Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.0436 | 0.2799 | 1 |
Brugia malayi | Peptidase family M1 containing protein | 0.0436 | 0.2799 | 0.2799 |
Echinococcus granulosus | membrane bound acyltransferase:hhat | 0.0045 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0851 | 0.0951 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Entamoeba histolytica | hypothetical protein | 0.0045 | 0.0106 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.1742 | 0.1948 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0153 | 0.0851 | 0.304 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0153 | 0.0851 | 0.0851 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0153 | 0.0851 | 0.517 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0106 | 0.0378 |
Brugia malayi | hypothetical protein | 0.0436 | 0.2799 | 0.2799 |
Brugia malayi | MBOAT family protein | 0.0045 | 0.0106 | 0.0106 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0153 | 0.0851 | 0.304 |
Echinococcus granulosus | acetylcholinesterase | 0.0797 | 0.5285 | 0.5285 |
Echinococcus multilocularis | diacylglycerol O acyltransferase 1 | 0.0269 | 0.1646 | 0.1646 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0135 | 0.0722 | 0.5 |
Loa Loa (eye worm) | hhat protein | 0.0045 | 0.0106 | 0.0118 |
Echinococcus granulosus | Membrane bound O acyl transferase MBOAT | 0.0045 | 0.0106 | 0.0106 |
Schistosoma mansoni | family M1 non-peptidase homologue (M01 family) | 0.0283 | 0.1742 | 0.3297 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0045 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0797 | 0.5285 | 0.5909 |
Echinococcus granulosus | neuroligin | 0.0135 | 0.0722 | 0.0722 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0153 | 0.0851 | 0.0851 |
Schistosoma mansoni | membrane-bound acyltransferase/hhat | 0.0045 | 0.0106 | 0.02 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.0153 | 0.0851 | 0.517 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0436 | 0.2799 | 0.2799 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0045 | 0.0106 | 0.02 |
Schistosoma mansoni | zinc finger protein | 0.0045 | 0.0106 | 0.02 |
Plasmodium falciparum | diacylglycerol O-acyltransferase | 0.0269 | 0.1646 | 1 |
Echinococcus multilocularis | Membrane bound O acyl transferase, MBOAT | 0.0045 | 0.0106 | 0.0106 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0436 | 0.2799 | 1 |
Toxoplasma gondii | acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha | 0.0269 | 0.1646 | 1 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0283 | 0.1742 | 0.6226 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0722 | 0.0808 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0436 | 0.2799 | 0.2799 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1198 | 0.8052 | 0.9003 |
Toxoplasma gondii | aminopeptidase n, putative | 0.0153 | 0.0851 | 0.517 |
Echinococcus granulosus | diacylglycerol O acyltransferase 1 | 0.0269 | 0.1646 | 0.1646 |
Trypanosoma cruzi | aminopeptidase, putative | 0.0436 | 0.2799 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0797 | 0.5285 | 0.5285 |
Loa Loa (eye worm) | aminopeptidase N | 0.0436 | 0.2799 | 0.3129 |
Toxoplasma gondii | aminopeptidase N, putative | 0.0153 | 0.0851 | 0.517 |
Onchocerca volvulus | 0.1481 | 1 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0045 | 0.0106 | 0.02 |
Loa Loa (eye worm) | carboxylesterase | 0.0797 | 0.5285 | 0.5909 |
Onchocerca volvulus | 0.0135 | 0.0722 | 0.0623 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0135 | 0.0722 | 0.2581 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0797 | 0.5285 | 0.5909 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0153 | 0.0851 | 0.0619 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0135 | 0.0722 | 0.1367 |
Echinococcus granulosus | acetylcholinesterase | 0.0797 | 0.5285 | 0.5285 |
Echinococcus granulosus | protein cysteine N palmitoyltransferase | 0.0045 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0722 | 0.0808 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0436 | 0.2799 | 0.2799 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0436 | 0.2799 | 0.2799 |
Loa Loa (eye worm) | carboxylesterase | 0.0135 | 0.0722 | 0.0808 |
Giardia lamblia | Beta tubulin | 0.003 | 0 | 0.5 |
Schistosoma mansoni | leukocyte receptor cluster (lrc) member 4 protein | 0.0045 | 0.0106 | 0.02 |
Trypanosoma cruzi | GUP1, putative | 0.0045 | 0.0106 | 0.0378 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0135 | 0.0722 | 0.0722 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0153 | 0.0851 | 0.0851 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0436 | 0.2799 | 0.2799 |
Onchocerca volvulus | 0.0135 | 0.0722 | 0.0623 | |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0045 | 0.0106 | 0.0106 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Giardia lamblia | Beta tubulin | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.0153 | 0.0851 | 0.304 |
