TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 464.598 | Formula: C24H40N4O5
H donors: 5 H acceptors: 4 LogP: 1.95 Rotable bonds: 16
Rule of 5 violations (Lipinski): 1
SMILES: N[C@H](C(=O)N[C@@H](C(=O)NCC(=O)NC(CC(C)C)C)COC(C)(C)C)Cc1ccc(cc1)O
InChi: 1S/C24H40N4O5/c1-15(2)11-16(3)27-21(30)13-26-23(32)20(14-33-24(4,5)6)28-22(31)19(25)12-17-7-9-18(29)10-8-17/h7-10,15-16,19-20,29H,11-14,25H2,1-6H3,(H,26,32)(H,27,30)(H,28,31)/t16?,19-,20+/m0/s1
InChiKey: PDXVJTHNKZZZIA-KHMGXFTDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Cavia porcellus	Mu opioid receptor	Starlite/ChEMBL	References
Rattus norvegicus	Mu opioid receptor	Starlite/ChEMBL	References
Rattus norvegicus	Delta opioid receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	tm gpcr rhodopsin	Get druggable targets OG5_139759	All targets in OG5_139759
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Get druggable targets OG5_139759	All targets in OG5_139759

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus multilocularis	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Echinococcus multilocularis	serotonin receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma japonicum	Probable G-protein coupled receptor No9, putative	Mu opioid receptor	98 aa	95 aa	28.4 %
Schistosoma japonicum	Alpha-1A adrenergic receptor, putative	Mu opioid receptor	98 aa	98 aa	34.7 %
Schistosoma japonicum	ko:K04207 neuropeptide Y receptor Y5, putative	Mu opioid receptor	98 aa	80 aa	31.2 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Delta opioid receptor	372 aa	330 aa	24.5 %
Echinococcus granulosus	neuropeptide Y receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	81 aa	34.6 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	38.2 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	98 aa	31.6 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	35.0 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Delta opioid receptor	372 aa	320 aa	25.6 %
Onchocerca volvulus	Programmed cell death protein 5 homolog	Mu opioid receptor	398 aa	323 aa	24.1 %
Schistosoma japonicum	ko:K04282 thyrotropin-releasing hormone receptor, putative	Mu opioid receptor	98 aa	100 aa	28.0 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	34.0 %
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Echinococcus multilocularis	allatostatin A receptor	Delta opioid receptor	372 aa	302 aa	28.5 %
Echinococcus granulosus	alpha 1A adrenergic receptor	Mu opioid receptor	98 aa	92 aa	21.7 %
Onchocerca volvulus		Delta opioid receptor	372 aa	386 aa	22.8 %
Onchocerca volvulus		Delta opioid receptor	372 aa	344 aa	22.1 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	79 aa	29.1 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Delta opioid receptor	372 aa	366 aa	22.7 %
Echinococcus granulosus	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	25.9 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Mu opioid receptor	98 aa	93 aa	33.3 %
Onchocerca volvulus		Mu opioid receptor	98 aa	81 aa	33.3 %
Onchocerca volvulus		Mu opioid receptor	98 aa	96 aa	24.0 %
Schistosoma japonicum	Rhodopsin, putative	Mu opioid receptor	398 aa	328 aa	23.2 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	97 aa	38.1 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	88 aa	39.8 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	100 aa	29.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	100 aa	25.0 %
Onchocerca volvulus		Delta opioid receptor	372 aa	316 aa	26.9 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	93 aa	30.1 %
Schistosoma japonicum	ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative	Mu opioid receptor	98 aa	97 aa	37.1 %
Echinococcus multilocularis	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma mansoni	adenoreceptor	Mu opioid receptor	98 aa	88 aa	38.6 %
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	Mu opioid receptor	98 aa	80 aa	37.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	21.5 %
Schistosoma japonicum	5-hydroxytryptamine receptor 4, putative	Mu opioid receptor	98 aa	79 aa	36.7 %
Onchocerca volvulus	Glycoprotein hormone beta 5 homolog	Mu opioid receptor	98 aa	92 aa	32.6 %
Echinococcus multilocularis	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Onchocerca volvulus		Mu opioid receptor	98 aa	85 aa	24.7 %
Schistosoma mansoni	thyrotropin-releasing hormone receptor	Mu opioid receptor	98 aa	100 aa	27.0 %
Schistosoma japonicum	Neuropeptide Y receptor type 2, putative	Mu opioid receptor	98 aa	79 aa	31.6 %
Schistosoma mansoni	biogenic amine (5HT) receptor	Mu opioid receptor	98 aa	97 aa	36.1 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Mu opioid receptor	398 aa	397 aa	22.7 %
Schistosoma japonicum	ko:K04165 Oamb gene product from transcript, putative	Mu opioid receptor	98 aa	79 aa	34.2 %
