Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adrenoceptor beta 3 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 1 | Starlite/ChEMBL | References |
Homo sapiens | adrenoceptor beta 2, surface | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activation (functional) | = 33 % | Agonism of human beta-3 adrenergic receptor | ChEMBL. | 9873681 |
Activation (functional) | = 33 % | Agonism of human beta-3 adrenergic receptor | ChEMBL. | 9873681 |
EC50 (functional) | = 68 nM | Agonism against Beta-3 adrenergic receptor | ChEMBL. | 9873681 |
EC50 (functional) | = 68 nM | Agonism against Beta-3 adrenergic receptor | ChEMBL. | 9873681 |
IC50 (binding) | = 2000 nM | Beta-1 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindolol | ChEMBL. | 9873681 |
IC50 (binding) | = 2000 nM | Beta-1 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindolol | ChEMBL. | 9873681 |
IC50 (binding) | = 8000 nM | Beta-2 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindolol | ChEMBL. | 9873681 |
IC50 (binding) | = 8000 nM | Beta-2 adrenergic receptor binding affinity in CHO cells expressing cloned human receptor in the presence of 125 I-iodocyanopindolol | ChEMBL. | 9873681 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.