Detailed information for compound 1739574

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.384 | Formula: C21H18FN3O3
  • H donors: 0 H acceptors: 3 LogP: 2.89 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1ncn2c1CN(Cc1ccccc1)C(=O)c1c2ccc(c1)F
  • InChi: 1S/C21H18FN3O3/c1-2-28-21(27)19-18-12-24(11-14-6-4-3-5-7-14)20(26)16-10-15(22)8-9-17(16)25(18)13-23-19/h3-10,13H,2,11-12H2,1H3
  • InChiKey: MHIGGZVRNLDMTE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0156 0.1233 0.1251
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0156 0.1233 0.1233
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Brugia malayi Cytochrome P450 family protein 0.0032 0.0107 0.0108
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0053 0.0299 0.2372
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0093 0.0658 0.2511
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0327 0.2773 0.2812
Onchocerca volvulus 0.013 0.0998 0.3501
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.013 0.0998 0.0998
Schistosoma mansoni axis inhibition protein axin 0.0023 0.003 0.003
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0337 0.0337
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.017 0.1361 0.138
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0476 0.4128 0.7877
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0998 0.0998
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0327 0.2773 0.2812
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.113 1
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0327 0.2773 0.2812
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.003 0.0058
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0026 1
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0998 0.0998
Echinococcus granulosus allatostatin A receptor 0.013 0.0998 0.0998
Schistosoma mansoni isocitrate dehydrogenase 0.0038 0.0161 0.0161
Schistosoma mansoni regulator of G protein signaling 0.0023 0.003 0.003
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0526 0.2009
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.031 0.2619 0.2619
Entamoeba histolytica hypothetical protein 0.0043 0.0214 0.036
Schistosoma mansoni acetylcholine receptor-related 0.0156 0.1233 0.1233
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.013 0.0998 0.0998
Brugia malayi putative neuropeptide receptor 0.013 0.0998 0.1011
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0023 0.003 0.0024
Echinococcus granulosus tm gpcr rhodopsin 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.017 0.1361 0.1374
Schistosoma mansoni axis inhibition protein axin 0.0023 0.003 0.003
Echinococcus granulosus somatostatin receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0998 0.0998
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0327 0.2773 0.2812
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0093 0.0658 0.5664
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0998 0.3812
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0998 0.3812
Brugia malayi regulator of G-protein signaling egl-10 0.0023 0.003 0.0031
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0026 0.0101
Mycobacterium ulcerans epimerase 0.0024 0.0041 0.0414
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1126 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.013 0.0998 0.0998
Echinococcus granulosus orexin receptor type 2 0.013 0.0998 0.0998
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0998 0.8793
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0581 0.5073 0.9692
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0038 0.0161 0.0156
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus granulosus tm gpcr rhodopsin 0.013 0.0998 0.0998
Schistosoma mansoni regulator of G protein signaling 0.0023 0.003 0.003
Schistosoma mansoni biogenic amine (5HT) receptor 0.013 0.0998 0.0998
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.013 0.0998 0.0998
Schistosoma mansoni nAChR subunit 0.0327 0.2773 0.2773
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.031 0.2619 0.2619
Schistosoma mansoni peptide (allatostatin)-like receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Echinococcus multilocularis Zinc finger, PHD finger 0.0078 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Echinococcus multilocularis tachykinin peptides receptor 99D 0.013 0.0998 0.0998
Schistosoma mansoni adenoreceptor 0.013 0.0998 0.0998
Schistosoma mansoni neuropeptide F-like receptor 0.013 0.0998 0.0998
Echinococcus granulosus alpha 1A adrenergic receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus multilocularis beta adrenergic receptor kinase 0.0023 0.003 0.003
Brugia malayi Dopamine receptor 0.013 0.0998 0.1011
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Echinococcus multilocularis G-protein coupled receptor, putative 0.013 0.0998 0.0998
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.003 0.0058
Echinococcus multilocularis biogenic amine (5HT) receptor 0.013 0.0998 0.0998
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0327 0.2773 0.2773
Echinococcus multilocularis g protein coupled receptor 0.013 0.0998 0.0998
Echinococcus multilocularis fmrfamide receptor 0.013 0.0998 0.0998
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0053 0.0299 0.1143
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.013 0.0998 0.1005
Schistosoma mansoni neuropeptide F-like receptor 0.013 0.0998 0.0998
Echinococcus multilocularis nAChR subunit 0.0327 0.2773 0.2773
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.02 0.1632 0.3118
