Detailed information for compound 1742643

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 850.967 | Formula: C39H58N14O8
  • H donors: 13 H acceptors: 8 LogP: -3.21 Rotable bonds: 22
    Rule of 5 violations (Lipinski): 3
  • SMILES: NC(=NCCC[C@@H](C(=O)N[C@H](C(=O)N)CCCN=C(N)N)NC(=O)[C@H]1CC(=O)NCCC[C@@H](C(=O)N[C@H](C(=O)N1)Cc1ccccc1)NC(=O)[C@H](Cc1ccc(cc1)O)N)N
  • InChi: 1S/C39H58N14O8/c40-25(19-23-12-14-24(54)15-13-23)33(57)50-27-10-5-16-46-31(55)21-30(53-36(60)29(52-35(27)59)20-22-7-2-1-3-8-22)37(61)51-28(11-6-18-48-39(44)45)34(58)49-26(32(41)56)9-4-17-47-38(42)43/h1-3,7-8,12-15,25-30,54H,4-6,9-11,16-21,40H2,(H2,41,56)(H,46,55)(H,49,58)(H,50,57)(H,51,61)(H,52,59)(H,53,60)(H4,42,43,47)(H4,44,45,48)/t25-,26-,27-,28-,29-,30+/m0/s1
  • InChiKey: UFLXRFZGSMQQIS-NXUCNJKMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Mu opioid receptor Starlite/ChEMBL References
Rattus norvegicus Delta opioid receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Delta opioid receptor   372 aa 316 aa 26.9 %
Schistosoma mansoni neuropeptide F-like receptor Mu opioid receptor   398 aa 335 aa 20.6 %
Onchocerca volvulus Delta opioid receptor   372 aa 344 aa 22.1 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Delta opioid receptor   372 aa 320 aa 25.6 %
Brugia malayi ORL1-like opioid receptor Delta opioid receptor   372 aa 300 aa 24.7 %
Loa Loa (eye worm) neuropeptide F receptor Delta opioid receptor   372 aa 317 aa 23.3 %
Schistosoma japonicum Rhodopsin, putative Mu opioid receptor   398 aa 328 aa 23.2 %
Echinococcus granulosus allatostatin A receptor Delta opioid receptor   372 aa 302 aa 27.8 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Delta opioid receptor   372 aa 366 aa 22.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.2 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Mu opioid receptor   398 aa 334 aa 23.1 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Delta opioid receptor   372 aa 315 aa 28.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Mu opioid receptor   398 aa 397 aa 22.7 %
Onchocerca volvulus Programmed cell death protein 5 homolog Mu opioid receptor   398 aa 323 aa 24.1 %
Echinococcus multilocularis allatostatin A receptor Delta opioid receptor   372 aa 302 aa 28.5 %
Onchocerca volvulus Delta opioid receptor   372 aa 386 aa 22.8 %
Brugia malayi GnHR receptor homolog Delta opioid receptor   372 aa 313 aa 18.5 %
Schistosoma mansoni peptide (allatostatin)-like receptor Delta opioid receptor   372 aa 353 aa 29.2 %
Onchocerca volvulus Delta opioid receptor   372 aa 349 aa 22.1 %
Onchocerca volvulus Delta opioid receptor   372 aa 353 aa 21.0 %
Echinococcus granulosus thyrotropin releasing hormone receptor Delta opioid receptor   372 aa 330 aa 24.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0038 0.0038
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0038 0.0324
Echinococcus multilocularis neutral amino acid transporter A 0.1359 0.5406 0.5406
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Plasmodium falciparum carbonic anhydrase 0.0309 0.1181 1
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis G-protein coupled receptor, putative 0.1097 0.4352 0.4352
Toxoplasma gondii isocitrate dehydrogenase 0.003 0.0059 0.0503
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.003 0.0059 0.0503
Loa Loa (eye worm) hypothetical protein 0.0238 0.0895 0.0895
Echinococcus multilocularis g protein coupled receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.1097 0.4352 0.4352
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1097 0.4352 0.4352
Echinococcus multilocularis musashi 0.0027 0.0045 0.0045
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.1097 0.4352 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Brugia malayi Esterase D 0.0035 0.008 0.008
Chlamydia trachomatis glutamate symporter 0.1359 0.5406 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0309 0.1181 0.1181
Schistosoma mansoni hypothetical protein 0.1097 0.4352 0.4352
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0059 0.0059
Onchocerca volvulus 0.0236 0.0885 0.1637
Loa Loa (eye worm) hypothetical protein 0.0195 0.0723 0.0723
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0015 0.0015
Loa Loa (eye worm) follicle stimulating hormone receptor 0.1097 0.4352 0.4352
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0059 0.0059
Brugia malayi steroid hormone receptor 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Secreted antigen 85-B FbpB (85B) (antigen 85 complex B) (mycolyl transferase 85B) (fibronectin-binding protein B) (extracellular 0.0035 0.008 0.0147
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus ecdysone induced protein 78C 0.0019 0.0015 0.0015
Onchocerca volvulus 0.1097 0.4352 0.8051
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.012 0.012
Loa Loa (eye worm) carbonic anhydrase 3 0.1244 0.494 0.494
Brugia malayi Melatonin receptor type 1A 0.1097 0.4352 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0019 0.0015 0.0015
