Detailed information for compound 1737180

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 388.191 | Formula: C17H11BrFN3O2
  • H donors: 1 H acceptors: 2 LogP: 4.67 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)oc1c2ncnc1Nc1ccc(cc1F)Br
  • InChi: 1S/C17H11BrFN3O2/c1-23-10-3-4-11-14(7-10)24-16-15(11)20-8-21-17(16)22-13-5-2-9(18)6-12(13)19/h2-8H,1H3,(H,20,21,22)
  • InChiKey: YYWCBZVTTQIXEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 5, regulatory subunit 1 (p35) References
Rattus norvegicus Dual specificity tyrosine-phosphorylation-regulated kinase 1A Starlite/ChEMBL References
Homo sapiens CDC-like kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Cyclin-dependent kinase 5 activator 2 precursor, putative Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania infantum serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Schistosoma mansoni cyclin-dependent kinase 5 activator Get druggable targets OG5_133447 All targets in OG5_133447
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Brugia malayi hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Schistosoma japonicum Serine/threonine-protein kinase minibrain, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania mexicana serine/threonine-protein kinase, putative,protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum expressed protein Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 Get druggable targets OG5_133447 All targets in OG5_133447
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum hypothetical protein Get druggable targets OG5_133447 All targets in OG5_133447
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei CMGC/DYRK protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense serine/threonine-protein kinase, putative Get druggable targets OG5_127901 All targets in OG5_127901
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127901 All targets in OG5_127901
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127901 All targets in OG5_127901
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus dual specificity Get druggable targets OG5_127901 All targets in OG5_127901
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis aldo keto reductase 0.0512 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Echinococcus multilocularis aldehyde reductase 0.0364 0.6613 0.6613
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0512 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0148 0.1694 0.1694
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Onchocerca volvulus 0.0512 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0512 1 1
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0109 0.0794 0.0794
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0512 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Schistosoma mansoni aldo-keto reductase 0.0512 1 1
Echinococcus granulosus aldo keto reductase 0.0512 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0512 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0512 1 1
Brugia malayi Protein kinase domain containing protein 0.0109 0.0794 0.0794
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Onchocerca volvulus 0.0512 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0109 0.0794 0.0794
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0512 1 1
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.0309 0.5364 0.5364
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0794 0.0794
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0512 1 1
Echinococcus multilocularis dual specificity 0.0109 0.0794 0.0794
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Plasmodium falciparum aldo-keto reductase, putative 0.0148 0.1694 1
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0109 0.0794 0.0794
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Brugia malayi NADH-dependent xylose reductase 0.0148 0.1694 0.1694
Loa Loa (eye worm) oxidoreductase 0.0512 1 1
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0148 0.1694 1
Echinococcus granulosus aldehyde reductase 0.0364 0.6613 0.6613
Trichomonas vaginalis aldo/keto reductase, putative 0.0512 1 1
Mycobacterium leprae Conserved hypothetical protein 0.0364 0.6613 0.5922
Trichomonas vaginalis aldo/keto reductase, putative 0.0512 1 1
Leishmania major prostaglandin f synthase, putative 0.0512 1 1
Mycobacterium ulcerans oxidoreductase 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1686 0.1686
Toxoplasma gondii aldo-keto reductase 0.0148 0.1694 0.1694
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0148 0.1694 0.1694
Echinococcus granulosus aldo keto reductase 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0148 0.1694 0.1694
Toxoplasma gondii aldose reductase, putative 0.0512 1 1
Trypanosoma brucei prostaglandin f synthase 0.0512 1 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0148 0.1694 0.1694
Giardia lamblia Aldose reductase 0.0512 1 1
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0148 0.1694 0.1694
Entamoeba histolytica aldose reductase, putative 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0148 0.1694 0.1694
Loa Loa (eye worm) oxidoreductase 0.0512 1 1
Onchocerca volvulus 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0148 0.1686 0.1686
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0512 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0148 0.1694 0.1694
Plasmodium vivax aldehyde reductase, putative 0.0148 0.1694 1
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.0309 0.5364 0.5364
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0109 0.0794 0.0794
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0148 0.1694 0.1694
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0148 0.1694 0.1694
Entamoeba histolytica aldose reductase, putative 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0512 1 1
Echinococcus granulosus dual specificity 0.0109 0.0794 0.0794
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0148 0.1694 0.1694
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0512 1 1
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0512 1 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0512 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0512 1 1
Echinococcus multilocularis voltage gated potassium channel subunit 0.0148 0.1694 0.1694
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Echinococcus multilocularis aldo keto reductase 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0512 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Echinococcus granulosus hypothetical protein 0.0512 1 1
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0512 1 1
Echinococcus multilocularis aldo keto reductase 0.0512 1 1
Loa Loa (eye worm) oxidoreductase 0.0512 1 1
Loa Loa (eye worm) oxidoreductase 0.0512 1 1
Echinococcus granulosus aldo keto reductase 0.0512 1 1
Onchocerca volvulus 0.0512 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0512 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0512 1 1
Onchocerca volvulus 0.0512 1 1
Schistosoma mansoni aldo-keto reductase 0.0512 1 1
Trypanosoma cruzi aldo-keto reductase 0.0512 1 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0148 0.1694 0.1694
Trypanosoma brucei aldo-keto reductase, putative 0.0512 1 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0148 0.1694 0.1694
Loa Loa (eye worm) oxidoreductase 0.0512 1 1
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0755 0.0755
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Entamoeba histolytica alcohol dehydrogenase, putative 0.0148 0.1694 0.0978
Entamoeba histolytica alcohol dehydrogenase, putative 0.0148 0.1694 0.0978
Loa Loa (eye worm) hypothetical protein 0.0309 0.5364 0.5364
Schistosoma mansoni pol-related 0.0512 1 1
Plasmodium falciparum aldehyde reductase, putative 0.0148 0.1694 1
Brugia malayi hypothetical protein 0.0148 0.1686 0.1686
Trichomonas vaginalis aldo/keto reductase, putative 0.0512 1 1
Entamoeba histolytica aldose reductase, putative 0.0512 1 1
Onchocerca volvulus 0.0512 1 1
Giardia lamblia Aldose reductase 0.0512 1 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0512 1 1
Echinococcus granulosus voltage gated potassium channel subunit 0.0148 0.1694 0.1694
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.0309 0.5364 0.5364
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0512 1 1
Trypanosoma brucei aldo/keto reductase, putative 0.0148 0.1694 0.1694
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0109 0.0794 0.0794
Leishmania major aldo-keto reductase-like protein 0.0512 1 1
Schistosoma mansoni potassium channel beta 0.0148 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0107 0.0755 0.0755
Echinococcus multilocularis aldo keto reductase 0.0512 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 10 uM Inhibition of human recombinant CLK1-GST expressed in Escherichia coli using GRSRSRSRSRSR as substrate ChEMBL. 23237976
IC50 (binding) > 10 uM Inhibition of rat recombinant DYRK1A-GST expressed in Escherichia coli using KKISGRLSPIMTEQ as substrate ChEMBL. 23237976
IC50 (binding) > 10 uM Inhibition of human recombinant CDK5/p25 after 30 mins by scintillation counting ChEMBL. 23237976

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.