TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 333.427 | Formula: C21H23N3O
H donors: 0 H acceptors: 2 LogP: 5.08 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: C1CCC(C1)Cc1nnc(n1c1ccccc1)COc1ccccc1
InChi: 1S/C21H23N3O/c1-3-11-18(12-4-1)24-20(15-17-9-7-8-10-17)22-23-21(24)16-25-19-13-5-2-6-14-19/h1-6,11-14,17H,7-10,15-16H2
InChiKey: YXDWQVFHROLZHH-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	valosin containing protein	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	microsomal protein of CDC48 family of ATPases	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma cruzi	Valosin-containing protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Cryptosporidium hominis	cell division cycle protein 48	Get druggable targets OG5_126926	All targets in OG5_126926
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma mansoni	cell division control protein 48 aaa family protein	Get druggable targets OG5_126926	All targets in OG5_126926
Babesia bovis	cell division control protein 48, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania braziliensis	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Cryptosporidium parvum	CDC48 like AAA ATPase ortholog	Get druggable targets OG5_126926	All targets in OG5_126926
Mycobacterium ulcerans	ATPase	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium knowlesi	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Entamoeba histolytica	transitional endoplasmic reticulum ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma brucei gambiense	valosin-containing protein homolog,Transitional endoplasmic reticulum ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium vivax	cell division cycle ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Neospora caninum	hypothetical protein	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium berghei	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma congolense	Valosin-containing protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma japonicum	ko:K01509 adenosinetriphosphatase [EC3.6.1.3], putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania major	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania donovani	Valosin-containing protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Echinococcus granulosus	transitional endoplasmic reticulum atpase	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium yoelii	cell division cycle protein 48 homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium vivax	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Plasmodium falciparum	cell division cycle protein 48 homologue, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Mycobacterium tuberculosis	Putative conserved ATPase	Get druggable targets OG5_126926	All targets in OG5_126926
Onchocerca volvulus	Transitional endoplasmic reticulum ATPase homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Entamoeba histolytica	cdc48-like protein, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Trypanosoma brucei	Valosin-containing protein	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma mansoni	cell division control protein 48 aaa family protein	Get druggable targets OG5_126926	All targets in OG5_126926
Theileria parva	cell division cycle protein 48, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania mexicana	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Candida albicans	microsomal protein of CDC48 family of ATPases	Get druggable targets OG5_126926	All targets in OG5_126926
Toxoplasma gondii	cell division protein CDC48CY	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma japonicum	Transitional endoplasmic reticulum ATPase homolog 2, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Loa Loa (eye worm)	VCP protein	Get druggable targets OG5_126926	All targets in OG5_126926
Brugia malayi	transitional endoplasmic reticulum ATPase TER94, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	Get druggable targets OG5_126926	All targets in OG5_126926
Theileria parva	cell division cycle protein 48, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Babesia bovis	cell division cycle protein ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Toxoplasma gondii	cell division protein CDC48AP	Get druggable targets OG5_126926	All targets in OG5_126926
Giardia lamblia	AAA family ATPase	Get druggable targets OG5_126926	All targets in OG5_126926
Schistosoma mansoni	cell division control protein 48 aaa family protein	Get druggable targets OG5_126926	All targets in OG5_126926
Leishmania infantum	Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog	Get druggable targets OG5_126926	All targets in OG5_126926
Toxoplasma gondii	transitional endoplasmic reticulum ATPase, putative	Get druggable targets OG5_126926	All targets in OG5_126926
Neospora caninum	hypothetical protein	Get druggable targets OG5_126926	All targets in OG5_126926
Trichomonas vaginalis	spermatogenesis associated factor, putative	Get druggable targets OG5_126926	All targets in OG5_126926

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	receptor protein kinase, putative	0.0144	0.3772	0.3393
Echinococcus multilocularis	protein kinase	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0362	1	1
Echinococcus multilocularis	transitional endoplasmic reticulum atpase	0.0034	0.0623	0.0576
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0362	1	1
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0218	0.5875	0.5601
Toxoplasma gondii	cell division protein CDC48CY	0.0034	0.0623	0.1108
Echinococcus granulosus	epidermal growth factor receptor	0.0144	0.3772	0.3358
Trypanosoma brucei	protein kinase, putative	0.0144	0.3772	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0144	0.3772	0.374
