Detailed information for compound 1737548

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.229 | Formula: C18H15BrN2O
  • H donors: 0 H acceptors: 1 LogP: 4.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)COc1ccc2c(c1)CCc1n2ccn1
  • InChi: 1S/C18H15BrN2O/c19-15-4-1-13(2-5-15)12-22-16-6-7-17-14(11-16)3-8-18-20-9-10-21(17)18/h1-2,4-7,9-11H,3,8,12H2
  • InChiKey: PFWFRRVQIVTSJX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus fibrillin 1 0.0102 0.0121 0.0126
Giardia lamblia Tenascin-like 0.0101 0.012 0.0263
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0228 0.0346 0.0446
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.008 0.0083 0.2288
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0237 0.0363 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Brugia malayi SWIRM domain containing protein 0.0218 0.0329 0.0329
Echinococcus granulosus epidermal growth factor receptor 0.0306 0.0485 0.0501
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0237 0.0363 1
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0097 0.0114 0.2103
Plasmodium vivax subtilisin-like protease 2, putative 0.0237 0.0363 1
Echinococcus granulosus protein arginine N methyltransferase 7 0.0035 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0078 0.0079 0.0079
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.0363 0.0613
Schistosoma mansoni site-1 peptidase (S08 family) 0.0237 0.0363 0.0375
Onchocerca volvulus 0.007 0.0066 0.1763
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.008 0.0083 0.2002
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0332 0.0532 1
Echinococcus multilocularis Furin 1 0.1311 0.2277 0.2933
Loa Loa (eye worm) TK/EGFR protein kinase 0.0306 0.0485 0.0485
Brugia malayi Disintegrin family protein 0.0094 0.0109 0.0109
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0064 0.0054 0.1176
Echinococcus multilocularis neuroendocrine convertase 2 0.3443 0.6077 0.7827
Leishmania major silent information regulator 2, putative 0.0332 0.0532 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0052 0.0053
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.008 0.0083 0.2002
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0101 0.012 0.0199
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.0028 0.0466
Toxoplasma gondii subtilisin SUB10 0.0237 0.0363 1
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0237 0.0363 0.0363
Echinococcus multilocularis epidermal growth factor receptor 0.0306 0.0485 0.0625
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1074 0.1854 0.3151
Brugia malayi Furin-like cysteine rich region family protein 0.0306 0.0485 0.0485
Loa Loa (eye worm) hypothetical protein 0.007 0.0066 0.0066
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0154 0.0216 0.0216
Schistosoma mansoni hypothetical protein 0.006 0.0047 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.0363 0.0613
Giardia lamblia Hypothetical protein 0.0332 0.0532 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.0363 0.0613
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.062 0.1045 0.1045
Echinococcus granulosus c4b binding protein beta chain 0.0034 0.0002 0.0002
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0013 0.0357
Plasmodium falciparum subtilisin-like protease 2 0.0237 0.0363 1
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0048 0.0025 0.0646
Plasmodium vivax NAD-dependent deacetylase, putative 0.0049 0.0028 0.0715
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0052 0.0083
Toxoplasma gondii subtilisin SUB12 0.0237 0.0363 1
Schistosoma mansoni septate junction protein 0.0052 0.0034 0.0035
Loa Loa (eye worm) hypothetical protein 0.0041 0.0013 0.0013
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0013 0.0315
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0237 0.0363 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0013 0.0315
Loa Loa (eye worm) hypothetical protein 0.0072 0.0069 0.0069
Onchocerca volvulus 0.01 0.0119 0.3238
Brugia malayi endoprotease bli-4 precursor 0.5463 0.9676 0.9676
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0049 0.0028 0.0029
Brugia malayi Integrin alpha pat-2 precursor 0.031 0.0493 0.0493
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0013 0.0315
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Echinococcus multilocularis fibrillin 1 0.0102 0.0121 0.0156
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0049 0.0028 0.0466
Leishmania major hypothetical protein, conserved 0.0048 0.0025 0.0419
