Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | valyl tRNA synthetase | 0.0062 | 0.0055 | 0.2166 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Trypanosoma brucei | long-chain-fatty-acid-CoA ligase, putative | 0.0094 | 0.0103 | 0.4613 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, mitochondrial | 0.0137 | 0.0167 | 0.6615 |
Trypanosoma cruzi | isoleucyl-tRNA synthetase, putative | 0.0174 | 0.0222 | 1 |
Entamoeba histolytica | valyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.24 |
Loa Loa (eye worm) | isoleucyl-tRNA synthetase | 0.0174 | 0.0222 | 1 |
Mycobacterium leprae | PROBABLE VALYL-tRNA SYNTHASE PROTEIN VALS (VALYL-tRNA SYNTHETASE) (VALINE--tRNA LIGASE) (VALINE TRANSLASE) ELONGS TO CLASS-I AMI | 0.0062 | 0.0055 | 0.011 |
Toxoplasma gondii | valyl-tRNA synthetase | 0.0062 | 0.0055 | 0.0111 |
Schistosoma mansoni | methyltransferase-related | 0.0039 | 0.0022 | 0.0865 |
Brugia malayi | Methyltransferase-like protein 4 | 0.0039 | 0.0022 | 0.0958 |
Trypanosoma brucei | valyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.246 |
Echinococcus multilocularis | acetyl coenzyme A synthetase, cytoplasmic | 0.0094 | 0.0103 | 0.4061 |
Mycobacterium tuberculosis | PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0081 | 0.0084 | 0.0083 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0094 | 0.0103 | 0.0102 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtE | 0.0141 | 0.0172 | 0.0172 |
Toxoplasma gondii | isoleucyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.0111 |
Schistosoma mansoni | valine-tRNA ligase | 0.0062 | 0.0055 | 0.2184 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0039 | 0.0022 | 0.0021 |
Brugia malayi | arginyl aa-tRNA synthetase protein 1 | 0.003 | 0.0008 | 0.0342 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0025 | 0.0001 | 0.0026 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0141 | 0.0172 | 0.7744 |
Mycobacterium ulcerans | valyl-tRNA synthetase | 0.0062 | 0.0055 | 0.0055 |
Echinococcus granulosus | isoleucyl trna synthetase mitochondrial | 0.0137 | 0.0167 | 0.6615 |
Plasmodium vivax | arginyl-tRNA synthetase, putative | 0.003 | 0.0008 | 0.0367 |
Loa Loa (eye worm) | methionyl-tRNA synthetase | 0.0025 | 0.0001 | 0.0026 |
Treponema pallidum | methionyl-tRNA synthetase | 0.0172 | 0.022 | 0.9866 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0094 | 0.0103 | 0.4627 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 0.0103 | 0.4613 |
Mycobacterium tuberculosis | Conserved polyketide synthase associated protein PapA1 | 0.0033 | 0.0013 | 0.0012 |
Echinococcus granulosus | leucyl tRNA synthetase | 0.0083 | 0.0087 | 0.3423 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE | 0.0047 | 0.0033 | 0.0065 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0107 | 0.0123 | 0.5462 |
Mycobacterium leprae | isoleucyl-tRNA synthetase IleS | 0.0174 | 0.0222 | 0.0448 |
Brugia malayi | glycyl-tRNA synthetase | 0.0065 | 0.006 | 0.2691 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0094 | 0.0103 | 0.4613 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0107 | 0.0123 | 0.0122 |
Loa Loa (eye worm) | glycyl-tRNA synthetase | 0.0065 | 0.006 | 0.271 |
Onchocerca volvulus | 0.0094 | 0.0103 | 0.5492 | |
Echinococcus granulosus | AMP dependent ligase | 0.0026 | 0.0002 | 0.007 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase | 0.0026 | 0.0002 | 0.0002 |
Echinococcus granulosus | isoleucyl tRNA synthetase, cytoplasmic | 0.0174 | 0.0222 | 0.8803 |
Brugia malayi | threonyl-tRNA synthetase, cytoplasmic | 0.006 | 0.0053 | 0.2357 |
Trichomonas vaginalis | methionine-tRNA synthetase, putative | 0.0025 | 0.0001 | 0.0026 |
