Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Peroxidase homolog | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0074 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0074 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.5 | 0.5 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0074 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0074 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0074 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0074 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0074 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0074 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0074 | 0.5 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0074 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0074 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0074 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0074 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = -29.9 % | Cytotoxicity against human HepG2 cells assessed as cellular growth at 50 uM incubated for 1 hr prior to TNF alpha stimulation measured after 48 hrs by SRB assay | ChEMBL. | 23219854 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.