Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 11, subfamily B, polypeptide 2 | Starlite/ChEMBL | References |
Homo sapiens | cytochrome P450, family 11, subfamily B, polypeptide 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Neospora caninum | Os02g0824100 protein, related | Get druggable targets OG5_134469 | All targets in OG5_134469 |
Toxoplasma gondii | cytochrome p450 superfamily protein | Get druggable targets OG5_134469 | All targets in OG5_134469 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.2206 | 1 | 1 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.2206 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2206 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.2206 | 1 | 1 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.2206 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2206 | 1 | 1 |
Onchocerca volvulus | 0.2206 | 1 | 1 | |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.2056 | 0.8308 | 0.8308 |
Schistosoma mansoni | lipoxygenase | 0.1438 | 0.1316 | 0.1316 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK protein kinase | 0.2206 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.2206 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.2206 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.2206 | 1 | 1 |
Onchocerca volvulus | 0.2206 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2206 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.2206 | 1 | 1 |
Brugia malayi | SRC-1 | 0.2206 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.2056 | 0.8308 | 0.8308 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.2206 | 1 | 1 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.2206 | 1 | 1 |
Echinococcus granulosus | c src tyrosine kinase | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.2206 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2206 | 1 | 1 |
Brugia malayi | SH2 domain containing protein | 0.2206 | 1 | 1 |
Onchocerca volvulus | 0.2206 | 1 | 1 | |
Brugia malayi | Protein kinase domain containing protein | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine kinase | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.2206 | 1 | 1 |
Brugia malayi | protein-tyrosine kinase | 0.2206 | 1 | 1 |
Echinococcus multilocularis | c src tyrosine kinase | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | SRC-1 | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2206 | 1 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine kinase | 0.2206 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.2056 | 0.8308 | 0.8308 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.2206 | 1 | 1 |
Onchocerca volvulus | 0.2206 | 1 | 1 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.2206 | 1 | 1 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.2206 | 1 | 1 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.2206 | 1 | 1 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.2206 | 1 | 1 |
Onchocerca volvulus | 0.2206 | 1 | 1 | |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.2206 | 1 | 1 |
Onchocerca volvulus | 0.2206 | 1 | 1 | |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.2206 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 347 nM | Inhibition of human CYP11B1 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxy-corticosterone as substrate | ChEMBL. | 23281812 |
IC50 (binding) | = 563 nM | Inhibition of human CYP11B2 expressed in hamster V79MZh cells using [1,2-3H]-11-deoxy-corticosterone as substrate | ChEMBL. | 23281812 |
IC50 (binding) | > 5000 nM | Inhibition of human CYP19 using [1beta-3H]androstenedione as substrate by 3H2O method | ChEMBL. | 23281812 |
Inhibition (binding) | < 3 % | Inhibition of human CYP17 expressed in Escherichia coli using progesterone as substrate at 2 uM | ChEMBL. | 23281812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.