia malayi hexokinase 0.0185 0.0659 0.1045
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0086 0.0255 0.2164
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0056 0.0134 0.0207
Leishmania major hexokinase, putative 0.0185 0.0659 0.2879
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.0135 0.0122
Onchocerca volvulus 0.0039 0.0065 0.0207
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0168 0.0589 0.0934
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0056 0.0134 0.0207
Brugia malayi RNA, U transporter 1 0.0082 0.0238 0.0373
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0026 0.0115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0043 0.0095
Leishmania major hypothetical protein, conserved 0.0039 0.0065 0.0283
Trichomonas vaginalis glutathione reductase, putative 0.003 0.0026 0.0058
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0207
Echinococcus granulosus GA binding protein alpha chain 0.007 0.019 0.0178
Loa Loa (eye worm) hypothetical protein 0.0363 0.1384 0.2203
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0083 0.0245 0.3113
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0135 0.0122
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0096
Onchocerca volvulus 0.0264 0.098 0.3352
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1126 0.449 0.7164
Echinococcus granulosus hexokinase 0.0185 0.0659 0.0646
Schistosoma mansoni hypothetical protein 0.2479 1 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0046 0.0093 0.008
Schistosoma mansoni transient receptor potential channel 0.0282 0.1055 0.1043
Plasmodium falciparum hexokinase 0.0185 0.0659 0.8893
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0056 0.0134 0.0121
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0026 0.0115
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0037 0.0056 0.0043
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0065 0.0595
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0061 0.0152 0.1273
Onchocerca volvulus Protein ultraspiracle homolog 0.0056 0.0134 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0056 0.0134 0.0207
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0134 0.0207
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0061 0.0152 0.1273
Echinococcus multilocularis acetylcholinesterase 0.1562 0.6265 0.626
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0343 0.1301 0.1289
Brugia malayi conserved hypotetical protein 0.0027 0.0013 0.0013
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0079 0.0228 0.1934
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0144 0.1205
Echinococcus granulosus tumor protein p63 0.0403 0.1545 0.1534
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0585 0.2288 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Brugia malayi nuclear receptor RXR 0.003 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0081 0.0233 0.0365
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0134 0.0207
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0026 0.0115
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0065 0.0144
Mycobacterium tuberculosis Probable dehydrogenase 0.0196 0.0703 0.6042
Trichomonas vaginalis glucosylceramidase, putative 0.0739 0.2913 0.6489
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0168 0.0589 0.0934
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0082 0.024 0.1049
Trichomonas vaginalis glucosylceramidase, putative 0.0739 0.2913 0.6489
Echinococcus granulosus histone acetyltransferase MYST2 0.0064 0.0166 0.0153
Onchocerca volvulus 0.0039 0.0065 0.0207
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0079 0.0228 0.0997
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0264 0.098 0.0968
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.0095
Schistosoma mansoni cellular tumor antigen P53 0.0059 0.0145 0.0132
Treponema pallidum exodeoxyribonuclease (exoA) 0.0079 0.0228 0.3193
Schistosoma mansoni gabp alpha 0.007 0.019 0.0178
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0135 0.0122
Echinococcus multilocularis isocitrate dehydrogenase 0.0083 0.0245 0.0232
Toxoplasma gondii histone lysine methyltransferase SET1 0.0283 0.1056 1
Schistosoma mansoni hypothetical protein 0.0359 0.1366 0.1355
Loa Loa (eye worm) beta-lactamase 0.0039 0.0065 0.0096
Toxoplasma gondii exonuclease III APE 0.0079 0.0228 0.1993
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0065 0.052
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0056 0.0135 0.0447
Schistosoma mansoni cpg binding protein 0.0149 0.0512 0.05
Loa Loa (eye worm) hypothetical protein 0.0059 0.0145 0.0224
Echinococcus multilocularis transient receptor potential gamma protein 0.0427 0.1644 0.1633
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.0095
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0005 0.002
