TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 944.125 | Formula: C53H65N7O9
H donors: 4 H acceptors: 6 LogP: 5.03 Rotable bonds: 15
Rule of 5 violations (Lipinski): 2
SMILES: COC(=O)[C@@]1(C[C@@H]2CN(CCc3c1[nH]c1c3cccc1)C[C@@](C2)(CC)NC(=O)NCc1ccccn1)c1cc2c(cc1OC)N([C@@H]1[C@@]32CCN2[C@H]3[C@@]([C@H]([C@]1(O)C(=O)OC)OC(=O)C)(CC)C=CC2)C
InChi: 1S/C53H65N7O9/c1-8-49(57-48(64)55-29-34-15-12-13-21-54-34)27-33-28-52(46(62)67-6,42-36(18-23-59(30-33)31-49)35-16-10-11-17-39(35)56-42)38-25-37-40(26-41(38)66-5)58(4)44-51(37)20-24-60-22-14-19-50(9-2,43(51)60)45(69-32(3)61)53(44,65)47(63)68-7/h10-17,19,21,25-26,33,43-45,56,65H,8-9,18,20,22-24,27-31H2,1-7H3,(H2,55,57,64)/t33-,43+,44-,45-,49+,50-,51-,52+,53+/m1/s1
InChiKey: KCTIIDXMWIYCNA-DEHDGIPMSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0124	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0124	0.0491
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0102	0.1373
Echinococcus multilocularis	cathepsin L	0.0019	0.005	0.0074
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0124	0.0174
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0124	0.0174
Plasmodium vivax	vivapain-2	0.0036	0.0124	0.0158
Plasmodium falciparum	protoporphyrinogen oxidase	0.0166	0.0676	0.0966
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0166	0.0676	0.1065
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0676	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0012	0.0021	0.0016
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Leishmania major	UDP-galactopyranose mutase	0.0166	0.0676	0.0861
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0603	0.2535	1
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.005	0.006
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0073	0.0937
Entamoeba histolytica	cysteine protease, putative	0.0036	0.0124	0.0301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0024	0.0073	0.0096
Schistosoma mansoni	hypothetical protein	0.0443	0.1854	0.2832
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0124	0.0846
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0124	0.0491
Plasmodium vivax	vivapain-1	0.0019	0.005	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0124	0.1704
Brugia malayi	hypothetical protein	0.0166	0.0676	0.102
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0124	0.0491
Onchocerca volvulus		0.0036	0.0124	0.0846
Echinococcus granulosus	cathepsin L cysteine protease	0.0019	0.005	0.0074
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.2359	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0124	0.1704
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Schistosoma mansoni	hypothetical protein	0.0184	0.0751	0.1145
Echinococcus multilocularis	microtubule associated protein 2	0.1495	0.6329	1
Schistosoma mansoni	hypothetical protein	0.0184	0.0751	0.1145
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0073	0.0289
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0603	0.2535	1
Echinococcus granulosus	cathepsin l1	0.0036	0.0124	0.0192
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0124	0.0192
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0124	0.0491
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.005	0.0071
Echinococcus granulosus	microtubule associated protein 2	0.1495	0.6329	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0109	0.0432	0.0631
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Loa Loa (eye worm)	cysteine protease	0.0036	0.0124	0.1704
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0102	0.0141
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.005	0.0044
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0019	0.005	0.0044
Echinococcus multilocularis	cysteine protease	0.0036	0.0124	0.0192
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0124	0.0192
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0603	0.2535	0.4002
Plasmodium vivax	unspecified product	0.0019	0.005	0.0044
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0603	0.2535	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0603	0.2535	0.3857
Schistosoma mansoni	dihydroorotate dehydrogenase	0.1544	0.6538	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0603	0.2535	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.005	0.0195
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0036	0.0124	0.1704
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.005	0.006
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0036	0.0124	0.0192
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.1544	0.6538	1
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0676	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.005	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0676	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.005	0.0071
Plasmodium vivax	vivapain-2	0.0036	0.0124	0.0158
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.1544	0.6538	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0168	0.0684	0.0873
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.005	0.0044
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0073	0.0096
Schistosoma mansoni	cpg binding protein	0.0031	0.0102	0.0152
Plasmodium falciparum	dihydroorotate dehydrogenase	0.1544	0.6538	1
Echinococcus granulosus	cathepsin l1	0.0024	0.0073	0.0111
Echinococcus granulosus	cpg binding protein	0.0033	0.011	0.0169
Plasmodium vivax	hypothetical protein, conserved	0.0166	0.0676	0.1006
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0221	0.015
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0124	0.0491
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.1544	0.6538	1
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0124	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0073	0.0937
Onchocerca volvulus		0.0166	0.0676	1
Onchocerca volvulus		0.0031	0.0102	0.0481
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0024	0.0073	0.0289
Onchocerca volvulus	Cathepsin F homolog	0.0036	0.0124	0.0846
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0166	0.0676	0.0966
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0012	0.0021	0.0152
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0124	0.0491
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0603	0.2535	1
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.1544	0.6538	0.5
Echinococcus granulosus	cysteine protease	0.0019	0.005	0.0074
Onchocerca volvulus		0.0036	0.0124	0.0846
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0166	0.0676	0.1006
Loa Loa (eye worm)	fibroinase	0.0036	0.0124	0.1704
Schistosoma mansoni	microtubule-associated protein tau	0.1495	0.6329	0.9681
Echinococcus granulosus	dnaJ subfamily B	0.0443	0.1854	0.2926
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.1544	0.6538	1
Leishmania major	cathepsin L-like protease	0.0138	0.0558	0.0676
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0166	0.0676	0.1031