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0337 0.1288
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.003 0.003
Plasmodium vivax SET domain protein, putative 0.0036 0.0147 0.0257
Schistosoma mansoni biogenic amine (5HT) receptor 0.0263 0.2201 0.2201
Echinococcus granulosus thymidylate synthase 0.013 0.0994 0.0994
Echinococcus multilocularis neuropeptide receptor A26 0.013 0.0998 0.0998
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Brugia malayi neuropeptide F receptor 0.013 0.0998 0.1011
Brugia malayi hypothetical protein 0.0156 0.1233 0.1251
Loa Loa (eye worm) acetylcholine receptor protein 0.0156 0.1233 0.1245
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0.0026 0.0266
Mycobacterium ulcerans thymidylate synthase 0.013 0.0994 1
Leishmania major isocitrate dehydrogenase, putative 0.0038 0.0161 0.0615
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0337 0.0589
Echinococcus multilocularis allatostatin A receptor 0.013 0.0998 0.0998
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.003 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.013 0.0998 0.0998
Echinococcus multilocularis serotonin receptor 0.0263 0.2201 0.2201
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0053 0.0299 0.3012
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0327 0.2773 0.2812
Brugia malayi Isocitrate dehydrogenase 0.031 0.2619 0.2656
Echinococcus granulosus glycine receptor subunit alpha 1 0.0327 0.2773 0.2773
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.013 0.0998 0.0998
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0327 0.2773 0.2812
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Schistosoma mansoni nAChR subunit 0.0156 0.1233 0.1233
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.003 0.003
Brugia malayi hypothetical protein 0.0023 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Brugia malayi Cation transporter family protein 0.0327 0.2773 0.2812
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Onchocerca volvulus 0.013 0.0998 0.3501
Brugia malayi G protein-coupled receptor F59B2.13 0.013 0.0998 0.1011
Echinococcus multilocularis Regulator of G protein signaling 20 0.0023 0.003 0.003
Schistosoma mansoni regulator of G protein signaling 0.0023 0.003 0.003
Brugia malayi hypothetical protein 0.0043 0.0214 0.0217
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0658 0.2511
Trypanosoma brucei trypanothione reductase 0.0057 0.0337 0.1288
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.017 0.1361 0.138
Schistosoma mansoni nAChR subunit 0.0327 0.2773 0.2773
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.02 0.1632 0.3118
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0327 0.2773 0.2773
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0388 0.3326 0.3373
Schistosoma mansoni survival motor neuron protein 0.0058 0.0348 0.0348
Loa Loa (eye worm) melatonin receptor type 1A 0.013 0.0998 0.1005
Echinococcus granulosus geminin 0.0205 0.1671 0.1671
Loa Loa (eye worm) hypothetical protein 0.017 0.1361 0.1374
Schistosoma mansoni histamine h1 receptor 0.013 0.0998 0.0998
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0024 0.0041 0.0042
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0147 0.0561
Schistosoma mansoni nAChR subunit 0.0327 0.2773 0.2773
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0327 0.2773 0.2773
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.003 0.003
Echinococcus multilocularis orexin receptor type 2 0.013 0.0998 0.0998
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0156 0.1233 0.1251
Schistosoma mansoni amine GPCR 0.0492 0.4271 0.4271
Schistosoma mansoni nAChR subunit 0.0156 0.1233 0.1233
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0327 0.2773 0.2812
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0024
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.02 0.1632 0.6229
Echinococcus multilocularis nAChR subunit 0.017 0.1361 0.1361
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0327 0.2773 0.2773
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0327 0.2773 0.2773
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Brugia malayi Melatonin receptor type 1A 0.013 0.0998 0.1011
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus multilocularis thymidylate synthase 0.013 0.0994 0.0994
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.013 0.0998 0.0998
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0147 0.0147
Loa Loa (eye worm) hypothetical protein 0.017 0.1361 0.1374
Onchocerca volvulus 0.0327 0.2773 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0183 0.1472 0.2813
Echinococcus granulosus expressed protein 0.0451 0.3895 0.3895
Brugia malayi G-protein coupled receptor 0.013 0.0998 0.1011
Brugia malayi gonadotropin-releasing hormone receptor 2 0.013 0.0998 0.1011
Onchocerca volvulus 0.0156 0.1233 0.4365
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0388 0.3326 0.3326
Echinococcus granulosus nAChR subunit 0.017 0.1361 0.1361
Brugia malayi hypothetical protein 0.0156 0.1233 0.1251
Onchocerca volvulus 0.013 0.0998 0.3501
Loa Loa (eye worm) ACC-1 protein 0.0327 0.2773 0.2807
Schistosoma mansoni hypothetical protein 0.0205 0.1671 0.1671
Schistosoma mansoni biogenic amine receptor 0.013 0.0998 0.0998
Echinococcus granulosus glycine receptor subunit alpha 1 0.0327 0.2773 0.2773
Loa Loa (eye worm) hypothetical protein 0.0036 0.0147 0.0142
Schistosoma mansoni neuropeptide f receptor 76f 0.013 0.0998 0.0998
Echinococcus multilocularis dihydrofolate reductase 0.0053 0.0299 0.0299
