TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 383.442 | Formula: C24H21N3O2
H donors: 3 H acceptors: 2 LogP: 4.07 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc2c(c1)c1CCN(Cc1[nH]2)C(=O)Nc1ccc(cc1)c1ccccc1
InChi: 1S/C24H21N3O2/c28-19-10-11-22-21(14-19)20-12-13-27(15-23(20)26-22)24(29)25-18-8-6-17(7-9-18)16-4-2-1-3-5-16/h1-11,14,26,28H,12-13,15H2,(H,25,29)
InChiKey: ACXFNIABNDSHLJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Transient receptor potential cation channel subfamily A member 1	Starlite/ChEMBL	References
Homo sapiens	transient receptor potential cation channel, subfamily V, member 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	Transient receptor potential cation channel subfamily A member 1, putative	Get druggable targets OG5_132409	All targets in OG5_132409
Schistosoma japonicum	Transient receptor potential cation channel subfamily A member 1, putative	Get druggable targets OG5_132409	All targets in OG5_132409
Schistosoma japonicum	ko:K04984 transient receptor potential cation channel, subfamily A, member 1, putative	Get druggable targets OG5_132409	All targets in OG5_132409
Echinococcus multilocularis	ankyrin repeat protein	Get druggable targets OG5_132409	All targets in OG5_132409
Schistosoma japonicum	Transient receptor potential cation channel subfamily A member 1, putative	Get druggable targets OG5_132409	All targets in OG5_132409
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	Get druggable targets OG5_132409	All targets in OG5_132409
Echinococcus multilocularis	transient receptor potential cation channel	Get druggable targets OG5_132409	All targets in OG5_132409
Echinococcus granulosus	transient receptor potential cation channel	Get druggable targets OG5_132409	All targets in OG5_132409
Echinococcus granulosus	ankyrin repeat protein	Get druggable targets OG5_132409	All targets in OG5_132409

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	geminin	0.0182	0.664	0.9023
Schistosoma mansoni	nck2/grb4	0.0076	0.1154	0.1612
Schistosoma mansoni	suppressor of cytokine signaling	0.0076	0.1154	0.1612
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0053	0.00000020798	0.00000031127
Trichomonas vaginalis	TKL family protein kinase	0.0053	0.00000020798	0.00000031127
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0076	0.1154	0.1565
Schistosoma mansoni	protein kinase	0.0054	0.0015	0.0021
Entamoeba histolytica	protein kinase, putative	0.0076	0.1154	0.1727
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0129	0.3912	0.5316
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.061	0.0913
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Echinococcus multilocularis		0.0076	0.1154	0.1565
Schistosoma mansoni	tyrosine kinase	0.0129	0.3927	0.5487
Entamoeba histolytica	SH2 domain containing protein	0.0076	0.1154	0.1727
Echinococcus granulosus	phosphoglycerate kinase 1	0.0183	0.6682	0.9079
Schistosoma mansoni	tensin	0.0076	0.1154	0.1612
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0129	0.3912	0.5305
Onchocerca volvulus		0.0076	0.1154	0.295
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0067	0.0707	0.1058
Brugia malayi	hypothetical protein	0.0129	0.3912	0.5855
Echinococcus granulosus	tyrosine kinase	0.0129	0.3912	0.5316
Echinococcus multilocularis	phosphoglycerate kinase 1	0.0183	0.6682	0.906
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0076	0.1154	0.1565
Echinococcus multilocularis	muscleblind protein 1	0.016	0.5527	0.7494
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0076	0.1154	0.1565
Echinococcus multilocularis	integrin linked protein kinase	0.0053	0.00000020798	0.00000028201
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0129	0.3912	0.5316
Schistosoma mansoni	SH2A	0.0076	0.1154	0.1612
Schistosoma mansoni	shc transforming protein	0.0076	0.1154	0.1612
Schistosoma mansoni	transient receptor potential cation channel subfamily A member	0.0192	0.7158	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0183	0.6682	1
Onchocerca volvulus		0.0076	0.1154	0.295
Loa Loa (eye worm)	hypothetical protein	0.0183	0.6682	1
Echinococcus granulosus	signal transduction protein lnk realted	0.0076	0.1154	0.1568