Loa Loa (eye worm) apoptosis regulator protein 0.006 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0043 0.0018 0.0018
Brugia malayi proprotein convertase 2 0.3443 0.6077 0.6077
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0035 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1311 0.2277 0.3871
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0237 0.0363 1
Giardia lamblia High cysteine membrane protein Group 2 0.202 0.354 1
Toxoplasma gondii subtilisin SUB11 0.0237 0.0363 1
Mycobacterium ulcerans polyketide synthase 0.0085 0.0093 0.2264
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0332 0.0532 0.09
Plasmodium falciparum cysteine repeat modular protein 1 0.0048 0.0025 0.0646
Echinococcus multilocularis integrin alpha 3 0.0238 0.0364 0.0469
Loa Loa (eye worm) fatty acid synthase 0.0082 0.0086 0.0086
Echinococcus multilocularis adam 0.0399 0.0651 0.0839
Echinococcus granulosus protein arginine N methyltransferase 8 0.0062 0.0052 0.0053
Schistosoma mansoni discoidin domain receptor 0.0044 0.0018 0.0019
Mycobacterium ulcerans polyketide synthase Pks9 0.0052 0.0033 0.057
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.008 0.0083 0.2288
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0049 0.0028 0.0466
Echinococcus multilocularis 0.0041 0.0013 0.0017
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0064 0.0054 0.1176
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0062 0.0052 0.0066
Trichomonas vaginalis hypothetical protein 0.0044 0.0018 0.0026
Brugia malayi Protein kinase domain containing protein 0.0048 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.5463 0.9676 0.9676
Mycobacterium leprae Polyketide synthase Pks13 0.0121 0.0156 0.4092
Brugia malayi hypothetical protein 0.0034 0.0002 0.0002
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.5463 0.9676 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0049 0.0028 0.0036
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0062 0.0052 0.1377
Brugia malayi hypothetical protein 0.007 0.0066 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Loa Loa (eye worm) integrin alpha pat-2 0.0478 0.0792 0.0792
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0049 0.0028 0.0466
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0044 0.0018 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0028 0.0042
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0028 0.0042
Brugia malayi hypothetical protein 0.0034 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.006 0.0047 0.006
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0896 0.1538 0.1538
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1311 0.2277 0.3871
Brugia malayi hypothetical protein 0.0034 0.0002 0.0002
Brugia malayi hypothetical protein 0.0097 0.0114 0.0114
Schistosoma mansoni hypothetical protein 0.006 0.0047 0.0048
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0237 0.0363 0.0363
Schistosoma mansoni protein kinase 0.0129 0.017 0.0176
Schistosoma mansoni glutamate receptor NMDA 0.0282 0.0442 0.0457
Toxoplasma gondii histone deacetylase SIR2-like 0.0049 0.0028 0.0715
Schistosoma mansoni discoidin domain receptor 0.0044 0.0018 0.0019
Toxoplasma gondii subtilisin SUB4 0.0237 0.0363 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0119 0.0153 0.0197
Mycobacterium ulcerans thioesterase 0.0069 0.0064 0.1442
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Onchocerca volvulus 0.0144 0.0198 0.5425
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3331 0.5877 1
Brugia malayi Protein arginine N-methyltransferase 0.0035 0.0003 0.0003
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0013 0.0315
Brugia malayi angiogenesis inhibito 0.0133 0.0178 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Toxoplasma gondii F5/8 type C domain-containing protein 0.0044 0.0018 0.045
Mycobacterium ulcerans Sir2-like regulatory protein 0.0049 0.0028 0.0412
Schistosoma mansoni amine oxidase 0.0041 0.0013 0.0014
Toxoplasma gondii subtilisin SUB5 0.0237 0.0363 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0085 0.0093 0.2264
Toxoplasma gondii type I fatty acid synthase, putative 0.0085 0.0093 0.2508
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1311 0.2277 0.3871
Schistosoma mansoni chromatin regulatory protein sir2 0.0332 0.0532 0.0549
Schistosoma mansoni hypothetical protein 0.0048 0.0025 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.3331 0.5877 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0013 0.0193