Schistosoma mansoni hypothetical protein 0.0043 0.0214 0.0214
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0526 0.1005
Echinococcus multilocularis neuropeptide receptor 0.013 0.0998 0.0998
Onchocerca volvulus 0.0327 0.2773 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0023 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0024
Brugia malayi isocitrate dehydrogenase 0.031 0.2619 0.2656
Toxoplasma gondii thioredoxin reductase 0.0057 0.0337 0.1288
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0327 0.2773 0.2807
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.031 0.2619 0.2619
Echinococcus multilocularis neuropeptides capa receptor 0.013 0.0998 0.0998
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0005 0.0005
Echinococcus granulosus tachykinin peptides receptor 99D 0.013 0.0998 0.0998
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0078 0.0526 0.1005
Brugia malayi Probable isocitrate dehydrogenase 0.0038 0.0161 0.0163
Echinococcus multilocularis regulator of G protein signaling 0.0023 0.003 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0998 0.0998
Loa Loa (eye worm) RecQ helicase 0.0026 0.0054 0.0048
Loa Loa (eye worm) hypothetical protein 0.018 0.1452 0.1466
Onchocerca volvulus 0.0156 0.1233 0.4365
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0054 0.0103
Loa Loa (eye worm) glutathione reductase 0.0057 0.0337 0.0335
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0327 0.2773 0.2773
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0998 0.0998
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0147 0.0147
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.113 0.4313
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0327 0.2773 0.2812
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0038 0.0161 0.1101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0024 0.0041 0.0157
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0998 0.0998
Schistosoma mansoni neurotransmitter gated ion channel 0.017 0.1361 0.1361
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.031 0.2619 0.2619
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0327 0.2773 0.2773
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0327 0.2773 0.2773
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0156 0.1233 0.1233
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0024 0.0041 0.0414
Onchocerca volvulus 0.013 0.0998 0.3501
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0327 0.2773 0.2773
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.003 0.003
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0078 0.0526 0.096
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.0994 0.3795
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0156 0.1233 0.1251
Echinococcus multilocularis isocitrate dehydrogenase 0.031 0.2619 0.2619
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0023 0.003 0.003
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.017 0.1361 0.138
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0998 0.0998
Echinococcus granulosus sex peptide receptor 0.013 0.0998 0.0998
Toxoplasma gondii exonuclease III APE 0.0023 0.0026 0.0101
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0038 0.0161 0.0161
Schistosoma mansoni biogenic amine (dopamine) receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus granulosus biogenic amine 5HT receptor 0.013 0.0998 0.0998
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0998 0.0998
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.0024 0.0041 0.0035
Loa Loa (eye worm) G-protein coupled receptor 0.013 0.0998 0.1005
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0214 0.0214
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0327 0.2773 0.2812
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Schistosoma mansoni neuropeptide receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Schistosoma mansoni hypothetical protein 0.013 0.0998 0.0998
Schistosoma mansoni myosin xvIII 0.013 0.0998 0.0998
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.031 0.2619 1
Brugia malayi Muscleblind-like protein 0.018 0.1452 0.1472
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0026 0.1641
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.013 0.0998 0.3501
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2402 0.2402
Echinococcus multilocularis sex peptide receptor 0.013 0.0998 0.0998
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0054 0.0054
Schistosoma mansoni hypothetical protein 0.0205 0.1671 0.1671
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0026 0.0101
Echinococcus granulosus glycine receptor subunit beta 0.0327 0.2773 0.2773
Echinococcus granulosus neuropeptide receptor 0.013 0.0998 0.0998
Brugia malayi Cation transporter family protein 0.0327 0.2773 0.2812
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Schistosoma mansoni hypothetical protein 0.013 0.0998 0.0998
Leishmania major phosphatidylinositol 3-kinase, putative 0.0078 0.0526 0.2009
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0327 0.2773 0.2773
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.013 0.0998 0.1005
Brugia malayi thymidylate synthase 0.013 0.0994 0.1008
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0038 0.0161 0.0163
Brugia malayi PXA domain containing protein 0.0023 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Loa Loa (eye worm) hypothetical protein 0.0388 0.3326 0.3368
Echinococcus multilocularis neuropeptide Y receptor 0.013 0.0998 0.0998