Loa Loa (eye worm) hexokinase 0.0185 0.0659 0.1045
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.003 0.0026 0.0018
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0065 0.052
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0238 0.0875 0.0863
Onchocerca volvulus 0.0264 0.098 0.3352
Plasmodium vivax hexokinase, putative 0.0185 0.0659 0.8893
Echinococcus granulosus raf serine:threonine protein kinase 0.024 0.0883 0.0871
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0056 0.0134 0.0207
Entamoeba histolytica hexokinase 2 0.0185 0.0659 0.8926
Loa Loa (eye worm) hypothetical protein 0.1562 0.6265 1
Echinococcus granulosus acetylcholinesterase 0.1562 0.6265 0.626
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.0095
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0134 0.0121
Brugia malayi exodeoxyribonuclease III family protein 0.0079 0.0228 0.0357
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0056 0.0134 0.0121
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0034
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0264 0.098 0.2182
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0005 0.0063
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0065 0.0144
Schistosoma mansoni hypothetical protein 0.0363 0.1384 0.1372
Brugia malayi Importin beta-1 subunit 0.0029 0.0022 0.0028
Brugia malayi CXXC zinc finger family protein 0.0149 0.0512 0.0811
Loa Loa (eye worm) fli-1 protein 0.0213 0.0771 0.1225
Trichomonas vaginalis glucosylceramidase, putative 0.0739 0.2913 0.6489
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.003 0.0026 0.0018
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0056 0.0134 0.0121
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0205 0.0738 0.3159
Echinococcus multilocularis carboxylesterase 5A 0.1562 0.6265 0.626
Brugia malayi nuclear hormone receptor family member odr-7 0.0027 0.0013 0.0013
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0082 0.024 0.0962
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0079 0.0228 0.0997
Brugia malayi hypothetical protein 0.0027 0.0013 0.0013
Onchocerca volvulus 0.0116 0.0378 0.1283
Loa Loa (eye worm) nuclear hormone receptor 0.0027 0.0013 0.0013
Echinococcus granulosus snurportin 1 0.0307 0.1156 0.1144
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0056 0.0134 0.0121
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.008 0.0229 0.0217
Echinococcus granulosus cpg binding protein 0.0158 0.0547 0.0535
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0065 0.0052
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.019 0.0297
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0026 0.0013
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0092 0.0281 0.2395
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.0095
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0092 0.0281 0.0269
Brugia malayi Probable ClpP-like protease 0.0092 0.0281 0.0442
Brugia malayi hexokinase type II 0.0059 0.0145 0.0224
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0205 0.0738 0.3225
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0207
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0205 0.0738 0.3225
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0056 0.0134 0.0207
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0207
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0196 0.0703 0.6042
Brugia malayi beta-lactamase 0.0039 0.0065 0.0096
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Schistosoma mansoni serine/threonine protein kinase 0.024 0.0883 0.0871
Brugia malayi hypothetical protein 0.0264 0.098 0.1557
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0065 0.0144
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0079 0.0228 0.0909
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0056 0.0134 0.0121
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0065 0.052
Toxoplasma gondii hypothetical protein 0.0094 0.0289 0.2585
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0056 0.0134 0.0207
Loa Loa (eye worm) hypothetical protein 0.006 0.0149 0.0231
Onchocerca volvulus Glucosylceramidase homolog 0.0739 0.2913 1
Loa Loa (eye worm) hexokinase 0.0116 0.0378 0.0596
Loa Loa (eye worm) hypothetical protein 0.0264 0.098 0.1557
Trichomonas vaginalis glucosylceramidase, putative 0.0779 0.3075 0.6849
Schistosoma mansoni importin beta-1 0.0029 0.0022 0.0009
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0144 0.1178
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0096
Schistosoma mansoni hypothetical protein 0.1715 0.689 0.6886
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0096
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0013 0.0029
Mycobacterium leprae Probable lipase LipE 0.0039 0.0065 0.0763