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus neuropeptide Y receptor 0.1097 0.4352 0.4352
Schistosoma mansoni carbonic anhydrase-related 0.0309 0.1181 0.1181
Brugia malayi Pre-SET motif family protein 0.003 0.0057 0.0057
Mycobacterium ulcerans hypothetical protein 0.0035 0.008 0.0242
Schistosoma mansoni biogenic amine receptor 0.1097 0.4352 0.4352
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.2501 1 1
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.003 0.0059 0.0059
Mycobacterium leprae SECRETED ANTIGEN 85-B FBPB (85B) (ANTIGEN 85 COMPLEX B) (MYCOLYL TRANSFERASE 85B) (FIBRONECTIN-BINDING PROTEIN B) (EXTRACELLULAR 0.0035 0.008 0.0242
Echinococcus granulosus g protein coupled receptor 0.1097 0.4352 0.4352
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.1097 0.4352 0.4352
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0019 0.0015 0.0015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.012 0.012
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.003 0.0059 0.0059
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0806 0.3181 0.3181
Echinococcus granulosus zinc finger transcription factor gli2 0.0286 0.1087 0.1087
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni thyroid hormone receptor 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi Nuclear hormone receptor-like 1 0.0019 0.0015 0.0015
Echinococcus multilocularis g protein coupled receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis tachykinin peptides receptor 99D 0.1097 0.4352 0.4352
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.1097 0.4352 0.8051
Brugia malayi RE15519p 0.1097 0.4352 0.4352
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0038 0.0324
Onchocerca volvulus 0.0027 0.0045 0.0084
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0019 0.0015 0.0015
Onchocerca volvulus 0.1097 0.4352 0.8051
Echinococcus granulosus neuropeptide receptor 0.1097 0.4352 0.4352
Onchocerca volvulus Huntingtin homolog 0.0122 0.0427 0.0791
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis neuropeptides capa receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0019 0.0015 0.0015
Schistosoma mansoni neuropeptide receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Matrixin family protein 0.0472 0.1838 0.1838
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0019 0.0015 0.0015
Echinococcus multilocularis sodium:dicarboxylate symporter 0.1359 0.5406 0.5406
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0238 0.0895 0.1655
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Onchocerca volvulus Huntingtin homolog 0.0122 0.0427 0.0791
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) matrix metalloproteinase 0.0195 0.0723 0.0723
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni biogenic amine receptor 0.1097 0.4352 0.4352
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.012 0.012
Echinococcus granulosus allatostatin A receptor 0.1097 0.4352 0.4352
Brugia malayi Serotonin receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.0195 0.0723 0.0723
Brugia malayi nuclear hormone receptor 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Treponema pallidum glutamate transporter 0.0602 0.2361 0.5
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus orexin receptor type 2 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus alpha 1A adrenergic receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0038 0.0324
Brugia malayi hypothetical protein 0.0069 0.0215 0.0215
Echinococcus granulosus carbonic anhydrase 0.0309 0.1181 0.1181
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.1097 0.4352 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Brugia malayi Excitatory amino acid transporter 0.1359 0.5406 0.5406
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0602 0.2361 0.2361
Echinococcus granulosus neuropeptide receptor A26 0.1522 0.6062 0.6062
Echinococcus granulosus neutral amino acid transporter 0.1359 0.5406 0.5406
Schistosoma mansoni myosin xvIII 0.1097 0.4352 0.4352
Echinococcus multilocularis carbonic anhydrase 0.0309 0.1181 0.1181
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0038 0.0038
Onchocerca volvulus 0.1097 0.4352 0.8051
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0019 0.0015 0.0015
Loa Loa (eye worm) zinc finger protein 0.0286 0.1087 0.1087
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1244 0.494 0.494
Onchocerca volvulus 0.1097 0.4352 0.8051
Loa Loa (eye worm) hypothetical protein 0.0068 0.021 0.021
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1244 0.494 0.494
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus Matrilysin homolog 0.0433 0.168 0.3109
Echinococcus multilocularis S formylglutathione hydrolase 0.0035 0.008 0.008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus 0.1097 0.4352 0.8051
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0019 0.0015 0.0015
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0064 0.0064
