Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phospholipase A2, group IIA (platelets, synovial fluid) | Starlite/ChEMBL | References |
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Brugia malayi | Phospholipase A2 family protein | phospholipase A2, group IIA (platelets, synovial fluid) | 144 aa | 125 aa | 28.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Phospholipase A2 family protein | 0.0111 | 0.1596 | 0.6508 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1596 | 0.1596 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0111 | 0.1596 | 1 |
Brugia malayi | hypothetical protein | 0.0128 | 0.2453 | 1 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 1 | 1 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0111 | 0.1596 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1596 | 0.1596 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.9 uM | Inhibition of human LTA4H aminopeptidase activity using Ala-p-nitroanilide as substrate incubated for 2 mins prior to substrate addition measured for 15 mins by spectrophotometric analysis | ChEMBL. | 23220644 |
IC50 (binding) | = 15.3 uM | Inhibition of human nonpancreatic secretory phospholipase A2 using 1,2-dimyristoyl-sn-glycero-3-phosphocholine as substrate after 10 mins by spectrophotometric analysis | ChEMBL. | 23220644 |
IC50 (binding) | > 100 uM | Inhibition of human LTA4H epoxide hydrolase activity using LTA4 as substrate incubated for 15 mins prior to substrate addition measured after 10 mins by ELISA | ChEMBL. | 23220644 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.