Echinococcus granulosus neuropeptide s receptor 0.1038 0.4132 0.4125
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0056 0.0134 0.0121
Loa Loa (eye worm) hypothetical protein 0.0531 0.2068 0.3296
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0056 0.0134 0.0207
Echinococcus granulosus thioredoxin glutathione reductase 0.0086 0.0257 0.0244
Schistosoma mansoni myelin transcription factor 1 myt1 0.0064 0.0166 0.0153
Mycobacterium ulcerans flavoprotein disulfide reductase 0.003 0.0026 0.0186
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0531 0.2068 0.3296
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0026 0.0018
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0228 0.0508
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0205 0.0738 0.3225
Trichomonas vaginalis esterase, putative 0.0039 0.0065 0.0144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0065 0.0052
Brugia malayi Ets-domain containing protein 0.007 0.019 0.0297
Echinococcus multilocularis thioredoxin glutathione reductase 0.0086 0.0257 0.0244
Brugia malayi Steroid receptor seven-up type 2 0.0056 0.0134 0.0207
Loa Loa (eye worm) hypothetical protein 0.0427 0.1644 0.2619
Echinococcus multilocularis acetylcholinesterase 0.1562 0.6265 0.626
Onchocerca volvulus Hexokinase homolog 0.0116 0.0378 0.1283
Mycobacterium ulcerans lipase LipD 0.0039 0.0065 0.052
Echinococcus multilocularis thyroid hormone receptor alpha 0.0056 0.0134 0.0121
Schistosoma mansoni ap endonuclease 0.0079 0.0228 0.0215
Schistosoma mansoni RAR-like nuclear receptor 0.0056 0.0134 0.0121
Brugia malayi beta-lactamase family protein 0.0039 0.0065 0.0096
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0065 0.0283
Toxoplasma gondii hypothetical protein 0.0032 0.0035 0.0121
Loa Loa (eye worm) hypothetical protein 0.0459 0.1775 0.2828
Echinococcus granulosus mixed lineage leukemia protein mll 0.0037 0.0056 0.0043
Loa Loa (eye worm) hexokinase 0.0057 0.0138 0.0213
Brugia malayi beta-lactamase family protein 0.0039 0.0065 0.0096
Trichomonas vaginalis glucosylceramidase, putative 0.1126 0.449 1
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0205 0.0738 1
Schistosoma mansoni retinoic acid receptor RXR 0.0056 0.0134 0.0121
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.003 0.0026 0.0018
Mycobacterium tuberculosis Conserved protein 0.0039 0.0065 0.052
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0052 0.0039
Onchocerca volvulus 0.0059 0.0145 0.0483
Onchocerca volvulus 0.0149 0.0512 0.1745
Loa Loa (eye worm) raf kinase 0.0239 0.0878 0.1396
Brugia malayi hypothetical protein 0.003 0.0026 0.0034
Brugia malayi Nuclear hormone receptor E75 0.0027 0.0013 0.0013
Loa Loa (eye worm) hexokinase 0.0185 0.0659 0.1045
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0034
Loa Loa (eye worm) hypothetical protein 0.0182 0.0644 0.1022
Trypanosoma cruzi trypanothione reductase, putative 0.0086 0.0255 0.1114
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0032 0.0035 0.0175
Brugia malayi Carboxylesterase family protein 0.0264 0.098 0.1557
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0065 0.0144
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.0095
Trichomonas vaginalis glucosylceramidase, putative 0.1126 0.449 1
Onchocerca volvulus 0.0185 0.0659 0.2248
Brugia malayi ecdysone receptor 0.0027 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0207
Schistosoma mansoni thyroid hormone receptor 0.0056 0.0134 0.0121
Onchocerca volvulus 0.0056 0.0135 0.0447
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.003 0.0026 0.0115
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0056 0.0134 0.0121
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0144 0.0131
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0032 0.0035 0.0381
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.01 0.0313 0.137
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.1562 0.6265 0.626
Mycobacterium ulcerans carboxylesterase, LipT 0.0264 0.098 0.8439
Onchocerca volvulus Bile acid receptor homolog 0.0056 0.0134 0.0445
Schistosoma mansoni neuroligin 3 (S09 family) 0.0264 0.098 0.0968
Brugia malayi photoreceptor-specific nuclear receptor 0.0056 0.0134 0.0207
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0065 0.0144
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0233 0.2945
Mycobacterium ulcerans hypothetical protein 0.0039 0.0065 0.052
Trypanosoma brucei hexokinase, putative 0.0185 0.0659 0.2809
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0056 0.0134 0.0207
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0037 0.0056 0.0043
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0065 0.0763
Echinococcus granulosus transient receptor potential ion channel A 0.0413 0.1586 0.1575
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0083 0.0245 0.208