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Mycobacterium tuberculosis Probable conserved exported protein 0.0035 0.008 0.0147
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis Excitatory amino acid transporter 0.1359 0.5406 0.5406
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.1097 0.4352 0.4352
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.1097 0.4352 0.4352
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0064 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1097 0.4352 0.4352
Brugia malayi G protein-coupled receptor 0.1097 0.4352 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0019 0.0015 0.0015
Leishmania major carbonic anhydrase-like protein 0.1244 0.494 0.494
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0019 0.0015 0.0015
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0015 0.0015
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0309 0.1181 0.1181
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.1359 0.5406 0.5
Loa Loa (eye worm) isocitrate dehydrogenase 0.003 0.0059 0.0059
Brugia malayi Isocitrate dehydrogenase 0.003 0.0059 0.0059
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.003 0.0059 0.011
Echinococcus multilocularis zinc finger transcription factor gli2 0.0286 0.1087 0.1087
Brugia malayi Protein kinase domain containing protein 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0045 0.0045
Schistosoma mansoni carbonic anhydrase 0.0309 0.1181 0.1181
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.1097 0.4352 0.4352
Echinococcus granulosus tm gpcr rhodopsin 0.1722 0.6866 0.6866
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.1359 0.5406 0.5406
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0019 0.0015 0.0015
Schistosoma mansoni growth hormone secretagogue receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis dual specificity mitogen activated protein 0.2501 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0059 0.0059
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0309 0.1181 0.1181
Echinococcus granulosus neutral amino acid transporter A 0.1359 0.5406 0.5406
Echinococcus granulosus neuropeptide FF receptor 2 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni steroid hormone receptor ad4bp 0.0019 0.0015 0.0015
Treponema pallidum glutamate/aspartate transporter 0.0602 0.2361 0.5
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni hypothetical protein 0.0277 0.1052 0.1052
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0309 0.1181 0.1181
Schistosoma mansoni transcription factor LCR-F1 0.0069 0.0215 0.0215
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni biogenic amine receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0019 0.0015 0.0015
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0057 0.0057
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0064 0.0064
Echinococcus multilocularis neuropeptides capa receptor 0.1097 0.4352 0.4352
Echinococcus granulosus dual specificity mitogen activated protein 0.2501 1 1
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0019 0.0015 0.0015
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0019 0.0015 0.0029
Brugia malayi Matrixin family protein 0.0195 0.0723 0.0723
Echinococcus granulosus S formylglutathione hydrolase 0.0035 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0602 0.2361 0.2361
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0057 0.0057
Echinococcus multilocularis neuropeptide receptor A26 0.1522 0.6062 0.6062
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis g protein coupled receptor 0.1097 0.4352 0.4352
Schistosoma mansoni opsin-like receptor 0.1097 0.4352 0.4352
Echinococcus granulosus serotonin receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, STE STE20 0.2501 1 1
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0064 0.0064
Echinococcus multilocularis somatostatin receptor 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi Dopamine receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) G-protein coupled receptor 0.1097 0.4352 0.4352
Brugia malayi nuclear receptor NHR-88 0.0019 0.0015 0.0015
Echinococcus multilocularis serotonin receptor 0.1097 0.4352 0.4352
Echinococcus granulosus dro:myosuppressin receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Toxoplasma gondii isocitrate dehydrogenase 0.003 0.0059 0.0503
Echinococcus multilocularis carbonic anhydrase 0.0309 0.1181 0.1181
Entamoeba histolytica protein kinase, putative 0.0016 0.000000024579 0.0000011427
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1244 0.494 0.494
Echinococcus multilocularis excitatory amino acid transporter 2 0.1359 0.5406 0.5406
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0045 0.0045
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.0122 0.0427 0.0427
Brugia malayi MH2 domain containing protein 0.0119 0.0415 0.0415
Schistosoma mansoni neuropeptide receptor 0.1097 0.4352 0.4352
