TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 421.512 | Formula: C23H23N3O3S
H donors: 1 H acceptors: 2 LogP: 4.35 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)NC1CCN(CC1)Cc1coc2c1ccc(c2)Oc1nc2c(s1)cccc2
InChi: 1S/C23H23N3O3S/c1-15(27)24-17-8-10-26(11-9-17)13-16-14-28-21-12-18(6-7-19(16)21)29-23-25-20-4-2-3-5-22(20)30-23/h2-7,12,14,17H,8-11,13H2,1H3,(H,24,27)
InChiKey: RDDQQKHXDCUMRC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	leukotriene A4 hydrolase	Starlite/ChEMBL	References
Homo sapiens	leukotriene A4 hydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	Get druggable targets OG5_129538	All targets in OG5_129538
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538
Loa Loa (eye worm)	leukotriene A4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Schistosoma japonicum	ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative	Get druggable targets OG5_129538	All targets in OG5_129538
Echinococcus multilocularis	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	leukotriene A4 hydrolase	611 aa	513 aa	24.0 %
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	leukotriene A4 hydrolase	611 aa	508 aa	22.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.003	0.0346	0.0346
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0346	0.0286
Loa Loa (eye worm)	peptidase family M1 containing protein	0.003	0.0346	0.0346
Brugia malayi	Peptidase family M1 containing protein	0.003	0.0346	0.0769
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.092	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0097	0.2804
Trypanosoma cruzi	Aminopeptidase M1, putative	0.003	0.0346	0.3312
Plasmodium falciparum	M1-family alanyl aminopeptidase, putative	0.003	0.0346	0.2312
Onchocerca volvulus	Cathepsin F homolog	0.0016	0.0097	0.2804
Trypanosoma cruzi	cruzipain precursor, putative	0.0061	0.092	1
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0097	0.0216
Loa Loa (eye worm)	TATA binding protein associated factor	0.003	0.0346	0.0346
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.003	0.0346	0.3312
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0097	0.0036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.0681	0.722
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.003	0.0346	0.3312
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0097	0.2804
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0075	0.1172	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0016	0.0097	0.0097
Loa Loa (eye worm)	cytochrome P450	0.0014	0.0061	0.0061
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0275	0.1659
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.003	0.0346	0.2312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Echinococcus multilocularis	aminopeptidase N	0.003	0.0346	0.0286
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0075	0.1172	0.5
Echinococcus multilocularis	cysteine protease	0.0016	0.0097	0.0036
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Echinococcus granulosus	aminopeptidase N	0.003	0.0346	0.0346
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0061	0.0136
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0061	0.0061
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0075	0.1172	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Leishmania major	cathepsin L-like protease	0.0016	0.0097	0.0419
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0097	0.0216
Echinococcus granulosus	cytochrome P450 2K1	0.0014	0.0061	0.0061
Brugia malayi	hypothetical protein	0.0256	0.4492	1
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.003	0.0346	0.0286
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0346	0.0346
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0097	0.2804
Mycobacterium ulcerans	aminopeptidase N PepN	0.003	0.0346	0.2561
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0049	0.0701	1
Brugia malayi	Peptidase family M1 containing protein	0.003	0.0346	0.0769
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0097	0.2804
Loa Loa (eye worm)	aminopeptidase N	0.003	0.0346	0.0346
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.003	0.0346	0.0346
Onchocerca volvulus		0.0016	0.0097	0.2804
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0346	0.0286
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0097	0.2804
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Leishmania major	cysteine peptidase A (CPA)	0.0016	0.0097	0.0419
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0075	0.1172	0.1118
Schistosoma mansoni	cytochrome P450	0.0014	0.0061	0.0061
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0075	0.1172	1
Onchocerca volvulus		0.0016	0.0097	0.2804
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0097	0.2804
Leishmania major	cathepsin L-like protease	0.0061	0.092	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Loa Loa (eye worm)	CYP4Cod1	0.0014	0.0061	0.0061
Plasmodium falciparum	M1-family alanyl aminopeptidase	0.003	0.0346	0.2312
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0346	0.0286
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Plasmodium vivax	M1-family alanyl aminopeptidase, putative	0.003	0.0346	0.2312
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0075	0.1172	1
Trypanosoma cruzi	aminopeptidase, putative	0.003	0.0346	0.3312
Loa Loa (eye worm)	hypothetical protein	0.003	0.0346	0.0346
Trypanosoma brucei	Aminopeptidase M1, putative	0.003	0.0346	0.3312
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.092	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0346	0.0346
Leishmania major	cathepsin L-like protease	0.0061	0.092	1
Loa Loa (eye worm)	fibroinase	0.0016	0.0097	0.0097
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.003	0.0346	0.3312
Loa Loa (eye worm)	transcription factor SMAD2	0.0114	0.1893	0.1893
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0346	0.0286
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0097	0.0036
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0097	0.2804
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Toxoplasma gondii	cathepsin CPL	0.0016	0.0097	0.0324
Onchocerca volvulus		0.003	0.0346	1
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0097	0.2804
Loa Loa (eye worm)	MH2 domain-containing protein	0.0114	0.1893	0.1893
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.003	0.0346	0.3312
Leishmania major	cathepsin L-like protease	0.0016	0.0097	0.0419
Entamoeba histolytica	cysteine proteinase, putative	0.0016	0.0097	0.2804
Leishmania major	cathepsin L-like protease	0.0061	0.092	1
Onchocerca volvulus		0.0016	0.0097	0.2804
Echinococcus granulosus	peptidase Clp S14 family	0.0049	0.0701	0.0701
