TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 409.408 | Formula: C23H13FNNaO2S
H donors: 0 H acceptors: 3 LogP: 5.84 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)c(C(=O)[O-])c1c(n2)c2ccc(cc2SC1)c1ccccc1.[Na+]
InChi: 1S/C23H14FNO2S.Na/c24-15-7-9-19-17(11-15)21(23(26)27)18-12-28-20-10-14(13-4-2-1-3-5-13)6-8-16(20)22(18)25-19;/h1-11H,12H2,(H,26,27);/q;+1/p-1
InChiKey: VKUOPYBOAOYBER-UHFFFAOYSA-M

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	dihydroorotate dehydrogenase (quinone)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania infantum	dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530	Get druggable targets OG5_127289	All targets in OG5_127289
Theileria parva	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium falciparum	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium berghei	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium knowlesi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Babesia bovis	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania major	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium yoelii	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma brucei gambiense	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	Get druggable targets OG5_127289	All targets in OG5_127289
Candida albicans	likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin	Get druggable targets OG5_127289	All targets in OG5_127289
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Schistosoma japonicum	ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	Get druggable targets OG5_127289	All targets in OG5_127289
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania donovani	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma congolense	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Schistosoma mansoni	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Neospora caninum	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Candida albicans	likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin	Get druggable targets OG5_127289	All targets in OG5_127289
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania mexicana	dihydroorotate dehydrogenase, putative	Get druggable targets OG5_127289	All targets in OG5_127289
Leishmania braziliensis	dihydroorotate dehydrogenase	Get druggable targets OG5_127289	All targets in OG5_127289

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	dihydroorotate dehydrogenase (quinone)	395 aa	361 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	biogenic amine 5HT receptor	0.0097	0.4338	1
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.4338	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0097	0.4338	1
Brugia malayi	Dopamine receptor protein 2	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus granulosus	neuropeptides capa receptor	0.0097	0.4338	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0097	0.4338	0.4338
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0097	0.4338	0.4338
Echinococcus multilocularis	neuropeptide receptor	0.0097	0.4338	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus granulosus	neuropeptide receptor	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0037	0.1064	0.2453
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0097	0.4338	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus multilocularis	somatostatin receptor	0.0097	0.4338	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0097	0.4338	1
Schistosoma mansoni	amine GPCR	0.0097	0.4338	0.4338
Echinococcus granulosus	neuropeptide receptor	0.0097	0.4338	1
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.4338	0.4338
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	opsin-like receptor	0.0097	0.4338	0.4338
Schistosoma mansoni	neuropeptide receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	sex peptide receptor	0.0097	0.4338	1
Schistosoma mansoni	histamine h1 receptor	0.0097	0.4338	0.4338
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.4338	0.4338
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0097	0.4338	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0097	0.4338	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0097	0.4338	1
Brugia malayi	G-protein coupled receptor	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus granulosus	somatostatin receptor	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Echinococcus granulosus	neuropeptide Y receptor	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Echinococcus granulosus	orexin receptor type 2	0.0097	0.4338	1
Schistosoma mansoni	opsin-like receptor	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0078	0.3328	0.7673
Schistosoma mansoni	neuropeptide receptor	0.0097	0.4338	0.4338
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3328	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	hypothetical protein	0.0097	0.4338	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.4338	1
Echinococcus multilocularis	fmrfamide receptor	0.0097	0.4338	1
Schistosoma mansoni	amine GPCR	0.0097	0.4338	0.4338
Leishmania major	dihydroorotate dehydrogenase	0.02	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0097	0.4338	0.4338
Loa Loa (eye worm)	TYRA-2 protein	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Mycobacterium leprae	Probable dihydroorotate dehydrogenase PyrD	0.02	1	1
Brugia malayi	Dopamine receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.4338	1
Brugia malayi	G protein-coupled receptor F59B2.13	0.0097	0.4338	0.4338
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0037	0.1064	0.2453
Brugia malayi	Zinc finger, C2H2 type family protein	0.0078	0.3328	0.3328