Echinococcus granulosus biogenic amine 5HT receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) neuropeptide F receptor 0.1097 0.4352 0.4352
Echinococcus granulosus excitatory amino acid transporter 2 0.1359 0.5406 0.5406
Leishmania major hypothetical protein, conserved 0.0025 0.0038 0.0038
Schistosoma mansoni neuropeptide F-like receptor 0.1097 0.4352 0.4352
Schistosoma mansoni carbonic anhydrase-related 0.0309 0.1181 0.1181
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Echinococcus multilocularis lamin 0.0027 0.0045 0.0045
Trypanosoma brucei carbonic anhydrase-like protein 0.1244 0.494 0.494
Trichomonas vaginalis TKL family protein kinase 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0309 0.1181 0.1181
Onchocerca volvulus Matrilysin homolog 0.0195 0.0723 0.1338
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0086 0.0284 0.0284
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.1359 0.5406 0.5406
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0045 0.0045
Echinococcus granulosus neuropeptides capa receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus G protein coupled receptor 139 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Trichomonas vaginalis STE family protein kinase 0.2501 1 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0057 0.0057
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0019 0.0015 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0015 0.0015
Echinococcus granulosus thyrotropin releasing hormone receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis alpha 1A adrenergic receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) excitatory amino acid transporter 0.1359 0.5406 0.5406
Trichomonas vaginalis TKL family protein kinase 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis neutral amino acid transporter A 0.1359 0.5406 0.5406
Echinococcus granulosus tachykinin peptides receptor 99D 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0099 0.0336 0.0336
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Trichomonas vaginalis STE family protein kinase 0.2501 1 1
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus carbonic anhydrase II 0.1244 0.494 0.494
Schistosoma mansoni peptide (allatostatin)-like receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus carbonic anhydrase 0.0309 0.1181 0.1181
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0057 0.0057
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0602 0.2361 0.2361
Echinococcus granulosus lamin 0.0027 0.0045 0.0045
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0053 0.0053
Brugia malayi ORL1-like opioid receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi sulfakinin receptor protein 0.1097 0.4352 0.4352
Onchocerca volvulus Matrix metalloproteinase homolog 0.0433 0.168 0.3109
Echinococcus granulosus lamin dm0 0.0027 0.0045 0.0045
Brugia malayi larval opioid receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0415 0.0415
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0057 0.0482
Brugia malayi putative neuropeptide receptor NPR1 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus 7TM GPCR rhodopsin 0.1097 0.4352 0.4352
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0309 0.1181 0.1181
Trichomonas vaginalis TKL family protein kinase 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus 0.1097 0.4352 0.8051
Loa Loa (eye worm) hypothetical protein 0.0309 0.1181 0.1181
Echinococcus granulosus sodium:dicarboxylate symporter 0.1359 0.5406 0.5406
Echinococcus multilocularis fmrfamide receptor 0.1097 0.4352 0.4352
Echinococcus granulosus neutral amino acid transporter A 0.1359 0.5406 0.5406
Echinococcus multilocularis fmrfamide receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni intermediate filament proteins 0.0027 0.0045 0.0045
Trypanosoma brucei isocitrate dehydrogenase, putative 0.003 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.003 0.0057 0.0057
Onchocerca volvulus 0.1097 0.4352 0.8051
Mycobacterium tuberculosis Conserved protein 0.0035 0.008 0.0147
Echinococcus granulosus neuropeptide s receptor 0.1522 0.6062 0.6062
Brugia malayi Serotonin receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.003 0.0059 0.0059
Onchocerca volvulus 0.1097 0.4352 0.8051
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi AKH receptor 0.1097 0.4352 0.4352
Onchocerca volvulus Protein ultraspiracle homolog 0.0019 0.0015 0.0029
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1722 0.6866 0.6866
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0336 0.0336
Brugia malayi Pre-SET motif family protein 0.0207 0.077 0.077
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.0016 0.0003 0.0003
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0238 0.0895 0.0895
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0035 0.008 0.0147
Schistosoma mansoni carbonic anhydrase-related 0.0309 0.1181 0.1181
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.071 0.2795 0.2795
Brugia malayi photoreceptor-specific nuclear receptor 0.0019 0.0015 0.0015