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0023 0.003 0.003
Brugia malayi Serotonin receptor 0.013 0.0998 0.1011
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0078 0.0526 0.0526
Loa Loa (eye worm) RGS-3 protein 0.0023 0.003 0.0024
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0078 0.0526 0.1005
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0599 0.5233 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.031 0.2619 0.2651
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0023 0.003 0.0024
Brugia malayi Cation transporter family protein 0.0327 0.2773 0.2812
Onchocerca volvulus 0.0058 0.0348 0.1122
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2402 0.2402
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.003 0.003
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0998 0.0998
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0026 0.0109
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Schistosoma mansoni neuropeptide receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) ACC-1 protein 0.0327 0.2773 0.2807
Brugia malayi putative neuropeptide receptor NPR1 0.013 0.0998 0.1011
Echinococcus granulosus g-protein coupled receptor 0.013 0.0998 0.0998
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0327 0.2773 0.2773
Schistosoma mansoni hypothetical protein 0.013 0.0998 0.0998
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0526 0.1005
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0337 0.0335
Echinococcus multilocularis G protein coupled receptor 139 0.013 0.0998 0.0998
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0078 0.0526 0.0527
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0327 0.2773 0.2807
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2407 0.4599
Onchocerca volvulus 0.013 0.0998 0.3501
Brugia malayi Dopamine receptor protein 1 0.013 0.0998 0.1011
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.003 0.003
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0147 0.0147
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.013 0.0998 0.1011
Schistosoma mansoni ap endonuclease 0.0023 0.0026 0.0026
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0026 0.0101
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus granulosus axis inhibition protein axin 0.0023 0.003 0.003
Brugia malayi sulfakinin receptor protein 0.013 0.0998 0.1011
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0327 0.2773 0.2773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0998 0.0998
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0078 0.0526 0.096
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0023 0.003 0.0058
Onchocerca volvulus 0.013 0.0998 0.3501
Echinococcus multilocularis neuropeptides capa receptor 0.013 0.0998 0.0998
Brugia malayi follicle stimulating hormone receptor 0.0408 0.3508 0.3557
Brugia malayi G protein-coupled receptor 0.013 0.0998 0.1011
Echinococcus granulosus thyrotropin releasing hormone receptor 0.013 0.0998 0.0998
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0078 0.0526 0.2009
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Brugia malayi neuropeptide F receptor 0.013 0.0998 0.1011
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0327 0.2773 0.2773
Schistosoma mansoni hypothetical protein 0.013 0.0998 0.0998
Onchocerca volvulus 0.013 0.0998 0.3501
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0327 0.2773 0.2812
Brugia malayi hypothetical protein 0.0286 0.2402 0.2436
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0327 0.2773 0.2773
Onchocerca volvulus 0.0286 0.2407 0.8659
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0289 0.2433 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.017 0.1361 0.138
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Schistosoma mansoni nAChR subunit 0.0327 0.2773 0.2773
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0327 0.2773 0.2773
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0026 0.0046
Schistosoma mansoni biogenic amine (dopamine) receptor 0.013 0.0998 0.0998
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0147 0.0147
Plasmodium falciparum glutathione reductase 0.0057 0.0337 0.1288
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0038 0.0161 0.0163
Schistosoma mansoni nAChR subunit 0.0327 0.2773 0.2773
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0078 0.0526 0.0534
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0156 0.1233 0.1233
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0024
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.0263 0.2201 0.2226
Schistosoma mansoni opsin-like receptor 0.013 0.0998 0.0998
Brugia malayi glutathione reductase 0.0057 0.0337 0.0342
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0078 0.0526 0.0526
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0078 0.0526 0.092
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0023 0.003 0.0024
Plasmodium vivax glutathione reductase, putative 0.0057 0.0337 0.0589
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus multilocularis g protein coupled receptor 0.013 0.0998 0.0998
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0327 0.2773 0.2773
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.0008
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0327 0.2773 0.2812
Brugia malayi AKH receptor 0.013 0.0998 0.1011
Echinococcus multilocularis glycine receptor subunit beta 0.0327 0.2773 0.2773
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0078 0.0526 0.0526
