Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | valosin containing protein | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | pantoate--beta-alanine ligase | 0.5131 | 1 | 1 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.002 | 0.0015 | 1 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.0032 | 0.0039 | 0.5 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0034 | 0.0043 | 1 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0034 | 0.0043 | 0.5 |
Echinococcus granulosus | transitional endoplasmic reticulum atpase | 0.0034 | 0.0043 | 0.5 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0034 | 0.0043 | 0.5 |
Mycobacterium tuberculosis | Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) | 0.5131 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0034 | 0.0043 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0015 | 1 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.0032 | 0.0039 | 0.5 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0034 | 0.0043 | 0.0027 |
Brugia malayi | valosin containing protein | 0.002 | 0.0015 | 1 |
Brugia malayi | vesicle-fusing ATPase | 0.002 | 0.0015 | 1 |
Giardia lamblia | AAA family ATPase | 0.002 | 0.0016 | 0.5 |
Entamoeba histolytica | cdc48-like protein, putative | 0.0032 | 0.0039 | 0.5 |
Toxoplasma gondii | cell division protein CDC48AP | 0.002 | 0.0016 | 0.000000026274 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.0032 | 0.0039 | 0.5 |
Toxoplasma gondii | pantoate-beta-alanine ligase | 0.5131 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0032 | 0.0039 | 0.9122 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.0032 | 0.0039 | 1 |
Trypanosoma brucei | Valosin-containing protein | 0.0032 | 0.0039 | 0.5 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.0032 | 0.0039 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.375 uM | Inhibition of human recombinant His-GST tagged VCP expressed in baculovirus infected Hi5 cells assessed as ADP formation incubated for 20 mins proir to substrate addition measured after 90 mins by NADH coupled assay | ChEMBL. | 23245311 |
IC50 (functional) | > 20 uM | Cytotoxicity against human HCT116 cells after 72 hrs by luciferase reporter gene assay | ChEMBL. | 23245311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.