Giardia lamblia	Kinase, NEK	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0218	0.5875	0.5601
Onchocerca volvulus		0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Brugia malayi	Variant SH3 domain containing protein	0.0218	0.5875	0.5854
Loa Loa (eye worm)	TK/FER protein kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Brugia malayi	Protein kinase domain containing protein	0.0362	1	1
Toxoplasma gondii	protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK/ALK protein kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK/EPH protein kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	conserved hypothetical protein	0.0144	0.3772	1
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0218	0.5875	0.5854
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus multilocularis	tensin	0.0218	0.5875	0.5854
Entamoeba histolytica	serine/threonine kinase, putative	0.0144	0.3772	0.3393
Trichomonas vaginalis	protein kinase atn1, putative	0.0144	0.3772	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.0362	1	1
Brugia malayi	C-terminal src kinase protein 1	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK protein kinase	0.0144	0.3772	0.374
Onchocerca volvulus		0.0362	1	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0144	0.3772	0.3358
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0144	0.3772	1
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0144	0.3772	0.3358
Echinococcus multilocularis	tyrosine kinase	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine kinase	0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0144	0.3772	0.3358
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Entamoeba histolytica	serine/threonine kinase, putative	0.0144	0.3772	0.3393
Echinococcus multilocularis	heat shock protein 70	0.0144	0.3772	0.374
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0218	0.5875	0.5854
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0218	0.5875	0.5854
Onchocerca volvulus		0.0218	0.5875	0.5601
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0144	0.3772	0.374
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Schistosoma mansoni	hypothetical protein	0.0218	0.5875	0.5854
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Onchocerca volvulus		0.0144	0.3772	0.3358
Brugia malayi	SRC-1	0.0362	1	1
Brugia malayi	SH2 domain containing protein	0.0218	0.5875	0.5854
Brugia malayi	Tensin	0.0218	0.5875	0.5854
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0362	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Trichomonas vaginalis	STE family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Schistosoma mansoni	tyrosine kinase	0.0362	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase csk	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK protein kinase	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0362	1	1
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0144	0.3772	0.374
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Giardia lamblia	Protein 21.1	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0144	0.3772	0.374
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	TK protein kinase	0.0362	1	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0218	0.5875	0.5854
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0362	1	1
Echinococcus granulosus	raf serine:threonine protein kinase	0.0144	0.3772	0.3358
Brugia malayi	Tyrosine-protein kinase PR2	0.0144	0.3772	0.374
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0362	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0218	0.5875	0.5854
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Onchocerca volvulus		0.0218	0.5875	0.5601
Brugia malayi	SH2 domain containing protein	0.0218	0.5875	0.5854
Brugia malayi	Raf kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0144	0.3772	0.374
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Trichomonas vaginalis	conserved hypothetical protein	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0218	0.5875	0.5854
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0218	0.5875	0.5854
Onchocerca volvulus		0.0144	0.3772	0.3358
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Brugia malayi	Protein kinase domain containing protein	0.0362	1	1
Onchocerca volvulus		0.0144	0.3772	0.3358
Echinococcus granulosus	tyrosine protein kinase csk	0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus granulosus	N chimaerin	0.0218	0.5875	0.5601
Schistosoma mansoni	serine/threonine RGC	0.0144	0.3772	0.374
Echinococcus granulosus	growth factor receptor bound protein 2	0.0218	0.5875	0.5601
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0362	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0144	0.3772	0.3393
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	tyrosine protein kinase csk	0.0144	0.3772	0.374
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Brugia malayi	Variant SH3 domain containing protein	0.0218	0.5875	0.5854
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0218	0.5875	0.5601
Echinococcus granulosus	SH2 motif	0.0218	0.5875	0.5601
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0144	0.3772	0.374
Echinococcus granulosus	activated cdc42 kinase 1	0.0144	0.3772	0.3358
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	activin receptor type	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK/RYK protein kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	TK protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	tensin-related	0.0218	0.5875	0.5854
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0362	1	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0362	1	1
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Brugia malayi	ephrin receptor 1 precursor	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0144	0.3772	0.374
