TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 407.896 | Formula: C22H22ClN5O
H donors: 1 H acceptors: 4 LogP: 3.93 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC1CCCN(C1)Cc1ccc2c(c1)n1c(nnc1c(n2)C)c1ccccc1Cl
InChi: 1S/C22H22ClN5O/c1-14-21-25-26-22(17-6-2-3-7-18(17)23)28(21)20-11-15(8-9-19(20)24-14)12-27-10-4-5-16(29)13-27/h2-3,6-9,11,16,29H,4-5,10,12-13H2,1H3
InChiKey: YCWMKHFHOBOJHS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Starlite/ChEMBL	References
Homo sapiens	phosphodiesterase 2A, cGMP-stimulated	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	Get druggable targets OG5_135549	All targets in OG5_135549
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	Get druggable targets OG5_135363	All targets in OG5_135363
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135549	All targets in OG5_135549
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	cGMP-dependent 3',5'-cyclic phosphodiesterase, putative	Get druggable targets OG5_135549	All targets in OG5_135549
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma japonicum	ko:K01120 3',5'-cyclic-nucleotide phosphodiesterase [EC3.1.4.17], putative	Get druggable targets OG5_135549	All targets in OG5_135549
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_135363	All targets in OG5_135363
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	Get druggable targets OG5_135549	All targets in OG5_135549

