Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 1 | 1 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0083 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0083 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0083 | 1 | 0.5 |
Chlamydia trachomatis | sulfite reductase | 0.0051 | 0.2291 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.0083 | 1 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0083 | 1 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0067 | 0.6235 | 0.6235 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0073 | 0.7709 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 1 | 0.5 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Schistosoma mansoni | P2X receptor subunit | 0.0067 | 0.6235 | 0.6235 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0083 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0083 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0051 | 0.2291 | 0.2291 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Brugia malayi | FAD binding domain containing protein | 0.0083 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0083 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0083 | 1 | 0.5 |
Schistosoma mansoni | P2X receptor subunit | 0.0067 | 0.6235 | 0.6235 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0083 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Loa Loa (eye worm) | hypothetical protein | 0.0083 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0083 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0083 | 1 | 1 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0083 | 1 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0083 | 1 | 1 |
Schistosoma mansoni | P2X receptor subunit | 0.0067 | 0.6235 | 0.6235 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0083 | 1 | 1 |
Echinococcus granulosus | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0083 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0083 | 1 | 1 |
Echinococcus multilocularis | p2X purinoceptor 4 | 0.0067 | 0.6235 | 0.5116 |
Giardia lamblia | Hypothetical protein | 0.0073 | 0.7709 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 80 nM | Cytotoxicity against vinblastine-resistant human HCT116/VM46 cells after 72 hrs by phosphatase assay | ChEMBL. | 23244701 |
Inhibition (binding) | = 45.1 % | Displacement of [3H]-vinblastine from pig tubulin at 7.2 x 10'-5 M after 60 mins | ChEMBL. | 23244701 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23244701 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.