Trypanosoma cruzi | acetyl-CoA synthetase, putative | 0.0094 | 0.0103 | 0.4627 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0094 | 0.0103 | 0.4627 |
Leishmania major | arginyl-tRNA synthetase, putative | 0.003 | 0.0008 | 0.0342 |
Echinococcus multilocularis | Threonyl tRNA synthetase, C | 0.006 | 0.0053 | 0.2075 |
Toxoplasma gondii | threonyl-tRNA synthetase family protein | 0.0053 | 0.0042 | 0.0085 |
Chlamydia trachomatis | threonine--tRNA ligase | 0.006 | 0.0053 | 0.1829 |
Echinococcus multilocularis | valyl tRNA synthetase | 0.0062 | 0.0055 | 0.2166 |
Brugia malayi | AMP-binding enzyme family protein | 0.006 | 0.0052 | 0.2319 |
Entamoeba histolytica | valyl tRNA synthetase, putative | 0.0062 | 0.0055 | 0.24 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.248 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0094 | 0.0103 | 0.4613 |
Mycobacterium leprae | POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0094 | 0.0103 | 0.0207 |
Plasmodium falciparum | methionine--tRNA ligase, putative | 0.0025 | 0.0001 | 0.0026 |
Echinococcus multilocularis | AMP dependent ligase | 0.0026 | 0.0002 | 0.007 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0103 | 0.4627 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsE | 0.0047 | 0.0033 | 0.0032 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.186 | 0.2726 | 0.2726 |
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.3357 | 0.4951 | 0.495 |
Echinococcus granulosus | valyl tRNA synthetase | 0.0062 | 0.0055 | 0.2166 |
Mycobacterium tuberculosis | Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) | 0.0062 | 0.0055 | 0.0055 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0107 | 0.0123 | 0.0122 |
Mycobacterium tuberculosis | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) | 0.0053 | 0.0042 | 0.0042 |
Trypanosoma brucei | arginyl-tRNA synthetase, putative | 0.003 | 0.0008 | 0.0342 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0037 | 0.0018 | 0.083 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Mycobacterium ulcerans | fatty-acid-CoA ligase FadD9 | 0.0026 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 0.0222 | 1 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.006 | 0.0053 | 0.2377 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0094 | 0.0103 | 0.457 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.0022 | 0.0021 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0141 | 0.0172 | 0.0172 |
Mycobacterium tuberculosis | Isoleucyl-tRNA synthetase IleS | 0.0113 | 0.0131 | 0.013 |
Mycobacterium leprae | Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) | 0.0107 | 0.0123 | 0.0246 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0094 | 0.0103 | 0.4627 |
Toxoplasma gondii | leucyl-tRNA synthetase | 0.0062 | 0.0055 | 0.0111 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0094 | 0.0103 | 0.0102 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 0.0103 | 0.4613 |
Trypanosoma cruzi | long-chain-fatty-acid-CoA ligase, putative | 0.0094 | 0.0103 | 0.4627 |
Mycobacterium tuberculosis | Possible conserved polyketide synthase associated protein PapA2 | 0.0033 | 0.0013 | 0.0012 |
Trypanosoma cruzi | threonyl-tRNA synthetase, putative | 0.006 | 0.0053 | 0.2377 |
Echinococcus granulosus | methionyl tRNA synthetase cytoplasmic | 0.0195 | 0.0253 | 1 |
Giardia lamblia | Valine-tRNA ligase | 0.0062 | 0.0055 | 0.246 |
Wolbachia endosymbiont of Brugia malayi | leucyl-tRNA synthetase | 0.0087 | 0.0092 | 0.4141 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0039 | 0.0022 | 0.0982 |
Brugia malayi | isoleucyl-tRNA synthetase family protein | 0.0174 | 0.0222 | 1 |
