Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adrenergic receptor alpha-1 | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | 0 nM | Displacement of clonidine from Alpha-2 adrenergic receptor of rat brain cortex | ChEMBL. | 9703460 |
Ki (binding) | > 10000 nM | Binding affinity towards Alpha-1 adrenergic receptor measured by displacement of [3H]-prazosin from rat brain cortex membranes | ChEMBL. | 9703460 |
Ki (binding) | > 10000 nM | Binding affinity towards Alpha-1 adrenergic receptor measured by displacement of [3H]-prazosin from rat brain cortex membranes | ChEMBL. | 9703460 |
Ratio (binding) | 0 | Relative affinity for alpha2 and alpha1 adrenergic receptors | ChEMBL. | 9703460 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.