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Giardia lamblia High cysteine protein 0.0101 0.012 0.0263
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.3331 0.5877 0.757
Plasmodium vivax subtilisin-like serine protease, putative 0.0237 0.0363 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Entamoeba histolytica hypothetical protein 0.0097 0.0114 0.2103
Echinococcus multilocularis protein kinase c epsilon type 0.0084 0.009 0.0115
Loa Loa (eye worm) TK/ALK protein kinase 0.007 0.0066 0.0066
Schistosoma mansoni hypothetical protein 0.006 0.0047 0.0048
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0065 0.0056 0.1545
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.0363 0.0613
Brugia malayi hypothetical protein 0.0034 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0028 0.0029
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0332 0.0532 1
Echinococcus granulosus furin 0.5463 0.9676 1
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.006 0.0047 0.0047
Brugia malayi Kelch motif family protein 0.0896 0.1538 0.1538
Giardia lamblia Tenascin-37 0.0101 0.012 0.0263
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0086 0.0093 0.5
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0013 0.0014
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.008 0.0083 0.0083
Mycobacterium ulcerans NAD-dependent deacetylase 0.0049 0.0028 0.0412
Loa Loa (eye worm) hypothetical protein 0.0104 0.0125 0.0125
Brugia malayi neuroendocrine convertase 1 precursor 0.3443 0.6077 0.6077
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0052 0.0053
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0121 0.0156 0.4303
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0228 0.0346 0.0358
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0028 0.0042
Onchocerca volvulus 0.0044 0.0018 0.045
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0018 0.045
Echinococcus granulosus growth factor receptor bound protein 2 0.0126 0.0165 0.017
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1074 0.1854 0.3151
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.007 0.0066 0.0068
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.0028 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1311 0.2277 0.3871
Trichomonas vaginalis conserved hypothetical protein 0.0237 0.0363 0.0613
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0263 0.0409 0.7684
Echinococcus granulosus glutamate NMDA receptor subunit 0.0282 0.0442 0.0457
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0041 0.0014 0.0015
Echinococcus multilocularis glutamate receptor 2 0.0051 0.0031 0.0039
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0332 0.0532 0.09
Schistosoma mansoni glutamate receptor NMDA 0.0051 0.0031 0.0032
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.006 0.0047 0.128
Loa Loa (eye worm) hypothetical protein 0.0137 0.0184 0.0184
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0085 0.0093 0.2264
Schistosoma mansoni amine oxidase 0.0041 0.0013 0.0014
Loa Loa (eye worm) hypothetical protein 0.0041 0.0013 0.0013
Mycobacterium ulcerans polyketide synthase Pks13 0.0121 0.0156 0.4092
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0041 0.0013 0.0315
Schistosoma mansoni ATP-binding cassette transporter 0.0035 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0035 0.0003 0.0003
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0013 0.0315
Echinococcus granulosus integrin alpha ps 0.0067 0.0059 0.0061
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0052 0.0083
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0052 0.0033 0.057
Chlamydia trachomatis glutamine binding protein 0.0086 0.0093 1
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0085 0.0093 0.2541
Brugia malayi amine oxidase, flavin-containing family protein 0.0058 0.0044 0.0044
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.0031 0.0032
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0201 0.0299 0.0309
Plasmodium falciparum LCCL domain-containing protein 0.0044 0.0018 0.045
Loa Loa (eye worm) hypothetical protein 0.0101 0.012 0.012
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0086 0.0093 0.2556
Brugia malayi Sex muscle abnormal protein 5 0.0126 0.0165 0.0165
Echinococcus multilocularis c4b binding protein beta chain 0.0034 0.0002 0.0002
Echinococcus granulosus membrane bound transcription factor site 1 0.0237 0.0363 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0013 0.0017
Schistosoma mansoni integrin alpha-ps 0.0072 0.0069 0.0072