Schistosoma mansoni | threonyl-tRNA synthetase | 0.0048 | 0.0035 | 0.1371 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0141 | 0.0172 | 0.0172 |
Trypanosoma cruzi | arginyl-tRNA synthetase, putative | 0.003 | 0.0008 | 0.0367 |
Trypanosoma cruzi | valyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.248 |
Treponema pallidum | isoleucyl-tRNA synthetase | 0.0174 | 0.0222 | 1 |
Schistosoma mansoni | leucyl-tRNA synthetase | 0.0087 | 0.0092 | 0.366 |
Mycobacterium ulcerans | threonyl-tRNA synthetase | 0.0053 | 0.0042 | 0.0042 |
Loa Loa (eye worm) | threonyl-tRNA synthetase | 0.006 | 0.0053 | 0.2377 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0025 | 0.0001 | 0.0023 |
Plasmodium falciparum | valine--tRNA ligase, putative | 0.0062 | 0.0055 | 0.248 |
Mycobacterium ulcerans | long-chain-acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Onchocerca volvulus | 0.0107 | 0.0123 | 0.6769 | |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0103 | 0.4627 |
Giardia lamblia | Methyltransferase like 2 | 0.0039 | 0.0022 | 0.0958 |
Brugia malayi | leucyl-tRNA synthetase | 0.0062 | 0.0055 | 0.246 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0094 | 0.0103 | 0.4627 |
Leishmania major | isoleucyl-tRNA synthetase, putative | 0.0174 | 0.0222 | 1 |
Mycobacterium leprae | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0002 | 0.0004 |
Loa Loa (eye worm) | bifunctional aminoacyl-tRNA synthetase | 0.0052 | 0.0041 | 0.1854 |
Mycobacterium ulcerans | peptide synthetase Nrp (peptide synthase) | 0.0141 | 0.0172 | 0.0172 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Echinococcus multilocularis | valyl tRNA synthetase | 0.0062 | 0.0055 | 0.2166 |
Mycobacterium tuberculosis | Possible DNA glycosylase | 0.0102 | 0.0115 | 0.0115 |
Mycobacterium tuberculosis | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) | 0.0102 | 0.0115 | 0.0115 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0087 | 0.0092 | 0.3645 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0174 | 0.0222 | 0.8806 |
Onchocerca volvulus | 0.0141 | 0.0172 | 1 | |
Mycobacterium ulcerans | polyketide synthase associated protein PapA3 | 0.0033 | 0.0013 | 0.0012 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0094 | 0.0103 | 0.0102 |
Mycobacterium ulcerans | bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase | 0.6756 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | valyl-tRNA synthetase | 0.0062 | 0.0055 | 0.246 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0094 | 0.0103 | 0.0102 |
Leishmania major | leucyl-tRNA synthetase, putative | 0.0087 | 0.0092 | 0.4141 |
Entamoeba histolytica | threonyl-tRNA synthetase, putative | 0.0053 | 0.0042 | 0.1814 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0094 | 0.0103 | 0.0102 |
Brugia malayi | protein ZK524.3 | 0.005 | 0.0037 | 0.1655 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0094 | 0.0103 | 0.4627 |
Mycobacterium leprae | PROBABLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA3 | 0.0033 | 0.0013 | 0.0025 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0094 | 0.0103 | 0.4613 |
Brugia malayi | Valyl-tRNA synthetase | 0.0062 | 0.0055 | 0.246 |
Trypanosoma cruzi | leucyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.248 |
Schistosoma mansoni | valine-tRNA ligase | 0.0062 | 0.0055 | 0.2184 |
Echinococcus granulosus | Threonyl tRNA synthetase C | 0.006 | 0.0053 | 0.2075 |
Entamoeba histolytica | leucyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.24 |
Leishmania major | long-chain-fatty-acid-CoA ligase, putative | 0.0094 | 0.0103 | 0.4613 |
Chlamydia trachomatis | leucine--tRNA ligase | 0.0062 | 0.0056 | 0.1947 |
Mycobacterium leprae | Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) | 0.0053 | 0.0042 | 0.0084 |
