TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 644.707 | Formula: C37H40O10
H donors: 3 H acceptors: 7 LogP: 3.25 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(ccc1O)CC(=O)OCC1=C[C@H]2[C@@H]3C([C@]3(OC(=O)Cc3ccccc3)C(=O)[C@H]([C@@]2([C@H]2[C@@](C1)(O)C(=O)C(=C2)C)O)C)(C)C
InChi: 1S/C37H40O10/c1-20-13-28-35(43,32(20)41)18-24(19-46-29(39)17-23-11-12-26(38)27(15-23)45-5)14-25-31-34(3,4)37(31,33(42)21(2)36(25,28)44)47-30(40)16-22-9-7-6-8-10-22/h6-15,21,25,28,31,38,43-44H,16-19H2,1-5H3/t21-,25+,28-,31-,35-,36-,37-/m1/s1
InChiKey: JCWZKGJSBHIYTA-DNBROBMWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Vanilloid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.0415	0.0415
Trypanosoma cruzi	cruzipain precursor, putative	0.0315	0.2074	0.1731
Loa Loa (eye worm)	ctsf protein	0.0957	1	1
Echinococcus multilocularis	cysteine protease	0.0957	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0957	1	1
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.0415	0.0415
Loa Loa (eye worm)	carboxylesterase	0.0182	0.0437	0.0437
Entamoeba histolytica	cysteine proteinase, putative	0.0495	0.4301	0.4054
Leishmania major	cathepsin L-like protease	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0495	0.4301	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0642	0.6114	0.6114
Brugia malayi	Carboxylesterase family protein	0.0182	0.0437	0.0437
Echinococcus multilocularis	cathepsin L cysteine protease	0.0957	1	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0181	0.0415	0.0415
Onchocerca volvulus		0.0957	1	1
Toxoplasma gondii	cathepsin CPL	0.0957	1	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0181	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2074	0.2074
Loa Loa (eye worm)	hypothetical protein	0.0332	0.2285	0.2285
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Onchocerca volvulus	Cathepsin F homolog	0.0957	1	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0181	0.0415	0.0415
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Brugia malayi	Cathepsin L-like precursor	0.0957	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0181	0.0415	0.0415
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Onchocerca volvulus		0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0957	1	1
Leishmania major	cathepsin L-like protease	0.0957	1	1
Echinococcus granulosus	carboxylesterase 5A	0.0182	0.0437	0.0437
Onchocerca volvulus		0.0642	0.6114	0.5946
Onchocerca volvulus		0.0957	1	1
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0957	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0332	0.2285	0.2285
Plasmodium vivax	vivapain-3	0.0495	0.4301	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.0415	0.0415
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0957	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0415	0.0415
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0332	0.2285	0.2285
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0181	0.0415	0.0415
Entamoeba histolytica	cysteine proteinase, putative	0.0495	0.4301	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0957	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0181	0.0415	0.0415
Brugia malayi	Cathepsin L-like precursor	0.0315	0.2074	0.2074
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0957	1	1
Echinococcus granulosus	acetylcholinesterase	0.0182	0.0437	0.0437
Echinococcus multilocularis	carboxylesterase 5A	0.0182	0.0437	0.0437
Echinococcus granulosus	cathepsin L	0.0495	0.4301	0.4301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Echinococcus multilocularis	cathepsin b	0.0332	0.2285	0.2285
Echinococcus granulosus	cathepsin b	0.0332	0.2285	0.2285
Brugia malayi	Papain family cysteine protease containing protein	0.0495	0.4301	0.4301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0642	0.6114	0.5946
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Schistosoma mansoni	cathepsin C	0.0181	0.0415	0.0415
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0415	0.0415
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Leishmania major	cathepsin L-like protease	0.0957	1	1
Brugia malayi	Cathepsin L-like precursor	0.0957	1	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0957	1	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0642	0.6114	0.6114
Leishmania major	cysteine peptidase A (CPA)	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0957	1	1
Brugia malayi	cathepsin L-like precursor	0.0642	0.6114	0.6114
