Detailed information for compound 1739407

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 420.484 | Formula: C22H20N4O3S
  • H donors: 0 H acceptors: 3 LogP: 3.28 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)N1CC2CC1CN2Cc1coc2c1ccc(c2)Oc1nc2c(s1)cccn2
  • InChi: 1S/C22H20N4O3S/c1-13(27)26-11-15-7-16(26)10-25(15)9-14-12-28-19-8-17(4-5-18(14)19)29-22-24-21-20(30-22)3-2-6-23-21/h2-6,8,12,15-16H,7,9-11H2,1H3
  • InChiKey: IVPRIRIFLMWNSH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens leukotriene A4 hydrolase Starlite/ChEMBL References
Mus musculus leukotriene A4 hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
Loa Loa (eye worm) leukotriene A4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Echinococcus multilocularis leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) Get druggable targets OG5_129538 All targets in OG5_129538
Schistosoma japonicum ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 leukotriene A4 hydrolase 611 aa 513 aa 24.0 %
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 leukotriene A4 hydrolase 611 aa 508 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0105 0.1423 0.1423
Trypanosoma cruzi Aminopeptidase M1, putative 0.003 0 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.003 0 0.5
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0558 1 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.003 0 0.5
Mycobacterium ulcerans aminopeptidase N PepN 0.003 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0105 0.1423 0.1423
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.003 0 0.5
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.003 0 0.5
Mycobacterium ulcerans aminopeptidase N PepN 0.003 0 0.5
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.003 0 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.003 0 0.5
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.003 0 0.5
Onchocerca volvulus 0.003 0 0.5
Toxoplasma gondii aminopeptidase N protein 0.003 0 0.5
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.003 0 0.5
Onchocerca volvulus 0.003 0 0.5
Trypanosoma cruzi aminopeptidase, putative 0.003 0 0.5
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0105 0.1423 0.1423
Brugia malayi amidase 0.0105 0.1423 0.3315
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.003 0 0.5
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0558 1 1
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.003 0 0.5
Echinococcus granulosus fatty acid amide hydrolase 1 0.0105 0.1423 0.1423
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.003 0 0.5
Entamoeba histolytica aminopeptidase, putative 0.003 0 0.5
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.003 0 0.5
Brugia malayi hypothetical protein 0.0256 0.4294 1
Plasmodium falciparum M1-family alanyl aminopeptidase 0.003 0 0.5
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.003 0 0.5
Echinococcus granulosus fatty acid amide hydrolase 1 0.0105 0.1423 0.1423
Toxoplasma gondii aminopeptidase N, putative 0.003 0 0.5
Schistosoma mansoni amidase 0.0105 0.1423 0.1423
Schistosoma mansoni fatty-acid amide hydrolase 0.0105 0.1423 0.1423
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0558 1 1
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.003 0 0.5
Trypanosoma brucei Aminopeptidase M1, putative 0.003 0 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.003 0 0.5
Trypanosoma cruzi aminopeptidase, putative 0.003 0 0.5
Toxoplasma gondii aminopeptidase n, putative 0.003 0 0.5
Onchocerca volvulus 0.003 0 0.5
Trypanosoma brucei Aminopeptidase M1, putative 0.003 0 0.5
Trypanosoma brucei aminopeptidase, putative 0.003 0 0.5
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.003 0 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.3 nM Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after 10 to 30 mins by enzyme immunoassay ChEMBL. 23260350
IC50 (binding) = 21 nM Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calcium ionophore challenge measured after 10 to 30 mins by enzyme immunoassay ChEMBL. 23260350

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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