Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0294 | 0.093 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0039 | 0.0294 | 0.0514 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0659 | 0.2061 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.2849 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0071 | 0.0707 | 0.1252 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1923 | 0.6316 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0192 | 0.0593 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0294 | 0.093 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0088 | 0.2849 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0039 | 0.0294 | 0.1041 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0019 | 0.004 | 0.0115 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0088 | 0.0158 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.3041 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.004 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0192 | 0.0672 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0608 | 0.2174 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0019 | 0.004 | 0.0115 |
Chlamydia trachomatis | DNA ligase | 0.0019 | 0.004 | 1 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0019 | 0.004 | 0.0035 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.0019 | 0.004 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.004 | 0.0115 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1923 | 0.6316 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0039 | 0.0294 | 0.1041 |
Brugia malayi | Carboxylesterase family protein | 0.0039 | 0.0294 | 0.0845 |
Schistosoma mansoni | topbp1 | 0.0019 | 0.004 | 0.0126 |
Onchocerca volvulus | 0.0039 | 0.0294 | 0.1347 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0039 | 0.0294 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0039 | 0.0294 | 0.1041 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0294 | 0.093 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0192 | 0.0504 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0039 | 0.0294 | 0.0514 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0019 | 0.004 | 0.5 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0088 | 0.2849 |
Echinococcus multilocularis | neuropeptide s receptor | 0.045 | 0.5612 | 0.561 |
Brugia malayi | Carboxylesterase family protein | 0.0039 | 0.0294 | 0.0845 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0249 |
Schistosoma mansoni | topbp1 | 0.0019 | 0.004 | 0.0126 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0039 | 0.0294 | 0.095 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1923 | 0.6316 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0088 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0088 | 0.0158 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0707 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0231 | 0.2777 | 0.4943 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0608 | 0.2174 |
Echinococcus multilocularis | acetylcholinesterase | 0.0231 | 0.2777 | 0.2773 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.0019 | 0.004 | 1 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0019 | 0.004 | 0.0000052491 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0047 | 0.0396 | 0.1187 |
Echinococcus granulosus | neuroligin | 0.0039 | 0.0294 | 0.0514 |
Schistosoma mansoni | acetylcholinesterase | 0.0039 | 0.0294 | 0.1041 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0707 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.1061 | 0.3402 |
Echinococcus multilocularis | neuroligin | 0.0039 | 0.0294 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.004 | 0.0093 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.023 | 0.2767 | 0.4925 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.5 |
Onchocerca volvulus | 0.0039 | 0.0294 | 0.1347 | |
Toxoplasma gondii | ATPase, AAA family protein | 0.0019 | 0.004 | 1 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0019 | 0.004 | 0.0062 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.004 | 0.0093 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.0608 | 0.1967 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0707 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0039 | 0.0294 | 0.0514 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0088 | 0.2982 |
Schistosoma mansoni | gliotactin | 0.0039 | 0.0294 | 0.1041 |
Echinococcus granulosus | neuropeptide s receptor | 0.045 | 0.5612 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.004 | 0.0115 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0039 | 0.0294 | 0.0289 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0608 | 0.2174 |
Schistosoma mansoni | DNA ligase IV | 0.0019 | 0.004 | 0.0126 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0294 | 0.0845 |
Echinococcus multilocularis | nibrin | 0.0019 | 0.004 | 0.0035 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0192 | 0.0186 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.2777 | 0.9127 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0088 | 0.0158 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0071 | 0.0707 | 0.0702 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0019 | 0.004 | 0.0115 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0012 | 0.0233 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0165 | 0.1923 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0088 | 0.2849 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.2038 | 0.6695 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.2849 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0012 | 0.0415 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0231 | 0.2777 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0088 | 0.2849 |
Brugia malayi | RNA binding protein | 0.0063 | 0.0608 | 0.1892 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0088 | 0.2849 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0192 | 0.0186 |
Echinococcus granulosus | nibrin | 0.0019 | 0.004 | 0.0062 |
Onchocerca volvulus | 0.0023 | 0.0088 | 0.0251 | |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.0017 | 0.0005 | 0.0186 |
Loa Loa (eye worm) | carboxylesterase | 0.0039 | 0.0294 | 0.093 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1923 | 0.6316 |
Entamoeba histolytica | hypothetical protein | 0.0071 | 0.0707 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.0608 | 0.0603 |
Brugia malayi | Carboxylesterase family protein | 0.0231 | 0.2777 | 0.9119 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0039 | 0.0294 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0192 | 0.0672 |