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0998 0.0998
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0266 0.2221 0.4215
Echinococcus granulosus glycine receptor subunit beta 0.0327 0.2773 0.2773
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0599 0.5233 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0327 0.2773 0.2773
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0078 0.0526 0.0526
Echinococcus multilocularis g protein coupled receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Onchocerca volvulus 0.0036 0.0147 0.0387
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.003 0.0058
Schistosoma mansoni nAChR subunit 0.0327 0.2773 0.2773
Loa Loa (eye worm) phosphatidylinositol 3 0.1004 0.8895 0.9018
Onchocerca volvulus 0.013 0.0998 0.3501
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.02 0.1632 0.3083
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.003 0.003
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.031 0.2619 1
Brugia malayi GnHR receptor homolog 0.013 0.0998 0.1011
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0026 0.0051
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0078 0.0526 0.1005
Loa Loa (eye worm) hypothetical protein 0.017 0.1361 0.1374
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Echinococcus granulosus g protein coupled receptor 0.013 0.0998 0.0998
Echinococcus multilocularis neuropeptide s receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) LGC-31 protein 0.0327 0.2773 0.2807
Schistosoma mansoni dihydrofolate reductase 0.0053 0.0299 0.0299
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0147 0.0147
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.013 0.0998 0.0998
Brugia malayi Regulator of G protein signaling domain containing protein 0.0023 0.003 0.0031
Onchocerca volvulus 0.013 0.0998 0.3501
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0327 0.2773 0.2773
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0038 0.0161 1
Schistosoma mansoni growth hormone secretagogue receptor 0.013 0.0998 0.0998
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.031 0.2619 1
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0337 0.0644
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0026 0.0026
Echinococcus multilocularis muscleblind protein 0.018 0.1452 0.1452
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0998 0.0998
Schistosoma mansoni biogenic amine (dopamine) receptor 0.013 0.0998 0.0998
Echinococcus multilocularis regulator of G protein signaling 7 0.0023 0.003 0.003
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0411 0.3538 0.6761
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) neuropeptide F receptor 0.013 0.0998 0.1005
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.1472 0.5621
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0038 0.0161 0.162
Echinococcus granulosus g protein coupled receptor 0.013 0.0998 0.0998
Schistosoma mansoni amine GPCR 0.013 0.0998 0.0998
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.013 0.0998 0.0998
Echinococcus multilocularis serotonin receptor 0.0263 0.2201 0.2201
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0038 0.0161 0.0161
Echinococcus granulosus 7tm_1 domain containing protein 0.013 0.0998 0.0998
Onchocerca volvulus 0.017 0.1361 0.483
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0599 0.5233 0.5306
Echinococcus multilocularis neuropeptide receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Onchocerca volvulus 0.013 0.0998 0.3501
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0327 0.2773 0.2807
Echinococcus multilocularis fmrfamide receptor 0.013 0.0998 0.0998
Echinococcus granulosus nAChR subunit 0.0327 0.2773 0.2773
Schistosoma mansoni z-protein (S1r protein) 0.0023 0.003 0.003
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0653 0.5722 1
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.017 0.1361 0.1361
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0214 0.0214
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0026 0.0027
Onchocerca volvulus 0.017 0.1361 0.483
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0183 0.1472 0.2573
Onchocerca volvulus 0.013 0.0998 0.3501
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0.0026 0.0101
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0408 0.3508 0.3553
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0078 0.0526 0.2009
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0078 0.0526 0.0526
Echinococcus granulosus regulator of G protein signaling 7 0.0023 0.003 0.003
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0998 0.3812
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0327 0.2773 0.2812
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0093 0.0658 0.115
Trypanosoma brucei isocitrate dehydrogenase, putative 0.031 0.2619 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.1452 0.1452
Echinococcus granulosus neuropeptide FF receptor 2 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.017 0.1361 0.1374
Brugia malayi A-kinase anchor protein 10, precursor 0.0023 0.003 0.0031
Loa Loa (eye worm) hypothetical protein 0.1111 0.9862 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Schistosoma mansoni biogenic amine receptor 0.013 0.0998 0.0998
Onchocerca volvulus 0.013 0.0998 0.3501
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0038 0.0161 0.0308
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0599 0.5233 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0156 0.1233 0.1233