Entamoeba histolytica | aminopeptidase, putative | 0.0436 | 0.2799 | 1 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0436 | 0.2799 | 0.2799 |
Leishmania major | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0045 | 0.0106 | 0.0106 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0045 | 0.0106 | 0.0106 |
Giardia lamblia | Beta tubulin | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.0153 | 0.0851 | 0.0753 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0106 | 0.0118 |
Brugia malayi | MBOAT family protein | 0.0045 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.1045 | 0.6996 | 0.7822 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0797 | 0.5285 | 0.5285 |
Loa Loa (eye worm) | hypothetical protein | 0.1328 | 0.8944 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0797 | 0.5285 | 0.5285 |
Onchocerca volvulus | 0.0135 | 0.0722 | 0.0623 | |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0436 | 0.2799 | 1 |
Trichomonas vaginalis | porcupine, putative | 0.0045 | 0.0106 | 0.0378 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0135 | 0.0722 | 0.1367 |
Schistosoma mansoni | gliotactin | 0.0135 | 0.0722 | 0.1367 |
Echinococcus granulosus | o acyltransferase membrane bound domain | 0.0045 | 0.0106 | 0.0106 |
Trypanosoma brucei | aminopeptidase, putative | 0.0153 | 0.0851 | 0.304 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0153 | 0.0851 | 0.0851 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0135 | 0.0722 | 0.0722 |
Loa Loa (eye worm) | hypothetical protein | 0.0797 | 0.5285 | 0.5909 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0045 | 0.0106 | 0.02 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1334 | 0.1492 |
Brugia malayi | MBOAT family protein | 0.0045 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0722 | 0.0808 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.0153 | 0.0851 | 0.304 |
Loa Loa (eye worm) | TATA binding protein associated factor | 0.0153 | 0.0851 | 0.0951 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0153 | 0.0851 | 0.304 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0045 | 0.0106 | 0.0378 |
Echinococcus multilocularis | membrane bound acyltransferase:hhat | 0.0045 | 0.0106 | 0.0106 |
Schistosoma mansoni | Tata binding protein associated factor (M01 family) | 0.0153 | 0.0851 | 0.161 |
Toxoplasma gondii | hypothetical protein | 0.0045 | 0.0106 | 0.0642 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0153 | 0.0851 | 0.161 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0135 | 0.0722 | 0.0722 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0045 | 0.0106 | 0.0106 |
Leishmania major | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0722 | 0.0808 |
Echinococcus granulosus | lysophospholipid acyltransferase 7 | 0.0045 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | diacylglycerol acyltransferase | 0.0269 | 0.1646 | 0.184 |
Echinococcus multilocularis | acetylcholinesterase | 0.0797 | 0.5285 | 0.5285 |
Trichomonas vaginalis | transmembrane protein nessy, putative | 0.0045 | 0.0106 | 0.0378 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0106 | 0.0118 |
Schistosoma mansoni | cytosol alanyl aminopeptidase (M01 family) | 0.0436 | 0.2799 | 0.5295 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0135 | 0.0722 | 0.0722 |
Onchocerca volvulus | 0.0135 | 0.0722 | 0.0623 | |
Brugia malayi | diacylglycerol acyltransferase | 0.0269 | 0.1646 | 0.1646 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0283 | 0.1742 | 0.1742 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0436 | 0.2799 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0045 | 0.0106 | 0.0378 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0436 | 0.2799 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0135 | 0.0722 | 0.0722 |
Leishmania major | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Echinococcus multilocularis | lysophospholipid acyltransferase 7 | 0.0045 | 0.0106 | 0.0106 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0436 | 0.2799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0106 | 0.0118 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0436 | 0.2799 | 0.2799 |
Loa Loa (eye worm) | MBOAT family protein | 0.0045 | 0.0106 | 0.0118 |
Brugia malayi | MBOAT family protein | 0.0045 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.1742 | 0.1948 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0045 | 0.0106 | 0.02 |
Echinococcus granulosus | aminopeptidase N | 0.1481 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0722 | 0.0808 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.0722 | 0.0722 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0135 | 0.0722 | 0.1367 |
Onchocerca volvulus | 0.0436 | 0.2799 | 0.2722 | |
Toxoplasma gondii | acyl-CoA:diacylglycerol acyltransferase 1-related enzyme | 0.0269 | 0.1646 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0045 | 0.0106 | 0.0378 |
