Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0735 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0735 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0735 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0735 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0735 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0735 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0735 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0735 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0735 | 0.5 | 0.5 | |
Brugia malayi | Protein kinase domain containing protein | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0735 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0735 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0735 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0735 | 0.5 | 0.5 |
Brugia malayi | hypothetical protein | 0.0735 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0735 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0735 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0735 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0735 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0735 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0735 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0735 | 0.5 | 0.5 | |
Onchocerca volvulus | 0.0735 | 0.5 | 0.5 | |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0735 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AD50 (functional) | = 2.52 nM mouse-1 | Compound was tested for antinociceptive potency using mouse writhing pain assay | ChEMBL. | 12825947 |
AD50 (functional) | = 2.52 nM mouse-1 | Compound was tested for antinociceptive potency using mouse writhing pain assay | ChEMBL. | 12825947 |
IC50 (functional) | = 3.52 uM | Compound was tested for inhibition against [3H]-Raclopride to Rat brain membranes | ChEMBL. | 12825947 |
Potency ratio (functional) | = 0.17 | Relative potency ratio of the compound was determined | ChEMBL. | 12825947 |
Potency ratio (functional) | = 9.12 | Potency ratio of the compound was determined in mouse writhing pain assay | ChEMBL. | 12825947 |
T1/2 (ADMET) | = 60 min | Compound was tested for the time of half maximal response decay of HN at dose 10 nmol administered in mouse | ChEMBL. | 12825947 |
T1/2 (ADMET) | = 60 min | Compound was tested for the time of half maximal response decay of HN at dose 10 nmol administered in mouse | ChEMBL. | 12825947 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.