Loa Loa (eye worm) proprotein convertase 2 0.1311 0.2277 0.2277
Toxoplasma gondii bicoid-interacting protein BIN3 0.0035 0.0003 0.0033
Schistosoma mansoni dihydroceramide desaturase 0.0094 0.0109 0.0112
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.0165 0.017
Echinococcus multilocularis 0.4389 0.7763 1
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0034 0.0002 0.0002
Echinococcus multilocularis protein arginine methyltransferase 0.0062 0.0052 0.0066
Trichomonas vaginalis hypothetical protein 0.1074 0.1854 0.3151
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0028 0.0042
Loa Loa (eye worm) hypothetical protein 0.0218 0.0329 0.0329
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0332 0.0532 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Loa Loa (eye worm) integrin beta-2 0.5645 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0028 0.0042
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0078 0.0079 0.216
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0113 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0058 0.0044 0.0044
Toxoplasma gondii subtilisin SUB2 0.0237 0.0363 1
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0054 0.0036 0.0956
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1311 0.2277 0.3871
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Giardia lamblia Tenascin precursor 0.0101 0.012 0.0263
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0237 0.0363 0.0375
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0086 0.0093 1
Plasmodium falciparum subtilisin-like protease 1 0.0237 0.0363 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0332 0.0532 0.0549
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0298 0.0471 0.0487
Echinococcus multilocularis integrin beta 2 0.416 0.7354 0.9473
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.3331 0.5877 0.6073
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0263 0.0409 0.7684
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0047 0.0025 0.0669
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0069 0.0064 0.1442
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0052 0.0033 0.057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Plasmodium vivax LCCL domain-containing protein 0.0044 0.0018 0.045
Loa Loa (eye worm) hypothetical protein 0.0228 0.0346 0.0346
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0085 0.0093 0.2541
Giardia lamblia Furin precursor putative serine protease 0.1074 0.1854 0.5199
Schistosoma mansoni protein kinase 0.0129 0.017 0.0176
Giardia lamblia hypothetical protein 0.0101 0.012 0.0263
Schistosoma mansoni serine/threonine protein kinase 0.0084 0.009 0.0093
Echinococcus granulosus C type lectin domian containing protein 0.0034 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0013 0.0315
Loa Loa (eye worm) reprolysin 0.0228 0.0346 0.0346
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Echinococcus multilocularis discoidin domain containing receptor 2 0.0044 0.0018 0.0023
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0062 0.0052 0.1377
Echinococcus granulosus fibrillin 2 0.0101 0.012 0.0124
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0237 0.0363 0.0468
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0129 0.017 0.022
Onchocerca volvulus 0.0101 0.012 0.3274
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0332 0.0532 0.0685
Toxoplasma gondii subtilisin SUB8 0.0237 0.0363 1
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.008 0.0084 0.2302
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0332 0.0532 1
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0083 0.2002
Brugia malayi hypothetical protein 0.0034 0.0002 0.0002
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.006 0.0047 0.0048
Brugia malayi GCC2 and GCC3 family protein 0.0043 0.0018 0.0018
Echinococcus granulosus discoidin domain receptor 0.0044 0.0018 0.0019
Loa Loa (eye worm) sirtuin 4 0.0049 0.0028 0.0028
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0028 0.0042
Brugia malayi Kringle domain containing protein 0.0048 0.0025 0.0025
Brugia malayi EGF-like domain containing protein 0.0101 0.012 0.012
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0063 0.0053 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Echinococcus multilocularis neuropeptides capa receptor 0.0216 0.0325 0.0419
Echinococcus granulosus integrin alpha ps 0.0139 0.0188 0.0194
Brugia malayi EGF-like domain containing protein 0.0101 0.012 0.012
