TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 507.413 | Formula: C23H28Cl2N6O3
H donors: 3 H acceptors: 4 LogP: 4.72 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: Clc1ccc(c(c1)CNc1ncc(c(n1)NC1CCCC1)C(=O)NCCCN1CCOC1=O)Cl
InChi: 1S/C23H28Cl2N6O3/c24-16-6-7-19(25)15(12-16)13-27-22-28-14-18(20(30-22)29-17-4-1-2-5-17)21(32)26-8-3-9-31-10-11-34-23(31)33/h6-7,12,14,17H,1-5,8-11,13H2,(H,26,32)(H2,27,28,29,30)
InChiKey: XYASHXPUZJDWIO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	TYRO3 protein tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	selectin P (granule membrane protein 140kDa, antigen CD62)	Starlite/ChEMBL	References
Homo sapiens	MER proto-oncogene, tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	neurotrophic tyrosine kinase, receptor, type 1	Starlite/ChEMBL	References
Homo sapiens	MET proto-oncogene, receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	ABL proto-oncogene 1, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	mitogen-activated protein kinase 1	Starlite/ChEMBL	References
Homo sapiens	AXL receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_132328	All targets in OG5_132328
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Leishmania mexicana	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Cryptosporidium hominis	MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Leishmania mexicana	mitogen-activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Brugia malayi	MAP kinase sur-1	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Mitogen-activated protein kinase 3, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/ABL protein kinase	Get druggable targets OG5_131234	All targets in OG5_131234
Leishmania infantum	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Giardia lamblia	Kinase, CMGC MAPK	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Cryptosporidium parvum	MAPK, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania donovani	mitogen-activated protein kinase 4	Get druggable targets OG5_126781	All targets in OG5_126781
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	tyrosine protein kinase Abl	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus granulosus	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase ABL1, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	ko:K04371 extracellular signal-regulated kinase 1/2, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase implicated in PKC1-controlled signalling pathway	Get druggable targets OG5_126781	All targets in OG5_126781
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	mitogen activated protein kinase 3	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus granulosus	tyrosine protein kinase ABL1	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma japonicum	Tyrosine-protein kinase transforming protein Abl, putative	Get druggable targets OG5_131234	All targets in OG5_131234
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_131234	All targets in OG5_131234
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Tyrosine-protein kinase abl-1	Get druggable targets OG5_131234	All targets in OG5_131234
Candida albicans	Serine/threonine protein kinase of MAP kinase family	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	Get druggable targets OG5_126781	All targets in OG5_126781
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Candida albicans	MAP kinase-like orf	Get druggable targets OG5_126781	All targets in OG5_126781
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	mitogen activated protein kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	protein kinase, putative,tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Leishmania braziliensis	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma congolense	tyrosine protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Trypanosoma brucei gambiense	mitogen-activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Leishmania donovani	mitogen activated protein kinase, putative	Get druggable targets OG5_126781	All targets in OG5_126781

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	mitogen-activated protein kinase 1	360 aa	361 aa	33.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0127	0.0127
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.035	1	1
Brugia malayi	hypothetical protein	0.0019	0.0094	0.0094
Echinococcus multilocularis	titin	0.0021	0.0144	0.0144
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5059	0.5059
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0185	0.5059	0.5059
Brugia malayi	Plexin repeat family protein	0.0021	0.0151	0.0151
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.035	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.035	1	1
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0028	0.0363	0.0363
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.035	1	1
Echinococcus granulosus	roundabout 2	0.0027	0.0347	0.0347
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0185	0.5059	0.5059
Echinococcus granulosus	c4b binding protein beta chain	0.0019	0.0094	0.0094
Echinococcus granulosus	Immunoglobulin	0.0022	0.0199	0.0199
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0165	0.4467	0.4415
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5059	0.5059
Loa Loa (eye worm)	hypothetical protein	0.035	1	1
Echinococcus multilocularis	roundabout 2	0.0027	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0017	0.0022	0.0022