Echinococcus granulosus	tyrosine protein kinase Blk	0.0129	0.3912	0.5316
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Schistosoma mansoni	GTPase activating protein	0.0076	0.1154	0.1612
Loa Loa (eye worm)	SH2 domain-containing protein	0.0076	0.1154	0.1727
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0067	0.0707	0.1058
Brugia malayi	Protein kinase domain containing protein	0.0129	0.3912	0.5855
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	SH2 motif	0.0076	0.1154	0.1565
Schistosoma mansoni	growth factor receptor-bound protein	0.0076	0.1154	0.1612
Brugia malayi	protein-tyrosine kinase	0.0129	0.3912	0.5855
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0076	0.1154	0.1727
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0129	0.3912	0.5305
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Echinococcus multilocularis	muscleblind protein	0.016	0.5527	0.7494
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0076	0.1154	0.1727
Schistosoma mansoni	tyrosine kinase	0.0129	0.3912	0.5465
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0076	0.1154	0.1565
Echinococcus granulosus	tyrosine protein kinase shark	0.0129	0.3927	0.5336
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0076	0.1154	0.1727
Echinococcus granulosus	integrin linked protein kinase	0.0053	0.00000020798	0.00000028259
Onchocerca volvulus		0.0076	0.1154	0.295
Echinococcus granulosus	SH2 motif	0.0076	0.1154	0.1568
Echinococcus granulosus	muscleblind protein	0.016	0.5527	0.751
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0076	0.1154	0.1727
Onchocerca volvulus		0.0129	0.3912	1
Wolbachia endosymbiont of Brugia malayi	phosphoglycerate kinase	0.0183	0.6682	0.5
Trypanosoma brucei	phosphoglycerate kinase	0.0067	0.0707	0.1058
Schistosoma mansoni	hypothetical protein	0.0076	0.1154	0.1612
Echinococcus granulosus	SH2 domain containing protein 7	0.0076	0.1154	0.1568
Loa Loa (eye worm)	SH2 domain-containing protein	0.0076	0.1154	0.1727
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0129	0.3912	0.5316
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0129	0.3912	0.5305
Loa Loa (eye worm)	SRC-1	0.0129	0.3912	0.5855
Echinococcus granulosus	SH2 motif	0.0076	0.1154	0.1568
Echinococcus multilocularis	transient receptor potential cation channel	0.0196	0.7375	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0129	0.3912	0.5316
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0129	0.3912	0.5305
Brugia malayi	Muscleblind-like protein	0.016	0.5527	0.8272
Treponema pallidum	phosphoglycerate kinase	0.0183	0.6682	0.5
Echinococcus granulosus	expressed conserved protein	0.0076	0.1154	0.1568
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.1154	0.1727
Schistosoma mansoni	tyrosine kinase	0.0129	0.3912	0.5465
Schistosoma mansoni	phosphoglycerate kinase	0.0183	0.6682	0.9335
Loa Loa (eye worm)	SH2 domain-containing protein	0.0076	0.1154	0.1727
Schistosoma mansoni	adapter molecule crk	0.0076	0.1154	0.1612
Onchocerca volvulus		0.0053	0.00000020798	0.00000053164
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.1154	0.1727
Trichomonas vaginalis	TKL family protein kinase	0.0053	0.00000020798	0.00000031127
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Leishmania major	phosphoglycerate kinase C, glycosomal	0.0183	0.6682	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0076	0.1154	0.1727
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0076	0.1154	0.1568
Echinococcus granulosus	hypothetical protein	0.0076	0.1154	0.1568
Echinococcus granulosus	SHC transforming protein 3	0.0076	0.1154	0.1568
Echinococcus granulosus	growth factor receptor bound protein 2	0.0076	0.1154	0.1568
Onchocerca volvulus		0.0076	0.1154	0.295
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0129	0.3912	0.5305
Toxoplasma gondii	phosphoglycerate kinase PGKI	0.0183	0.6682	1
Plasmodium falciparum	phosphoglycerate kinase	0.0183	0.6682	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0129	0.3912	0.5316
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0053	0.00000020798	0.00000031127
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Leishmania major	PAS-domain containing phosphoglycerate kinase, putative	0.0067	0.0707	0.1058