Onchocerca volvulus		0.0362	1	1
Loa Loa (eye worm)	TK/ACK protein kinase	0.0144	0.3772	0.374
Entamoeba histolytica	tyrosin kinase, putative	0.0144	0.3772	0.3393
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine protein kinase HCK	0.0144	0.3772	0.3358
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Brugia malayi	hypothetical protein	0.0218	0.5875	0.5854
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0144	0.3772	0.3393
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Giardia lamblia	Kinase	0.0144	0.3772	1
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	SH2 domain containing protein 7	0.0218	0.5875	0.5854
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Schistosoma mansoni	growth factor receptor-bound protein	0.0218	0.5875	0.5854
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Echinococcus granulosus	activated cdc42 kinase 1	0.0144	0.3772	0.3358
Brugia malayi	Sex muscle abnormal protein 5	0.0218	0.5875	0.5854
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0362	1	1
Leishmania major	protein kinase, putative	0.0144	0.3772	1
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0144	0.3772	0.374
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Onchocerca volvulus		0.0362	1	1
Brugia malayi	Receptor family ligand binding region containing protein	0.0144	0.3772	0.374
Plasmodium falciparum	protein kinase, putative	0.0144	0.3772	1
Echinococcus granulosus	protein kinase	0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	serine/threonine protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	hypothetical protein	0.0218	0.5875	0.5854
Loa Loa (eye worm)	hypothetical protein	0.002	0.0219	0.017
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0144	0.3772	1
Schistosoma mansoni	tyrosine kinase	0.0362	1	1
Echinococcus multilocularis	tyrosine kinase	0.0362	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0218	0.5875	0.5601
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0144	0.3772	0.374
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0144	0.3772	1
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0218	0.5875	0.5854
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0144	0.3772	1
Brugia malayi	SH2 domain containing protein	0.0218	0.5875	0.5854
Brugia malayi	valosin containing protein	0.002	0.0219	0.017
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0144	0.3772	1
Plasmodium vivax	cell division cycle protein 48 homologue, putative	0.0032	0.0573	0.1519
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus multilocularis	NCK adaptor protein	0.0218	0.5875	0.5854
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0144	0.3772	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	SH2 motif	0.0218	0.5875	0.5854
Entamoeba histolytica	tyrosin kinase, putative	0.0144	0.3772	0.3393
Loa Loa (eye worm)	vesicle-fusing ATPase	0.002	0.0219	0.017
Echinococcus granulosus	receptor type guanylyl cyclase	0.0144	0.3772	0.3358
Trichomonas vaginalis	TK family protein kinase	0.0144	0.3772	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0144	0.3772	0.374
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0362	1	1
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0362	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0362	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	FL cytokine receptor	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0144	0.3772	0.3358
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0144	0.3772	0.3358
Onchocerca volvulus		0.0218	0.5875	0.5601
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0362	1	1
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0144	0.3772	0.374
Schistosoma mansoni	shc transforming protein	0.0218	0.5875	0.5854
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	N chimaerin	0.0218	0.5875	0.5854
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0218	0.5875	0.5854
Schistosoma mansoni	SH2A	0.0218	0.5875	0.5854
Loa Loa (eye worm)	TK/INSR protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0362	1	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	GTPase activating protein	0.0218	0.5875	0.5854
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.0218	0.5875	0.5854
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Schistosoma mansoni	signal transduction protein lnk-related	0.0218	0.5875	0.5854
Loa Loa (eye worm)	TK/DDR protein kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	TK/CSK protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0362	1	1
Echinococcus multilocularis	c src tyrosine kinase	0.0362	1	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0218	0.5875	0.5601
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Brugia malayi	SH2 domain containing protein	0.0218	0.5875	0.5854
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0144	0.3772	1
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Echinococcus granulosus	signal transduction protein lnk realted	0.0218	0.5875	0.5601
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0218	0.5875	0.5854
Echinococcus multilocularis	tyrosine protein kinase csk	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus multilocularis	SH2 motif	0.0218	0.5875	0.5854
Trichomonas vaginalis	CAMK family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Loa Loa (eye worm)	TK/FER protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0144	0.3772	0.374
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0218	0.5875	0.5854
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0362	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0144	0.3772	1
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0144	0.3772	0.3358
Onchocerca volvulus		0.0144	0.3772	0.3358