Echinococcus granulosus hypothetical protein 0.013 0.0998 0.0998
Onchocerca volvulus 0.0327 0.2773 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0026 0.0051
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0038 0.0161 0.0615
Entamoeba histolytica hypothetical protein 0.0043 0.0214 0.036
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0024
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0054 0.0055
Echinococcus granulosus biogenic amine 5HT receptor 0.0263 0.2201 0.2201
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0147 0.0147
Echinococcus multilocularis g-protein coupled receptor 0.013 0.0998 0.0998
Schistosoma mansoni hypothetical protein 0.0058 0.0348 0.0348
Loa Loa (eye worm) phosphatidylinositol 3 0.0183 0.1471 0.1486
Brugia malayi hypothetical protein 0.0156 0.1233 0.1251
Echinococcus granulosus regulator of G protein signaling 3 0.0023 0.003 0.003
Schistosoma mansoni unc-13 (munc13) 0.0038 0.0161 0.0161
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0327 0.2773 0.2812
Echinococcus granulosus neuropeptide receptor A26 0.013 0.0998 0.0998
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0998 0.0998
Echinococcus granulosus neuropeptide Y receptor 0.013 0.0998 0.0998
Schistosoma mansoni amine GPCR 0.013 0.0998 0.0998
Echinococcus multilocularis somatostatin receptor 0.013 0.0998 0.0998
Schistosoma mansoni opsin-like receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus granulosus muscleblind protein 0.018 0.1452 0.1452
Echinococcus granulosus neuropeptide receptor 0.013 0.0998 0.0998
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Brugia malayi Probable isocitrate dehydrogenase 0.0038 0.0161 0.0163
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.017 0.1361 0.1361
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) dihydrofolate reductase 0.0053 0.0299 0.0297
Echinococcus granulosus fmrfamide receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.1067 0.9468 0.96
Onchocerca volvulus Neuropeptide F receptor homolog 0.013 0.0998 0.3501
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Loa Loa (eye worm) hypothetical protein 0.018 0.1452 0.1466
Echinococcus granulosus neuropeptide Y receptor 0.013 0.0998 0.0998
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.031 0.2619 1
Echinococcus granulosus G protein coupled receptor 139 0.013 0.0998 0.0998
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0327 0.2773 0.2812
Loa Loa (eye worm) hypothetical protein 0.017 0.1361 0.1374
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0038 0.0161 0.0163
Entamoeba histolytica hypothetical protein 0.0476 0.4128 0.7877
Echinococcus multilocularis neuropeptide FF receptor 2 0.013 0.0998 0.0998
Brugia malayi Pre-SET motif family protein 0.0036 0.0147 0.0149
Toxoplasma gondii endonuclease IV APN 0.0093 0.0658 0.2511
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Onchocerca volvulus 0.013 0.0998 0.3501
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0183 0.1471 0.2811
Loa Loa (eye worm) hypothetical protein 0.0263 0.2201 0.2226
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.013 0.0998 0.0998
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0998 0.3812
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0599 0.5233 1
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Echinococcus granulosus beta-adrenergic receptor kinase 0.0023 0.003 0.003
Schistosoma mansoni neurotransmitter gated ion channel 0.0156 0.1233 0.1233
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.02 0.1632 0.3083
Onchocerca volvulus 0.013 0.0998 0.3501
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0023 0.003 0.003
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.013 0.0998 0.0998
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.0008
Onchocerca volvulus 0.013 0.0994 0.3488
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0062 0.0379 0.0724
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.013 0.0998 0.0998
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.0994 0.8752
Schistosoma mansoni acetylcholine receptor subunit beta 0.0156 0.1233 0.1233
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0183 0.1472 0.5621
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.003 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0998 0.0998
Schistosoma mansoni neurotransmitter gated ion channel 0.0156 0.1233 0.1233
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.1472 0.5621
Brugia malayi hypothetical protein 0.0023 0.003 0.0031
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0527 0.4588 0.4652
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Schistosoma mansoni serine/threonine protein kinase 0.0023 0.003 0.003
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0054 0.0103
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0327 0.2773 0.2773
Brugia malayi Tachykinin-like peptides receptor 99D 0.013 0.0998 0.1011
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0998 0.3812
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0327 0.2773 0.2812
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0337 0.0337
Brugia malayi hypothetical protein 0.0156 0.1233 0.1251
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0327 0.2773 0.2773
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0998 0.0998
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0156 0.1233 0.1251
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0026 0.002
Leishmania major trypanothione reductase 0.0057 0.0337 0.1288
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.0994 0.0994
