Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0024 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0024 | 0.0024 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0001 | 0.0001 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0135 | 0.0135 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.1595 | 0.1595 |
Echinococcus granulosus | carboxylesterase 5A | 0.1456 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.1595 | 0.1595 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0001 | 0.0001 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0246 | 0.1595 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.1456 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1456 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.1456 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.1456 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1456 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0246 | 0.1595 | 0.1595 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0024 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0246 | 0.1595 | 0.1595 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0246 | 0.1595 | 0.1595 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.002 | 0.0024 | 0.0024 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0001 | 0.0001 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0024 | 0.5 |
Onchocerca volvulus | 0.0246 | 0.1595 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.1595 | 0.1595 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1456 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0024 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | carboxylesterase | 0.0246 | 0.1595 | 0.1595 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0246 | 0.1595 | 1 |
Onchocerca volvulus | 0.0246 | 0.1595 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0246 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1595 | 0.1595 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0246 | 0.1595 | 0.1595 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0024 | 0.5 |
Echinococcus multilocularis | ankyrin repeat protein | 0.0511 | 0.3439 | 0.3439 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0135 | 0.0135 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0024 | 0.5 |
Onchocerca volvulus | 0.0246 | 0.1595 | 0.5 | |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0001 | 0.0001 |
Echinococcus multilocularis | acetylcholinesterase | 0.1456 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1456 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0246 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0251 | 0.0251 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1595 | 0.1595 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0001 | 0.0001 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.1595 | 0.1595 |
Schistosoma mansoni | transient receptor potential cation channel subfamily A member | 0.0511 | 0.3439 | 0.3439 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0024 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0024 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0024 | 0.0024 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0527 | 0.3547 | 0.3547 |
Onchocerca volvulus | 0.0246 | 0.1595 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.1456 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1595 | 0.1595 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.1595 | 0.1595 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0251 | 0.0251 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0246 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.1456 | 1 | 1 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0016 | 0.000000037258 | 0.000000037258 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0024 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1456 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0001 | 0.0001 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1595 | 0.1595 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0246 | 0.1595 | 0.1595 |
Schistosoma mansoni | gliotactin | 0.0246 | 0.1595 | 0.1595 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0246 | 0.1595 | 0.1595 |
Brugia malayi | Carboxylesterase family protein | 0.0246 | 0.1595 | 0.1595 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0001 | 0.0001 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0246 | 0.1595 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.0024 | 0.5 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0528 | 0.3553 | 0.3553 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1595 | 0.1595 |
Echinococcus granulosus | ankyrin repeat protein | 0.0511 | 0.3439 | 0.3439 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0135 | 0.0135 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0251 | 0.0251 |
Echinococcus granulosus | neuroligin | 0.0246 | 0.1595 | 0.1595 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.1595 | 0.1595 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0001 | 0.0001 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0246 | 0.1595 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.002 | 0.0024 | 0.0024 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0246 | 0.1595 | 0.1595 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0246 | 0.1595 | 0.1595 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0246 | 0.1595 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0246 | 0.1595 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0251 | 0.0251 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0024 | 0.0024 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0016 | 0.000000037258 | 0.000000037258 |
Onchocerca volvulus | 0.0246 | 0.1595 | 0.5 | |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0001 | 0.0001 |
Brugia malayi | hypothetical protein | 0.0246 | 0.1595 | 0.1595 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0024 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.