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0642	0.6114	0.5946
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0332	0.2285	0.2285
Giardia lamblia	Cathepsin B precursor	0.0227	0.0993	1
Onchocerca volvulus	Cathepsin L homolog	0.0957	1	1
Onchocerca volvulus		0.0957	1	1
Brugia malayi	cathepsin L-like cysteine proteinase	0.0181	0.0415	0.0415
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0957	1	1
Entamoeba histolytica	cysteine proteinase 2	0.0495	0.4301	0.4054
Echinococcus granulosus	cysteine protease	0.0495	0.4301	0.4301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0181	0.0415	0.0415
Entamoeba histolytica	cysteine proteinase, putative	0.0957	1	1
Echinococcus granulosus	cathepsin l1	0.0642	0.6114	0.6114
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0315	0.2074	0.2074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0495	0.4301	0.3672
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0227	0.0993	0.0604
Trypanosoma cruzi	cysteine peptidase, putative	0.0957	1	1
Leishmania major	cathepsin L-like protease	0.0957	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0642	0.6114	0.6114
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0415	0.0415
Toxoplasma gondii	cathepsin B	0.0227	0.0993	0.0604
Entamoeba histolytica	cysteine proteinase 1, putative	0.0495	0.4301	0.4054
Brugia malayi	cathepsin L precursor	0.0181	0.0415	0.0415
Brugia malayi	Cathepsin L-like precursor	0.0642	0.6114	0.6114
Echinococcus multilocularis	cathepsin L cysteine protease	0.0957	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0495	0.4301	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Echinococcus multilocularis	acetylcholinesterase	0.0182	0.0437	0.0437
Brugia malayi	Papain family cysteine protease containing protein	0.0181	0.0415	0.0415
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0315	0.2074	0.2074
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0332	0.2285	0.2285
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0957	1	1
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Onchocerca volvulus		0.0957	1	1
Loa Loa (eye worm)	hypothetical protein	0.0642	0.6114	0.6114
Schistosoma mansoni	cathepsin s	0.0315	0.2074	0.2074
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0182	0.0437	0.0437
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0957	1	1
Brugia malayi	cathepsin B-like cysteine proteinase	0.0332	0.2285	0.2285
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0181	0.0415	0.0415
Onchocerca volvulus		0.0957	1	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0181	0.0415	0.0415
Onchocerca volvulus	Cathepsin L homolog	0.0957	1	1
Brugia malayi	fibroinase precursor	0.0181	0.0415	0.0415
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Echinococcus granulosus	cathepsin L	0.0181	0.0415	0.0415
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0181	0.0415	0.0415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Loa Loa (eye worm)	cysteine protease	0.0957	1	1
Echinococcus multilocularis	cathepsin b	0.0332	0.2285	0.2285
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Brugia malayi	Cathepsin L-like precursor	0.0957	1	1
Echinococcus multilocularis	cathepsin L	0.0181	0.0415	0.0415
Brugia malayi	Cathepsin L-like precursor	0.0642	0.6114	0.6114
Brugia malayi	cathepsin F-like cysteine proteinase	0.0315	0.2074	0.2074
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0642	0.6114	0.5946
Entamoeba histolytica	cysteine proteinase, putative	0.0642	0.6114	0.5946
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0495	0.4301	0.4054
Loa Loa (eye worm)	cathepsin B	0.0227	0.0993	0.0993
Plasmodium vivax	vivapain-2	0.0957	1	1
Leishmania major	cathepsin L-like protease	0.0957	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0315	0.2074	0.1731
Leishmania major	cathepsin L-like protease	0.0957	1	1
Giardia lamblia	Cathepsin B precursor	0.0227	0.0993	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0332	0.2285	0.1951
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0957	1	1
Echinococcus granulosus	acetylcholinesterase	0.0182	0.0437	0.0437
Plasmodium vivax	unspecified product	0.0315	0.2074	0.1731
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0227	0.0993	0.0604
Brugia malayi	Cathepsin L-like precursor	0.0957	1	1
Echinococcus multilocularis	acetylcholinesterase	0.0182	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2074	0.2074
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0957	1	1
