Detailed information for compound 1740326

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1607.75 | Formula: C69H77F3N14O18S5
  • H donors: 10 H acceptors: 18 LogP: 3.83 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC(=O)C(F)(F)F.CO/C(=C\1/NC(=O)[C@@H](NC(=O)c2csc(n2)c2cc(O)c(nc2c2csc(n2)[C@H]2NC(=O)c3nc([C@@H](NC(=O)c4nc1sc4)[C@@H]1OCc4c5c(COC(=O)[C@H]1O[C@@H]1O[C@@H](C)[C@H]([C@@](C1)(C)O)N(C)C)cccc5n(c4C(=O)OC2)O)sc3)c1scc(n1)CNCC(N1CCCCC1)(C)C)[C@H](O)C)/C
  • InChi: 1S/C67H76N14O16S5.C2HF3O2/c1-30(82)46-58(87)77-47(31(2)92-9)61-73-41(28-101-61)57(86)78-50-52-53(97-44-19-67(6,90)54(79(7)8)32(3)96-44)65(89)94-21-33-14-13-15-42-45(33)36(22-93-52)51(81(42)91)64(88)95-23-37(70-55(84)39-27-102-63(50)74-39)60-71-38(25-100-60)48-35(59-72-40(26-99-59)56(85)76-46)18-43(83)49(75-48)62-69-34(24-98-62)20-68-29-66(4,5)80-16-11-10-12-17-80;3-2(4,5)1(6)7/h13-15,18,24-28,30,32,37,44,46,50,52-54,68,82-83,90-91H,10-12,16-17,19-23,29H2,1-9H3,(H,70,84)(H,76,85)(H,77,87)(H,78,86);(H,6,7)/b47-31+;/t30-,32+,37+,44+,46+,50+,52+,53+,54-,67+;/m1./s1
  • InChiKey: NNXRWZLLZOZILS-ODKRUETDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0069 0.07 0.1882
Echinococcus granulosus ETHE1 protein 0.0304 0.3722 0.4049
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1311 0.3522
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0229 0.0615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Brugia malayi hypothetical protein 0.0304 0.3722 1
Echinococcus multilocularis dna polymerase eta 0.0019 0.0064 0.0064
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0159 0.1857 0.202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.013 0.035
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Echinococcus multilocularis ETHE1 protein 0.0304 0.3722 0.3722
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Toxoplasma gondii hydroxyacylglutathione hydrolase 0.0304 0.3722 1
Echinococcus multilocularis alkaline phosphatase 0.0159 0.1857 0.1857
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1106 0.2973
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0195 0.0524
Brugia malayi Pre-SET motif family protein 0.0203 0.2417 0.6494
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0164 0.044
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0304 0.3722 1
Brugia malayi Isocitrate dehydrogenase 0.0114 0.1282 0.3445
Echinococcus granulosus intestinal type alkaline phosphatase 0.0159 0.1857 0.202
Entamoeba histolytica hypothetical protein 0.0038 0.0311 0.0835
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1106 0.2973
Schistosoma mansoni DNA polymerase eta 0.0019 0.0064 0.007
Echinococcus multilocularis tumor protein p63 0.0335 0.4116 0.4116
Trypanosoma brucei metallo-beta-lactamase-like protein, putative 0.0304 0.3722 1
Brugia malayi hypothetical protein 0.015 0.1739 0.4673
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0064 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0276 0.0588
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0276 0.0708
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0014 0.0038
Echinococcus multilocularis GPCR, family 2 0.0032 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0173
Schistosoma mansoni hypothetical protein 0.0166 0.1949 0.2121
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.07 0.1882
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0195 0.0365
Trypanosoma brucei unspecified product 0.0019 0.0064 0.0135
Trichomonas vaginalis A-type flavoprotein 0.0304 0.3722 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0061 0.0165
Mycobacterium ulcerans hypothetical protein 0.0304 0.3722 1
Trichomonas vaginalis set domain proteins, putative 0.0231 0.2775 0.7457
Leishmania major hypothetical protein, conserved 0.0304 0.3722 1
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Onchocerca volvulus 0.0231 0.2775 0.7316
Mycobacterium tuberculosis Possible hydrolase 0.0304 0.3722 1
Brugia malayi metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Leishmania major metallo-beta-lactamase family protein-like protein 0.0304 0.3722 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0393 0.1057
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0393 0.1057
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0114 0.1282 0.1395
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0114 0.1282 0.3445
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0064 0.0173
Entamoeba histolytica hypothetical protein, conserved 0.0304 0.3722 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Entamoeba histolytica metallo-beta-lactamase family protein 0.0304 0.3722 1
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Giardia lamblia GTOR 0.0045 0.0393 0.0907
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0064 0.0173
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0393 0.0393
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0276 0.0743
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0277 0.0744
Mycobacterium ulcerans glyoxalase II, GloB 0.0304 0.3722 1
Entamoeba histolytica metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0114 0.1282 0.342
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Treponema pallidum ribonuclease Z 0.0304 0.3722 1
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0114 0.1282 0.3335
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.1868 0.2032
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0276 0.0743
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0064 0.007
Loa Loa (eye worm) hypothetical protein 0.01 0.1106 0.2973
Schistosoma mansoni hypothetical protein 0.0166 0.1949 0.2121
Mycobacterium tuberculosis Beta lactamase like protein 0.0304 0.3722 1
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0304 0.3722 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0304 0.3722 1
Trypanosoma brucei cleavage and polyadenylation specificity factor subunit, putative 0.0304 0.3722 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0443 0.0443