Onchocerca volvulus	Cathepsin L homolog	0.0016	0.0097	0.2804
Trypanosoma cruzi	puromycin-sensitive aminopeptidase-like protein, putative	0.003	0.0346	0.3312
Trypanosoma cruzi	aminopeptidase, putative	0.003	0.0346	0.3312
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0016	0.0097	0.0097
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0275	0.1659
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0049	0.0701	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0016	0.0097	0.0036
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0049	0.0701	0.5758
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0016	0.0097	0.0097
Brugia malayi	Probable ClpP-like protease	0.0075	0.1172	0.261
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.003	0.0346	0.0346
Onchocerca volvulus		0.003	0.0346	1
Toxoplasma gondii	hypothetical protein	0.0026	0.0275	0.1929
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Brugia malayi	MH2 domain containing protein	0.0114	0.1893	0.4215
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0097	0.0216
Toxoplasma gondii	aminopeptidase n, putative	0.003	0.0346	0.2561
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0097	0.2804
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.003	0.0346	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.003	0.0346	1
Brugia malayi	Papain family cysteine protease containing protein	0.0016	0.0097	0.0216
Leishmania major	cathepsin L-like protease	0.0016	0.0097	0.0419
Brugia malayi	TATA binding protein associated factor	0.003	0.0346	0.0769
Onchocerca volvulus		0.0016	0.0097	0.2804
Entamoeba histolytica	aminopeptidase, putative	0.003	0.0346	1
Trypanosoma brucei	Aminopeptidase M1, putative	0.003	0.0346	0.3312
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0061	0.0136
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.003	0.0346	0.0286
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0346	0.0346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0016	0.0097	0.2804
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0097	0.2804
Schistosoma mansoni	peptidase Clp (S14 family)	0.0075	0.1172	0.1172
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0097	0.0216
Onchocerca volvulus		0.0016	0.0097	0.2804
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0346	0.0346
Brugia malayi	cytochrome P450	0.0014	0.0061	0.0136
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0075	0.1172	1
Loa Loa (eye worm)	hypothetical protein	0.0075	0.1172	0.1172
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.003	0.0346	1
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0049	0.0701	0.0644
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0061	0.0061
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0016	0.0097	0.0097
Schistosoma mansoni	cathepsin F (C01 family)	0.0016	0.0097	0.0097
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Brugia malayi	Peptidase family M1 containing protein	0.003	0.0346	0.0769
Mycobacterium ulcerans	aminopeptidase N PepN	0.003	0.0346	0.2561
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0026	0.0275	0.1929
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0061	0.092	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0075	0.1172	1
Brugia malayi	hypothetical protein	0.003	0.0346	0.0769
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0097	0.0216
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0056	0.0823	0.8873
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0061	0.0136
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0097	0.2804
Schistosoma mansoni	aminopeptidase A (M01 family)	0.003	0.0346	0.0346
Echinococcus granulosus	cathepsin l1	0.0016	0.0097	0.0097
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0016	0.0097	0.2804
Toxoplasma gondii	aminopeptidase N protein	0.003	0.0346	0.2561
Leishmania major	cathepsin L-like protease	0.0016	0.0097	0.0419
Entamoeba histolytica	cysteine protease, putative	0.0016	0.0097	0.2804
Brugia malayi	hypothetical protein	0.003	0.0346	0.0769
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0075	0.1172	1
Onchocerca volvulus		0.0016	0.0097	0.2804
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0075	0.1172	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.003	0.0346	0.3312
Loa Loa (eye worm)	hypothetical protein	0.003	0.0346	0.0346
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0558	1	1
Schistosoma mansoni	hypothetical protein	0.0014	0.0061	0.0061
Leishmania major	puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.003	0.0346	0.3312
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.003	0.0346	0.3312
Onchocerca volvulus		0.003	0.0346	1
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0558	1	1
Loa Loa (eye worm)	cysteine protease	0.0016	0.0097	0.0097
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0346	0.0346
Brugia malayi	Cathepsin L-like precursor	0.0016	0.0097	0.0216
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0016	0.0097	0.0036
Leishmania major	cathepsin L-like protease	0.0016	0.0097	0.0419
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0558	1	1
Onchocerca volvulus		0.0016	0.0097	0.2804
Toxoplasma gondii	aminopeptidase N, putative	0.003	0.0346	0.2561
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0075	0.1172	0.5
Trypanosoma brucei	aminopeptidase, putative	0.003	0.0346	0.3312
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.003	0.0346	0.0346
Trypanosoma cruzi	cysteine peptidase, putative	0.0016	0.0097	0.0419
Echinococcus multilocularis	cysteine protease	0.0016	0.0097	0.0036
Brugia malayi	Cytochrome P450 family protein	0.0014	0.0061	0.0136
Loa Loa (eye worm)	hypothetical protein	0.003	0.0346	0.0346
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0016	0.0097	0.2804
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.003	0.0346	0.3312
Loa Loa (eye worm)	cytochrome P450 family protein	0.0014	0.0061	0.0061
Loa Loa (eye worm)	ctsf protein	0.0016	0.0097	0.0097
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0075	0.1172	0.5
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0075	0.1172	0.1172
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.003	0.0346	0.3312
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0061	0.092	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 26 nM	Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after 10 to 30 mins by enzyme immunoassay	ChEMBL.	23260350
IC50 (binding)	= 100 nM	Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calcium ionophore challenge measured after 10 to 30 mins by enzyme immunoassay	ChEMBL.	23260350

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2313568

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1737050