TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 435.559 | Formula: C26H33N3O3
H donors: 1 H acceptors: 2 LogP: 3.65 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCc1ccccc1CN1CCC2(Oc3c1cccc3)CCN(CC2)C(=O)CNC(=O)C
InChi: 1S/C26H33N3O3/c1-3-21-8-4-5-9-22(21)19-29-17-14-26(32-24-11-7-6-10-23(24)29)12-15-28(16-13-26)25(31)18-27-20(2)30/h4-11H,3,12-19H2,1-2H3,(H,27,30)
InChiKey: MHBKRUHJDFYEHD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Acyl-CoA desaturase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium berghei	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma congolense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium knowlesi	stearoyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma brucei gambiense	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Trypanosoma cruzi	fatty acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Loa Loa (eye worm)	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania braziliensis	stearic acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania donovani	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania major	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	stearic acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium yoelii	delta-9 fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Neospora caninum	fatty acyl-CoA desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania mexicana	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Brugia malayi	acyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Onchocerca volvulus		Get druggable targets OG5_126939	All targets in OG5_126939
Plasmodium falciparum	stearoyl-CoA desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9-fatty acid desaturase	Get druggable targets OG5_126939	All targets in OG5_126939
Leishmania infantum	fatty-acid desaturase, putative	Get druggable targets OG5_126939	All targets in OG5_126939

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %
Candida albicans	one of two potential fatty acid desaturase genes similar to S. cerevisiae OLE1 (YGL055W) delta-9 fatty acid desaturase	Acyl-CoA desaturase 1	358 aa	317 aa	27.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0088	0.0088
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0021	0.0302	0.0419
Echinococcus granulosus	FTZ F1 alpha	0.0021	0.0302	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0088	0.0088
Trypanosoma cruzi	fatty acid desaturase, putative	0.0068	0.2492	0.7358
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0331	0.0527
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0302	0.0302
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0021	0.0302	0.0419
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0018	0.0185	0.0294
Echinococcus granulosus	GPCR family 2	0.0016	0.0088	0.0141
Loa Loa (eye worm)	TAR-binding protein	0.0127	0.519	0.519
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0021	0.0302	0.0233
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0938	0.0873
Echinococcus granulosus	lamin	0.0029	0.069	0.1097
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0302	0.0302
Echinococcus granulosus	muscleblind protein	0.0151	0.6288	1
Loa Loa (eye worm)	steroid hormone receptor	0.0021	0.0302	0.0302
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0088	0.0018
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0302	0.0233
Onchocerca volvulus		0.0086	0.332	1
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0088	0.0141
Leishmania major	fatty-acid desaturase, putative	0.0086	0.332	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0021	0.0302	0.0481
Loa Loa (eye worm)	acyl-CoA desaturase	0.0068	0.2492	0.2492
Loa Loa (eye worm)	RNA binding protein	0.0127	0.519	0.519
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0331	0.0331
Echinococcus granulosus	RUN	0.0021	0.0331	0.0527
Echinococcus multilocularis	FTZ F1 alpha	0.0021	0.0302	0.0481
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0088	0.0141
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0021	0.0302	0.0302
Onchocerca volvulus	Bile acid receptor homolog	0.0021	0.0302	0.0375
Schistosoma mansoni	lamin	0.0029	0.069	0.1179
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0021	0.0302	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0151	0.6288	0.6288
Echinococcus granulosus	Fatty acid desaturase type 1	0.0018	0.0185	0.0294
Brugia malayi	steroid hormone receptor	0.0021	0.0302	0.0233
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0021	0.0302	0.0419
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0.0185	0.5
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0666	0.0666
Brugia malayi	Delta5 fatty acid desaturase	0.0018	0.0185	0.0115
Brugia malayi	hypothetical protein	0.0036	0.1	0.0936
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0088	0.0141
Brugia malayi	TAR-binding protein	0.0127	0.519	0.5155
Mycobacterium ulcerans	transmembrane alkane 1-monooxygenase AlkB	0.0018	0.0185	0.5
Mycobacterium tuberculosis	Possible electron transfer protein FdxB	0.0018	0.0185	0.5
Mycobacterium ulcerans	electron transfer protein FdxB	0.0018	0.0185	0.5