Entamoeba histolytica heat shock transcription factor, putative 0.0101 0.1118 0.3005
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.0127
Loa Loa (eye worm) hydroxyacylglutathione hydrolase 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.013 0.035
Schistosoma mansoni zinc phosphodiesterase 0.0304 0.3722 0.4049
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0064 0.0173
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0393 0.0428
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0393 0.1023
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.2417 0.6494
Entamoeba histolytica heat shock transcription factor, putative 0.0101 0.1118 0.3005
Schistosoma mansoni alpha-glucosidase 0.0137 0.1583 0.1722
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0304 0.3722 0.4049
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Echinococcus multilocularis zinc phosphodiesterase 0.0304 0.3722 0.3722
Echinococcus granulosus dna polymerase kappa 0.0019 0.0064 0.007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Entamoeba histolytica hypothetical protein 0.0038 0.0311 0.0835
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0014 0.0014
Chlamydia trachomatis ribonuclease Z 0.0304 0.3722 0.5
Schistosoma mansoni alpha-glucosidase 0.0137 0.1583 0.1722
Loa Loa (eye worm) hypothetical protein 0.0032 0.0229 0.0615
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0159 0.1857 0.202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0131 0.0351
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0451 0.0491
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0014 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0229 0.0249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Onchocerca volvulus 0.015 0.1739 0.4379
Loa Loa (eye worm) hypothetical protein 0.0304 0.3722 1
Mycobacterium ulcerans Zn-dependent glyoxylase 0.0304 0.3722 1
Schistosoma mansoni alpha glucosidase 0.0035 0.0276 0.0301
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0067
Schistosoma mansoni alkaline phosphatase 0.0159 0.1857 0.202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0131 0.0351
Echinococcus multilocularis isocitrate dehydrogenase 0.0114 0.1282 0.1282
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0276 0.0708
Onchocerca volvulus 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Schistosoma mansoni hypothetical protein 0.0038 0.0311 0.0338
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0135
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Mycobacterium tuberculosis Conserved protein 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0164 0.044
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0311 0.0338
Echinococcus multilocularis hydroxyacylglutathione hydrolase 0.0304 0.3722 0.3722
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.1282 0.1282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0443 0.0443
Echinococcus granulosus tumor protein p63 0.0335 0.4116 0.4479
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0114 0.1282 0.342
Leishmania major cleavage and polyadenylation specificity factor, putative 0.0304 0.3722 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0061 0.0061
Plasmodium vivax SET domain protein, putative 0.0029 0.0195 0.0365
Toxoplasma gondii metallo-beta-lactamase domain-containing protein 0.0304 0.3722 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0061 0.0165
Mycobacterium tuberculosis Conserved hypothetical protein 0.0304 0.3722 1
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Loa Loa (eye worm) hypothetical protein 0.0304 0.3722 1
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0276 0.0743
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Entamoeba histolytica type A flavoprotein, putative 0.0304 0.3722 1
Giardia lamblia Metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0451 0.1212
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Echinococcus multilocularis microtubule associated protein 2 0.0732 0.9191 0.9191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2244 0.6031
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0061 0.0067
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0114 0.1282 0.3445
Mycobacterium ulcerans hypothetical protein 0.0304 0.3722 1
Mycobacterium ulcerans hydrolase 0.0304 0.3722 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.1868 0.5018
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0393 0.1057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0393 0.1057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0443 0.0482
Onchocerca volvulus Glucosylceramidase homolog 0.0179 0.2121 0.5461
Trypanosoma cruzi glyoxalase II 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.1282 0.1282
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0165
Echinococcus granulosus microtubule associated protein 2 0.0732 0.9191 1
Mycobacterium ulcerans hypothetical protein 0.0304 0.3722 1
Leishmania major hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative 0.0304 0.3722 1
Mycobacterium ulcerans hypothetical protein 0.0304 0.3722 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0064 0.0173
Onchocerca volvulus 0.0049 0.0451 0.0727
Brugia malayi metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0443 0.1191
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0393 0.1057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0443 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0159 0.1857 0.1857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0193 0.0519
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0061 0.0165
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0229 0.0615
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Mycobacterium leprae Beta-lactamase-like protein 0.0304 0.3722 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0393 0.1023
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0304 0.3722 1
Toxoplasma gondii isocitrate dehydrogenase 0.0114 0.1282 0.3335
