Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | spcc417.12 protein, putative | 0.09 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5325 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.5325 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5325 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5325 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.09 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5325 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5325 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.5325 | 1 | 1 |
Onchocerca volvulus | 0.09 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.09 | 0 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.09 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.09 | 0 | 0.5 |
Onchocerca volvulus | 0.09 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.5325 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.09 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5325 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5325 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.5325 | 1 | 1 |
Onchocerca volvulus | 0.09 | 0 | 0.5 | |
Onchocerca volvulus | 0.09 | 0 | 0.5 | |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.4432 | 0.798 | 0.798 |
Brugia malayi | Carboxylesterase family protein | 0.5325 | 1 | 1 |
Onchocerca volvulus | 0.09 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.