Echinococcus granulosus	ephrin type A receptor 4 A	0.0144	0.3772	0.3358
Schistosoma mansoni	serine/threonine protein kinase	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0362	1	1
Echinococcus granulosus	epidermal growth factor receptor	0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	epidermal growth factor receptor	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Plasmodium falciparum	tyrosine kinase-like protein	0.0144	0.3772	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0218	0.5875	0.5601
Echinococcus granulosus	SHC transforming protein 3	0.0218	0.5875	0.5601
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	cysteine surface protein, putative	0.0144	0.3772	0.3393
Plasmodium falciparum	protein kinase, putative	0.0144	0.3772	1
Schistosoma mansoni	ephrin receptor	0.0144	0.3772	0.374
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Mycobacterium tuberculosis	Putative conserved ATPase	0.002	0.0231	0.5
Echinococcus granulosus	tyrosine protein kinase	0.0144	0.3772	0.3358
Brugia malayi	Tyrosine-protein kinase abl-1	0.0362	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0218	0.5875	0.5854
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0218	0.5875	0.5854
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0144	0.3772	0.3393
Loa Loa (eye worm)	TK/FER protein kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Entamoeba histolytica	receptor protein kinase, putative	0.0144	0.3772	0.3393
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0218	0.5875	0.5854
Brugia malayi	hypothetical protein	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK protein kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Schistosoma mansoni	suppressor of cytokine signaling	0.0218	0.5875	0.5854
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0362	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0362	1	1
Echinococcus granulosus	NCK adaptor protein	0.0218	0.5875	0.5601
Entamoeba histolytica	serine/threonine kinase, putative	0.0144	0.3772	0.3393
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	epidermal growth factor receptor	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Brugia malayi	vesicle-fusing ATPase	0.002	0.0219	0.017
Loa Loa (eye worm)	TK/FAK protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0144	0.3772	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Entamoeba histolytica	ankyrin repeat protein	0.0144	0.3772	0.3393
Loa Loa (eye worm)	TK protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0218	0.5875	0.5854
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Schistosoma mansoni	tyrosine kinase	0.0362	1	1
Loa Loa (eye worm)	TK/Met protein kinase	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0362	1	1
Trichomonas vaginalis	AGC family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein kinase, putative	0.0218	0.5875	0.5624
Leishmania major	hypothetical protein, conserved	0.0144	0.3772	1
Echinococcus granulosus	tyrosine kinase	0.0362	1	1
Echinococcus granulosus	activin receptor type	0.0144	0.3772	0.3358
Echinococcus granulosus	kinase suppressor of Ras 1	0.0144	0.3772	0.3358
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0144	0.3772	0.374
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0144	0.3772	0.374
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0144	0.3772	0.3358
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0144	0.3772	0.3393
Brugia malayi	protein-tyrosine kinase	0.0362	1	1
Brugia malayi	RhoGAP domain containing protein	0.0218	0.5875	0.5854
Brugia malayi	Guanylyl cyclase protein 23	0.0144	0.3772	0.374
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0144	0.3772	0.374
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0218	0.5875	0.5854
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Plasmodium falciparum	protein kinase, putative	0.0144	0.3772	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus granulosus	protein tyrosine kinase	0.0144	0.3772	0.3358
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0218	0.5875	0.5624
Echinococcus granulosus	hypothetical protein	0.0218	0.5875	0.5601
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Onchocerca volvulus		0.0144	0.3772	0.3358
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0218	0.5875	0.5601
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Schistosoma mansoni	vav2	0.0218	0.5875	0.5854
Trichomonas vaginalis	conserved hypothetical protein	0.0144	0.3772	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0218	0.5875	0.5854
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0032	0.0573	0.0525
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK protein kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0144	0.3772	1
Plasmodium vivax	protein kinase, putative	0.0144	0.3772	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0144	0.3772	0.3393
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0362	1	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0144	0.3772	0.374
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Brugia malayi	Protein kinase domain containing protein	0.0362	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0144	0.3772	0.374
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0218	0.5875	0.5601
Echinococcus granulosus	tyrosine protein kinase csk	0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0362	1	1
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Schistosoma mansoni	adapter molecule crk	0.0218	0.5875	0.5854
Echinococcus granulosus	insulin receptor	0.0144	0.3772	0.3358
Echinococcus granulosus	tyrosine protein kinase csk	0.0144	0.3772	0.3358
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Echinococcus multilocularis	tensin	0.0218	0.5875	0.5854