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0229 0.0229
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0304 0.3722 0.3722
Loa Loa (eye worm) hydroxyacylglutathione hydrolase cytoplasmic 0.0304 0.3722 1
Toxoplasma gondii isocitrate dehydrogenase 0.0114 0.1282 0.3335
Trypanosoma cruzi glyoxalase II 0.0304 0.3722 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0131 0.0351
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0135
Echinococcus granulosus metallo beta lactamase domain containing protein 0.0304 0.3722 0.4049
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0101 0.1118 0.2619
Entamoeba histolytica heat shock transcription factor, putative 0.0101 0.1118 0.3005
Plasmodium vivax unspecified product 0.0304 0.3722 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0064 0.0173
Echinococcus granulosus dna polymerase eta 0.0019 0.0064 0.007
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0159 0.1857 0.1857
Mycobacterium tuberculosis Possible hydrolase 0.0304 0.3722 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0061 0.0127
Loa Loa (eye worm) hypothetical protein 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.016 0.0431
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0393 0.1057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Entamoeba histolytica type A flavoprotein, putative 0.0304 0.3722 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0014 0.0038
Schistosoma mansoni zinc phosphodiesterase 0.0304 0.3722 0.4049
Echinococcus granulosus alkaline phosphatase 0.0159 0.1857 0.202
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0114 0.1282 0.342
Mycobacterium ulcerans hydrolase 0.0304 0.3722 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0304 0.3722 1
Trypanosoma cruzi metallo-beta-lactamase superfamily, putative 0.0304 0.3722 1
Trypanosoma brucei glucosidase, putative 0.0035 0.0276 0.0708
Brugia malayi HSF-type DNA-binding domain containing protein 0.0101 0.1118 0.3005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0229 0.0615
Echinococcus granulosus GPCR family 2 0.0032 0.0229 0.0249
Entamoeba histolytica metallo-beta-lactamase family protein 0.0304 0.3722 1
Trypanosoma cruzi metallo-beta-lactamase-like protein, putative 0.0304 0.3722 1
Schistosoma mansoni alkaline phosphatase 0.0159 0.1857 0.202
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0277 0.0709
Trypanosoma brucei hydroxyacylglutathione hydrolase, putative 0.0304 0.3722 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0304 0.3722 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0061 0.0165
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0393 0.1023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0061 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0443 0.1191
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.016 0.0431
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0273 0.3325 0.8934
Plasmodium vivax hydroxyacyl glutathione hydrolase, putative 0.0304 0.3722 1
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0304 0.3722 1
Echinococcus multilocularis geminin 0.0166 0.1949 0.1949
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0249
Loa Loa (eye worm) hypothetical protein 0.015 0.1739 0.4673
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0064 0.007
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0276 0.0301
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0277 0.0709
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0249
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0276 0.0743
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.1868 0.5018
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0064 0.0173
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0276 0.0743
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0443 0.0482
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0276 0.0743
Echinococcus granulosus hydroxyacylglutathione hydrolase 0.0304 0.3722 0.4049
Trypanosoma brucei glyoxalase II 0.0304 0.3722 1
Leishmania major metallo-beta-lactamase family-like protein 0.0304 0.3722 1
Brugia malayi ethe1-prov protein 0.0304 0.3722 1
Echinococcus multilocularis metallo beta lactamase domain containing protein 0.0304 0.3722 0.3722
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0276 0.0743
Wolbachia endosymbiont of Brugia malayi metallo-beta-lactamase superfamily hydrolase 0.0304 0.3722 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0393 0.1023
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0014 0.0015
Loa Loa (eye worm) metallo-beta-lactamase superfamily protein 0.0304 0.3722 1
Schistosoma mansoni hypothetical protein 0.0304 0.3722 0.4049
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0249
Mycobacterium tuberculosis Conserved protein 0.0304 0.3722 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0064 0.0135
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.006 0.0123
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0114 0.1282 0.1282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Brugia malayi isocitrate dehydrogenase 0.0114 0.1282 0.3445
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0067
Mycobacterium leprae conserved hypothetical protein 0.0304 0.3722 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0276 0.0276
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0195 0.0195
Entamoeba histolytica hypothetical protein 0.0038 0.0311 0.0835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0195 0.0212
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0165
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0247 0.0508
Entamoeba histolytica alkyl sulfatase, putative 0.0304 0.3722 1
Schistosoma mansoni hypothetical protein 0.0304 0.3722 0.4049
Loa Loa (eye worm) hypothetical protein 0.0304 0.3722 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Leishmania major DNA polymerase kappa, putative 0.0019 0.0064 0.0173
Giardia lamblia Hydroxyacylglutathione hydrolase 0.0304 0.3722 1