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0165	0.4467	0.4467
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5059	0.5059
Echinococcus granulosus	roundabout 2	0.005	0.102	0.102
Schistosoma mansoni	vesicular amine transporter	0.0022	0.0199	0.0178
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.137	0.5
Schistosoma mansoni	nuclear receptor	0.0165	0.4467	0.4455
Echinococcus granulosus	epidermal growth factor receptor	0.0188	0.5173	0.5173
Schistosoma mansoni	tyrosine kinase	0.0105	0.2676	0.266
Brugia malayi	Immunoglobulin I-set domain containing protein	0.002	0.0127	0.0127
Onchocerca volvulus		0.0021	0.0144	0.0051
Plasmodium vivax	apical sushi protein, putative	0.0019	0.0094	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.035	1	1
Echinococcus multilocularis	insulin receptor	0.0066	0.15	0.15
Loa Loa (eye worm)	nuclear hormone receptor	0.0165	0.4467	0.4467
Loa Loa (eye worm)	plexin A	0.0025	0.0266	0.0266
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0062	0.137	0.5
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.035	1	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0165	0.4467	0.4467
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.003	0.0419	0.0419
Schistosoma mansoni	tyrosine kinase	0.0096	0.2395	0.2378
Brugia malayi	hypothetical protein	0.0185	0.5059	0.5059
Echinococcus multilocularis	transfer RNA-Phe	0.002	0.0127	0.0127
Loa Loa (eye worm)	CAMK protein kinase	0.0021	0.0144	0.0144
Onchocerca volvulus		0.035	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.035	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.035	1	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0607	0.0607
Echinococcus granulosus	ecdysone induced protein 78C	0.035	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0165	0.4467	0.4467
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0105	0.2676	0.2676
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.002	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5059	0.5059
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0017	0.0022	0.0022
Echinococcus multilocularis	Immunoglobulin	0.0022	0.0199	0.0199
Brugia malayi	Tyrosine-protein kinase abl-1	0.0154	0.4136	0.4136
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0419	0.0419
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0062	0.137	0.5
Schistosoma mansoni	tyrosine kinase	0.0258	0.727	0.7264
Echinococcus multilocularis	ecdysone induced protein 78C	0.035	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0017	0.0022	0.0022
Schistosoma mansoni	tyrosine kinase	0.0096	0.2395	0.2378
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0151	0.0151
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.035	1	1
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0021	0.0153	0.0153
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0017	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0607	0.0607
Onchocerca volvulus		0.0165	0.4467	0.4415
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0199	0.0199
Loa Loa (eye worm)	TK/INSR protein kinase	0.0066	0.15	0.15
Brugia malayi	hypothetical protein	0.0019	0.0094	0.0094
Brugia malayi	hypothetical protein	0.0165	0.4467	0.4467
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.002	0.0127	0.0127
Onchocerca volvulus	Bile acid receptor homolog	0.035	1	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0262	0.7379	0.7379
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0094	0.0094
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0347	0.0347
Brugia malayi	protein unc-22	0.0021	0.0144	0.0144
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0062	0.137	0.137
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.137	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0021	0.0153	0.0153
Schistosoma mansoni	thyroid hormone receptor	0.035	1	1
Loa Loa (eye worm)	DR-78	0.0165	0.4467	0.4467
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.035	1	1
Schistosoma mansoni	tyrosine kinase	0.0066	0.15	0.1482
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0094	0.0094
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.137	0.5
Schistosoma mansoni	hypothetical protein	0.002	0.0127	0.0106
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0165	0.4467	0.4467
Schistosoma mansoni	nuclear hormone receptor	0.0165	0.4467	0.4455
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.002	0.0127	0.0127
Echinococcus granulosus	defective proboscis extension response	0.0022	0.0199	0.0199
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0017	0.0022	0.0022
Echinococcus multilocularis	plexin a4	0.0025	0.0266	0.0266
Echinococcus granulosus	nuclear receptor nhr 48	0.0165	0.4467	0.4467
Brugia malayi	Fibronectin type III domain containing protein	0.0036	0.0607	0.0607
Echinococcus multilocularis	FTZ F1 alpha	0.035	1	1
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0022	0.0199	0.0199
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.035	1	1
Schistosoma mansoni	tyrosine kinase	0.0023	0.022	0.0198
Brugia malayi	hypothetical protein	0.0019	0.0094	0.0094
Echinococcus granulosus	thyroid hormone receptor alpha	0.0165	0.4467	0.4467
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.035	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0165	0.4467	0.4467
Schistosoma mansoni	myosin-binding protein-related	0.002	0.0127	0.0106
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.035	1	1
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0062	0.137	0.5