Echinococcus granulosus ecdysone induced protein 78C 0.0056 0.0134 0.0121
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0092 0.0281 0.2509
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0083 0.0245 0.0983
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0205 0.0738 0.1171
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0065 0.0188
Brugia malayi mbt repeat family protein 0.0056 0.0135 0.0208
Plasmodium vivax thioredoxin reductase, putative 0.0086 0.0255 0.325
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.003 0.0026 0.0034
Echinococcus granulosus neuroligin 0.0264 0.098 0.0968
Loa Loa (eye worm) hypothetical protein 0.0264 0.098 0.1557
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0083 0.0245 0.0232
Echinococcus multilocularis neuropeptide s receptor 0.1038 0.4132 0.4125
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0228 0.2878
Loa Loa (eye worm) hypothetical protein 0.0157 0.0545 0.0864
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0264 0.098 0.8439
Brugia malayi follicle stimulating hormone receptor 0.0983 0.3906 0.6231
Schistosoma mansoni BC026374 protein (S09 family) 0.0264 0.098 0.0968
Trichomonas vaginalis glucosylceramidase, putative 0.0779 0.3075 0.6849
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0079 0.0228 0.2878
Loa Loa (eye worm) thioredoxin reductase 0.0086 0.0255 0.0399
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0079 0.0228 0.0215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0343 0.1301 0.1289
Echinococcus multilocularis ecdysone induced protein 78C 0.0056 0.0134 0.0121
Onchocerca volvulus 0.0056 0.0134 0.0445
Loa Loa (eye worm) carboxylesterase 0.0264 0.098 0.1557
Echinococcus multilocularis peptidase Clp (S14 family) 0.0061 0.0152 0.0139
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0196 0.0703 0.6042
Brugia malayi latrophilin 2 splice variant baaae 0.0363 0.1384 0.2203
Schistosoma mansoni hexokinase 0.0185 0.0659 0.0646
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0196 0.0703 0.8869
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0205 0.0738 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0081 0.0233 0.1018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0056 0.0134 0.0207
Toxoplasma gondii LsmAD domain-containing protein 0.0081 0.0233 0.2039
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0026 0.0115
Entamoeba histolytica hexokinase 1 0.0185 0.0659 0.8926
Loa Loa (eye worm) hypothetical protein 0.0264 0.098 0.1557
Echinococcus granulosus GPCR family 2 0.0168 0.0589 0.0577
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0056 0.0134 0.0121
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0207
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0168 0.0589 0.0577
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.003 0.0026 0.0013
Echinococcus granulosus importin subunit beta 1 0.0029 0.0022 0.0009
Echinococcus multilocularis neuropeptide receptor A26 0.1038 0.4132 0.4125
Echinococcus multilocularis hexokinase type 2 0.0185 0.0659 0.0646
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.0281 1
Brugia malayi Raf kinase 0.0232 0.0849 0.1349
Entamoeba histolytica hypothetical protein 0.008 0.0229 0.311
Echinococcus multilocularis short transient receptor potential channel 6 0.0282 0.1055 0.1043
Mycobacterium tuberculosis Carboxylesterase LipT 0.0264 0.098 0.8439
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.0135 0.0122
Loa Loa (eye worm) isocitrate dehydrogenase 0.0083 0.0245 0.0384
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0056 0.0134 0.0121
Leishmania major dihydrolipoamide dehydrogenase, putative 0.003 0.0026 0.0115
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0056 0.0134 0.0207
Brugia malayi Hexokinase family protein 0.0116 0.0378 0.0596
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0064 0.0166 0.0153
Trypanosoma cruzi trypanothione reductase, putative 0.003 0.0026 0.0115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0144 0.1205
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.003 0.0026 0.0039
Loa Loa (eye worm) hypothetical protein 0.0268 0.0997 0.1585
Brugia malayi hypothetical protein 0.008 0.0229 0.0359
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0264 0.098 0.0968
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0027 0.0013 0.0029
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0065 0.052
Brugia malayi hypothetical protein 0.0052 0.0117 0.0179
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0037 0.0056 0.0043
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0056 0.0134 0.0121
Brugia malayi Muscleblind-like protein 0.0459 0.1775 0.2828
Brugia malayi Nuclear hormone receptor-like 1 0.0056 0.0134 0.0207
Brugia malayi Thioredoxin reductase 0.0086 0.0255 0.0399