Wolbachia endosymbiont of Brugia malayi | threonyl-tRNA synthetase | 0.0053 | 0.0042 | 0.1878 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 0.0103 | 0.4613 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0094 | 0.0103 | 0.457 |
Schistosoma mansoni | isoleucine--tRNA ligase | 0.0174 | 0.0222 | 0.8806 |
Onchocerca volvulus | 0.0137 | 0.0167 | 0.9677 | |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0094 | 0.0103 | 0.457 |
Echinococcus multilocularis | arginyl tRNA synthetase, cytoplasmic | 0.003 | 0.0008 | 0.0301 |
Trypanosoma brucei | threonyl-tRNA synthetase, putative | 0.006 | 0.0053 | 0.2357 |
Wolbachia endosymbiont of Brugia malayi | formamidopyrimidine-DNA glycosylase | 0.0102 | 0.0115 | 0.5177 |
Toxoplasma gondii | propionate-CoA ligase | 0.0094 | 0.0103 | 0.0208 |
Trichomonas vaginalis | valyl-tRNA synthetase, putative | 0.0037 | 0.0018 | 0.083 |
Onchocerca volvulus | 0.0141 | 0.0172 | 1 | |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0094 | 0.0103 | 0.4613 |
Entamoeba histolytica | isoleucyl-tRNA synthetase, putative | 0.0174 | 0.0222 | 1 |
Entamoeba histolytica | methionyl-tRNA synthetase, putative | 0.0172 | 0.022 | 0.9869 |
Trypanosoma cruzi | valyl-tRNA synthetase, putative | 0.0037 | 0.0018 | 0.083 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0107 | 0.0123 | 0.5498 |
Brugia malayi | valyl-tRNA synthetase family protein | 0.0062 | 0.0055 | 0.246 |
Schistosoma mansoni | methionine-tRNA synthetase | 0.0195 | 0.0253 | 1 |
Giardia lamblia | Threonyl-tRNA synthetase | 0.0053 | 0.0042 | 0.1878 |
Treponema pallidum | threonyl-tRNA synthetase | 0.0053 | 0.0042 | 0.1591 |
Mycobacterium tuberculosis | Probable conserved polyketide synthase associated protein PapA3 | 0.0033 | 0.0013 | 0.0012 |
Leishmania major | valyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.246 |
Trypanosoma brucei | leucyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.246 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.0197 | 0.8876 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0094 | 0.0103 | 0.4074 |
Plasmodium falciparum | threonine--tRNA ligase | 0.0053 | 0.0042 | 0.1899 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.0164 | 0.0207 | 0.932 |
Brugia malayi | AMP-binding enzyme family protein | 0.0141 | 0.0172 | 0.7738 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 0.0103 | 0.4613 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.3357 | 0.4951 | 1 |
Toxoplasma gondii | methionyl-tRNA synthetase | 0.004 | 0.0023 | 0.0046 |
Chlamydia trachomatis | methionine--tRNA ligase | 0.0195 | 0.0253 | 1 |
Echinococcus multilocularis | methionyl tRNA synthetase, cytoplasmic | 0.0195 | 0.0253 | 1 |
Trichomonas vaginalis | isoleucyl tRNA synthetase, putative | 0.0174 | 0.0222 | 1 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0102 | 0.0115 | 0.0115 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 0.0103 | 0.4613 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0094 | 0.0103 | 0.0208 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0018 | 0.083 |
Giardia lamblia | Isoleucyl-tRNA synthetase | 0.0174 | 0.0222 | 1 |
Mycobacterium ulcerans | acetyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.3357 | 0.4951 | 0.495 |
Mycobacterium ulcerans | phenyloxazoline synthase MbtB | 0.0692 | 0.0991 | 0.0991 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.0022 | 0.0958 |
Echinococcus multilocularis | isoleucyl tRNA synthetase, cytoplasmic | 0.0174 | 0.0222 | 0.8803 |
Brugia malayi | methionyl-tRNA synthetase | 0.0172 | 0.022 | 0.987 |
Toxoplasma gondii | tRNA ligases class I (M) protein | 0.0025 | 0.0001 | 0.0001 |