Loa Loa (eye worm)	melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	98 aa	37.8 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Schistosoma mansoni	hypothetical protein	Mu opioid receptor	98 aa	100 aa	23.0 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	31.5 %
Loa Loa (eye worm)	neuropeptide F receptor	Delta opioid receptor	372 aa	317 aa	23.3 %
Echinococcus granulosus	allatostatin A receptor	Delta opioid receptor	372 aa	302 aa	27.8 %
Onchocerca volvulus		Mu opioid receptor	98 aa	96 aa	28.1 %
Echinococcus granulosus	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Echinococcus multilocularis	neuropeptide FF receptor 2	Mu opioid receptor	98 aa	84 aa	31.0 %
Schistosoma japonicum	FMRFamide receptor, putative	Mu opioid receptor	98 aa	109 aa	28.4 %
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	Mu opioid receptor	98 aa	96 aa	29.2 %
Echinococcus granulosus	biogenic amine 5HT receptor	Mu opioid receptor	98 aa	96 aa	30.2 %
Schistosoma japonicum	Muscarinic acetylcholine receptor M1, putative	Mu opioid receptor	98 aa	95 aa	30.5 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	96 aa	31.2 %
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	Mu opioid receptor	98 aa	96 aa	32.3 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	85 aa	37.6 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	27.8 %
Onchocerca volvulus	26S proteasome non-ATPase regulatory subunit 1 homolog	Mu opioid receptor	98 aa	80 aa	28.8 %
Loa Loa (eye worm)	TYRA-2 protein	Mu opioid receptor	98 aa	87 aa	31.0 %
Schistosoma mansoni	neuropeptide F-like receptor	Mu opioid receptor	398 aa	335 aa	20.6 %
Schistosoma mansoni	neuropeptide receptor	Mu opioid receptor	98 aa	95 aa	32.6 %
Schistosoma japonicum	Neuropeptide Y receptor, putative	Mu opioid receptor	98 aa	88 aa	23.9 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	92 aa	23.9 %
Brugia malayi	G protein-coupled receptor	Mu opioid receptor	98 aa	90 aa	31.1 %
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Brugia malayi	ORL1-like opioid receptor	Delta opioid receptor	372 aa	300 aa	24.7 %
Echinococcus granulosus	g protein coupled receptor	Mu opioid receptor	98 aa	81 aa	24.7 %
Onchocerca volvulus	Mitochondrial inner membrane protein homolog	Mu opioid receptor	398 aa	334 aa	23.1 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Delta opioid receptor	372 aa	315 aa	28.6 %
Onchocerca volvulus		Delta opioid receptor	372 aa	349 aa	22.1 %
Echinococcus multilocularis	rhodopsin orphan GPCR	Mu opioid receptor	98 aa	80 aa	23.8 %
Brugia malayi	larval opioid receptor	Mu opioid receptor	98 aa	100 aa	24.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	86 aa	33.7 %
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	Mu opioid receptor	98 aa	99 aa	36.4 %
Echinococcus multilocularis	neuropeptide receptor	Mu opioid receptor	98 aa	88 aa	22.7 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	90 aa	28.9 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Delta opioid receptor	372 aa	330 aa	24.2 %
Schistosoma mansoni	neuropeptide F-like receptor	Mu opioid receptor	98 aa	85 aa	32.9 %
Brugia malayi	Serotonin/octopamine receptor family protein 7	Mu opioid receptor	98 aa	85 aa	32.9 %
Schistosoma mansoni	amine GPCR	Mu opioid receptor	98 aa	86 aa	32.6 %
Onchocerca volvulus		Mu opioid receptor	98 aa	79 aa	31.6 %
Schistosoma japonicum	Octopamine receptor, putative	Mu opioid receptor	98 aa	88 aa	37.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	101 aa	20.8 %
Onchocerca volvulus	RB1-inducible coiled-coil protein 1 homolog	Mu opioid receptor	98 aa	96 aa	31.2 %
Brugia malayi	GnHR receptor homolog	Delta opioid receptor	372 aa	313 aa	18.5 %
Schistosoma japonicum	ko:K04145 dopamine receptor D2, putative	Mu opioid receptor	98 aa	89 aa	40.4 %
Onchocerca volvulus	Phospholipase d-related homolog	Mu opioid receptor	98 aa	82 aa	25.6 %
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	Mu opioid receptor	98 aa	100 aa	29.0 %
Loa Loa (eye worm)	hypothetical protein	Mu opioid receptor	98 aa	81 aa	35.8 %
Schistosoma mansoni	growth hormone secretagogue receptor	Mu opioid receptor	98 aa	93 aa	24.7 %
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	Mu opioid receptor	98 aa	97 aa	36.1 %
Schistosoma japonicum	IPR000276,Rhodopsin-like GPCR superfamily,domain-containing	Mu opioid receptor	98 aa	93 aa	25.8 %
Schistosoma mansoni	opsin-like receptor	Mu opioid receptor	98 aa	80 aa	25.0 %
Echinococcus granulosus	tachykinin peptides receptor 99D	Mu opioid receptor	98 aa	93 aa	25.8 %
Brugia malayi	Melatonin receptor type 1A	Mu opioid receptor	98 aa	80 aa	22.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	93 aa	36.6 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	91 aa	38.5 %