Brugia malayi	plexin A	0.0025	0.0266	0.0266
Echinococcus multilocularis	neuroglian	0.0029	0.0393	0.0393
Brugia malayi	Immunoglobulin I-set domain containing protein	0.002	0.0127	0.0127
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0017	0.0022	0.0022
Onchocerca volvulus	Tyrosine kinase homolog	0.0182	0.4994	0.4947
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0185	0.5059	0.5049
Schistosoma mansoni	c4b-binding protein beta chain	0.0019	0.0094	0.0072
Brugia malayi	Immunoglobulin I-set domain containing protein	0.002	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Loa Loa (eye worm)	hypothetical protein	0.0105	0.266	0.266
Onchocerca volvulus		0.0021	0.0151	0.0058
Echinococcus granulosus	epidermal growth factor receptor	0.0105	0.2676	0.2676
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.035	1	1
Schistosoma mansoni	neuroglian	0.0027	0.0347	0.0326
Schistosoma mansoni	tyrosine kinase	0.0105	0.2676	0.266
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0206	0.5694	0.5694
Echinococcus granulosus	mitogen activated protein kinase 3	0.0062	0.137	0.137
Loa Loa (eye worm)	hypothetical protein	0.035	1	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.035	1	1
Brugia malayi	GCC2 and GCC3 family protein	0.0019	0.0094	0.0094
Schistosoma mansoni	nuclear hormone receptor	0.035	1	1
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0062	0.137	0.5
Plasmodium falciparum	apical sushi protein	0.0019	0.0094	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0027	0.0347	0.0347
Schistosoma mansoni	RAR-like nuclear receptor	0.035	1	1
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0262	0.7379	0.7379
Echinococcus granulosus	mitogen activated protein kinase	0.0062	0.137	0.137
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.035	1	1
Schistosoma mansoni	nephrin	0.0043	0.08	0.078
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0062	0.137	1
Onchocerca volvulus		0.002	0.0127	0.0034
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.137	0.5
Schistosoma mansoni	tyrosine kinase	0.0096	0.2395	0.2378
Echinococcus multilocularis	mitogen activated protein kinase	0.0062	0.137	0.137
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0185	0.5059	0.5059
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.137	0.1351
Brugia malayi	nuclear receptor NHR-88	0.035	1	1
Schistosoma mansoni	tyrosine kinase	0.0066	0.15	0.1482
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0017	0.0022	0.0022
Brugia malayi	Protein kinase domain containing protein	0.0066	0.15	0.15
Brugia malayi	conserved hypotetical protein	0.0165	0.4467	0.4467
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.035	1	1
Brugia malayi	hypothetical protein	0.0165	0.4467	0.4467
Loa Loa (eye worm)	hypothetical protein	0.035	1	1
Echinococcus multilocularis	neuroglian	0.0027	0.0347	0.0347
Brugia malayi	nuclear hormone receptor family member odr-7	0.0165	0.4467	0.4467
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0027	0.0347	0.0347
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0017	0.0022	0.0022
Echinococcus multilocularis	epidermal growth factor receptor	0.0188	0.5173	0.5173
Echinococcus granulosus	nephrin	0.002	0.0127	0.0127
Echinococcus granulosus	c src tyrosine kinase	0.0017	0.0022	0.0022
Schistosoma mansoni	titin	0.002	0.0127	0.0106
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.035	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0188	0.5173	0.5173
Echinococcus granulosus	titin	0.0021	0.0144	0.0144
Loa Loa (eye worm)	hypothetical protein	0.0185	0.5059	0.5059
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0017	0.0022	0.0022
Echinococcus multilocularis	C type lectin domian containing protein	0.0019	0.0094	0.0094
Loa Loa (eye worm)	hypothetical protein	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0165	0.4467	0.4467
Brugia malayi	Nuclear hormone receptor-like 1	0.0185	0.5059	0.5059
Schistosoma mansoni	thyroid hormone receptor	0.035	1	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0017	0.0022	0.0022
Schistosoma mansoni	nuclear receptor nhr-48	0.0165	0.4467	0.4455
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0165	0.4467	0.4467
Loa Loa (eye worm)	SRC-1	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0607	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0094	0.0094
Giardia lamblia	Kinase, CMGC MAPK	0.0062	0.137	0.5
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0094	0.0094
Schistosoma mansoni	cell adhesion molecule	0.002	0.0127	0.0106
Echinococcus multilocularis	nuclear receptor nhr 48	0.0165	0.4467	0.4467
Schistosoma mansoni	hemicentin	0.002	0.0127	0.0106
Trypanosoma brucei	protein kinase, putative	0.0062	0.137	0.5
Onchocerca volvulus		0.0167	0.452	0.4468
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0206	0.5694	0.5694
Brugia malayi	nuclear hormone receptor	0.035	1	1
Loa Loa (eye worm)	hypothetical protein	0.035	1	1
Echinococcus granulosus	neuroglian	0.0027	0.0347	0.0347
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0022	0.0199	0.0178
Schistosoma mansoni	cell adhesion molecule	0.0027	0.0347	0.0326
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0157	0.0157
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0021	0.0153	0.0153
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.035	1	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.035	1	1
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0165	0.4467	0.4467
