Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epoxide hydrolase 2, cytoplasmic | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | epoxide hydrolase EphA | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | Get druggable targets OG5_129061 | All targets in OG5_129061 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.9622 | 1 | 0.5 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.3757 | 0.3777 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3757 | 0.3777 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.9622 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3757 | 0.3777 | 0.5 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.9622 | 1 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3757 | 0.3777 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3757 | 0.3777 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.9622 | 1 | 1 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.9622 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.9622 | 1 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3757 | 0.3777 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.9622 | 1 | 0.5 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3757 | 0.3777 | 0.5 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.3757 | 0.3777 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.9622 | 1 | 1 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.3757 | 0.3777 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.3757 | 0.3777 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.9622 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.3757 | 0.3777 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.9622 | 1 | 1 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.9622 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.9622 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.9622 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.9622 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 43 nM | Inhibition of human sEH assessed as 6-methoxy-2-naphthaldehyde generation preincubated for 10 before addition of cyano(2-methyl-oxynaphthalen-6-yl)methyl trans-(3-phenyloxyran-2-yl) methyl carbonate by fluorescence analysis | ChEMBL. | 23237835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.