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0129	0.3912	0.5305
Brugia malayi	SH2 domain containing protein	0.0076	0.1154	0.1727
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0129	0.3912	0.5316
Onchocerca volvulus		0.0129	0.3912	1
Onchocerca volvulus		0.0129	0.3912	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0129	0.3912	0.5316
Echinococcus multilocularis	NCK adaptor protein	0.0076	0.1154	0.1565
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Onchocerca volvulus		0.0129	0.3912	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0076	0.1154	0.1727
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.061	0.0827
Brugia malayi	Protein kinase domain containing protein	0.0129	0.3912	0.5855
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Brugia malayi	Protein kinase domain containing protein	0.0129	0.3912	0.5855
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0076	0.1154	0.1568
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0129	0.3912	0.5465
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	tensin	0.0076	0.1154	0.1565
Brugia malayi	Tensin	0.0076	0.1154	0.1727
Entamoeba histolytica	protein kinase, putative	0.0053	0.00000020798	0.00000031127
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0129	0.3912	0.5305
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Brugia malayi	SRC-1	0.0129	0.3912	0.5855
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0129	0.3912	0.5855
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0076	0.1154	0.1568
Giardia lamblia	Phosphoglycerate kinase	0.0183	0.6682	1
Schistosoma mansoni	suppressor of cytokine signaling	0.0076	0.1154	0.1612
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0129	0.3912	0.5305
Brugia malayi	Variant SH3 domain containing protein	0.0076	0.1154	0.1727
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0076	0.1154	0.1568
Schistosoma mansoni	tensin-related	0.0076	0.1154	0.1612
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0183	0.6682	1
Trypanosoma cruzi	phosphoglycerate kinase, putative	0.0183	0.6682	1
Entamoeba histolytica	phosphoglycerate kinase, putative	0.0183	0.6682	1
Onchocerca volvulus		0.0076	0.1154	0.295
Schistosoma mansoni	tensin	0.0076	0.1154	0.1612
Onchocerca volvulus		0.0129	0.3912	1
Onchocerca volvulus		0.0076	0.1154	0.295
Loa Loa (eye worm)	STAT protein	0.0076	0.1154	0.1727
Chlamydia trachomatis	phosphoglycerate kinase	0.0183	0.6682	0.5
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0076	0.1154	0.1565
Echinococcus granulosus	ankyrin repeat protein	0.0192	0.7158	0.9726
Brugia malayi	RhoGAP domain containing protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0129	0.3912	0.5305
Echinococcus multilocularis	signal transduction protein lnk realted	0.0076	0.1154	0.1565
Echinococcus multilocularis	c src tyrosine kinase	0.0129	0.3912	0.5305
Echinococcus multilocularis	SH2 domain containing protein 7	0.0076	0.1154	0.1565
Echinococcus multilocularis	SH2 motif	0.0076	0.1154	0.1565
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0076	0.1154	0.295
Echinococcus granulosus	NCK adaptor protein	0.0076	0.1154	0.1568
Brugia malayi	hypothetical protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	SH2 motif	0.0076	0.1154	0.1565
Toxoplasma gondii	phosphoglycerate kinase PGKII	0.0183	0.6682	1
Trichomonas vaginalis	TKL family protein kinase	0.0053	0.00000020798	0.00000031127
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0129	0.3912	0.5305
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0129	0.3912	0.5305
Loa Loa (eye worm)	TK protein kinase	0.0129	0.3912	0.5855
Brugia malayi	SH2 domain containing protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0129	0.3912	0.5305
Schistosoma mansoni	growth factor receptor-bound protein	0.0076	0.1154	0.1612
Schistosoma mansoni	tyrosine kinase	0.0129	0.3912	0.5465
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0076	0.1154	0.1568
Loa Loa (eye worm)	hypothetical protein	0.016	0.5527	0.8272
Brugia malayi	SH2 domain containing protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	geminin	0.0182	0.664	0.9004
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0129	0.3912	0.5305