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0092 0.0281 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0585 0.2288 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0064 0.0166 0.0258
Schistosoma mansoni hypothetical protein 0.0168 0.0589 0.0577
Trichomonas vaginalis glucosylceramidase, putative 0.0739 0.2913 0.6489
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0343 0.1301 0.207
Loa Loa (eye worm) MH2 domain-containing protein 0.0272 0.1013 0.1611
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0159 0.0552 0.0539
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0136 0.046 0.0727
Loa Loa (eye worm) mbt repeat family protein 0.0056 0.0135 0.0208
Toxoplasma gondii hexokinase 0.0185 0.0659 0.6158
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0082 0.024 0.1049
Echinococcus multilocularis raf serine:threonine protein kinase 0.024 0.0883 0.0871
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0079 0.0228 0.3092
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0218 0.0792 0.6813
Schistosoma mansoni ets-related 0.0213 0.0771 0.0759
Loa Loa (eye worm) hypothetical protein 0.1562 0.6265 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0079 0.0228 0.0997
Schistosoma mansoni hypothetical protein 0.0036 0.0052 0.0039
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Echinococcus granulosus short transient receptor potential channel 6 0.0282 0.1055 0.1043
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0056 0.0134 0.0121
Plasmodium falciparum ataxin-2 like protein, putative 0.0081 0.0233 0.2945
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0065 0.052
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0079 0.0228 0.7912
Loa Loa (eye worm) hypothetical protein 0.0092 0.0281 0.0442
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0218 0.0792 1
Leishmania major trypanothione reductase 0.0086 0.0255 0.1114
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0182 0.0644 0.8731
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0144 0.0629
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0079 0.0228 0.0357
Mycobacterium ulcerans beta-lactamase 0.0039 0.0065 0.052
Trichomonas vaginalis glucosylceramidase, putative 0.1126 0.449 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.0552 0.0874
Entamoeba histolytica hypothetical protein 0.008 0.0229 0.311
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0005 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0739 0.2913 0.6489
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0056 0.0134 0.0207
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.0245 0.2156
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0034
Brugia malayi Carboxylesterase family protein 0.0264 0.098 0.1557
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.003 0.0026 0.0013
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0083 0.0245 0.0232
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0026 0.0115
Brugia malayi nuclear hormone receptor 0.0056 0.0134 0.0207
Loa Loa (eye worm) histone methyltransferase 0.0046 0.0093 0.0141
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0005 0.0063
Echinococcus multilocularis BC026374 protein (S09 family) 0.0264 0.098 0.0968
Echinococcus granulosus FTZ F1 alpha 0.0056 0.0134 0.0121
Echinococcus granulosus acetylcholinesterase 0.1562 0.6265 0.626
Loa Loa (eye worm) latrophilin receptor protein 2 0.0168 0.0589 0.0934
Echinococcus multilocularis muscleblind protein 1 0.0459 0.1775 0.1764
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.003 0.0026 0.0057
Echinococcus granulosus peptidase Clp S14 family 0.0061 0.0152 0.0139
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0056 0.0134 0.0207
Brugia malayi hypothetical protein 0.0157 0.0545 0.0864
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0245 0.0232
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0251 0.0926 0.7972
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0065 0.0052
Echinococcus granulosus hexokinase 0.0185 0.0659 0.0646
Loa Loa (eye worm) hexokinase type II 0.0185 0.0659 0.1045
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0043 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0056 0.0134 0.0207
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0043 0.0095
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0092 0.0281 0.3622
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0205 0.0738 0.1171
Loa Loa (eye worm) hypothetical protein 0.003 0.0026 0.0034
Leishmania major hypothetical protein, conserved 0.0081 0.0233 0.1018
Plasmodium falciparum glutathione reductase 0.003 0.0026 0.0057
Plasmodium falciparum thioredoxin reductase 0.003 0.0026 0.0057
Echinococcus granulosus BC026374 protein S09 family 0.0264 0.098 0.0968
Echinococcus granulosus TRP transient receptor potential channel 0.0159 0.0552 0.0539