Onchocerca volvulus		Mu opioid receptor	98 aa	87 aa	32.2 %
Schistosoma mansoni	biogenic amine (dopamine) receptor	Mu opioid receptor	98 aa	97 aa	35.1 %
Schistosoma mansoni	biogenic amine receptor	Mu opioid receptor	98 aa	98 aa	35.7 %
Onchocerca volvulus		Delta opioid receptor	372 aa	353 aa	21.0 %
Onchocerca volvulus		Mu opioid receptor	98 aa	80 aa	22.5 %
Echinococcus multilocularis	g protein coupled receptor	Mu opioid receptor	98 aa	92 aa	26.1 %
Schistosoma mansoni	rhodopsin-like orphan GPCR	Mu opioid receptor	98 aa	85 aa	25.9 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Delta opioid receptor	372 aa	353 aa	29.2 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0087	0.0087
Echinococcus granulosus	dro:myosuppressin receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	g protein coupled receptor	0.01	0.1134	0.1134
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.01	0.1134	0.1134
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0095	0.0095
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Onchocerca volvulus		0.01	0.1134	0.6518
Schistosoma mansoni	cpg binding protein	0.0031	0.0273	0.0273
Onchocerca volvulus		0.01	0.1134	0.6518
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0318	0.0318
Onchocerca volvulus		0.0136	0.1589	0.9131
Schistosoma mansoni	alpha-1 adrenergic receptor	0.01	0.1134	0.1134
Brugia malayi	putative neuropeptide receptor	0.01	0.1134	0.1134
Schistosoma mansoni	histamine h1 receptor	0.01	0.1134	0.1134
Echinococcus granulosus	replication factor c subunit 1	0.001	0.00000033901	0.00000033901
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0041	0.097
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0295	0.0295
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	amine GPCR	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1718	0.1718
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0066	0.1541
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus granulosus	peptide allatostatin:somatostatin	0.01	0.1134	0.1134
Schistosoma mansoni	hypothetical protein	0.0015	0.0066	0.0066
Loa Loa (eye worm)	carboxylesterase	0.0136	0.1589	0.1589
Echinococcus multilocularis	dro:myosuppressin receptor	0.01	0.1134	0.1134
Brugia malayi	Tachykinin-like peptides receptor 99D	0.01	0.1134	0.1134
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0071	0.0071
Echinococcus granulosus	g protein coupled receptor	0.01	0.1134	0.1134
Echinococcus granulosus	allatostatin A receptor	0.01	0.1134	0.1134
Schistosoma mansoni	opsin-like receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	neuropeptide receptor A26	0.01	0.1134	0.1134
Brugia malayi	larval opioid receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0087	0.0087
Schistosoma mansoni	biogenic amine (5HT) receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	serotonin receptor	0.01	0.1134	0.1134
Chlamydia trachomatis	DNA ligase	0.001	0	0.5
Schistosoma mansoni	hypothetical protein	0.0035	0.0322	0.0322
Schistosoma mansoni	zinc finger protein	0.0021	0.0138	0.0138
Echinococcus granulosus	transient receptor potential ion channel A	0.0091	0.1026	0.1026
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01	0.1134	0.1134
Loa Loa (eye worm)	carboxylesterase	0.0803	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.01	0.1134	0.1134
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.01	0.1134	0.1134
Echinococcus granulosus	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0148	0.174	0.174
Trichomonas vaginalis	spcc417.12 protein, putative	0.0136	0.1589	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0019	0.0115	0.0721
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0071	0.0071
Onchocerca volvulus		0.01	0.1134	0.6518
Echinococcus granulosus	biogenic amine 5HT receptor	0.01	0.1134	0.1134
Onchocerca volvulus		0.0148	0.174	1
Loa Loa (eye worm)	G-protein coupled receptor	0.01	0.1134	0.1134
Trypanosoma brucei	unspecified product	0.0019	0.0115	0.2689
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0095	0.0095
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0071	0.0071
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0031	0.0263	0.4597
Brugia malayi	G-protein coupled receptor	0.01	0.1134	0.1134
Schistosoma mansoni	neuropeptide receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	TYRA-2 protein	0.01	0.1134	0.1134
Brugia malayi	AKH receptor	0.01	0.1134	0.1134
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.006	0.0629	0.0629
Schistosoma mansoni	amine GPCR	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus granulosus	biogenic amine 5HT receptor	0.01	0.1134	0.1134
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0019	0.0115	0.3556
Brugia malayi	G protein-coupled receptor	0.01	0.1134	0.1134