Echinococcus multilocularis	tyrosine kinase	0.0129	0.3912	0.5305
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Brugia malayi	Sex muscle abnormal protein 5	0.0076	0.1154	0.1727
Giardia lamblia	Kinase, NEK	0.0054	0.0015	0.0023
Brugia malayi	Tyrosine-protein kinase abl-1	0.0129	0.3912	0.5855
Schistosoma mansoni	hypothetical protein	0.0182	0.664	0.9277
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0076	0.1154	0.1565
Brugia malayi	Protein kinase domain containing protein	0.0129	0.3912	0.5855
Leishmania major	phosphoglycerate kinase B, cytosolic	0.0183	0.6682	1
Echinococcus granulosus	tensin	0.0076	0.1154	0.1568
Giardia lamblia	Protein 21.1	0.0053	0.00000020798	0.00000031127
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Schistosoma mansoni	tensin	0.0076	0.1154	0.1612
Entamoeba histolytica	protein kinase, putative	0.0053	0.00000020798	0.00000031127
Trypanosoma brucei	phosphoglycerate kinase, putative	0.0067	0.0707	0.1058
Mycobacterium tuberculosis	Probable phosphoglycerate kinase Pgk	0.0183	0.6682	0.6466
Trypanosoma cruzi	3-phosphoglycerate kinase, glycosomal	0.0067	0.0707	0.1058
Echinococcus granulosus	transient receptor potential cation channel	0.0196	0.736	1
Echinococcus granulosus	tyrosine protein kinase Srms	0.0129	0.3912	0.5316
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.061	0.0852
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0076	0.1154	0.1568
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0067	0.0707	0.1058
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0076	0.1154	0.1727
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0076	0.1154	0.1727
Schistosoma mansoni	tyrosine kinase	0.0129	0.3912	0.5465
Schistosoma mansoni	vav2	0.0076	0.1154	0.1612
Trypanosoma cruzi	PAS-domain containing phosphoglycerate kinase, putative	0.0067	0.0707	0.1058
Schistosoma mansoni	tensin-related	0.0076	0.1154	0.1612
Trypanosoma brucei	phosphoglycerate kinase	0.0183	0.6682	1
Schistosoma mansoni	hypothetical protein	0.0076	0.1154	0.1612
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Plasmodium vivax	phosphoglycerate kinase, putative	0.0183	0.6682	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0076	0.1154	0.1727
Brugia malayi	SH2 domain containing protein	0.0129	0.3912	0.5855
Loa Loa (eye worm)	TK/ABL protein kinase	0.0129	0.3912	0.5855
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0076	0.1154	0.1612
Brugia malayi	SH2 domain containing protein	0.0076	0.1154	0.1727
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Mycobacterium ulcerans	phosphoglycerate kinase	0.0183	0.6682	1
Schistosoma mansoni	tyrosine kinase	0.0129	0.3912	0.5465
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0076	0.1154	0.1612
Brugia malayi	Phosphoglycerate kinase	0.0067	0.0707	0.1058
Echinococcus multilocularis	SHC transforming protein 3	0.0076	0.1154	0.1565
Echinococcus multilocularis	tensin	0.0076	0.1154	0.1565
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0129	0.3912	0.5316
Brugia malayi	SH2 domain containing protein	0.0076	0.1154	0.1727
Echinococcus granulosus	N chimaerin	0.0076	0.1154	0.1568
Trypanosoma brucei	phosphoglycerate kinase	0.0183	0.6682	1
Schistosoma mansoni	phosphoglycerate kinase	0.0183	0.6682	0.9335
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0129	0.3912	0.5316
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0053	0.00000020798	0.00000031127
Echinococcus multilocularis	tyrosine protein kinase shark	0.0129	0.3927	0.5325
Brugia malayi	Phosphoglycerate kinase	0.0183	0.6682	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.1154	0.1612
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0076	0.1154	0.1568
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0129	0.3912	0.5316
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0076	0.1154	0.295
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.061	0.0913
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0076	0.1154	0.1568
Entamoeba histolytica	ankyrin repeat protein	0.0053	0.00000020798	0.00000031127
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0129	0.3912	0.5316
Brugia malayi	Protein kinase domain containing protein	0.0129	0.3912	0.5855
Echinococcus granulosus	c src tyrosine kinase	0.0129	0.3912	0.5316