Schistosoma mansoni hypothetical protein 0.007 0.0066 0.0068
Trypanosoma brucei subtilisin peptidase 0.0237 0.0363 0.6814
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0049 0.0028 0.0466
Leishmania major sir2-family protein-like protein 0.0049 0.0028 0.0466
Loa Loa (eye worm) hypothetical protein 0.0097 0.0114 0.0114
Schistosoma mansoni site-1 peptidase (S08 family) 0.0237 0.0363 0.0375
Echinococcus multilocularis nmda type glutamate receptor 0.0119 0.0153 0.0197
Echinococcus granulosus integrin alpha 3 0.0238 0.0364 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Brugia malayi Sushi domain 0.0034 0.0002 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0028 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Brugia malayi hypothetical protein 0.087 0.1492 0.1492
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Echinococcus multilocularis disintegrin and metalloproteinase 0.0094 0.0109 0.014
Brugia malayi Protein kinase domain containing protein 0.0044 0.0018 0.0018
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0332 0.0532 1
Loa Loa (eye worm) hypothetical protein 0.087 0.1492 0.1492
Loa Loa (eye worm) hypothetical protein 0.007 0.0066 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Brugia malayi hypothetical protein 0.0034 0.0002 0.0002
Toxoplasma gondii hypothetical protein 0.0101 0.012 0.3274
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0084 0.009 0.009
Echinococcus multilocularis protein jagged 2 0.0101 0.012 0.0155
Echinococcus granulosus protein kinase c epsilon type 0.0084 0.009 0.0093
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.008 0.0083 0.2002
Schistosoma mansoni tyrosine kinase 0.0306 0.0485 0.0501
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0049 0.0028 0.0036
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.0031 0.0039
Loa Loa (eye worm) hypothetical protein 0.0243 0.0374 0.0374
Brugia malayi NAD-dependent deacetylase SIRT1 0.0049 0.0028 0.0028
Leishmania major arginine N-methyltransferase-like protein 0.0062 0.0052 0.0918
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0051 0.0031 0.0032
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.0031 0.0039
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0071 0.0068 0.007
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0051 0.0031 0.0039
Echinococcus granulosus Furin 1 0.1311 0.2277 0.2353
Plasmodium falciparum subtilisin-like protease 3 0.0237 0.0363 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0085 0.0093 0.2541
Onchocerca volvulus 0.0048 0.0025 0.0646
Trypanosoma cruzi subtilisin peptidase 0.0237 0.0363 0.6814
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0035 0.0003 0.0003
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0028 0.0029
Echinococcus granulosus serine:threonine protein kinase N2 0.0068 0.0062 0.0064
Schistosoma mansoni chromatin regulatory protein sir2 0.0049 0.0028 0.0029
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Brugia malayi Stress-activated protein kinase jnk-1 0.0251 0.0388 0.0388
Onchocerca volvulus Fatty acid synthase homolog 0.015 0.0207 0.568
Brugia malayi pregnancy-associated plasma protein-A 0.0034 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0234 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0067 0.0059 0.0059
Trypanosoma brucei SIR2-like protein 4, putative 0.0049 0.0028 0.0466
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0097 0.0114 0.2103
Loa Loa (eye worm) hypothetical protein 0.0237 0.0363 0.0363
Entamoeba histolytica PH domain containing protein kinase, putative 0.0068 0.0062 0.1121
Loa Loa (eye worm) hypothetical protein 0.0201 0.0299 0.0299
Mycobacterium leprae Possible secreted protease 0.0237 0.0363 1
Toxoplasma gondii subtilisin SUB6 0.0237 0.0363 1
Echinococcus multilocularis discoidin domain containing receptor 2 0.0044 0.0018 0.0023
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0049 0.0028 0.0036
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.1311 0.2277 0.3871
Mycobacterium tuberculosis Polyketide synthase Pks2 0.008 0.0084 0.2302
Loa Loa (eye worm) hypothetical protein 0.0101 0.012 0.012
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0028 0.0042
Brugia malayi ADAM-TS Spacer 1 family protein 0.0133 0.0178 0.0178
Onchocerca volvulus 0.007 0.0066 0.1763
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0237 0.0363 0.0375
Brugia malayi ADAMTS-like protease 0.0133 0.0178 0.0178
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0044 0.0018 0.0139