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0066	0.1541
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0087	0.0087
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.01	0.1134	0.1134
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Brugia malayi	CXXC zinc finger family protein	0.0028	0.023	0.023
Treponema pallidum	DNA ligase (lig)	0.001	0	0.5
Echinococcus multilocularis	muscleblind protein 1	0.0146	0.1718	0.1718
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	somatostatin receptor	0.01	0.1134	0.1134
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1589	0.1589
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0087	0.0087
Echinococcus multilocularis	acetylcholinesterase	0.0803	1	1
Echinococcus multilocularis	neuropeptide s receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Onchocerca volvulus		0.01	0.1134	0.6518
Echinococcus multilocularis	neuropeptide receptor	0.01	0.1134	0.1134
Echinococcus granulosus	7TM GPCR rhodopsin	0.01	0.1134	0.1134
Echinococcus multilocularis	cpg binding protein	0.0031	0.0273	0.0273
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0725	0.901	0.901
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1589	0.1589
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.01	0.1134	0.1134
Loa Loa (eye worm)	acetylcholinesterase 1	0.0803	1	1
Schistosoma mansoni	hypothetical protein	0.01	0.1134	0.1134
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.01	0.1134	0.1134
Echinococcus multilocularis	fmrfamide receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0028	0.023	0.023
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Echinococcus multilocularis	neuropeptide FF receptor 2	0.01	0.1134	0.1134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Brugia malayi	Dopamine receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Trypanosoma brucei	ISWI complex protein	0.0015	0.0066	0.1541
Onchocerca volvulus		0.0028	0.023	0.1321
Plasmodium falciparum	replication factor C subunit 1, putative	0.001	0.00000033901	0.5
Echinococcus multilocularis	transient receptor potential ion channel A	0.0091	0.1026	0.1026
Echinococcus multilocularis	neuropeptides capa receptor	0.01	0.1134	0.1134
Brugia malayi	Carboxylesterase family protein	0.0803	1	1
Echinococcus granulosus	hypothetical protein	0.01	0.1134	0.1134
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.00000033901	0.0000021338
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus multilocularis	replication factor c subunit 1	0.001	0.00000033901	0.00000033901
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.01	0.1134	0.1134
Brugia malayi	Bromodomain containing protein	0.0037	0.0347	0.0347
Echinococcus granulosus	neuropeptide Y receptor	0.01	0.1134	0.1134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01	0.1134	0.1134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Schistosoma mansoni	neuropeptide F-like receptor	0.01	0.1134	0.1134
Echinococcus granulosus	BC026374 protein S09 family	0.0136	0.1589	0.1589
Brugia malayi	Carboxylesterase family protein	0.0136	0.1589	0.1589
Echinococcus granulosus	alpha 1A adrenergic receptor	0.01	0.1134	0.1134
Onchocerca volvulus	Neuropeptide F receptor homolog	0.01	0.1134	0.6518
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0488	0.0488
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus multilocularis	short transient receptor potential channel 6	0.0062	0.0664	0.0664
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Onchocerca volvulus		0.01	0.1134	0.6518
Onchocerca volvulus		0.0136	0.1589	0.9131
Onchocerca volvulus		0.01	0.1134	0.6518
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Echinococcus granulosus	neuropeptide Y receptor	0.01	0.1134	0.1134
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.01	0.1134	0.1134
Onchocerca volvulus		0.01	0.1134	0.6518
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0573	1
Echinococcus granulosus	sex peptide receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	para nitrobenzyl esterase	0.0136	0.1589	0.1589
Schistosoma mansoni	cpg binding protein	0.0031	0.0273	0.0273
Echinococcus granulosus	G protein coupled receptor 139	0.01	0.1134	0.1134
Loa Loa (eye worm)	carboxylesterase	0.0136	0.1589	0.1589
Echinococcus multilocularis	transient receptor potential gamma protein	0.0094	0.1065	0.1065
Echinococcus multilocularis	dna polymerase eta	0.0043	0.0426	0.0426
Schistosoma mansoni	hypothetical protein	0.0015	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1589	0.1589
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.01	0.1134	0.1134
Echinococcus multilocularis	zinc finger protein	0.0021	0.0138	0.0138
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Brugia malayi	sulfakinin receptor protein	0.01	0.1134	0.1134