Brugia malayi	Fatty acid desaturase family protein	0.0018	0.0185	0.0115
Onchocerca volvulus		0.0021	0.0331	0.0468
Brugia malayi	Intermediate filament tail domain containing protein	0.0029	0.069	0.0624
Onchocerca volvulus		0.0021	0.0302	0.0375
Echinococcus multilocularis	musashi	0.0029	0.069	0.1097
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0302	0.0233
Brugia malayi	hypothetical protein	0.0021	0.0331	0.0262
Brugia malayi	hypothetical protein	0.0021	0.0331	0.0262
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0331	0.0527
Schistosoma mansoni	rab6-interacting	0.0021	0.0331	0.0476
Trypanosoma cruzi	fatty acid desaturase, putative	0.0068	0.2492	0.7358
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0021	0.0302	0.0419
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.167	0.167
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.519	1
Echinococcus multilocularis	muscleblind protein	0.0151	0.6288	1
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0059	0.2086	0.3318
Echinococcus multilocularis	tar DNA binding protein	0.0127	0.519	0.8253
Entamoeba histolytica	hypothetical protein	0.0036	0.1	0.5
Echinococcus granulosus	lipoxygenase domain containing protein	0.0021	0.0331	0.0527
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0021	0.0302	0.0233
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0021	0.0302	0.0375
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0021	0.0302	0.0233
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0302	0.0481
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0021	0.0302	0.0233
Onchocerca volvulus		0.0029	0.069	0.1611
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0021	0.0331	0.0527
Schistosoma mansoni	intermediate filament proteins	0.0029	0.069	0.1179
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0302	0.0419
Toxoplasma gondii	sphingolipid delta 4 desaturase/c-4 hydroxylase protein des2 family protein	0.0018	0.0185	0.5
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0302	0.0419
Brugia malayi	ecdysteroid receptor	0.0021	0.0302	0.0233
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0088	0.0141
Brugia malayi	nuclear hormone receptor	0.0021	0.0302	0.0233
Schistosoma mansoni	lipoxygenase	0.0059	0.2086	0.3917
Loa Loa (eye worm)	FAT-3 protein	0.0018	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0302	0.0302
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0021	0.0302	0.0481
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0185	0.5
Brugia malayi	acyl-CoA desaturase	0.0068	0.2492	0.2438
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0021	0.0302	0.0481
Mycobacterium ulcerans	hypothetical protein	0.0018	0.0185	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0021	0.0302	0.0233
Schistosoma mansoni	polycystin 1-related	0.0021	0.0331	0.0476
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0232	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.167	0.161
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.519	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0302	0.0233
Schistosoma mansoni	retinoic acid receptor RXR	0.0021	0.0302	0.0419
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0302	0.0233
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.1	0.1787
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0185	0.0185
Schistosoma mansoni	RAR-like nuclear receptor	0.0021	0.0302	0.0419
Brugia malayi	Doublecortin family protein	0.0021	0.0331	0.0262
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0021	0.0302	0.0481
Plasmodium vivax	stearoyl-CoA desaturase (acyl-CoA desaturase, faty acid desaturase), putative	0.0068	0.2492	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0021	0.0302	0.0233
Echinococcus multilocularis	Fatty acid desaturase, type 1	0.0018	0.0185	0.0294
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.167	0.161
Schistosoma mansoni	loxhd1	0.0021	0.0331	0.0476
Brugia malayi	nuclear receptor NHR-88	0.0021	0.0302	0.0233
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0088	0.0018
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.519	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0127	0.519	0.519
Brugia malayi	Fatty acid desaturase family protein	0.0018	0.0185	0.0115
Onchocerca volvulus	Protein ultraspiracle homolog	0.0021	0.0302	0.0375
Echinococcus multilocularis	ecdysone induced protein 78C	0.0021	0.0302	0.0481
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0088	0.0141
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0021	0.0302	0.0481
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.1	0.159
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0021	0.0302	0.0233
Echinococcus multilocularis	lamin dm0	0.0029	0.069	0.1097
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0021	0.0302	0.0481
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0021	0.0302	0.0302
Schistosoma mansoni	fatty acid desaturase	0.0018	0.0185	0.0189
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.519	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.6288	0.6288
Echinococcus multilocularis	lamin	0.0029	0.069	0.1097