Mycobacterium tuberculosis | Possible conserved polyketide synthase associated protein PapA5 | 0.0033 | 0.0013 | 0.0012 |
Trypanosoma brucei | isoleucyl-tRNA synthetase, putative | 0.0174 | 0.0222 | 1 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0094 | 0.0103 | 0.0207 |
Echinococcus multilocularis | leucyl tRNA synthetase | 0.0062 | 0.0055 | 0.2166 |
Mycobacterium ulcerans | isoleucyl-tRNA synthetase | 0.0174 | 0.0222 | 0.0222 |
Mycobacterium leprae | Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) | 0.0102 | 0.0115 | 0.0232 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0037 | 0.1676 |
Brugia malayi | bifunctional aminoacyl-tRNA synthetase | 0.0065 | 0.006 | 0.2691 |
Plasmodium falciparum | arginine--tRNA ligase | 0.003 | 0.0008 | 0.0367 |
Brugia malayi | AMP-binding enzyme family protein | 0.0094 | 0.0103 | 0.4613 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0052 | 0.2339 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Wolbachia endosymbiont of Brugia malayi | isoleucyl-tRNA synthetase | 0.0174 | 0.0222 | 1 |
Echinococcus granulosus | leucyl tRNA synthetase | 0.0062 | 0.0055 | 0.2166 |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0094 | 0.0103 | 0.0208 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0094 | 0.0103 | 0.0102 |
Trichomonas vaginalis | isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative | 0.0037 | 0.0018 | 0.083 |
Leishmania major | acetyl-CoA synthetase, putative | 0.0094 | 0.0103 | 0.4613 |
Leishmania major | threonyl-tRNA synthetase, putative | 0.006 | 0.0053 | 0.2357 |
Onchocerca volvulus | 0.0062 | 0.0055 | 0.2387 | |
Mycobacterium leprae | Probable cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC | 0.1462 | 0.2135 | 0.4312 |
Mycobacterium tuberculosis | Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC | 0.1462 | 0.2135 | 0.2135 |
Schistosoma mansoni | arginyl-tRNA synthetase | 0.003 | 0.0008 | 0.0323 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0103 | 0.4627 |
Mycobacterium ulcerans | arginyl-tRNA synthetase | 0.003 | 0.0008 | 0.0008 |
Echinococcus granulosus | glycyl tRNA synthetase | 0.0065 | 0.006 | 0.2369 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.0002 | 0.0005 |
Treponema pallidum | leucyl-tRNA synthetase | 0.0062 | 0.0056 | 0.2221 |
Mycobacterium ulcerans | thioesterase | 0.0551 | 0.0782 | 0.0782 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Entamoeba histolytica | arginyl-tRNA synthetase | 0.003 | 0.0008 | 0.0265 |
Mycobacterium ulcerans | O-succinylbenzoic acid--CoA ligase | 0.0094 | 0.0103 | 0.0102 |
Onchocerca volvulus | 0.0094 | 0.0103 | 0.5492 | |
Plasmodium vivax | isoleucine--tRNA ligase, putative | 0.0174 | 0.0222 | 1 |
Mycobacterium leprae | POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) | 0.0094 | 0.0103 | 0.0207 |
Chlamydia trachomatis | valine--tRNA ligase | 0.0062 | 0.0055 | 0.1923 |
Echinococcus granulosus | arginyl tRNA synthetase cytoplasmic | 0.003 | 0.0008 | 0.0301 |
Toxoplasma gondii | tRNA synthetase, putative | 0.0062 | 0.0055 | 0.0111 |
Plasmodium falciparum | isoleucine--tRNA ligase, putative | 0.0174 | 0.0222 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0094 | 0.0103 | 0.0102 |
Trypanosoma brucei | acetyl-CoA synthetase, putative | 0.0094 | 0.0103 | 0.4613 |
Trichomonas vaginalis | leucyl-tRNA synthetase, putative | 0.0062 | 0.0055 | 0.248 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0103 | 0.4627 |
Mycobacterium ulcerans | formamidopyrimidine-DNA glycosylase | 0.0102 | 0.0115 | 0.0115 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0094 | 0.0103 | 0.4627 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0094 | 0.0103 | 0.0102 |