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.01	0.1134	0.1134
Loa Loa (eye worm)	melatonin receptor type 1A	0.01	0.1134	0.1134
Schistosoma mansoni	BC026374 protein (S09 family)	0.0136	0.1589	0.1589
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0322	0.0322
Brugia malayi	Carboxylesterase family protein	0.0136	0.1589	0.1589
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0019	0.0115	0.0115
Brugia malayi	ImpB/MucB/SamB family protein	0.0019	0.0115	0.0115
Schistosoma mansoni	opsin-like receptor	0.01	0.1134	0.1134
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0322	0.0322
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	hypothetical protein	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus granulosus	acetylcholinesterase	0.0803	1	1
Brugia malayi	Transient-receptor-potential like protein	0.0035	0.032	0.032
Brugia malayi	hypothetical protein	0.0136	0.1589	0.1589
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Schistosoma mansoni	biogenic amine receptor	0.01	0.1134	0.1134
Echinococcus granulosus	para nitrobenzyl esterase	0.0136	0.1589	0.1589
Schistosoma mansoni	neuropeptide f receptor 76f	0.01	0.1134	0.1134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0069	0.0743	0.0743
Onchocerca volvulus		0.01	0.1134	0.6518
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	g-protein coupled receptor	0.01	0.1134	0.1134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Plasmodium vivax	replication factor C subunit 1, putative	0.001	0.00000033901	0.5
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0019	0.0115	0.0115
Echinococcus multilocularis	sex peptide receptor	0.01	0.1134	0.1134
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	neuropeptide Y receptor	0.01	0.1134	0.1134
Onchocerca volvulus		0.01	0.1134	0.6518
Entamoeba histolytica	hypothetical protein	0.0035	0.0322	1
Echinococcus multilocularis	serotonin receptor	0.01	0.1134	0.1134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01	0.1134	0.1134
Entamoeba histolytica	hypothetical protein	0.0035	0.0322	1
Trypanosoma brucei	unspecified product	0.0013	0.0041	0.097
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Echinococcus multilocularis	G-protein coupled receptor, putative	0.01	0.1134	0.1134
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0071	0.0071
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0095	0.0095
Echinococcus multilocularis	g protein coupled receptor	0.01	0.1134	0.1134
Echinococcus granulosus	transient receptor potential gamma protein	0.0094	0.1065	0.1065
Echinococcus multilocularis	neuroligin	0.0136	0.1589	0.1589
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0322	0.0322
Schistosoma mansoni	hypothetical protein	0.01	0.1134	0.1134
Trichomonas vaginalis	replication factor C large subunit, putative	0.001	0.00000033901	0.0000021338
Loa Loa (eye worm)	hypothetical protein	0.0035	0.032	0.032
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.01	0.1134	0.1134
Echinococcus granulosus	tachykinin peptides receptor 99D	0.01	0.1134	0.1134
Onchocerca volvulus		0.01	0.1134	0.6518
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus granulosus	tm gpcr rhodopsin	0.0725	0.901	0.901
Trypanosoma cruzi	DNA polymerase eta, putative	0.0031	0.0263	0.618
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus multilocularis	dna polymerase kappa	0.0019	0.0115	0.0115
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.01	0.1134	0.1134
Mycobacterium ulcerans	carboxylesterase, LipT	0.0136	0.1589	1
Schistosoma mansoni	chromosome transmission fidelity factor	0.001	0.00000033901	0.00000033901
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0071	0.0071
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0032	0.028	0.028
Brugia malayi	hypothetical protein	0.0148	0.174	0.174
Trichomonas vaginalis	chromosome transmission fidelity factor, putative	0.001	0.00000033901	0.0000021338
Leishmania major	DNA polymerase kappa, putative	0.0019	0.0115	0.1357
Echinococcus multilocularis	carboxylesterase 5A	0.0803	1	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	transient receptor potential channel	0.0062	0.0664	0.0664
Onchocerca volvulus		0.01	0.1134	0.6518
Brugia malayi	Dopamine receptor protein 1	0.01	0.1134	0.1134
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0136	0.1589	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.01	0.1134	0.1134
Echinococcus granulosus	short transient receptor potential channel 6	0.0062	0.0664	0.0664
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0009	0.0009
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.01	0.1134	0.1134
Brugia malayi	PHD-finger family protein	0.0026	0.0203	0.0203
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Leishmania major	DNA polymerase eta, putative	0.0031	0.0263	0.5484