Leishmania major	cathepsin L-like protease	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Plasmodium vivax	unspecified product	0.0495	0.4301	0.4054
Plasmodium vivax	vivapain-1	0.0495	0.4301	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Echinococcus multilocularis	cathepsin L	0.0495	0.4301	0.4301
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0495	0.4301	0.4301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0415	0.0415
Entamoeba histolytica	cysteine proteinase, putative	0.0495	0.4301	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0181	0.0415	0.0415
Trypanosoma cruzi	cysteine proteinase, putative	0.0495	0.4301	0.4054
Schistosoma mansoni	cathepsin F (C01 family)	0.0957	1	1
Entamoeba histolytica	cysteine proteinase, putative	0.0957	1	1
Loa Loa (eye worm)	hypothetical protein	0.0315	0.2074	0.2074
Brugia malayi	Cathepsin L-like precursor	0.0957	1	1
Plasmodium vivax	vivapain-2	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Loa Loa (eye worm)	fibroinase	0.0957	1	1
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0181	0.0415	0.0415
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0957	1	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0495	0.4301	0.4301
Trypanosoma cruzi	cysteine protease, putative	0.0495	0.4301	0.4054
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0495	0.4301	0.4301
Trypanosoma cruzi	cysteine peptidase, putative	0.0957	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0957	1	1
Leishmania major	cathepsin L-like protease	0.0957	1	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0181	0.0415	0.0415
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Brugia malayi	Papain family cysteine protease containing protein	0.0495	0.4301	0.4301
Giardia lamblia	Cathepsin B precursor	0.0227	0.0993	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0495	0.4301	0.4054
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0181	0.0415	0.0415
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0495	0.4301	0.4054
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0227	0.0993	0.0993
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0957	1	1
Onchocerca volvulus		0.0957	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0957	1	1
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0415	0.0415
Loa Loa (eye worm)	acetylcholinesterase 1	0.0182	0.0437	0.0437
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0957	1	1
Brugia malayi	Carboxylesterase family protein	0.0182	0.0437	0.0437
Loa Loa (eye worm)	hypothetical protein	0.0642	0.6114	0.6114
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0495	0.4301	0.3672
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0181	0.0415	0.0415
Echinococcus multilocularis	cysteine protease	0.0957	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0957	1	1
Loa Loa (eye worm)	hypothetical protein	0.0957	1	1
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Trypanosoma cruzi	cysteine peptidase, putative	0.0495	0.4301	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0437	0.0437
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0957	1	1
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Trypanosoma cruzi	cysteine proteinase, putative	0.0495	0.4301	0.4054
Loa Loa (eye worm)	hypothetical protein	0.0181	0.0415	0.0415
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0437	0.0437
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0957	1	1
Echinococcus granulosus	cathepsin b	0.0332	0.2285	0.2285
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0495	0.4301	0.4301
Echinococcus granulosus	cathepsin l1	0.0957	1	1
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Entamoeba histolytica	cysteine protease, putative	0.0495	0.4301	0.4054
Brugia malayi	cathepsin F-like cysteine proteinase	0.0181	0.0415	0.0415
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0957	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Hill coefficient (functional)	= 0.9	Effect on cooperativity of Resiniferatoxin (RTX) binding (Hill coefficient)	ChEMBL.	8759633
Hill coefficient (functional)	= 0.9	Effect on cooperativity of Resiniferatoxin (RTX) binding (Hill coefficient)	ChEMBL.	8759633
Ki (binding)	= 1.3 uM	Displacement of [3H]-RTX from Vanilloid receptor in Rat spinal cord membranes	ChEMBL.	8759633
Ki (binding)	= 1.3 uM	Displacement of [3H]-RTX from Vanilloid receptor in Rat spinal cord membranes	ChEMBL.	8759633

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL322621
PubChem: 10532218

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 174054