Brugia malayi | Hhat protein | 0.0045 | 0.0106 | 0.0106 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0106 | 0.0378 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0135 | 0.0722 | 0.2581 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0045 | 0.0106 | 0.0378 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0153 | 0.0851 | 0.0951 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.0153 | 0.0851 | 0.304 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.0436 | 0.2799 | 1 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.0436 | 0.2799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0722 | 0.0808 |
Brugia malayi | hypothetical protein | 0.0135 | 0.0722 | 0.0722 |
Brugia malayi | hypothetical protein | 0.0153 | 0.0851 | 0.0851 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0135 | 0.0722 | 0.1367 |
Echinococcus granulosus | puromycin sensitive aminopeptidase | 0.0436 | 0.2799 | 0.2799 |
Brugia malayi | MBOAT family protein | 0.0045 | 0.0106 | 0.0106 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.0153 | 0.0851 | 0.304 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0436 | 0.2799 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0135 | 0.0722 | 0.1367 |
Leishmania major | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0436 | 0.2799 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0851 | 0.0951 |
Schistosoma mansoni | acetylcholinesterase | 0.0135 | 0.0722 | 0.1367 |
Trypanosoma cruzi | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.0153 | 0.0851 | 0.517 |
Echinococcus multilocularis | aminopeptidase N | 0.1481 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.0851 | 0.0951 |
Schistosoma mansoni | o-acyltransferase (membrane bound) domain containing protein | 0.0045 | 0.0106 | 0.02 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0797 | 0.5285 | 1 |
Schistosoma mansoni | aminopeptidase A (M01 family) | 0.0153 | 0.0851 | 0.161 |
Echinococcus granulosus | carboxylesterase 5A | 0.0797 | 0.5285 | 0.5285 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0135 | 0.0722 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0135 | 0.0722 | 0.0722 |
Brugia malayi | TATA binding protein associated factor | 0.0153 | 0.0851 | 0.0851 |
Toxoplasma gondii | aminopeptidase N protein | 0.0153 | 0.0851 | 0.517 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.0153 | 0.0851 | 0.517 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.0722 | 0.0722 |
Loa Loa (eye worm) | membrane bound O-acyltransferase domain containing 1 | 0.0045 | 0.0106 | 0.0118 |
Loa Loa (eye worm) | hypothetical protein | 0.0135 | 0.0722 | 0.0808 |
Trypanosoma cruzi | GUP1, putative | 0.0045 | 0.0106 | 0.0378 |
Loa Loa (eye worm) | carboxylesterase | 0.0135 | 0.0722 | 0.0808 |
Trypanosoma brucei | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Entamoeba histolytica | vacuolar protein sorting 26 | 0.0045 | 0.0106 | 0.0378 |
Schistosoma mansoni | diacylglycerol O-acyltransferase 1 | 0.0269 | 0.1646 | 0.3114 |
Onchocerca volvulus | 0.0135 | 0.0722 | 0.0623 | |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0106 | 0.0118 |
Echinococcus multilocularis | acetylcholinesterase | 0.0797 | 0.5285 | 0.5285 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0135 | 0.0722 | 0.0722 |
Echinococcus multilocularis | Peptidase M1, membrane alanine aminopeptidase, N terminal | 0.0436 | 0.2799 | 0.2799 |
Loa Loa (eye worm) | MBOAT family protein | 0.0045 | 0.0106 | 0.0118 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0045 | 0.0106 | 0.0378 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0045 | 0.0106 | 0.0106 |
Loa Loa (eye worm) | hhat protein | 0.0045 | 0.0106 | 0.0118 |
Loa Loa (eye worm) | MBOAT family protein | 0.0045 | 0.0106 | 0.0118 |
Echinococcus multilocularis | puromycin sensitive aminopeptidase | 0.0436 | 0.2799 | 0.2799 |
Echinococcus multilocularis | o acyltransferase (membrane bound) domain | 0.0045 | 0.0106 | 0.0106 |
Plasmodium vivax | diacylglycerol O-acyltransferase, putative | 0.0269 | 0.1646 | 1 |
Treponema pallidum | alginate O-acetylation protein (algI) | 0.0045 | 0.0106 | 0.5 |
Brugia malayi | Peptidase family M1 containing protein | 0.0153 | 0.0851 | 0.0851 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.0722 | 0.0722 |
Brugia malayi | Carboxylesterase family protein | 0.0135 | 0.0722 | 0.0722 |
Entamoeba histolytica | membrane-bound O-acyltransferase (MBOAT ) family protein | 0.0045 | 0.0106 | 0.0378 |
Echinococcus multilocularis | protein cysteine N palmitoyltransferase | 0.0045 | 0.0106 | 0.0106 |
Leishmania major | glycerol uptake protein, putative | 0.0045 | 0.0106 | 0.0378 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0135 | 0.0722 | 0.5 |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.0153 | 0.0851 | 0.304 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.0436 | 0.2799 | 0.5295 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 23356786 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.