Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -5.9 | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = -5.6 | Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = 1.3 uM | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = 1.3 uM | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = 2.6 uM | Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats | ChEMBL. | 2296019 |
IC50 (binding) | = 2.6 uM | Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats | ChEMBL. | 2296019 |
Log IC50 (binding) | = -5.9 | Ability to inhibit HMG-CoA reductase (HMGR) by cholesterol synthesis inhibition screen (CSI) in rats | ChEMBL. | 2296019 |
Log IC50 (binding) | = -5.6 | Ability to inhibit HMG-CoA reductase (HMGR) by CoA reductase inhibition screen (COR) in rats | ChEMBL. | 2296019 |
Relative potency (binding) | = 1.8 | Ratio of inhibitory activity of compound against HMG-CoA reductase to that of compactin | ChEMBL. | 2296019 |
Relative potency (binding) | = 1.8 | Ratio of inhibitory activity of compound against HMG-CoA reductase to that of compactin | ChEMBL. | 2296019 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.