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0097	0.4338	1
Wolbachia endosymbiont of Brugia malayi	dihydroorotate dehydrogenase 2	0.02	1	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.4338	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.4338	0.4338
Schistosoma mansoni	growth hormone secretagogue receptor	0.0097	0.4338	0.4338
Brugia malayi	Dopamine receptor protein 1	0.0097	0.4338	0.4338
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.4338	0.4338
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0078	0.3328	0.7673
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Mycobacterium tuberculosis	Probable dihydroorotate dehydrogenase PyrD	0.02	1	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0097	0.4338	1
Echinococcus granulosus	g protein coupled receptor	0.0097	0.4338	1
Echinococcus granulosus	neuropeptide s receptor	0.0097	0.4338	1
Echinococcus granulosus	G protein coupled receptor 139	0.0097	0.4338	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	neuropeptide receptor A26	0.0097	0.4338	1
Echinococcus multilocularis	allatostatin A receptor	0.0097	0.4338	1
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.1249	0.1249
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0097	0.4338	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	dihydropyrimidine dehydrogenase NADP	0.0078	0.3328	0.7673
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.4338	1
Echinococcus multilocularis	fmrfamide receptor	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.4338	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Echinococcus granulosus	allatostatin A receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus granulosus	g protein coupled receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Brugia malayi	GnHR receptor homolog	0.0097	0.4338	0.4338
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.4338	1
Brugia malayi	putative neuropeptide receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0097	0.4338	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0097	0.4338	1
Brugia malayi	Dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	1	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0097	0.4338	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0799	0.1841
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0097	0.4338	1
Brugia malayi	AKH receptor	0.0097	0.4338	0.4338
Trypanosoma cruzi	dihydroorotate dehydrogenase (fumarate), putative	0.02	1	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0097	0.4338	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.4338	0.4338
Schistosoma mansoni	amine GPCR	0.0097	0.4338	0.4338
Trichomonas vaginalis	dihydropyrimidine dehydrogenase, putative	0.0078	0.3328	1
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0097	0.4338	0.4338
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0097	0.4338	0.4338
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.4338	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0097	0.4338	0.4338
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0097	0.4338	1
Schistosoma mansoni	hypothetical protein	0.0097	0.4338	0.4338
Echinococcus granulosus	g protein coupled receptor	0.0097	0.4338	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0097	0.4338	0.4338
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Brugia malayi	G protein-coupled receptor	0.0097	0.4338	0.4338
Plasmodium falciparum	dihydroorotate dehydrogenase	0.02	1	0.5
Echinococcus multilocularis	dro:myosuppressin receptor	0.0097	0.4338	1
Schistosoma mansoni	adenoreceptor	0.0097	0.4338	0.4338
Echinococcus granulosus	dro:myosuppressin receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.4338	1
Brugia malayi	RE15519p	0.0097	0.4338	0.4338
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0097	0.4338	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.4338	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0037	0.1064	0.1064
Echinococcus multilocularis	G protein coupled receptor 139	0.0097	0.4338	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0097	0.4338	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0097	0.4338	0.4338
Echinococcus granulosus	biogenic amine 5HT receptor	0.0097	0.4338	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3328	1
Onchocerca volvulus		0.0097	0.4338	0.5
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0097	0.4338	1
Echinococcus multilocularis	serotonin receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0097	0.4338	1
Brugia malayi	G-protein coupled receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0097	0.4338	1
Brugia malayi	Serotonin receptor	0.0097	0.4338	0.4338
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0097	0.4338	0.4338
Echinococcus multilocularis	sex peptide receptor	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Onchocerca volvulus		0.0097	0.4338	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0073	0.306	0.7055
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.02	1	1
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0097	0.4338	0.4338
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.4338	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.4338	1
Mycobacterium ulcerans	dihydroorotate dehydrogenase 2	0.02	1	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.4338	0.4338
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.4338	1
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0097	0.4338	1
Brugia malayi	ORL1-like opioid receptor	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Brugia malayi	Serotonin receptor	0.0097	0.4338	0.4338
