Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Bos taurus | Arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0545 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0545 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0545 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0545 | 1 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0142 | 0.1106 | 0.1106 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0545 | 1 | 1 |
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0142 | 0.1106 | 0.1106 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0092 | 0 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.01 | 0.0164 | 0.0164 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0142 | 0.1106 | 0.1106 |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.1106 | 0.1106 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0092 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0545 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0092 | 0 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0142 | 0.1106 | 0.1106 |
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0092 | 0 | 0.5 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0545 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0545 | 1 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0142 | 0.1106 | 0.1106 |
Echinococcus granulosus | carboxylesterase 5A | 0.0545 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0545 | 1 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.111 | 0.111 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.111 | 0.111 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.111 | 0.111 |
Schistosoma mansoni | choline o-acyltransferase | 0.0142 | 0.1106 | 0.1106 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DD (functional) | = 6.34 | Deoxyribose degradaton (DD) as micromol of malondialdehyde/mmol of deoxyribose released by 75 uM | ChEMBL. | 8759634 |
IC50 (functional) | = 1.9 uM | Tested for antiproliferative activity against HaCaT cells | ChEMBL. | 8759634 |
IC50 (functional) | = 1.9 uM | Tested for antiproliferative activity against HaCaT cells | ChEMBL. | 8759634 |
IC50 (binding) | = 2 uM | Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNL | ChEMBL. | 8759634 |
IC50 (binding) | = 2 uM | Tested for inhibition of 5-lipoxygenase as inhibition of 5-HETE and LTB4 biosynthesis in bovine PMNL | ChEMBL. | 8759634 |
IC50 (binding) | = 30 uM | Tested for inhibition of 12-LO (12-lipoxygenase) as an inhibitor of 12(S)-HETE biosynthesis in mouse epidermal homogenates | ChEMBL. | 8759634 |
IC50 (binding) | = 30 uM | Tested for inhibition of 12-LO (12-lipoxygenase) as an inhibitor of 12(S)-HETE biosynthesis in mouse epidermal homogenates | ChEMBL. | 8759634 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 8759634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.