Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | tyrosine protein kinase Fps85D | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0759 | 0.5 | 0.5 |
Brugia malayi | SRC-1 | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0759 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0759 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0759 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | c src tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0759 | 0.5 | 0.5 | |
Brugia malayi | SH2 domain containing protein | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Blk | 0.0759 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase|tyrosine protein kinase Fyn | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0759 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK protein kinase | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Brugia malayi | SH2 domain containing protein | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0759 | 0.5 | 0.5 |
Entamoeba histolytica | SH2-protein kinase domain containing protein | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Srms | 0.0759 | 0.5 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0759 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0759 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0759 | 0.5 | 0.5 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0759 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0759 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Blk | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fps85D | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0759 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0759 | 0.5 | 0.5 | |
Brugia malayi | hypothetical protein | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Srms | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0759 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0759 | 0.5 | 0.5 | |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | SRC-1 | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0759 | 0.5 | 0.5 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0759 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/FER protein kinase | 0.0759 | 0.5 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0759 | 0.5 | 0.5 | |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0759 | 0.5 | 0.5 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0759 | 0.5 | 0.5 |
Brugia malayi | protein-tyrosine kinase | 0.0759 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 8 | Activity expressed as no. of revertants per plate in Salmonella typhimurium TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 50 ug | ChEMBL. | 6827551 |
Activity (functional) | = 9 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 500 ug | ChEMBL. | 6827551 |
Activity (functional) | = 11 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 100 ug | ChEMBL. | 6827551 |
Activity (functional) | = 13 | Activity expressed as no. of revertants per plate in strain TA1535 with hamster S9 cells (3 mg/plate) | ChEMBL. | 6827551 |
Activity (functional) | = 14 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 1 ug | ChEMBL. | 6827551 |
Activity (functional) | = 14 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 1000 ug | ChEMBL. | 6827551 |
Activity (functional) | = 15 | Mutagenicity against Salmonella tester strain TA 1535 without hamster S9 mix (3 mg/plate) in cells. | ChEMBL. | 3510299 |
Activity (functional) | = 16 | Activity expressed as no. of revertants per plate in Salmonella typhimurium TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 50 ug | ChEMBL. | 6827551 |
Activity (functional) | = 16 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 250 ug | ChEMBL. | 6827551 |
Activity (functional) | = 17 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells. | ChEMBL. | 3510299 |
Activity (functional) | = 19 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 2.5 ug | ChEMBL. | 6827551 |
Activity (functional) | = 19 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells. Activity expressed as no. of cells | ChEMBL. | 3510299 |
Activity (functional) | = 21 | Activity expressed as no. of revertants per plate in strain TA1535 with hamster S9 cells (3 mg/plate) | ChEMBL. | 6827551 |
Activity (functional) | = 21 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells. | ChEMBL. | 3510299 |
Activity (functional) | = 23 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 10 ug | ChEMBL. | 6827551 |
Activity (functional) | = 25 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 1 ug | ChEMBL. | 6827551 |
Activity (functional) | = 26 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 2.5 ug | ChEMBL. | 6827551 |
Activity (functional) | = 27 | Activity expressed as no. of revertants per plate in Salmonella typhimurium TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 50 ug | ChEMBL. | 6827551 |
Activity (functional) | = 29 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 5 ug | ChEMBL. | 6827551 |
Activity (functional) | = 29 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 25 ug | ChEMBL. | 6827551 |
Activity (functional) | = 30 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 5 ug | ChEMBL. | 6827551 |
Activity (functional) | = 32 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 10 ug | ChEMBL. | 6827551 |
Activity (functional) | = 45 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 25 ug | ChEMBL. | 6827551 |
Activity (functional) | = 101 | Activity expressed as no. of revertants per plate in Salmonella typhimurium TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 50 ug | ChEMBL. | 6827551 |
Activity (functional) | = 222 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 100 ug | ChEMBL. | 6827551 |
Activity (functional) | = 623 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 250 ug | ChEMBL. | 6827551 |
Activity (functional) | = 718 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 500 ug | ChEMBL. | 6827551 |
Activity (functional) | = 789 | Activity expressed as no. of revertants per plate in strain TA1535 with and without hamster S9 cells (3 mg/plate) at the dose of 1000 ug | ChEMBL. | 6827551 |
Log 1/C (ADMET) | = -2.78 | Concentration in nanomoles/plate to induce 50 revertants/plate. | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 12 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 1 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 12 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 10 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 12 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 50 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 12 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 500 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 13 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 5 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 15 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 2.5 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 15 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 250 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 16 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 5 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 16 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 25 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 16 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 100 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 16 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with out hamster S9 mix (3 mg/plate) in cells at dose of 1000 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 18 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 2.5 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 21 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 1 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 23 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 10 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 28 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 25 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 37 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 50 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 42 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 100 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 98 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 250 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 180 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 500 ug | ChEMBL. | 3510299 |
No. of revertants per plate (functional) | = 234 | compound was tested for mutagenicity against Salmonella tester strain TA 1535 with hamster S9 mix (3 mg/plate) in cells at dose of 1000 ug | ChEMBL. | 3510299 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.