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.003 0.0026 0.0013
Brugia malayi Transient-receptor-potential like protein 0.0159 0.0552 0.0874
Leishmania major mitochondrial DNA polymerase beta 0.0585 0.2288 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0264 0.098 0.0968
Loa Loa (eye worm) hypothetical protein 0.0056 0.0134 0.0207
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0079 0.0228 0.1934
Trypanosoma brucei PAB1-binding protein , putative 0.0081 0.0233 0.093
Brugia malayi nuclear receptor RXR 0.0027 0.0013 0.0013
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0083 0.0245 0.0232
Echinococcus multilocularis cpg binding protein 0.0158 0.0547 0.0535
Brugia malayi MH2 domain containing protein 0.0272 0.1013 0.1611
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.003 0.0026 0.0186
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0056 0.0134 0.0121
Onchocerca volvulus 0.0264 0.098 0.3352
Echinococcus multilocularis para nitrobenzyl esterase 0.0264 0.098 0.0968
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0144 0.1205
Schistosoma mansoni cpg binding protein 0.0158 0.0547 0.0535
Loa Loa (eye worm) MBCTL1 0.0064 0.0166 0.0258
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.003 0.0026 0.0057
Brugia malayi hypothetical protein 0.0081 0.0233 0.0365
Loa Loa (eye worm) nuclear receptor NHR-67 0.0027 0.0013 0.0013
Schistosoma mansoni transient receptor potential channel 4 0.0427 0.1644 0.1633
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0092 0.0281 0.3622
Loa Loa (eye worm) hypothetical protein 0.0264 0.098 0.1557
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.003 0.0026 0.0115
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0065 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0065 0.0096
Onchocerca volvulus 0.0027 0.0013 0.0029
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0205 0.0738 0.0726
Onchocerca volvulus 0.0185 0.0659 0.2248
Trichomonas vaginalis glucosylceramidase, putative 0.0739 0.2913 0.6489
Echinococcus granulosus dnaJ subfamily B 0.1715 0.689 0.6886
Schistosoma mansoni hypothetical protein 0.0168 0.0589 0.0577
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0144 0.0131
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0043 0.0095
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0083 0.0245 0.0232
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0064 0.0166 0.0258
Loa Loa (eye worm) hypothetical protein 0.0459 0.1775 0.2828
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Toxoplasma gondii isocitrate dehydrogenase 0.0083 0.0245 0.2156
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.003 0.0026 0.0034
Loa Loa (eye worm) glutathione reductase 0.0086 0.0255 0.0399
Leishmania major acetoin dehydrogenase e3 component-like protein 0.003 0.0026 0.0115
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0034 0.0043 0.0095
Plasmodium vivax glutathione reductase, putative 0.0086 0.0255 0.325
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0052 0.0039
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.003 0.0026 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0013 0.0013
Mycobacterium tuberculosis Probable oxidoreductase 0.0218 0.0792 0.6813
Echinococcus granulosus muscleblind protein 0.0459 0.1775 0.1764
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0043 0.0095
Echinococcus multilocularis GPCR, family 2 0.0168 0.0589 0.0577
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0032 0.0035 0.0134
Brugia malayi Ets-domain containing protein 0.007 0.019 0.0297
Echinococcus granulosus SAM and MBT domain containing protein 0.0056 0.0135 0.0122
Onchocerca volvulus 0.0185 0.0659 0.2248
Trichomonas vaginalis glucosylceramidase, putative 0.1126 0.449 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0034 0.0043 0.0095
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.019 0.0178
Trichomonas vaginalis spcc417.12 protein, putative 0.0264 0.098 0.2182
Echinococcus granulosus hexokinase 0.0185 0.0659 0.0646
Echinococcus multilocularis hexokinase 0.0185 0.0659 0.0646
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0027 0.0013 0.0013
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0983 0.3906 0.6231
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.003 0.0026 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0079 0.0228 0.0508
Schistosoma mansoni peptidase Clp (S14 family) 0.0092 0.0281 0.0269
Schistosoma mansoni steroid hormone receptor ad4bp 0.0056 0.0134 0.0121
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0205 0.0738 0.6925

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 2.6 nM Agonist activity at P2Y1 receptor expressed in human HEK293 cells ChEMBL. 20175517

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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