Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin E synthase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K00799 glutathione S-transferase [EC2.5.1.18], putative | Get druggable targets OG5_131112 | All targets in OG5_131112 |
Schistosoma japonicum | ko:K00799 glutathione S-transferase [EC2.5.1.18], putative | Get druggable targets OG5_131112 | All targets in OG5_131112 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | Get druggable targets OG5_131112 | All targets in OG5_131112 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0889 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0889 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0889 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.5259 | 1 | 1 |
Onchocerca volvulus | 0.0889 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0889 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.5259 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5259 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5259 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5259 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5259 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5259 | 1 | 1 |
Onchocerca volvulus | 0.0889 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0889 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5259 | 1 | 1 |
Onchocerca volvulus | 0.0889 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0889 | 0 | 0.5 |
Onchocerca volvulus | 0.0889 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.5259 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5259 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.5259 | 1 | 1 |
Onchocerca volvulus | 0.0889 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.5259 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Inhibition of mPGES1 (unknown origin) using PGH2 as substrate incubated for 30 mins prior to substrate addition by PGH2-coupled spectrophotometric analysis | ChEMBL. | 23218602 |
Inhibition (binding) | Inhibition of human recombinant COX2 using PGH2 as substrate at 1 mM incubated for 10 mins prior to substrate addition measured for 2 mins by enzyme immunoassay | ChEMBL. | 23218602 | |
Inhibition (binding) | = 18.1 % | Inhibition of human recombinant mPGES1 using PGH2 as substrate at 10 uM incubated for 5 mins prior to substrate addition measured after 5 mins by HPLC analysis in presence of triton-X-100 | ChEMBL. | 23218602 |
Inhibition (binding) | = 50 % | Inhibition of ovine COX1 using PGH2 as substrate at 1 mM incubated for 10 mins prior to substrate addition measured for 2 mins by enzyme immunoassay | ChEMBL. | 23218602 |
Inhibition (binding) | = 69.1 % | Inhibition of human recombinant mPGES1 using PGH2 as substrate at 10 uM incubated for 5 mins prior to substrate addition measured after 5 mins by HPLC analysis | ChEMBL. | 23218602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.