Entamoeba histolytica alkyl sulfatase, putative 0.0304 0.3722 1
Mycobacterium tuberculosis Conserved protein 0.0304 0.3722 1
Plasmodium falciparum cytosolic glyoxalase II 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0064 0.0173
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0229 0.0249
Schistosoma mansoni hypothetical protein 0.0083 0.088 0.0957
Entamoeba histolytica metallo-beta-lactamase family protein 0.0304 0.3722 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0114 0.1282 0.3335
Trypanosoma cruzi glyoxalase II 0.0304 0.3722 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0014 0.0015
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0093 0.0212
Brugia malayi hypothetical protein 0.0038 0.0311 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0014 0.0038
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0061 0.0165
Loa Loa (eye worm) isocitrate dehydrogenase 0.0114 0.1282 0.3445
Loa Loa (eye worm) hypothetical protein 0.0029 0.0195 0.0524
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0195 0.0212
Schistosoma mansoni hypothetical protein 0.0304 0.3722 0.4049
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0064 0.0173
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.2121 0.5698
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0114 0.1282 0.342
Onchocerca volvulus Putative hydrolase PNKD 0.0304 0.3722 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0195 0.0212
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0393 0.1057
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0273 0.3325 0.8934
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0061 0.0165
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0064 0.0135
Trichomonas vaginalis apoptosis inducing factor, putative 0.0304 0.3722 1
Brugia malayi Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. 0.0304 0.3722 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0311 0.0338
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0064 0.0064
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0276 0.0743
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0276 0.0743
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0064 0.007
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0195 0.0212
Trichomonas vaginalis conserved hypothetical protein 0.0304 0.3722 1
Leishmania major DNA polymerase eta, putative 0.0019 0.0064 0.0173
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0195 0.0195
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1868 0.1868
Trichomonas vaginalis glucosylceramidase, putative 0.0189 0.2244 0.6031
Schistosoma mansoni hypothetical protein 0.0069 0.07 0.0762
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0131 0.0351
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0443 0.0482
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1311 0.3522
Onchocerca volvulus 0.0304 0.3722 1
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0064 0.0173
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0393 0.1057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1106 0.2973
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0229 0.0229
Schistosoma mansoni hypothetical protein 0.0032 0.0229 0.0249
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0164 0.044
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0064 0.0173
Mycobacterium leprae conserved hypothetical protein 0.0304 0.3722 1
Echinococcus granulosus geminin 0.0166 0.1949 0.2121
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0195 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0393 0.1057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Schistosoma mansoni microtubule-associated protein tau 0.0732 0.9191 1
Trichomonas vaginalis glucosylceramidase, putative 0.0273 0.3325 0.8934
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0311 0.0311
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0181 0.0197
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0276 0.0743
Brugia malayi MH2 domain containing protein 0.0116 0.1311 0.3522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.031 0.0833
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0114 0.1282 0.1282
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135
Mycobacterium ulcerans hydrolase 0.0304 0.3722 1
Trypanosoma cruzi hydroxyacylglutathione hydrolase, putative 0.0304 0.3722 1
Onchocerca volvulus Hydroxyacylglutathione hydrolase, mitochondrial homolog 0.0304 0.3722 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.1868 0.1868
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0247 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0277 0.0743
Mycobacterium ulcerans beta lactamase-like protein 0.0304 0.3722 1
Onchocerca volvulus 0.0092 0.1005 0.2298
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0205 0.0552
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0014 0.0038
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0064 0.0135
Trichomonas vaginalis beta lactamase domain, putative 0.0304 0.3722 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0443 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.013 0.035
Echinococcus granulosus zinc phosphodiesterase 0.0304 0.3722 0.4049
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0159 0.1857 0.1857
Schistosoma mansoni hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) 0.0304 0.3722 0.4049
Loa Loa (eye worm) hypothetical protein 0.0101 0.1118 0.3005
Giardia lamblia DINP protein human, muc B family 0.0019 0.0064 0.0008
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0393 0.0428
Mycobacterium leprae POSSIBLE HYDROLASE 0.0304 0.3722 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0114 0.1282 0.1395
Entamoeba histolytica hypothetical protein 0.0038 0.0311 0.0835
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0064 0.0135

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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