Loa Loa (eye worm) hypothetical protein 0.0133 0.0178 0.0178
Loa Loa (eye worm) subtilase 0.0237 0.0363 0.0363
Schistosoma mansoni c4b-binding protein beta chain 0.0034 0.0002 0.0002
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0013 0.0014
Schistosoma mansoni integrin beta subunit 0.3289 0.5803 0.5997
Loa Loa (eye worm) hypothetical protein 0.0101 0.012 0.012
Mycobacterium ulcerans polyketide synthase 0.008 0.0083 0.2002
Brugia malayi Carm1-pending protein 0.0035 0.0003 0.0003
Loa Loa (eye worm) metalloprotease 0.0063 0.0053 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.0031 0.0032
Onchocerca volvulus 0.0078 0.0079 0.2125
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0064 0.0054 0.1176
Loa Loa (eye worm) hypothetical protein 0.0101 0.012 0.012
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0228 0.0346 0.0358
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0237 0.0363 1
Loa Loa (eye worm) transcriptional regulator 0.0049 0.0028 0.0028
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0013 0.0193
Toxoplasma gondii type I fatty acid synthase, putative 0.0059 0.0046 0.1215
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0121 0.0156 0.4303
Echinococcus granulosus protein arginine methyltransferase 0.0062 0.0052 0.0053
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0083 0.2002
Brugia malayi metalloprotease 0.0063 0.0053 0.0053
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0237 0.0363 1
Schistosoma mansoni hypothetical protein 0.0067 0.0059 0.0061
Echinococcus granulosus integrin beta 2 0.416 0.7354 0.76
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0028 0.0042
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0035 0.0003 0.0003
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0049 0.0028 0.0755
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0237 0.0363 0.6814
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0086 0.0093 0.228
Echinococcus granulosus tissue type plasminogen activator 0.0048 0.0025 0.0026
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0028 0.0466
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0044 0.0018 0.0023
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0747 0.1272 0.1638
Echinococcus granulosus disintegrin and metalloproteinase 0.0094 0.0109 0.0112
Leishmania major subtilisin-like serine peptidase 0.0237 0.0363 0.6814
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Brugia malayi hypothetical protein 0.0041 0.0013 0.0013
Echinococcus multilocularis serine:threonine protein kinase N2 0.0077 0.0077 0.0099
Echinococcus granulosus discoidin domain containing receptor 2 0.0044 0.0018 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0025 0.0025
Toxoplasma gondii subtilisin SUB9 0.0237 0.0363 1
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0114 0.2103
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0094 0.0109 0.014
Echinococcus granulosus chromatin regulatory protein sir2 0.0332 0.0532 0.0549
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0062 0.0052 0.0083
Echinococcus multilocularis growth factor receptor bound protein 2 0.0126 0.0165 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Echinococcus multilocularis membrane bound transcription factor site 1 0.0237 0.0363 0.0468
Giardia lamblia Tenascin-X 0.0101 0.012 0.0263
Schistosoma mansoni integrin alpha 0.031 0.0493 0.0509
Echinococcus multilocularis C type lectin domian containing protein 0.0034 0.0002 0.0002
Toxoplasma gondii kringle domain-containing protein 0.0048 0.0025 0.0646
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Loa Loa (eye worm) transcriptional regulator 0.0332 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0048 0.0025 0.0025
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.1311 0.2277 0.2353
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0094 0.0109 0.0112
Giardia lamblia High cysteine protein 0.0101 0.012 0.0263
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0078 0.0079 0.0079
Onchocerca volvulus 0.0044 0.0018 0.045
Toxoplasma gondii subtilisin SUB7 0.0237 0.0363 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0747 0.1272 0.1314
Brugia malayi Angiotensin-converting enzyme family protein 0.062 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0201 0.0299 0.0299
Schistosoma mansoni apoptosis regulator bax 0.006 0.0047 0.0048
Schistosoma mansoni chromatin regulatory protein sir2 0.0332 0.0532 0.0549
Brugia malayi Subtilase family protein 0.0237 0.0363 0.0363