Onchocerca volvulus		0.0136	0.1589	0.9131
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.01	0.1134	0.6518
Echinococcus granulosus	acetylcholinesterase	0.0803	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	g protein coupled receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0624	0.0624
Brugia malayi	Muscleblind-like protein	0.0146	0.1718	0.1718
Brugia malayi	G-protein coupled receptor	0.01	0.1134	0.1134
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0438	0.0438
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0426	0.0426
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.01	0.1134	0.1134
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0136	0.1589	0.1589
Echinococcus multilocularis	orexin receptor type 2	0.01	0.1134	0.1134
Schistosoma mansoni	hypothetical protein	0.0015	0.0071	0.0071
Brugia malayi	G protein-coupled receptor F59B2.13	0.01	0.1134	0.1134
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0048	0.0488	0.0488
Echinococcus granulosus	serotonin receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1589	0.1589
Trypanosoma brucei	DNA polymerase eta, putative	0.0043	0.0426	1
Brugia malayi	hypothetical protein	0.0035	0.0322	0.0322
Schistosoma mansoni	growth hormone secretagogue receptor	0.01	0.1134	0.1134
Echinococcus granulosus	g protein coupled receptor	0.01	0.1134	0.1134
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	allatostatin A receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	hypothetical protein	0.0015	0.0071	0.0071
Onchocerca volvulus		0.01	0.1134	0.6518
Echinococcus granulosus	TRP transient receptor potential channel	0.0035	0.032	0.032
Trichomonas vaginalis	DNA polymerase eta, putative	0.0019	0.0115	0.0721
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01	0.1134	0.1134
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.01	0.1134	0.1134
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0136	0.1589	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	amine GPCR	0.01	0.1134	0.1134
Onchocerca volvulus		0.01	0.1134	0.6518
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	transient receptor potential channel	0.0062	0.0664	0.0664
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	neuropeptide F-like receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	short transient receptor potential channel 6	0.0062	0.0664	0.0664
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0071	0.0071
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0438	0.0438
Echinococcus granulosus	g protein coupled receptor	0.01	0.1134	0.1134
Echinococcus granulosus	tm gpcr rhodopsin	0.01	0.1134	0.1134
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0136	0.1589	0.1589
Schistosoma mansoni	neuropeptide receptor	0.01	0.1134	0.1134
Schistosoma mansoni	hypothetical protein	0.0033	0.0295	0.0295
Echinococcus granulosus	orexin receptor type 2	0.01	0.1134	0.1134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Echinococcus granulosus	short transient receptor potential channel 6	0.0062	0.0664	0.0664
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.01	0.1134	0.1134
Echinococcus granulosus	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0136	0.1589	0.1589
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0438	0.0438
Schistosoma mansoni	DNA polymerase eta	0.0043	0.0426	0.0426
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0136	0.1589	0.1589
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.01	0.1134	0.1134
Echinococcus granulosus	fmrfamide receptor	0.01	0.1134	0.1134
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	biogenic amine (5HT) receptor	0.01	0.1134	0.1134
Trypanosoma brucei	unspecified product	0.0013	0.0041	0.097
Schistosoma mansoni	biogenic amine receptor	0.01	0.1134	0.1134
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.0624	0.0624
Brugia malayi	follicle stimulating hormone receptor	0.01	0.1134	0.1134
Brugia malayi	neuropeptide F receptor	0.01	0.1134	0.1134
Schistosoma mansoni	zinc finger protein	0.0015	0.0066	0.0066
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0438	0.0438
Onchocerca volvulus		0.01	0.1134	0.6518
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0136	0.1589	1
Echinococcus multilocularis	muscleblind protein	0.0146	0.1718	0.1718
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0115	0.2689
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0438	0.0438
Echinococcus granulosus	somatostatin receptor	0.01	0.1134	0.1134
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.01	0.1134	0.1134
Schistosoma mansoni	transient receptor potential channel	0.0094	0.1065	0.1065
Schistosoma mansoni	adenoreceptor	0.01	0.1134	0.1134
Echinococcus multilocularis	fmrfamide receptor	0.01	0.1134	0.1134
