Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | thymidylate synthase | 0.106 | 0.3905 | 0.9198 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.1145 | 0.4264 | 0.4264 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1492 | 0.5723 | 0.5 |
Mycobacterium leprae | Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) | 0.1114 | 0.4135 | 1 |
Mycobacterium tuberculosis | Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) | 0.1114 | 0.4135 | 1 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0674 | 0.2281 | 0.1717 |
Treponema pallidum | penicillin-binding protein (pbp-3) | 0.0441 | 0.13 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1145 | 0.4264 | 0.4264 |
Mycobacterium ulcerans | bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 | 0.0441 | 0.13 | 0.0126 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.1145 | 0.4264 | 0.4264 |
Schistosoma mansoni | tyrosine kinase | 0.1145 | 0.4264 | 0.4264 |
Mycobacterium tuberculosis | Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen | 0.0441 | 0.13 | 0.0126 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.106 | 0.3905 | 0.9198 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1145 | 0.4264 | 0.4264 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.1145 | 0.4264 | 0.4264 |
Schistosoma mansoni | tyrosine kinase | 0.1145 | 0.4264 | 0.4264 |
Mycobacterium leprae | PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN | 0.0441 | 0.13 | 0.0126 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0432 | 0.1264 | 0.1264 |
Mycobacterium ulcerans | serine/threonine-protein kinase B PknB | 0.1114 | 0.4135 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0432 | 0.1264 | 0.1264 |
Brugia malayi | thymidylate synthase | 0.106 | 0.3905 | 0.3905 |
Loa Loa (eye worm) | thymidylate synthase | 0.106 | 0.3905 | 0.3905 |
Schistosoma mansoni | tyrosine kinase | 0.1117 | 0.4148 | 0.4148 |
Echinococcus granulosus | dihydrofolate reductase | 0.0432 | 0.1264 | 0.1264 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0504 | 0.1567 | 0.1055 |
Echinococcus granulosus | epidermal growth factor receptor | 0.1145 | 0.4264 | 0.4264 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.106 | 0.3905 | 0.3905 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.2508 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1363 | 0.5182 | 0.5182 |
Brugia malayi | Protein kinase domain containing protein | 0.1391 | 0.5298 | 0.5298 |
Schistosoma mansoni | tyrosine kinase | 0.1117 | 0.4148 | 0.4148 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1492 | 0.5723 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1145 | 0.4264 | 0.4264 |
Echinococcus multilocularis | thymidylate synthase | 0.106 | 0.3905 | 0.3905 |
Schistosoma mansoni | dihydrofolate reductase | 0.0432 | 0.1264 | 0.1264 |
Onchocerca volvulus | 0.106 | 0.3905 | 1 | |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0674 | 0.2281 | 0.1717 |
Echinococcus multilocularis | 0.0327 | 0.0821 | 0.0821 | |
Brugia malayi | hypothetical protein | 0.0504 | 0.1567 | 0.1567 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0674 | 0.2281 | 0.1717 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1492 | 0.5723 | 0.5 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.2508 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.1117 | 0.4148 | 0.4148 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1492 | 0.5723 | 0.5 |
Trypanosoma cruzi | NEK family Serine/threonine-protein kinase, putative | 0.0674 | 0.2281 | 0.1717 |
Echinococcus granulosus | thymidylate synthase | 0.106 | 0.3905 | 0.3905 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.1145 | 0.4264 | 0.4264 |
Treponema pallidum | hypothetical protein | 0.0441 | 0.13 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.2508 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0432 | 0.1264 | 0.1264 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0504 | 0.1567 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0432 | 0.1264 | 0.1264 |
Echinococcus multilocularis | insulin receptor | 0.2508 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1492 | 0.5723 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0432 | 0.1264 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.106 | 0.3905 | 0.9198 |
Schistosoma mansoni | tyrosine kinase | 0.2508 | 1 | 1 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.2508 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1492 | 0.5723 | 1 |
Echinococcus granulosus | insulin receptor | 0.2508 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | Agonist activity at human GABAA alpha1beta2gamma2S receptor expressed in TSA201 cells after 1 min by FLIPR assay | ChEMBL. | 23294161 | |
EC50 (binding) | Agonist activity at human GABAA rho1 receptor expressed in TSA201 cells after 1 min by FLIPR assay | ChEMBL. | 23294161 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.