Schistosoma mansoni neuropeptide receptor 0.013 0.0998 0.0998
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0156 0.1233 0.1251
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.02 0.1632 0.3118
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.013 0.0998 0.0998
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0327 0.2773 0.2807
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0183 0.1472 0.5621
Loa Loa (eye worm) hypothetical protein 0.0286 0.2402 0.2431
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.013 0.0998 0.0998
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.02 0.1632 0.1654
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.013 0.0998 0.1011
Brugia malayi RE15519p 0.013 0.0998 0.1011
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.1111 0.9862 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.113 0.4313
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Onchocerca volvulus 0.0327 0.2773 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0024
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.013 0.0998 0.0998
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.013 0.0998 0.1005
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0998 0.0998
Brugia malayi Serotonin receptor 0.013 0.0998 0.1011
Brugia malayi Dopamine receptor protein 2 0.013 0.0998 0.1011
Echinococcus granulosus peptide allatostatin:somatostatin 0.013 0.0998 0.0998
Brugia malayi ORL1-like opioid receptor 0.013 0.0998 0.1011
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.013 0.0998 0.0998
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0388 0.3326 0.3326
Schistosoma mansoni amine GPCR 0.013 0.0998 0.0998
Entamoeba histolytica tartrate dehydrogenase, putative 0.0038 0.0161 0.0259
Echinococcus granulosus dro:myosuppressin receptor 0.013 0.0998 0.0998
Echinococcus granulosus tm gpcr rhodopsin 0.013 0.0998 0.0998
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0526 0.2009
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Echinococcus granulosus axis inhibition protein axin 0.0023 0.003 0.003
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Brugia malayi hypothetical protein 0.0147 0.115 0.1166
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.013 0.0998 0.0998
Onchocerca volvulus 0.013 0.0998 0.3501
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.013 0.0998 0.0998
Brugia malayi PXA domain containing protein 0.0023 0.003 0.0031
Entamoeba histolytica hypothetical protein 0.0043 0.0214 0.036
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0026 0.0051
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0026 0.0098
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0026 0.0051
Schistosoma mansoni nAChR subunit 0.0327 0.2773 0.2773
Schistosoma mansoni biogenic amine receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Mycobacterium ulcerans endonuclease IV 0.0093 0.0658 0.6618
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0327 0.2773 0.2773
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.02 0.1632 0.3118
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.031 0.2619 0.2619
Echinococcus granulosus neuropeptides capa receptor 0.013 0.0998 0.0998
Echinococcus granulosus neuropeptide s receptor 0.013 0.0998 0.0998
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.031 0.2619 0.5005
Loa Loa (eye worm) hypothetical protein 0.0955 0.845 0.8567
Echinococcus multilocularis neuropeptide Y receptor 0.013 0.0998 0.0998
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.031 0.2619 0.4578
Brugia malayi dihydrofolate reductase family protein 0.0053 0.0299 0.0304
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0156 0.1233 0.1245
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.013 0.0998 0.1011
Onchocerca volvulus 0.013 0.0998 0.3501
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Brugia malayi G-protein coupled receptor 0.013 0.0998 0.1011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0135 0.0135
Onchocerca volvulus Putative nachr subunit 0.0327 0.2773 1
Loa Loa (eye worm) hypothetical protein 0.017 0.1361 0.1374
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.2093 0.2117
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) hypothetical protein 0.0093 0.0658 0.066
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0998 0.0998
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0998 0.0998
Loa Loa (eye worm) G-protein coupled receptor 0.013 0.0998 0.1005
Schistosoma mansoni amine GPCR 0.013 0.0998 0.0998
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.013 0.0998 0.0998
Echinococcus multilocularis regulator of G protein signaling 3 0.0023 0.003 0.003
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0327 0.2773 0.2773
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.003 0.0058
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0078 0.0526 0.2009
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0156
Echinococcus granulosus bloom syndrome protein 0.0026 0.0054 0.0054
Loa Loa (eye worm) TYRA-2 protein 0.013 0.0998 0.1005
Brugia malayi larval opioid receptor 0.013 0.0998 0.1011
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1126 1 1
Brugia malayi excitatory GABA receptor EXP-1A 0.0327 0.2773 0.2812
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0023 0.003 0.0031
Chlamydia trachomatis endonuclease IV 0.0093 0.0658 1
Mycobacterium tuberculosis Probable reductase 0.013 0.0998 0.3812
Trichomonas vaginalis conserved hypothetical protein 0.0062 0.0379 0.0724