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0166	0.0676	0.1065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0124	0.0186
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Onchocerca volvulus		0.0036	0.0124	0.0846
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0124	0.0192
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0603	0.2535	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0603	0.2535	1
Echinococcus multilocularis	cysteine protease	0.0036	0.0124	0.0192
Onchocerca volvulus		0.0036	0.0124	0.0846
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0124	0.0491
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.1544	0.6538	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.0251	0.0379
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0676	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0152
Schistosoma mansoni	cathepsin F (C01 family)	0.0024	0.0073	0.0108
Trypanosoma cruzi	cysteine protease, putative	0.0019	0.005	0.0044
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0124	0.0174
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0166	0.0676	0.1006
Schistosoma mansoni	amine oxidase	0.0166	0.0676	0.1031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Leishmania major	cathepsin L-like protease	0.0138	0.0558	0.0676
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0166	0.0676	0.0966
Plasmodium vivax	hypothetical protein, conserved	0.0166	0.0676	0.1006
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0036	0.0124	0.0115
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0166	0.0676	0.1006
Leishmania major	dihydroorotate dehydrogenase	0.1544	0.6538	1
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.1544	0.6538	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0138	0.0558	0.0824
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0124	0.0491
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0124	0.0174
Echinococcus granulosus	geminin	0.0184	0.0751	0.1183
Echinococcus multilocularis	dnaJ subfamily B	0.0443	0.1854	0.2926
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0036	0.0124	0.0115
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0124	0.0491
Leishmania major	cathepsin L-like protease	0.0138	0.0558	0.0676
Onchocerca volvulus		0.0036	0.0124	0.0846
Entamoeba histolytica	cysteine proteinase, putative	0.0024	0.0073	0.0096
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0166	0.0676	0.1065
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0166	0.0676	0.5
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0019	0.005	0.0071
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0036	0.0124	0.0115
Brugia malayi	Cathepsin L-like precursor	0.0024	0.0073	0.0096
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Trypanosoma cruzi	cruzipain precursor, putative	0.0138	0.0558	0.0824
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0124	0.0846
Onchocerca volvulus		0.0036	0.0124	0.0846
Echinococcus multilocularis	cpg binding protein	0.0033	0.011	0.0169
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Brugia malayi	cathepsin L-like precursor	0.0024	0.0073	0.0096
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Schistosoma mansoni	amine oxidase	0.0166	0.0676	0.1031
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0152
Onchocerca volvulus		0.0036	0.0124	0.0846
Trypanosoma cruzi	cysteine proteinase, putative	0.0019	0.005	0.0044
Brugia malayi	SWIRM domain containing protein	0.0166	0.0676	0.102
Trypanosoma cruzi	cysteine peptidase, putative	0.0036	0.0124	0.0158
Brugia malayi	amine oxidase, flavin-containing family protein	0.0166	0.0676	0.102
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0124	0.0174
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0124	0.0491
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0073	0.0937
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.1544	0.6538	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0021	0.0152
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.1544	0.6538	1
Schistosoma mansoni	cpg binding protein	0.0033	0.011	0.0164
Trypanosoma cruzi	cysteine peptidase, putative	0.0138	0.0558	0.0824
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0126	0.0507	0.0746
Echinococcus multilocularis		0.0166	0.0676	0.1065
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.1544	0.6538	1
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0603	0.2535	0.4002
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0012	0.0021	0.0016
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0166	0.0676	0.1065
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.2193	0.9294	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0124	0.0192
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0036	0.0124	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0676	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Schistosoma mansoni	cathepsin s	0.0012	0.0021	0.0028
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0124	0.0491
Loa Loa (eye worm)	ctsf protein	0.0036	0.0124	0.1704
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0138	0.0558	0.0784
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0603	0.2535	0.4002
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0124	0.0301
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0124	0.0174
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.1544	0.6538	0.6802
Echinococcus granulosus	cathepsin L	0.0019	0.005	0.0074
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0011	0.0013
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0166	0.0676	0.1006
Toxoplasma gondii	histone lysine-specific demethylase	0.0166	0.0676	0.0861
Echinococcus multilocularis	geminin	0.0184	0.0751	0.1183
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.1544	0.6538	0.6287
Trypanosoma cruzi	cysteine peptidase, putative	0.0138	0.0558	0.0824
Plasmodium vivax	vivapain-3	0.0019	0.005	0.0044
Schistosoma mansoni	cpg binding protein	0.0033	0.011	0.0164
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0603	0.2535	0.4002
Brugia malayi	Zinc finger, C2H2 type family protein	0.0603	0.2535	0.3867
Loa Loa (eye worm)	hypothetical protein	0.0166	0.0676	1
Entamoeba histolytica	cysteine proteinase, putative	0.0036	0.0124	0.0301
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0021	0.0016
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0124	0.0491
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0166	0.0676	0.1031
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0011	0.0013

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 670 nM	Cytotoxicity against vinblastine-resistant human HCT116/VM46 cells after 72 hrs by phosphatase assay	ChEMBL.	23244701

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	23244701

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2314552

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1737150