Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0019 | 1 | 0.5 |
Schistosoma mansoni | DNA polymerase eta | 0.0019 | 1 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Echinococcus multilocularis | dna polymerase eta | 0.0019 | 1 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 1 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | unspecified product | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0019 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 1 | 0.5 |
Leishmania major | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 1 | 0.5 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0019 | 1 | 0.5 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0019 | 1 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0019 | 1 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 1 | 0.5 |
Echinococcus multilocularis | dna polymerase kappa | 0.0019 | 1 | 0.5 |
Echinococcus granulosus | dna polymerase kappa | 0.0019 | 1 | 0.5 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 1 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0019 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0019 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (ADMET) | = 1.889 uM | Cytotoxicity against human MRC5 cells assessed as growth inhibition after 72 hrs by MTT assay | ChEMBL. | 23276209 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23276209 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.