Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1052 | 0.3787 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0018 | 0.0009 | 0.0009 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2751 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1052 | 0.3787 | 1 |
Echinococcus multilocularis | tumor protein p63 | 0.0334 | 0.1162 | 0.1154 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.0373 | 0.0373 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0009 | 0.0009 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1052 | 0.3787 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2751 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2751 | 1 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.2751 | 1 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.2751 | 1 | 1 |
Echinococcus granulosus | tumor protein p63 | 0.0334 | 0.1162 | 0.1154 |
Onchocerca volvulus | 0.0049 | 0.012 | 1 | |
Echinococcus granulosus | dihydrofolate reductase | 0.2751 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0018 | 0.0009 | 0.0009 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2751 | 1 | 0.5 |
Brugia malayi | nuclear receptor NHR-88 | 0.0018 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.012 | 0.0111 |
Brugia malayi | ecdysteroid receptor | 0.0018 | 0.0009 | 0.0009 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2751 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0018 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.0373 | 0.0364 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1052 | 0.3787 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0032 | 0.0032 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0018 | 0.0009 | 0.0009 |
Schistosoma mansoni | dihydrofolate reductase | 0.2751 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.0373 | 0.0364 |
Brugia malayi | steroid hormone receptor | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0018 | 0.0009 | 0.0009 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0032 | 0.0024 |
Brugia malayi | nuclear hormone receptor | 0.0018 | 0.0009 | 0.0009 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0801 | 0.2871 | 0.2865 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0018 | 0.0009 | 0.0009 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0018 | 0.0009 | 0.0009 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1052 | 0.3787 | 1 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.012 | 0.0111 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1052 | 0.3787 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.