Trypanosoma brucei	dihydroorotate dehydrogenase (fumarate)	0.02	1	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.4338	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	myosin xvIII	0.0097	0.4338	0.4338
Plasmodium vivax	dihydroorotate dehydrogenase, mitochondrial precursor, putative	0.02	1	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.4338	1
Schistosoma mansoni	biogenic amine receptor	0.0097	0.4338	0.4338
Brugia malayi	neuropeptide F receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0037	0.1064	0.2453
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0097	0.4338	0.4338
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0097	0.4338	0.4338
Schistosoma mansoni	neuropeptide f receptor 76f	0.0097	0.4338	0.4338
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3328	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3328	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0097	0.4338	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0097	0.4338	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0097	0.4338	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0097	0.4338	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.4338	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0097	0.4338	1
Trichomonas vaginalis	dihydroorotate dehydrogenase, putative	0.0078	0.3328	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.4338	0.4338
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0097	0.4338	1
Echinococcus multilocularis	serotonin receptor	0.0097	0.4338	1
Brugia malayi	Cytochrome P450 family protein	0.0073	0.306	0.306
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0097	0.4338	1
Toxoplasma gondii	dihydroorotate dehydrogenase reveal, putative	0.02	1	1
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Echinococcus multilocularis	orexin receptor type 2	0.0097	0.4338	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0097	0.4338	1
Echinococcus multilocularis	neuropeptide receptor	0.0097	0.4338	1
Schistosoma mansoni	opsin-like receptor	0.0097	0.4338	0.4338
Schistosoma mansoni	amine GPCR	0.0097	0.4338	0.4338
Onchocerca volvulus		0.0097	0.4338	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	neuropeptide receptor	0.0097	0.4338	0.4338
Onchocerca volvulus		0.0097	0.4338	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0097	0.4338	1
Schistosoma mansoni	neuropeptide receptor	0.0097	0.4338	0.4338
Brugia malayi	sulfakinin receptor protein	0.0097	0.4338	0.4338
Schistosoma mansoni	hypothetical protein	0.0097	0.4338	0.4338
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus multilocularis	g-protein coupled receptor	0.0097	0.4338	1
Echinococcus granulosus	fmrfamide receptor	0.0097	0.4338	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	hypothetical protein	0.0097	0.4338	0.4338
Echinococcus multilocularis	dihydropyrimidine dehydrogenase (NADP+)	0.0078	0.3328	0.7673
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	hypothetical protein	0.0097	0.4338	0.4338
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.4338	0.4338
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0097	0.4338	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0097	0.4338	1
Schistosoma mansoni	biogenic amine receptor	0.0097	0.4338	0.4338
Brugia malayi	neuropeptide F receptor	0.0097	0.4338	0.4338
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.0078	0.3328	0.3328
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0097	0.4338	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	neuropeptide Y receptor	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0097	0.4338	1
Brugia malayi	Melatonin receptor type 1A	0.0097	0.4338	0.4338
Echinococcus multilocularis	neuropeptide s receptor	0.0097	0.4338	1
Schistosoma mansoni	biogenic amine receptor	0.0097	0.4338	0.4338
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Schistosoma mansoni	voltage-gated potassium channel	0.004	0.1249	0.1249
Schistosoma mansoni	amine GPCR	0.0097	0.4338	0.4338
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.4338	0.4338
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.4338	1
Schistosoma mansoni	dihydroorotate dehydrogenase	0.02	1	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.4338	1
Brugia malayi	larval opioid receptor	0.0097	0.4338	0.4338
Brugia malayi	follicle stimulating hormone receptor	0.0097	0.4338	0.4338
Trypanosoma cruzi	dihydroorotate dehydrogenase, putative	0.02	1	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Onchocerca volvulus		0.0097	0.4338	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0097	0.4338	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0097	0.4338	0.4338
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.4338	1
Echinococcus granulosus	serotonin receptor	0.0097	0.4338	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0097	0.4338	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0097	0.4338	1
Echinococcus granulosus	g-protein coupled receptor	0.0097	0.4338	1
Brugia malayi	hypothetical protein	0.0097	0.4338	0.4338
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0097	0.4338	0.4338
Loa Loa (eye worm)	hypothetical protein	0.0097	0.4338	1
Entamoeba histolytica	dihydropyrimidine dehydrogenase, putative	0.0078	0.3328	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 16 nM	Concentration required to inhibit proliferation in a mixture of human lymphocytes using mixed lymphocyte reaction test	ChEMBL.	9871675
Ki (binding)	= 17 nM	Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)	ChEMBL.	9871675
Ki (binding)	= 17 nM	Inhibition of human recombinant dihydroorotate dehydrogenase (DHODase)	ChEMBL.	9871675

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL104302

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 173855