Brugia malayi	Immunoglobulin I-set domain containing protein	0.002	0.0127	0.0127
Schistosoma mansoni	tyrosine kinase	0.0188	0.5173	0.5162
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.035	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.035	1	1
Echinococcus granulosus	insulin receptor	0.0066	0.15	0.15
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Echinococcus granulosus	neuroglian	0.0029	0.0393	0.0393
Brugia malayi	Nuclear hormone receptor E75	0.0165	0.4467	0.4467
Brugia malayi	nuclear hormone receptor	0.0165	0.4467	0.4467
Echinococcus multilocularis	c4b binding protein beta chain	0.0019	0.0094	0.0094
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0027	0.0347	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0165	0.4467	0.4467
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0165	0.4467	0.4467
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0022	0.0199	0.0178
Schistosoma mansoni	cell adhesion molecule	0.002	0.0127	0.0106
Brugia malayi	Nuclear hormone receptor-like 1	0.0185	0.5059	0.5059
Echinococcus granulosus	FTZ F1 alpha	0.035	1	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.035	1	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0062	0.137	0.5
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0165	0.4467	0.4455
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0612	0.0612
Echinococcus granulosus	plexin a4	0.0025	0.0266	0.0266
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.035	1	1
Brugia malayi	hypothetical protein	0.0019	0.0094	0.0094
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0188	0.5173	0.5173
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.035	1	1
Echinococcus multilocularis	roundabout 2	0.0027	0.0347	0.0347
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.035	1	1
Brugia malayi	nuclear receptor RXR	0.0185	0.5059	0.5059
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0036	0.0607	0.0607
Echinococcus multilocularis	thyroid hormone receptor alpha	0.035	1	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.002	0.0127	0.0127
Schistosoma mansoni	nuclear hormone receptor	0.0165	0.4467	0.4455
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0165	0.4467	0.4467
Schistosoma mansoni	steroid hormone receptor ad4bp	0.035	1	1
Schistosoma mansoni	cell adhesion molecule	0.0043	0.0827	0.0807
Brugia malayi	orphan nuclear receptor NR2E1	0.0165	0.4467	0.4467
Loa Loa (eye worm)	steroid hormone receptor	0.035	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.035	1	1
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0017	0.0022	0.0022
Brugia malayi	pregnancy-associated plasma protein-A	0.0019	0.0094	0.0094
Brugia malayi	Sushi domain	0.0019	0.0094	0.0094
Brugia malayi	SRC-1	0.0017	0.0022	0.0022
Schistosoma mansoni	nephrin	0.0027	0.0347	0.0326
Brugia malayi	Steroid receptor seven-up type 2	0.035	1	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0165	0.4467	0.4467
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0021	0.0153	0.0153
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0021	0.0144	0.0144
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0027	0.0347	0.0326
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0017	0.0022	0.0022
Echinococcus granulosus	twitchin	0.0029	0.041	0.041
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0094	0.0094
Loa Loa (eye worm)	pregnancy-associated plasma protein-E	0.0019	0.0094	0.0094
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0027	0.0347	0.0347
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0062	0.137	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0165	0.4467	0.4467
Schistosoma mansoni	nuclear receptor	0.0165	0.4467	0.4455
Brugia malayi	nuclear receptor RXR	0.0165	0.4467	0.4467
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0204	0.0204
Brugia malayi	Nuclear hormone receptor E75	0.0165	0.4467	0.4467
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0612	0.0612
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.035	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0017	0.0022	0.0022
Loa Loa (eye worm)	TK/ABL protein kinase	0.0262	0.7379	0.7379
Brugia malayi	hypothetical protein	0.0019	0.0094	0.0094
Brugia malayi	hypothetical protein	0.0185	0.5059	0.5059
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0165	0.4467	0.4467
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0027	0.0347	0.0347
Brugia malayi	Immunoglobulin I-set domain containing protein	0.002	0.0127	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0094	0.0094
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0017	0.0022	0.0022
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.035	1	1
Echinococcus granulosus	contactin	0.0027	0.0347	0.0347
Schistosoma mansoni	zinc finger protein	0.0165	0.4467	0.4455
Echinococcus multilocularis	c src tyrosine kinase	0.0017	0.0022	0.0022
Brugia malayi	nuclear receptor NHR-88	0.0165	0.4467	0.4467
Brugia malayi	ecdysone receptor	0.0165	0.4467	0.4467
Brugia malayi	hypothetical protein	0.0019	0.0094	0.0094
Schistosoma mansoni	cell adhesion molecule	0.0027	0.0347	0.0326
Loa Loa (eye worm)	hypothetical protein	0.035	1	1
Echinococcus granulosus	roundabout 2	0.0027	0.0347	0.0347
Echinococcus granulosus	C type lectin domian containing protein	0.0019	0.0094	0.0094
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0112	0.2876	0.2876
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.035	1	1
Brugia malayi	MAP kinase sur-1	0.0062	0.137	0.137
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0094	0.0094
