Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 513 aa | 24.0 % |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.003 | 0 | 0.5 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.003 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0105 | 0.1423 | 0.1423 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.003 | 0 | 0.5 |
Leishmania major | puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.003 | 0 | 0.5 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.003 | 0 | 0.5 |
Toxoplasma gondii | aminopeptidase n, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0105 | 0.1423 | 0.1423 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.003 | 0 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, clan MA(E), family M1, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Trypanosoma cruzi | aminopeptidase, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | Aminopeptidase M1, putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0105 | 0.1423 | 0.1423 |
Trypanosoma brucei | aminopeptidase, putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0558 | 1 | 1 |
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | 0.003 | 0 | 0.5 |
Trypanosoma brucei | metallo-peptidase, Clan MA(E) Family M1 | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Leishmania major | aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 | 0.003 | 0 | 0.5 |
Onchocerca volvulus | 0.003 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1423 | 0.1423 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0558 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0256 | 0.4294 | 1 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.003 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0105 | 0.1423 | 0.1423 |
Trypanosoma brucei | Aminopeptidase M1, putative | 0.003 | 0 | 0.5 |
Plasmodium vivax | M1-family alanyl aminopeptidase, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0558 | 1 | 1 |
Toxoplasma gondii | aminopeptidase N protein | 0.003 | 0 | 0.5 |
Entamoeba histolytica | aminopeptidase, putative | 0.003 | 0 | 0.5 |
Plasmodium falciparum | M1-family alanyl aminopeptidase, putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | amidase | 0.0105 | 0.1423 | 0.1423 |
Trypanosoma cruzi | metallo-peptidase, Clan MA(E) Family M1 | 0.003 | 0 | 0.5 |
Toxoplasma gondii | aminopeptidase N, putative | 0.003 | 0 | 0.5 |
Trypanosoma cruzi | aminopeptidase, putative | 0.003 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0105 | 0.1423 | 0.1423 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.003 | 0 | 0.5 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.003 | 0 | 0.5 |
Brugia malayi | amidase | 0.0105 | 0.1423 | 0.3315 |
Trypanosoma cruzi | puromycin-sensitive aminopeptidase-like protein, putative | 0.003 | 0 | 0.5 |
Plasmodium falciparum | M1-family alanyl aminopeptidase | 0.003 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.3 nM | Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after 10 to 30 mins by enzyme immunoassay | ChEMBL. | 23260350 |
IC50 (binding) | = 21 nM | Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calcium ionophore challenge measured after 10 to 30 mins by enzyme immunoassay | ChEMBL. | 23260350 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.