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0438	0.0438
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1589	0.1589
Schistosoma mansoni	neuropeptide receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0438	0.0438
Echinococcus granulosus	fetal alzheimer antigen falz	0.0023	0.0174	0.0174
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0136	0.1589	0.1589
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0023	0.0174	0.0174
Echinococcus multilocularis	dnaJ subfamily B	0.0397	0.488	0.488
Brugia malayi	Serotonin receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.01	0.1134	0.1134
Brugia malayi	putative neuropeptide receptor NPR1	0.01	0.1134	0.1134
Echinococcus granulosus	neuropeptide FF receptor 2	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0043	0.042	0.042
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0019	0.0115	0.0115
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0136	0.1589	0.1589
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.01	0.1134	0.1134
Schistosoma mansoni	amine GPCR	0.01	0.1134	0.1134
Echinococcus granulosus	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Loa Loa (eye worm)	G-protein coupled receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0803	1	1
Echinococcus granulosus	dnaJ subfamily B	0.0397	0.488	0.488
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0136	0.1589	0.1589
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0803	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0295	0.0295
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0115	0.2689
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.01	0.1134	0.1134
Echinococcus granulosus	g-protein coupled receptor	0.01	0.1134	0.1134
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0048	0.0488	0.0488
Onchocerca volvulus		0.0136	0.1589	0.9131
Brugia malayi	RE15519p	0.01	0.1134	0.1134
Echinococcus granulosus	neuropeptide receptor A26	0.01	0.1134	0.1134
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.01	0.1134	0.1134
Toxoplasma gondii	ATPase, AAA family protein	0.001	0.00000033901	0.0000059177
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0017	0.0095	0.0095
Echinococcus multilocularis	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Brugia malayi	Bromodomain containing protein	0.0074	0.0816	0.0816
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0048	0.0488	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0803	1	1
Echinococcus granulosus	neuropeptide receptor	0.01	0.1134	0.1134
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0095	0.0095
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0071	0.0071
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Brugia malayi	Dopamine receptor protein 2	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.01	0.1134	0.1134
Echinococcus granulosus	dna polymerase kappa	0.0019	0.0115	0.0115
Trypanosoma brucei	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.01	0.1134	0.1134
Brugia malayi	Melatonin receptor type 1A	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	acetylcholinesterase	0.0136	0.1589	0.1589
Onchocerca volvulus		0.0136	0.1589	0.9131
Schistosoma mansoni	amine GPCR	0.01	0.1134	0.1134
Brugia malayi	ImpB/MucB/SamB family protein	0.0043	0.0426	0.0426
Trypanosoma cruzi	DNA polymerase eta, putative	0.0043	0.0426	1
Onchocerca volvulus		0.01	0.1134	0.6518
Onchocerca volvulus		0.01	0.1134	0.6518
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01	0.1134	0.1134
Entamoeba histolytica	hypothetical protein	0.0035	0.0322	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.01	0.1134	0.1134
Brugia malayi	ORL1-like opioid receptor	0.01	0.1134	0.1134
Schistosoma mansoni	hypothetical protein	0.002	0.0131	0.0131
Brugia malayi	hypothetical protein	0.01	0.1134	0.1134
Echinococcus granulosus	carboxylesterase 5A	0.0803	1	1
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1589	0.1589
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Brugia malayi	GnHR receptor homolog	0.01	0.1134	0.1134
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0019	0.0115	0.0115
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0115	0.0721
Echinococcus granulosus	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0041	0.097
Brugia malayi	Carboxylesterase family protein	0.0136	0.1589	0.1589
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Echinococcus multilocularis	neuropeptide receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1589	0.1589
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Entamoeba histolytica	hypothetical protein	0.0035	0.0322	1
Onchocerca volvulus		0.01	0.1134	0.6518
Loa Loa (eye worm)	hypothetical protein	0.0094	0.1065	0.1065