Echinococcus granulosus	titin	0.0021	0.0144	0.0144
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0017	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0199	0.0199
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0079	0.1908	0.1908
Schistosoma mansoni	titin	0.0021	0.0144	0.0122
Schistosoma mansoni	plexin	0.0021	0.0151	0.013
Trichomonas vaginalis	CMGC family protein kinase	0.0062	0.137	0.5
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0062	0.137	0.137
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.035	1	1
Echinococcus multilocularis		0.0056	0.1196	0.1196
Schistosoma mansoni	coup transcription factor	0.035	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0027	0.0347	0.0347
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0165	0.4467	0.4455
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0017	0.0022	0.0022
Brugia malayi	nuclear receptor NHR-67	0.0165	0.4467	0.4467
Brugia malayi	hypothetical protein	0.0019	0.0094	0.0094
Echinococcus multilocularis	Immunoglobulin	0.0022	0.0199	0.0199
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0185	0.5059	0.5049
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0027	0.0347	0.0347
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.035	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.035	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.002	0.0127	0.0127
Brugia malayi	steroid hormone receptor	0.035	1	1
Onchocerca volvulus		0.002	0.0127	0.0034
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0079	0.1908	0.1908
Onchocerca volvulus		0.0165	0.4467	0.4415
Onchocerca volvulus	Protein ultraspiracle homolog	0.035	1	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0112	0.2876	0.2876
Loa Loa (eye worm)	projectin	0.002	0.0127	0.0127
Schistosoma mansoni	ephrin receptor	0.0023	0.0214	0.0193
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.035	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.035	1	1
Brugia malayi	Nuclear hormone receptor-like 1	0.035	1	1
Echinococcus multilocularis	roundabout 2	0.005	0.102	0.102
Echinococcus multilocularis	epidermal growth factor receptor	0.0105	0.2676	0.2676
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.035	1	1
Schistosoma mansoni	retinoic acid receptor RXR	0.035	1	1
Brugia malayi	hypothetical protein	0.0036	0.0607	0.0607
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0094	0.0094
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0017	0.0022	0.0022
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0027	0.0347	0.0347
Schistosoma mansoni	serine/threonine protein kinase	0.0021	0.0144	0.0122
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.035	1	1
Brugia malayi	tailless protein	0.0165	0.4467	0.4467
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0165	0.4467	0.4415

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.07 uM	Inhibition of Sky (unknown origin) in presence of 60 uM ATP by ELISA	ChEMBL.	23312472
IC50 (binding)	= 0.07 uM	Inhibition of Sky (unknown origin) by ELISA kinase assay in presence of 60 uM ATP	ChEMBL.	23312943
IC50 (binding)	= 0.775 uM	Inhibition of Mer (unknown origin)	ChEMBL.	23312472
IC50 (binding)	= 3.99 uM	Inhibition of Axl (unknown origin)	ChEMBL.	23312472
IC50 (binding)	= 4.09 uM	Inhibition of EGFR (unknown origin)	ChEMBL.	23312472
IC50 (binding)	= 6 uM	Inhibition of HGFR (unknown origin)	ChEMBL.	23312472
IC50 (binding)	= 7.4 uM	Inhibition of P-selectin aggregation in platelet surface (unknown origin)	ChEMBL.	23312943
IC50 (binding)	= 7.71 uM	Inhibition of TRKA (unknown origin)	ChEMBL.	23312472
IC50 (binding)	= 15.95 uM	Inhibition of MAPK1/ERK2 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	= 15.96 uM	Inhibition of VEGFR2/FLK1 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	= 16.36 uM	Inhibition of ABL (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of TAOK3 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of SRC (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of SGK (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of PKCzeta (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of PIM2 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of PDK1 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of PAK4 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of MAPKAP-K2 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of LCK (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of INSR (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of IKKi (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of IKKbeta (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of GSK3beta (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of FGFR1 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of CK1delta (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of CHK2 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of CHK1 (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of CDK2/cyclin A (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of BTK (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of Aurora A (unknown origin)	ChEMBL.	23312472
IC50 (binding)	> 30 uM	Inhibition of AKT1 (unknown origin)	ChEMBL.	23312472
Inhibition (binding)	= 33 %	Displacement of [3H]dofetilide from human ERG at 10 uM	ChEMBL.	23312943

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2312304

Bibliographic References

2 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1740591