Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.6361 | 0.5845 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.3251 | 0.5 |
Echinococcus granulosus | fucosidase alpha L 1 tissue | 0.0908 | 0.8355 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.3251 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.6361 | 0.5845 |
Echinococcus multilocularis | geminin | 0.0189 | 0.1283 | 0.1536 |
Echinococcus multilocularis | thymidylate synthase | 0.0389 | 0.3251 | 0.3891 |
Brugia malayi | thymidylate synthase | 0.0389 | 0.3251 | 0.2294 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0743 | 0.6735 | 0.6272 |
Loa Loa (eye worm) | alpha-L-fucosidase | 0.0549 | 0.4822 | 0.2328 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 1 | 1 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0185 | 0.1241 | 0.3818 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0389 | 0.3251 | 1 |
Schistosoma mansoni | alpha-l-fucosidase | 0.0549 | 0.4822 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0389 | 0.3251 | 0.5 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.0908 | 0.8355 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.6361 | 0.5845 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.3251 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.6361 | 0.5845 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.6361 | 0.5845 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.1283 | 0.2661 |
Brugia malayi | Alpha-L-fucosidase family protein | 0.0549 | 0.4822 | 0.4088 |
Echinococcus granulosus | geminin | 0.0189 | 0.1283 | 0.1536 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0257 | 0.195 | 0.5999 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.1075 | 1 | 1 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.0908 | 0.8355 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.6361 | 0.5845 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0241 | 0.1788 | 0.0625 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.3251 | 0.6742 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0705 | 0.6361 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.3251 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0389 | 0.3251 | 1 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0241 | 0.1788 | 0.0625 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0389 | 0.3251 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.1075 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0705 | 0.6361 | 0.5845 |
Echinococcus granulosus | thymidylate synthase | 0.0389 | 0.3251 | 0.3891 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0743 | 0.6735 | 0.6272 |
Schistosoma mansoni | hypothetical protein | 0.0189 | 0.1283 | 0.2661 |
Mycobacterium ulcerans | thymidylate synthase | 0.0389 | 0.3251 | 0.3891 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Control (functional) | = 95 % | Percent control of the compound for L1210 cell growth in the presence of thymidine (in vitro) | ChEMBL. | 2231608 |
Control (functional) | = 95 % | Percent control of the compound for L1210 cell growth in the presence of thymidine (in vitro) | ChEMBL. | 2231608 |
IC50 (binding) | = 7.17 | Inhibition of thymidylate synthase | ChEMBL. | 20153089 |
IC50 (binding) | = 0.067 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
IC50 (binding) | = 0.067 uM | Inhibition of partially purified thymidylate synthase (TS) | ChEMBL. | 2231608 |
IC50 (functional) | = 3 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
IC50 (functional) | = 3 uM | Growth inhibition of L1210 cells in culture. | ChEMBL. | 2231608 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Mus musculus | ChEMBL23 | 2231608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.