Toxoplasma gondii F5/8 type C domain-containing protein 0.0044 0.0018 0.045
Brugia malayi hypothetical protein 0.0034 0.0002 0.0002
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0237 0.0363 0.0375
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0013 0.0315
Loa Loa (eye worm) hypothetical protein 0.0049 0.0028 0.0028
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0201 0.0299 0.0385
Schistosoma mansoni integrin alpha-ps 0.0139 0.0188 0.0194
Brugia malayi protein kinase C II. 0.0084 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0044 0.0018 0.0019
Schistosoma mansoni chromatin regulatory protein sir2 0.0332 0.0532 0.0549
Loa Loa (eye worm) acyl carrier protein 0.0038 0.0008 0.0008
Onchocerca volvulus 0.0237 0.0363 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0085 0.0093 0.2264
Brugia malayi Calcium binding EGF domain containing protein 0.0035 0.0002 0.0002
Echinococcus multilocularis MAM 0.007 0.0066 0.0084
Loa Loa (eye worm) hypothetical protein 0.0063 0.0053 0.0053
Brugia malayi celfurPC protein 0.4389 0.7763 0.7763
Toxoplasma gondii histone deacetylase SIR2 0.0049 0.0028 0.0715
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0113 0.0141 0.0141
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0263 0.0409 0.7684
Echinococcus granulosus methyltransferase protein 5 0.0035 0.0003 0.0003
Schistosoma mansoni protein arginine n-methyltransferase 0.0035 0.0003 0.0003
Brugia malayi transcriptional regulator, Sir2 family protein 0.0332 0.0532 0.0532
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0049 0.0028 0.0029
Brugia malayi Protein kinase domain containing protein 0.007 0.0066 0.0066
Echinococcus granulosus neuroendocrine convertase 2 0.3443 0.6077 0.628
Toxoplasma gondii PA14 domain-containing protein 0.0044 0.0018 0.045
Toxoplasma gondii subtilisin SUB1 0.0237 0.0363 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0015 0.037
Schistosoma mansoni btb and poz domain-containing protein 0.0044 0.0018 0.0019
Loa Loa (eye worm) transcriptional regulator 0.0049 0.0028 0.0028
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0044 0.0018 0.0019
Mycobacterium ulcerans thioesterase TesA 0.0069 0.0064 0.1442
Schistosoma mansoni dock 0.0044 0.0018 0.0019
Echinococcus granulosus glutamate receptor 2 0.0051 0.0031 0.0032
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0044 0.0018 0.0026
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0251 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.0133 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.007 0.0066 0.0066
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0126 0.0165 0.0165
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0062 0.0052 0.1377
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0282 0.0442 0.057
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0049 0.0028 0.0715
Onchocerca volvulus Putative cubilin 0.0035 0.0002 0.0007
Brugia malayi transcriptional regulator, Sir2 family protein 0.0049 0.0028 0.0028
Echinococcus granulosus c-Jun N-terminal kinases 0.0251 0.0388 0.0401
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0035 0.0003 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0044 0.0018 0.0491
Loa Loa (eye worm) endoprotease bli-4 0.5463 0.9676 0.9676
Brugia malayi Reprolysin 0.0133 0.0178 0.0178
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0086 0.0093 0.5
Echinococcus granulosus adam 0.0399 0.0651 0.0673
Schistosoma mansoni hypothetical protein 0.1074 0.1854 0.1916
Mycobacterium leprae Probable polyketide synthase Pks1 0.0085 0.0093 0.2264
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1074 0.1854 0.3151
Echinococcus granulosus adam 17 protease 0.0094 0.0109 0.0112
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0083 0.2002
Echinococcus granulosus nmda type glutamate receptor 0.0119 0.0153 0.0158
Plasmodium vivax subtilisin-like protease 1 0.0237 0.0363 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0085 0.0093 0.2264
Loa Loa (eye worm) hypothetical protein 0.007 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.0171 0.0245 0.0245
Echinococcus granulosus discoidin domain containing receptor 2 0.0044 0.0018 0.0019
Loa Loa (eye worm) angiogenesis inhibito 0.0063 0.0053 0.0053
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0013 0.0315
Plasmodium vivax LCCL domain-containing protein 0.0044 0.0018 0.045
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.008 0.0083 0.2288
Loa Loa (eye worm) hypothetical protein 0.0094 0.0109 0.0109