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	672 aa	30.2 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	655 aa	24.1 %
Leishmania donovani	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.2 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.6 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	711 aa	26.2 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	25.7 %
Trypanosoma congolense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	656 aa	30.9 %
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	712 aa	25.0 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	716 aa	26.0 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	26.5 %
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	24.7 %
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	29.0 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Leishmania mexicana	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.8 %
Drosophila melanogaster	Phosphodiesterase 6	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	684 aa	32.2 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	668 aa	30.5 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	686 aa	24.1 %
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	30.5 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	679 aa	26.7 %
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	688 aa	29.1 %
Leishmania infantum	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	671 aa	30.4 %
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	23.5 %
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	682 aa	28.9 %
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	phosphodiesterase 2A, cGMP-stimulated	934 aa	748 aa	27.1 %
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	22.7 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	29.1 %
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	683 aa	27.5 %
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	693 aa	25.3 %
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	665 aa	23.5 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	699 aa	25.5 %
Trypanosoma brucei gambiense	cAMP-specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	661 aa	30.3 %
Leishmania braziliensis	cAMP specific phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	674 aa	29.1 %
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	689 aa	22.8 %
Trypanosoma brucei	cAMP-specific phosphodiesterase	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	666 aa	30.5 %
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	794 aa	653 aa	23.0 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	phosphoglucomutase	0.0161	0.1159	0.058
Trypanosoma brucei	aldo-keto reductase, putative	0.0462	0.7165	0.6979
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0313	0.4199	0.5472
Treponema pallidum	ribonuclease H (rnhA)	0.0161	0.1159	0.5
Plasmodium vivax	aldehyde reductase, putative	0.0134	0.0615	0.5
Plasmodium vivax	oxidoreductase, aldo/keto reductase domain containing protein	0.0134	0.0615	0.5
Trypanosoma brucei	ribonuclease H1	0.0161	0.1159	0.058
Echinococcus multilocularis	aldo keto reductase	0.0462	0.7165	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Trypanosoma cruzi	ribonuclease H1, putative	0.0161	0.1159	0.0831
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0462	0.7165	1
Trypanosoma brucei	RNA helicase, putative	0.0604	1	1
Trichomonas vaginalis	alcohol dehydrogenase, putative	0.0134	0.0615	0.0858
Wolbachia endosymbiont of Brugia malayi	ribonuclease HI	0.0161	0.1159	0.5
Schistosoma mansoni	phosphoglucomutase	0.0161	0.1159	0.058
Mycobacterium leprae	Conserved hypothetical protein	0.0328	0.4494	0.5922
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0462	0.7165	1
Onchocerca volvulus		0.0462	0.7165	1
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0462	0.7165	1
Echinococcus multilocularis	aldo keto reductase	0.0462	0.7165	1
Echinococcus multilocularis	ribonuclease H1	0.0161	0.1159	0.0831
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0134	0.0615	0.0858
Leishmania major	prostaglandin f synthase, putative	0.0462	0.7165	1
Trypanosoma brucei	ingi protein (ORF1)	0.0175	0.1432	0.0871
Toxoplasma gondii	ribonuclease HI protein	0.0161	0.1159	0.0831
Onchocerca volvulus		0.0462	0.7165	1
Brugia malayi	RNase H family protein	0.0161	0.1159	0.0831
Echinococcus multilocularis	aldo keto reductase	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0462	0.7165	1
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0313	0.4199	0.5472
Onchocerca volvulus		0.0462	0.7165	1
Echinococcus multilocularis	aldehyde reductase	0.0328	0.4494	0.5922
Trypanosoma brucei	prostaglandin f synthase	0.0462	0.7165	0.6979
Trypanosoma cruzi	ribonuclease H1, putative	0.0161	0.1159	0.0831
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0313	0.4199	0.5472
Toxoplasma gondii	aldose reductase, putative	0.0462	0.7165	1
Mycobacterium ulcerans	oxidoreductase	0.0462	0.7165	1
Echinococcus granulosus	aldo keto reductase	0.0462	0.7165	1
Schistosoma mansoni	phosphoglucomutase	0.0161	0.1159	0.058
Trypanosoma brucei	ingi protein (ORF1)	0.0175	0.1432	0.0871
Loa Loa (eye worm)	oxidoreductase	0.0462	0.7165	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Loa Loa (eye worm)	oxidoreductase	0.0462	0.7165	1
Schistosoma mansoni	aldo-keto reductase	0.0462	0.7165	0.6979
Echinococcus granulosus	aldo keto reductase	0.0462	0.7165	1
Schistosoma mansoni	pol-related	0.0462	0.7165	0.6979
Loa Loa (eye worm)	hypothetical protein	0.0161	0.116	0.0832
Trichomonas vaginalis	aldo/keto reductase, putative	0.0462	0.7165	1
Trypanosoma brucei	retrotransposon hot spot protein 4 (RHS4), interrupted	0.0175	0.1432	0.0871
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Plasmodium falciparum	aldehyde reductase, putative	0.0134	0.0615	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0161	0.116	0.0832
Onchocerca volvulus		0.0462	0.7165	1
Trypanosoma cruzi	aldo-keto reductase	0.0462	0.7165	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0462	0.7165	1
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0462	0.7165	1
Leishmania major	aldo-keto reductase-like protein	0.0462	0.7165	1
Plasmodium falciparum	aldo-keto reductase, putative	0.0134	0.0615	0.5
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0134	0.0615	0.0858
Loa Loa (eye worm)	oxidoreductase	0.0462	0.7165	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0462	0.7165	1
Loa Loa (eye worm)	oxidoreductase	0.0462	0.7165	1
Trichomonas vaginalis	conserved hypothetical protein	0.0134	0.0615	0.0858
Onchocerca volvulus		0.0462	0.7165	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0462	0.7165	1
Giardia lamblia	Aldose reductase	0.0462	0.7165	1
Brugia malayi	RNase H family protein	0.0161	0.1159	0.0831
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0462	0.7165	1
Loa Loa (eye worm)	oxidoreductase	0.0462	0.7165	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0462	0.7165	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0462	0.7165	1
Onchocerca volvulus		0.0462	0.7165	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0462	0.7165	1
Trichomonas vaginalis	ribonuclease H1, putative	0.0161	0.1159	0.1617
Trypanosoma brucei	hypothetical protein, conserved	0.0175	0.1432	0.0871
Echinococcus granulosus	aldo keto reductase	0.0462	0.7165	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0462	0.7165	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0134	0.0615	0.0858
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Leishmania major	ribonuclease H1, putative	0.0161	0.1159	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Entamoeba histolytica	aldose reductase, putative	0.0462	0.7165	1
Entamoeba histolytica	aldose reductase, putative	0.0462	0.7165	1
Schistosoma mansoni	aldo-keto reductase	0.0462	0.7165	0.6979
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Loa Loa (eye worm)	hypothetical protein	0.0297	0.3882	0.4989
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0462	0.7165	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Echinococcus granulosus	aldehyde reductase	0.0328	0.4494	0.5922
Echinococcus granulosus	hypothetical protein	0.0462	0.7165	1
Echinococcus multilocularis	aldo keto reductase	0.0462	0.7165	1
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0462	0.7165	1
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0462	0.7165	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0462	0.7165	1
Onchocerca volvulus	Ribonuclease H1 homolog	0.0161	0.1159	0.0831
Trichomonas vaginalis	aldo-keto reductase, putative	0.0462	0.7165	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Giardia lamblia	Aldose reductase	0.0462	0.7165	1
Loa Loa (eye worm)	hypothetical protein	0.0256	0.3062	0.3737
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0462	0.7165	1
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Brugia malayi	RNase H family protein	0.0161	0.1159	0.0831
Brugia malayi	oxidoreductase, aldo/keto reductase family protein	0.0462	0.7165	1
Trypanosoma brucei	unspecified product	0.0175	0.1432	0.0871
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0462	0.7165	1
Echinococcus granulosus	ribonuclease H1	0.0161	0.1159	0.0831
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0161	0.116	0.0581
Entamoeba histolytica	aldose reductase, putative	0.0462	0.7165	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 6.3 nM	Inhibition of human recombinant PDE2A expressed in Sf9 cells by scintillation proximity assay	ChEMBL.	23260348
IC50 (binding)	= 21 nM	Inhibition of rat PDE10A expressed in Sf9 cells by scintillation proximity assay	ChEMBL.	23260348

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2313242

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1739277