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	biogenic amine receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	G protein coupled receptor 139	0.01	0.1134	0.1134
Schistosoma mansoni	neuropeptide receptor	0.01	0.1134	0.1134
Giardia lamblia	DINP protein human, muc B family	0.0019	0.0115	1
Echinococcus granulosus	tm gpcr rhodopsin	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus granulosus	dna polymerase eta	0.0043	0.0426	0.0426
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0019	0.0115	0.2689
Brugia malayi	Serotonin receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.01	0.1134	0.1134
Echinococcus multilocularis	neuropeptides capa receptor	0.01	0.1134	0.1134
Mycobacterium leprae	PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+])	0.001	0	0.5
Schistosoma mansoni	gliotactin	0.0136	0.1589	0.1589
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0131	0.0131
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0318	0.0318
Brugia malayi	Carboxylesterase family protein	0.0136	0.1589	0.1589
Schistosoma mansoni	hypothetical protein	0.0397	0.488	0.488
Loa Loa (eye worm)	hypothetical protein	0.004	0.0377	0.0377
Schistosoma mansoni	opsin-like receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0438	0.0438
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus granulosus	neuropeptides capa receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0348	0.0348
Schistosoma mansoni	cpg binding protein	0.0028	0.023	0.023
Schistosoma mansoni	hypothetical protein	0.0015	0.0071	0.0071
Leishmania major	DNA polymerase eta, putative	0.0043	0.0426	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0071	0.0071
Mycobacterium ulcerans	DNA polymerase IV	0.0019	0.0115	0.0721
Trypanosoma brucei	DNA polymerase IV, putative	0.0019	0.0115	0.2689
Schistosoma mansoni	myosin xvIII	0.01	0.1134	0.1134
Echinococcus multilocularis	acetylcholinesterase	0.0803	1	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0136	0.1589	1
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.01	0.1134	0.1134
Wolbachia endosymbiont of Brugia malayi	NAD-dependent DNA ligase, Lig	0.001	0	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0095	0.0095
Echinococcus granulosus	muscleblind protein	0.0146	0.1718	0.1718
Trypanosoma brucei	DNA polymerase kappa, putative	0.0013	0.0041	0.097
Echinococcus granulosus	neuropeptide receptor	0.01	0.1134	0.1134
Brugia malayi	neuropeptide F receptor	0.01	0.1134	0.1134
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0785	0.9767	0.9767
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0019	0.0115	0.0115
Echinococcus granulosus	neuropeptides capa receptor	0.01	0.1134	0.1134
Loa Loa (eye worm)	hypothetical protein	0.01	0.1134	0.1134
Schistosoma mansoni	transient receptor potential channel 4	0.0094	0.1065	0.1065
Echinococcus granulosus	GPCR family 2	0.0015	0.0071	0.0071
Echinococcus granulosus	neuroligin	0.0136	0.1589	0.1589
Echinococcus granulosus	7tm_1 domain containing protein	0.01	0.1134	0.1134
Echinococcus granulosus	neuropeptide s receptor	0.01	0.1134	0.1134
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0019	0.0115	0.1357
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.006	0.0629	0.0629
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0035	0.032	0.032
Loa Loa (eye worm)	hypothetical protein	0.0146	0.1718	0.1718
Echinococcus granulosus	cpg binding protein	0.0031	0.0273	0.0273
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0438	0.0438
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01	0.1134	0.1134
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0023	0.0174	0.0174
Echinococcus granulosus	zinc finger protein	0.0021	0.0138	0.0138
Loa Loa (eye worm)	neuropeptide F receptor	0.01	0.1134	0.1134
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.01	0.1134	0.1134
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.01	0.1134	0.1134
Schistosoma mansoni	bromodomain containing protein	0.0063	0.0672	0.0672
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.01	0.1134	0.1134
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.01	0.1134	0.1134
Echinococcus multilocularis	neuropeptide Y receptor	0.01	0.1134	0.1134

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 111 nM	Inhibition of electrically evoked contraction of guinea pig ileum (myenteric plexus:longitudinal muscle preparation) by antagonist action at mu 1 opioid receptors	ChEMBL.	2828622
Ki (binding)	= 13.7 nM	Inhibition of [3H]-DAGO binding to mu 1 opioid receptor in rat brain membranes	ChEMBL.	2828622
Ki (binding)	= 39 nM	Inhibition of [3H]-DSLET binding to delta 1 opioid receptors in rat brain membranes	ChEMBL.	2828622

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2370600

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1742578