Echinococcus multilocularis tissue type plasminogen activator 0.0048 0.0025 0.0032
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0035 0.0003 0.0033
Brugia malayi hypothetical protein 0.0298 0.0471 0.0471
Echinococcus multilocularis integrin alpha ps 0.0067 0.0059 0.0076
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Loa Loa (eye worm) hypothetical protein 0.0034 0.0002 0.0002
Schistosoma mansoni protein kinase 0.0129 0.017 0.0176
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0049 0.0028 0.0042
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0035 0.0003 0.0004
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0049 0.0028 0.0466
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Echinococcus granulosus lysine specific histone demethylase 1A 0.0201 0.0299 0.0309
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.0165 0.017
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0237 0.0363 1
Trichomonas vaginalis conserved hypothetical protein 0.1074 0.1854 0.3151
Echinococcus multilocularis integrin alpha ps 0.0139 0.0188 0.0242
Giardia lamblia Neurogenic locus notch-like protein 0.0101 0.012 0.0263
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0044 0.0018 0.0026
Brugia malayi EGF-like domain containing protein 0.0101 0.012 0.012
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0097 0.0114 0.2103
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Leishmania major UDP-galactopyranose mutase 0.0041 0.0013 0.0193
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0051 0.0031 0.0032
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0051 0.0031 0.0039
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0035 0.0003 0.0033
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0234 0.0358 0.0358
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0388 0.0401
Loa Loa (eye worm) hypothetical protein 0.0044 0.0018 0.0018
Echinococcus multilocularis integrin alpha ps 0.0139 0.0188 0.0242
Trypanosoma cruzi hypothetical protein, conserved 0.0048 0.0025 0.0419
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0049 0.0028 0.0715
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.006 0.0047 0.0048
Loa Loa (eye worm) hypothetical protein 0.006 0.0047 0.0047
Echinococcus multilocularis discoidin domain receptor 0.0044 0.0018 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Schistosoma mansoni furin-1 (S08 family) 0.2369 0.4163 0.4302
Echinococcus granulosus MAM 0.007 0.0066 0.0068
Onchocerca volvulus 0.0218 0.0329 0.9052
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0228 0.0346 0.0358
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0044 0.0018 0.0023
Echinococcus granulosus discoidin domain containing receptor 2 0.0044 0.0018 0.0019
Toxoplasma gondii F5/8 type C domain-containing protein 0.0044 0.0018 0.045
Giardia lamblia Neurogenic locus Notch protein precursor 0.0101 0.012 0.0263
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0028 0.0715
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0237 0.0363 1
Loa Loa (eye worm) Carm1-pending protein 0.0035 0.0003 0.0003
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0013 0.0357
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0049 0.0028 0.0029
Echinococcus granulosus neuropeptides capa receptor 0.0216 0.0325 0.0336
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0062 0.0052 0.0053
Loa Loa (eye worm) hypothetical protein 0.2132 0.374 0.374
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0237 0.0363 1
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0018 0.0026
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0251 0.0388 0.05
Mycobacterium tuberculosis Probable thioesterase TesA 0.0069 0.0064 0.1748
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0129 0.017 0.0176
Echinococcus multilocularis fibrillin 2 0.0101 0.012 0.0155
Trichomonas vaginalis hypothetical protein 0.0101 0.012 0.0199
Brugia malayi EGF-like domain containing protein 0.0101 0.012 0.012
Echinococcus multilocularis chromatin regulatory protein sir2 0.0332 0.0532 0.0685
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0237 0.0363 0.0613
Echinococcus multilocularis discoidin domain containing receptor 2 0.0044 0.0018 0.0023

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 25 ug ml-1 Antibacterial activity against Escherichia coli ATCC 8739 assessed as growth inhibition after 20 hrs by NCCLS broth microdilution method ChEMBL. 23321259

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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