Onchocerca volvulus | 0.0047 | 0.0396 | 0.1892 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0039 | 0.0294 | 0.0289 |
Brugia malayi | Carboxylesterase family protein | 0.0039 | 0.0294 | 0.0845 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0019 | 0.004 | 0.0126 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0608 | 0.2174 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0088 | 0.0709 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.3041 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0294 | 0.093 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.004 | 0.0115 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.004 | 0.0093 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0039 | 0.0294 | 0.095 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.3041 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.045 | 0.5612 | 0.561 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0251 | 0.3041 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.3041 | 1 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.0017 | 0.0005 | 0.0186 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0039 | 0.0294 | 0.1041 |
Onchocerca volvulus | 0.0039 | 0.0294 | 0.1347 | |
Onchocerca volvulus | 0.0039 | 0.0294 | 0.1347 | |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0192 | 0.0332 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.0019 | 0.004 | 0.121 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0249 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0231 | 0.2777 | 0.2773 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0039 | 0.0294 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0039 | 0.0294 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0019 | 0.004 | 0.5 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0019 | 0.004 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0039 | 0.0294 | 0.0845 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.0608 | 0.2174 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0019 | 0.004 | 0.5 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0088 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0231 | 0.2777 | 0.9119 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0019 | 0.004 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0174 | 0.2038 | 0.6695 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0192 | 0.0332 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1923 | 0.6316 |
Echinococcus multilocularis | acetylcholinesterase | 0.0231 | 0.2777 | 0.2773 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0192 | 0.0332 |
Loa Loa (eye worm) | carboxylesterase | 0.0231 | 0.2777 | 0.9127 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.0608 | 0.1892 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0039 | 0.0294 | 0.1041 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0088 | 0.2849 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0088 | 0.0249 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.045 | 0.5612 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0088 | 1 |
Brugia malayi | hypothetical protein | 0.023 | 0.2767 | 0.9086 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0294 | 0.093 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0251 | 0.3041 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1923 | 0.6316 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.0608 | 0.1892 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0294 | 0.093 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0088 | 0.0709 |
Echinococcus granulosus | carboxylesterase 5A | 0.0231 | 0.2777 | 0.4943 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0192 | 0.0504 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.0608 | 0.1967 |
Echinococcus granulosus | acetylcholinesterase | 0.0231 | 0.2777 | 0.4943 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0192 | 0.0672 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0192 | 0.0186 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.3041 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0659 | 0.2135 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0165 | 0.1923 | 0.6316 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0019 | 0.004 | 0.0115 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0659 | 0.2358 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0251 | 0.3041 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1061 | 0.3464 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0192 | 0.0672 |
Brugia malayi | hypothetical protein | 0.0071 | 0.0707 | 0.2222 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0071 | 0.0707 | 0.2532 |
Treponema pallidum | DNA ligase (lig) | 0.0019 | 0.004 | 1 |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.0019 | 0.004 | 0.4245 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.1061 | 0.3402 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0019 | 0.004 | 0.0115 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0088 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0294 | 0.093 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0019 | 0.004 | 0.0115 |
Onchocerca volvulus | 0.0039 | 0.0294 | 0.1347 | |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0088 | 0.2982 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0231 | 0.2777 | 0.9127 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.0019 | 0.004 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.004 | 0.0093 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.0608 | 0.1967 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0019 | 0.004 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.023 | 0.2767 | 0.9094 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.1061 | 0.3464 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.0608 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.004 | 0.0093 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0192 | 0.0593 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0039 | 0.0294 | 0.0289 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.2777 | 0.9127 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.023 | 0.2767 | 0.2763 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.004 | 0.0093 |
Loa Loa (eye worm) | carboxylesterase | 0.0039 | 0.0294 | 0.093 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.0396 | 0.1411 |
Schistosoma mansoni | survival motor neuron protein | 0.0047 | 0.0396 | 0.1411 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.0707 | 0.2532 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 30 uM | Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir to substrate addition measured after 90 mins by NADH coupled assay | ChEMBL. | 23245311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.