Mycobacterium tuberculosis	Probable conserved membrane protein	0.0018	0.0185	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0302	0.0302
Schistosoma mansoni	hypothetical protein	0.0034	0.0938	0.1665
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0021	0.0302	0.0481
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0029	0.069	0.069
Trypanosoma brucei	fatty acid desaturase, putative	0.0086	0.332	1
Echinococcus multilocularis	muscleblind protein 1	0.0151	0.6288	1
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0021	0.0302	0.0481
Loa Loa (eye worm)	hypothetical protein	0.005	0.167	0.167
Onchocerca volvulus		0.0029	0.069	0.1611
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0302	0.0302
Echinococcus granulosus	tar DNA binding protein	0.0127	0.519	0.8253
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3	0.0018	0.0185	0.5
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0302	0.0302
Leishmania major	stearic acid desaturase, putative	0.0086	0.332	1
Schistosoma mansoni	nuclear hormone receptor	0.0021	0.0302	0.0419
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0021	0.0302	0.0302
Schistosoma mansoni	thyroid hormone receptor	0.0021	0.0302	0.0419
Schistosoma mansoni	tar DNA-binding protein	0.0127	0.519	1
Schistosoma mansoni	rab6-interacting	0.0021	0.0331	0.0476
Schistosoma mansoni	coup transcription factor	0.0021	0.0302	0.0419
Echinococcus granulosus	intermediate filament protein	0.0029	0.069	0.1097
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0021	0.0302	0.0419
Entamoeba histolytica	hypothetical protein	0.0036	0.1	0.5
Mycobacterium tuberculosis	Probable transmembrane alkane 1-monooxygenase AlkB (alkane 1-hydroxylase) (lauric acid omega-hydroxylase) (omega-hydroxylase) (f	0.0018	0.0185	0.5
Trypanosoma cruzi	fatty acid desaturase, putative	0.0086	0.332	1
Onchocerca volvulus		0.0086	0.332	1
Mycobacterium ulcerans	linoleoyl-CoA desaturase, DesA3_2	0.0018	0.0185	0.5
Schistosoma mansoni	lipoxygenase	0.0021	0.0331	0.0476
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0071	0.0071
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0021	0.0302	0.0233
Echinococcus granulosus	Polycystic kidney disease protein	0.0021	0.0331	0.0527
Schistosoma mansoni	hypothetical protein	0.0021	0.0331	0.0476
Plasmodium falciparum	stearoyl-CoA desaturase	0.0068	0.2492	1
Echinococcus multilocularis	Polycystic kidney disease protein	0.0021	0.0331	0.0527
Brugia malayi	RNA binding protein	0.0127	0.519	0.5155
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0938	0.0938
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0302	0.0481
Brugia malayi	RNA recognition motif domain containing protein	0.0127	0.519	0.5155
Schistosoma mansoni	hypothetical protein	0.0036	0.1	0.1787
Brugia malayi	Muscleblind-like protein	0.0151	0.6288	0.6262
Entamoeba histolytica	hypothetical protein	0.0036	0.1	0.5
Schistosoma mansoni	lamin	0.0029	0.069	0.1179
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0021	0.0302	0.0302
Echinococcus multilocularis	RUN	0.0021	0.0331	0.0527
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0021	0.0302	0.0481
Entamoeba histolytica	hypothetical protein	0.0036	0.1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0029	0.069	0.069
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0302	0.0302
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0021	0.0302	0.0302
Brugia malayi	photoreceptor-specific nuclear receptor	0.0021	0.0302	0.0233
Loa Loa (eye worm)	intermediate filament protein	0.0029	0.069	0.069
Loa Loa (eye worm)	fatty acid desaturase	0.0018	0.0185	0.0185
Echinococcus granulosus	lamin dm0	0.0029	0.069	0.1097
Onchocerca volvulus		0.0021	0.0331	0.0468
Echinococcus granulosus	ecdysone induced protein 78C	0.0021	0.0302	0.0481
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.1	0.159
Brugia malayi	Steroid receptor seven-up type 2	0.0021	0.0302	0.0233
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0059	0.2086	0.3318
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0021	0.0302	0.0481
Echinococcus multilocularis	Peptidase M, neutral zinc metallopeptidases, zinc binding site	0.0018	0.0185	0.0294
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0021	0.0302	0.0419
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0021	0.0302	0.0302
Loa Loa (eye worm)	fatty acid desaturase	0.0018	0.0185	0.0185
Brugia malayi	intermediate filament protein	0.0029	0.069	0.0624
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0021	0.0302	0.0481
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0021	0.0302	0.0233
Echinococcus granulosus	Sphingolipid delta4 desaturase DES1	0.0018	0.0185	0.0294
Loa Loa (eye worm)	doublecortin family protein	0.0021	0.0331	0.0331
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0302	0.0302
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0021	0.0302	0.0481
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0021	0.0302	0.0233

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.43 uM	Inhibition of rat SCD1 by rat microsomal assay	ChEMBL.	23265904

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2315509

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1736636