Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.0726 | 1 | 1 |
Leishmania major | N-myristoyl transferase, putative | 0.0585 | 0.5867 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0585 | 0.5867 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0726 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0585 | 0.5867 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0726 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0726 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0726 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0726 | 1 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0585 | 0.5867 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0726 | 1 | 1 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0585 | 0.5867 | 0.5 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0585 | 0.5867 | 0.5 |
Giardia lamblia | CDC72 | 0.0585 | 0.5867 | 0.5 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0585 | 0.5867 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0726 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0726 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0726 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0585 | 0.5867 | 0.5 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0585 | 0.5867 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0726 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 8 ug ml-1 | Antimicrobial activity against Escherichia coli DH52 after 24 hrs by microbroth dilution method | ChEMBL. | No reference |
MIC (functional) | = 8 ug ml-1 | Antibacterial activity against Escherichia coli DH52 by two fold serial dilution method | ChEMBL. | 23312473 |
MIC80 (functional) | = 8 ug ml-1 | Antimicrobial activity against Candida mycoderma after 24 hrs by microbroth dilution method | ChEMBL. | No reference |
MIC80 (functional) | = 16 ug ml-1 | Antimicrobial activity against Candida albicans ATCC 90029 after 24 hrs by microbroth dilution method | ChEMBL. | No reference |
MIC80 (functional) | = 16 ug ml-1 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 9763 after 24 hrs by microbroth dilution method | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.