Giardia lamblia	Kinase, NEK	0.0144	0.3772	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0144	0.3772	0.374
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0362	1	1
Schistosoma mansoni	tyrosine protein kinase	0.0144	0.3772	0.374
Entamoeba histolytica	tyrosin kinase, putative	0.0144	0.3772	0.3393
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0218	0.5875	0.5854
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Brugia malayi	SH2 domain containing protein	0.0362	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0362	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Loa Loa (eye worm)	TK/FER protein kinase	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0144	0.3772	1
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Entamoeba histolytica	ankyrin repeat protein	0.0144	0.3772	0.3393
Loa Loa (eye worm)	TK protein kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0144	0.3772	0.374
Mycobacterium ulcerans	ATPase	0.002	0.0231	0.5
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0144	0.3772	0.374
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0144	0.3772	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0362	1	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	protein tyrosine kinase	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Echinococcus granulosus	tensin	0.0218	0.5875	0.5601
Toxoplasma gondii	STE kinase	0.0144	0.3772	1
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Trypanosoma brucei	Pseudokinase, putative	0.0144	0.3772	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0144	0.3772	0.374
Trichomonas vaginalis	conserved hypothetical protein	0.0144	0.3772	1
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Onchocerca volvulus		0.0218	0.5875	0.5601
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Schistosoma mansoni	cell division control protein 48 aaa family protein	0.0034	0.0623	0.0576
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0362	1	1
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0218	0.5875	0.5854
Onchocerca volvulus		0.0218	0.5875	0.5601
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0144	0.3772	0.374
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0144	0.3772	0.374
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0144	0.3772	0.3358
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0144	0.3772	0.3358
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Brugia malayi	hypothetical protein	0.0362	1	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0218	0.5875	0.5854
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0218	0.5875	0.5601
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Onchocerca volvulus		0.0362	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0144	0.3772	0.3358
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0144	0.3772	0.3393
Echinococcus multilocularis	signal transduction protein lnk realted	0.0218	0.5875	0.5854
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0144	0.3772	0.3358
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Onchocerca volvulus		0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.0362	1	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Onchocerca volvulus		0.0144	0.3772	0.3358
Schistosoma mansoni	tyrosine kinase	0.0362	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Echinococcus multilocularis	tyrosine protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	SH2 motif	0.0218	0.5875	0.5854
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0144	0.3772	1
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine protein kinase Blk	0.0362	1	1
Loa Loa (eye worm)	STAT protein	0.0218	0.5875	0.5854
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Echinococcus granulosus	integrin linked protein kinase	0.0144	0.3772	0.3358
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Loa Loa (eye worm)	TK/FER protein kinase	0.0144	0.3772	0.374
Trypanosoma cruzi	protein kinase, putative	0.0144	0.3772	1
Onchocerca volvulus		0.0362	1	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0218	0.5875	0.5854
Brugia malayi	SH2 domain containing protein	0.0218	0.5875	0.5854
Echinococcus multilocularis	integrin linked protein kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Schistosoma mansoni	ephrin receptor	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine protein kinase shark	0.0362	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0144	0.3772	0.3358
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Brugia malayi	SH2 domain containing protein	0.0218	0.5875	0.5854
Loa Loa (eye worm)	SH2 domain-containing protein	0.0218	0.5875	0.5854
Schistosoma mansoni	suppressor of cytokine signaling	0.0218	0.5875	0.5854
Echinococcus multilocularis	insulin receptor	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0144	0.3772	0.374
Schistosoma mansoni	serine/threonine protein kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0144	0.3772	0.3358
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0144	0.3772	0.374
Loa Loa (eye worm)	hypothetical protein	0.0362	1	1
Toxoplasma gondii	protein kinase domain-containing protein	0.0144	0.3772	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Toxoplasma gondii	cell division protein CDC48AP	0.002	0.0231	0.0000010849
Loa Loa (eye worm)	SH2 domain-containing protein	0.0218	0.5875	0.5854
Brugia malayi	integrin-linked kinase	0.0144	0.3772	0.374
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0144	0.3772	1
Entamoeba histolytica	hypothetical protein, conserved	0.0144	0.3772	0.3393
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK protein kinase	0.0144	0.3772	0.374
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0144	0.3772	0.374
Echinococcus multilocularis	transfer RNA-Thr	0.0144	0.3772	0.374