Trichomonas vaginalis | threonyl-tRNA synthetase, putative | 0.0053 | 0.0042 | 0.1899 |
Mycobacterium ulcerans | non-ribosomal peptide synthetase MbtF | 0.0141 | 0.0172 | 0.0172 |
Treponema pallidum | valyl-tRNA synthetase | 0.0062 | 0.0055 | 0.2194 |
Mycobacterium leprae | Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.3357 | 0.4951 | 1 |
Plasmodium falciparum | valine--tRNA ligase, putative | 0.0062 | 0.0055 | 0.248 |
Mycobacterium ulcerans | leucyl-tRNA synthetase | 0.0062 | 0.0056 | 0.0055 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Toxoplasma gondii | leucyl-tRNA synthetase (LeuRS2) | 0.0062 | 0.0055 | 0.0111 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0094 | 0.0103 | 0.0102 |
Loa Loa (eye worm) | multisynthetase complex auxiliary component p43 | 0.0147 | 0.0182 | 0.8194 |
Trypanosoma cruzi | methionyl-tRNA synthetase, putative | 0.0025 | 0.0001 | 0.0026 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0094 | 0.0103 | 0.0102 |
Brugia malayi | isoleucyl-tRNA synthetase | 0.0174 | 0.0222 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0026 | 0.0002 | 0.0002 |
Plasmodium vivax | valine--tRNA ligase, putative | 0.0062 | 0.0055 | 0.248 |
Plasmodium vivax | methionine--tRNA ligase, putative | 0.0025 | 0.0001 | 0.0026 |
Chlamydia trachomatis | isoleucine--tRNA ligase | 0.0174 | 0.0222 | 0.8766 |
Wolbachia endosymbiont of Brugia malayi | arginyl-tRNA synthetase | 0.003 | 0.0008 | 0.0342 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0026 | 0.0002 | 0.0005 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Echinococcus multilocularis | glycyl tRNA synthetase | 0.0065 | 0.006 | 0.2369 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0094 | 0.0103 | 0.4613 |
Loa Loa (eye worm) | oxidoreductase | 0.0094 | 0.0103 | 0.4627 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0103 | 0.4627 |
Plasmodium falciparum | methionine--tRNA ligase | 0.0025 | 0.0001 | 0.0026 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0094 | 0.0103 | 0.0102 |
Echinococcus granulosus | acetyl coenzyme A synthetase cytoplasmic | 0.0094 | 0.0103 | 0.4061 |
Plasmodium falciparum | leucine--tRNA ligase, putative | 0.0062 | 0.0055 | 0.248 |
Schistosoma mansoni | glycyl-tRNA synthetase | 0.0065 | 0.006 | 0.2386 |
Toxoplasma gondii | isoleucyl-tRNA synthetase family protein | 0.0174 | 0.0222 | 0.0449 |
Plasmodium vivax | threonine--tRNA ligase, putative | 0.0053 | 0.0042 | 0.1899 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.0167 | 0.752 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0055 | 0.248 |
Mycobacterium ulcerans | cysteinyl-tRNA synthetase | 0.1462 | 0.2135 | 0.2135 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0094 | 0.0103 | 0.0102 |
Mycobacterium leprae | POSSIBLE CONSERVED POLYKETIDE SYNTHASE ASSOCIATED PROTEIN PAPA5 | 0.0033 | 0.0013 | 0.0025 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0094 | 0.0103 | 0.0207 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0056 | 0.2506 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0094 | 0.0103 | 0.4627 |
Mycobacterium ulcerans | hypothetical protein | 0.0094 | 0.0103 | 0.0102 |
Plasmodium vivax | hypothetical protein, conserved | 0.0087 | 0.0092 | 0.4156 |
Mycobacterium tuberculosis | Unknown protein | 0.0033 | 0.0013 | 0.0012 |
Giardia lamblia | Leucyl-tRNA synthetase | 0.005 | 0.0037 | 0.1655 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0141 | 0.0172 | 0.0172 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0094 | 0.0103 | 0.0102 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 1.43 uM | Growth inhibition of human DU145 cells by SRB assay | ChEMBL. | 23274123 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.