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0076	0.1154	0.1612
Trichomonas vaginalis	phosphoglycerate kinase, putative	0.0183	0.6682	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0076	0.1154	0.1565
Brugia malayi	integrin-linked kinase	0.0053	0.00000020798	0.00000031127
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0129	0.3912	0.5316
Brugia malayi	SH2 domain containing protein	0.0076	0.1154	0.1727
Mycobacterium leprae	Probable phosphoglycerate kinase Pgk	0.0183	0.6682	0.5
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0076	0.1154	0.1612
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Schistosoma mansoni	signal transduction protein lnk-related	0.0076	0.1154	0.1612
Echinococcus multilocularis	ankyrin repeat protein	0.0192	0.7158	0.9706
Echinococcus granulosus	tyrosine kinase	0.0129	0.3912	0.5316
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0129	0.3912	0.5305
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0129	0.3912	0.5305
Trichomonas vaginalis	TKL family protein kinase	0.0053	0.00000020798	0.00000031127
Brugia malayi	Protein kinase domain containing protein	0.0053	0.00000020798	0.00000031127
Loa Loa (eye worm)	hypothetical protein	0.0129	0.3912	0.5855
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0076	0.1154	0.1568
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.061	0.0829
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Brugia malayi	SH2 domain containing protein	0.0129	0.3912	0.5855
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0076	0.1154	0.1565
Schistosoma mansoni	hypothetical protein	0.0182	0.664	0.9277
Loa Loa (eye worm)	hypothetical protein	0.0076	0.1154	0.1727
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0129	0.3912	0.5305
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0076	0.1154	0.1727
Loa Loa (eye worm)	hypothetical protein	0.016	0.5527	0.8272
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.061	0.0852
Brugia malayi	SH2 domain containing protein	0.0076	0.1154	0.1727
Loa Loa (eye worm)	TK/FER protein kinase	0.0129	0.3912	0.5855
Schistosoma mansoni	protein kinase	0.0054	0.0015	0.0021
Echinococcus multilocularis	N chimaerin	0.0076	0.1154	0.1565
Onchocerca volvulus		0.0129	0.3912	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0076	0.1154	0.1565
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0076	0.1154	0.1565

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (binding)	= 0.17 uM	Agonist activity at human TRPV1 overexpressed in HEK293 cells assessed as increase in ionomycin-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis	ChEMBL.	23206861
EC50 (binding)	= 1.82 uM	Agonist activity at rat TRPA1 overexpressed in HEK293 cells assessed as increase in allyl isothiocyanate-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis	ChEMBL.	23206861
Efficacy (binding)	= 73.9 %	Agonist activity at human TRPV1 overexpressed in HEK293 cells assessed as increase in ionomycin-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis relative to control	ChEMBL.	23206861
Efficacy (binding)	= 93.3 %	Agonist activity at rat TRPA1 overexpressed in HEK293 cells assessed as increase in allyl isothiocyanate-induced intracellular Ca2+ level by Fluo-4 based spectrofluorimetric analysis relative to control	ChEMBL.	23206861
IC50 (binding)	= 0.14 uM	Antagonist activity at human TRPV1 overexpressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level incubated for 5 mins prior to capsaicin addition by Fluo-4 based spectrofluorimetric analysis	ChEMBL.	23206861
IC50 (binding)	= 18.84 uM	Antagonist activity at rat TRPA1 overexpressed in HEK293 cells assessed as inhibition of allyl isothiocyanate-induced intracellular Ca2+ level incubated for 5 mins prior to allyl isothiocyanate addition by Fluo-4 based spectrofluorimetric analysis	ChEMBL.	23206861
IC50 (binding)	> 50 uM	Inhibition of FAAH in rat brain homogenates using [14C]anandamide as substrate assessed as formation of [14C]ethanolamine after 30 mins by scintillation counting analysis	ChEMBL.	23206861

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2312054

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1740606