Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0072 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0072 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0072 | 1 | 0.5 |
Entamoeba histolytica | trans-2,3-enoyl-CoA reductase, putative | 0.0047 | 0 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0072 | 1 | 1 |
Mycobacterium leprae | putative cytochrome p450 | 0.0072 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0072 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0072 | 1 | 1 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0047 | 0 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0047 | 0 | 0.5 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0072 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0072 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0047 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0072 | 1 | 1 |
Trypanosoma brucei | cytochrome P450, putative | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0072 | 1 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0047 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0072 | 1 | 0.5 |
Leishmania major | lanosterol 14-alpha-demethylase, putative | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0072 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0072 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0072 | 1 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0047 | 0 | 0.5 |
Trypanosoma brucei | Lanosterol 14-alpha demethylase | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0072 | 1 | 1 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0072 | 1 | 1 |
Onchocerca volvulus | 0.0047 | 0 | 0.5 | |
Loa Loa (eye worm) | cytochrome P450 | 0.0072 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0072 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0072 | 1 | 1 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0047 | 0 | 0.5 |
Schistosoma mansoni | cytochrome P450 | 0.0072 | 1 | 1 |
Plasmodium vivax | polyprenol reductase, putative | 0.0047 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0072 | 1 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0072 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0072 | 1 | 0.5 |
Echinococcus multilocularis | 0.0072 | 1 | 1 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0072 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0072 | 1 | 1 |
Entamoeba histolytica | 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0072 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0072 | 1 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0072 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0072 | 1 | 1 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0072 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0072 | 1 | 0.5 |
Leishmania major | cytochrome p450-like protein | 0.0072 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0072 | 1 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0047 | 0 | 0.5 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0047 | 0 | 0.5 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0072 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0072 | 1 | 0.5 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0047 | 0 | 0.5 |
Trichomonas vaginalis | synaptic glycoprotein sc2, putative | 0.0047 | 0 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0072 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0072 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0072 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0072 | 1 | 1 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0072 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0072 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0047 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0072 | 1 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0047 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.