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Echinococcus granulosus	SH2 motif	0.0218	0.5875	0.5601
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus granulosus	tyrosine protein kinase pr2	0.0144	0.3772	0.3358
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Schistosoma mansoni	tensin	0.0218	0.5875	0.5854
Echinococcus multilocularis	activated cdc42 kinase 1	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0144	0.3772	0.3358
Schistosoma mansoni	serine/threonine protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	nck2/grb4	0.0218	0.5875	0.5854
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	SRC-1	0.0362	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0362	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Trypanosoma cruzi	protein kinase, putative	0.0144	0.3772	1
Brugia malayi	Variant SH3 domain containing protein	0.0218	0.5875	0.5854
Brugia malayi	Furin-like cysteine rich region family protein	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0144	0.3772	0.374
Echinococcus multilocularis		0.0218	0.5875	0.5854
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0362	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Loa Loa (eye worm)	TK/ROR protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	tensin	0.0218	0.5875	0.5854
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0218	0.5875	0.5854
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Onchocerca volvulus		0.0362	1	1
Schistosoma mansoni	tensin-related	0.0218	0.5875	0.5854
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0144	0.3772	0.3358
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0144	0.3772	0.374
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Brugia malayi	SH2 domain containing protein	0.0218	0.5875	0.5854
Entamoeba histolytica	hypothetical protein	0.0144	0.3772	0.3393
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0144	0.3772	0.3358
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0362	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0218	0.5875	0.5854
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0362	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0362	1	1
Schistosoma mansoni	tensin	0.0218	0.5875	0.5854
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0218	0.5875	0.5854
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Schistosoma mansoni	hypothetical protein	0.0144	0.3772	0.374
Brugia malayi	Protein kinase domain containing protein	0.0144	0.3772	0.374
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0218	0.5875	0.5854
Brugia malayi	SH2 domain containing protein	0.0362	1	1
Leishmania major	protein kinase, putative	0.0144	0.3772	1
Entamoeba histolytica	tyrosin kinase, putative	0.0144	0.3772	0.3393
Trichomonas vaginalis	conserved hypothetical protein	0.0144	0.3772	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0144	0.3772	0.374
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Onchocerca volvulus	Tyrosine kinase homolog	0.0144	0.3772	0.3358
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0218	0.5875	0.5601
Echinococcus granulosus	tyrosine kinase	0.0362	1	1
Schistosoma mansoni	protein tyrosine kinase	0.0144	0.3772	0.374
Echinococcus granulosus	SH2 domain containing protein 7	0.0218	0.5875	0.5601
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	hypothetical protein	0.0144	0.3772	0.374
Onchocerca volvulus		0.0218	0.5875	0.5601
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0144	0.3772	0.374
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0144	0.3772	0.3393
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0144	0.3772	0.374
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0218	0.5875	0.5601
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5875	0.5854
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0144	0.3772	0.3358
Schistosoma mansoni	tyrosine kinase	0.0362	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0144	0.3772	1
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	TK protein kinase	0.0144	0.3772	0.374
Schistosoma mansoni	serine/threonine protein kinase	0.0144	0.3772	0.374
Echinococcus granulosus	c src tyrosine kinase	0.0362	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Echinococcus granulosus	expressed conserved protein	0.0218	0.5875	0.5601
Schistosoma mansoni	protein kinase	0.0144	0.3772	0.374
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0218	0.5875	0.5854
Entamoeba histolytica	protein kinase, putative	0.0144	0.3772	0.3393
Brugia malayi	hypothetical protein	0.0144	0.3772	0.374
Echinococcus granulosus	tyrosine protein kinase Srms	0.0362	1	1
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0218	0.5875	0.5854
Entamoeba histolytica	SH2 domain containing protein	0.0218	0.5875	0.5624
Entamoeba histolytica	protein kinase domain containing protein	0.0144	0.3772	0.3393
Entamoeba histolytica	tyrosine kinase, putative	0.0144	0.3772	0.3393
Echinococcus multilocularis	SHC transforming protein 3	0.0218	0.5875	0.5854
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0144	0.3772	1
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0144	0.3772	1
Trichomonas vaginalis	TKL family protein kinase	0.0144	0.3772	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0362	1	1
Schistosoma mansoni	tyrosine kinase	0.0144	0.3772	0.374
Onchocerca volvulus		0.0144	0.3772	0.3358
Trichomonas vaginalis	conserved hypothetical protein	0.0144	0.3772	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.97 uM	Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir to substrate addition measured after 90 mins by NADH coupled assay	ChEMBL.	23245311

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2315764

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1736993