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.014 0.1087 0.4467
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0038 0.0161 0.0161
Onchocerca volvulus 0.013 0.0998 0.3501
Echinococcus multilocularis expressed protein 0.0451 0.3895 0.3895
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0599 0.5233 1
Loa Loa (eye worm) hypothetical protein 0.0383 0.3284 0.3325
Entamoeba histolytica hypothetical protein 0.0023 0.003 0.0008
Loa Loa (eye worm) GABA receptor subunit 0.017 0.1361 0.1374
Loa Loa (eye worm) neuropeptide F receptor 0.013 0.0998 0.1005
Echinococcus granulosus glycine receptor subunit alpha 1 0.0327 0.2773 0.2773
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0156 0.1233 0.1251
Schistosoma mansoni opsin-like receptor 0.013 0.0998 0.0998
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.013 0.0998 0.0998
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0348 0.0352
Echinococcus multilocularis geminin 0.0205 0.1671 0.1671
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0038 0.0161 0.0161
Echinococcus multilocularis dro:myosuppressin receptor 0.013 0.0998 0.0998
Onchocerca volvulus 0.0327 0.2773 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.013 0.0998 0.1011
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Loa Loa (eye worm) PXA domain-containing protein 0.0023 0.003 0.0024
Toxoplasma gondii isocitrate dehydrogenase 0.031 0.2619 1
Entamoeba histolytica hypothetical protein 0.0043 0.0214 0.036
Onchocerca volvulus 0.0156 0.1233 0.4365
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0038 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Chlamydia trachomatis dihydrofolate reductase 0.0053 0.0299 0.4552
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0147 0.0147
Echinococcus granulosus Regulator of G protein signaling 20 0.0023 0.003 0.003
Onchocerca volvulus 0.0327 0.2773 1
Brugia malayi Thioredoxin reductase 0.0057 0.0337 0.0342
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0093 0.0658 0.0667
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.02 0.1632 0.1632
Schistosoma mansoni ap endonuclease 0.0023 0.0026 0.0026
Toxoplasma gondii isocitrate dehydrogenase 0.031 0.2619 1
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0156 0.1233 0.1233
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0327 0.2773 0.2773
Echinococcus granulosus dihydrofolate reductase 0.0053 0.0299 0.0299
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.113 0.4313
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.013 0.0998 0.0998
Schistosoma mansoni rhodopsin-like orphan GPCR 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.031 0.2619 0.2619
Loa Loa (eye worm) hypothetical protein 0.0211 0.1728 0.1746
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0599 0.5233 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Brugia malayi hypothetical protein 0.0156 0.1233 0.1251
Echinococcus granulosus serotonin receptor 0.013 0.0998 0.0998
Echinococcus multilocularis rhodopsin orphan GPCR 0.013 0.0998 0.0998
Echinococcus granulosus 7TM GPCR rhodopsin 0.013 0.0998 0.0998
Echinococcus granulosus rhodopsin orphan GPCR 0.013 0.0998 0.0998
Brugia malayi Dihydrofolate reductase 0.0053 0.0299 0.0304
Brugia malayi hypothetical protein 0.0062 0.0379 0.0384
Loa Loa (eye worm) hypothetical protein 0.0023 0.003 0.0024
Brugia malayi Pre-SET motif family protein 0.0251 0.2093 0.2122
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0327 0.2773 0.2807
Schistosoma mansoni regulator of G protein signaling 0.0023 0.003 0.003
Mycobacterium ulcerans hypothetical protein 0.0024 0.0041 0.0414
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.031 0.2619 0.5005
Loa Loa (eye worm) hypothetical protein 0.0327 0.2773 0.2807
Echinococcus granulosus g protein coupled receptor 0.013 0.0998 0.0998
Brugia malayi hypothetical protein 0.013 0.0998 0.1011
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0327 0.2773 0.2807
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0107 0.0101
Echinococcus multilocularis glycine receptor subunit beta 0.0327 0.2773 0.2773
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Loa Loa (eye worm) hypothetical protein 0.017 0.1361 0.1374
Echinococcus granulosus neuropeptides capa receptor 0.013 0.0998 0.0998
Schistosoma mansoni regulator of G protein signaling 0.0023 0.003 0.003
Entamoeba histolytica hypothetical protein 0.017 0.1361 0.2562
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Plasmodium falciparum thioredoxin reductase 0.0057 0.0337 0.1288
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0327 0.2773 0.2773
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0156 0.1233 0.1245
Schistosoma mansoni neuropeptide receptor 0.013 0.0998 0.0998
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0411 0.3538 0.6761
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Schistosoma mansoni alpha-1 adrenergic receptor 0.013 0.0998 0.0998
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.003 0.0058
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.013 0.0998 0.1005
Echinococcus multilocularis alpha 1A adrenergic receptor 0.013 0.0998 0.0998
Loa Loa (eye worm) hypothetical protein 0.0156 0.1233 0.1245
Echinococcus multilocularis axis inhibition protein axin 0.0023 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.013 0.0998 0.1005
Mycobacterium tuberculosis Hypothetical protein 0.0062 0.0379 0.1447
Loa Loa (eye worm) thymidylate synthase 0.013 0.0994 0.1002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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