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.003 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1244 0.494 0.494
Schistosoma mansoni alpha-1 adrenergic receptor 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis neuropeptide Y receptor 0.1097 0.4352 0.4352
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.003 0.0059 1
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Brugia malayi intermediate filament protein 0.0027 0.0045 0.0045
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus neuropeptides capa receptor 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0031 0.0064 0.0064
Schistosoma mansoni coup transcription factor 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Mycobacterium tuberculosis Secreted antigen 85-C FbpC (85C) (antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-binding protein C) 0.0831 0.3281 0.607
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Echinococcus granulosus somatostatin receptor 0.1097 0.4352 0.4352
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0122 0.0427 0.0427
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0019 0.0015 0.0015
Trichomonas vaginalis set domain proteins, putative 0.0236 0.0885 0.0885
Entamoeba histolytica hypothetical protein 0.0069 0.0215 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Echinococcus granulosus g protein coupled receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis excitatory amino acid transporter 2 0.1359 0.5406 0.5406
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.0195 0.0723 0.0723
Schistosoma mansoni protein kinase 0.2501 1 1
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.2501 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1244 0.494 0.494
Brugia malayi G protein-coupled receptor F59B2.13 0.1097 0.4352 0.4352
Schistosoma mansoni opsin-like receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis G protein coupled receptor 139 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus 0.003 0.0057 0.0105
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Echinococcus granulosus sex peptide receptor 0.1097 0.4352 0.4352
Schistosoma mansoni histamine h1 receptor 0.1097 0.4352 0.4352
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.071 0.2795 0.2795
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis neuropeptide receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus Excitatory amino acid transporter 0.1359 0.5406 0.5406
Onchocerca volvulus 0.1097 0.4352 0.8051
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.003 0.0059 0.0059
Echinococcus multilocularis isocitrate dehydrogenase 0.003 0.0059 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0019 0.0015 0.0015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0336 0.0336
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0019 0.0015 0.0015
Echinococcus multilocularis GPCR, family 2 0.0031 0.0064 0.0064
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.1097 0.4352 0.4352
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0336 0.0336
Loa Loa (eye worm) G-protein coupled receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Onchocerca volvulus 0.1097 0.4352 0.8051
Trichomonas vaginalis STE family protein kinase 0.2501 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.1097 0.4352 0.4352
Mycobacterium leprae SECRETED ANTIGEN 85-C FBPC (85C) (ANTIGEN 85 COMPLEX C) (AG58C) (MYCOLYL TRANSFERASE 85C) (FIBRONECTIN-BINDING PROTEIN C) 0.0831 0.3281 1
Brugia malayi neuropeptide F receptor 0.1097 0.4352 0.4352
Mycobacterium tuberculosis Secreted antigen 85-a FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0035 0.008 0.0147
Entamoeba histolytica hypothetical protein 0.0069 0.0215 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.1097 0.4352 0.4352
Echinococcus granulosus biogenic amine 5HT receptor 0.1097 0.4352 0.4352
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0019 0.0015 0.0015
Onchocerca volvulus 0.0027 0.0045 0.0084
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.1097 0.4352 0.4352
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.1359 0.5406 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.1097 0.4352 0.8051
Loa Loa (eye worm) hypothetical protein 0.0031 0.0064 0.0064
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0057 0.0057
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.1097 0.4352 0.4352
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1097 0.4352 0.4352
Onchocerca volvulus 0.1097 0.4352 0.8051
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi GnHR receptor homolog 0.1097 0.4352 0.4352
Mycobacterium ulcerans hypothetical protein 0.0035 0.008 0.0242
Echinococcus granulosus excitatory amino acid transporter 2 0.1359 0.5406 0.5406
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0038 0.645
Trichomonas vaginalis TKL family protein kinase 0.0016 0.0000000050008 0.0000000050008
Mycobacterium ulcerans secreted Mpt51/Mpb51 antigen protein FbpD 0.0035 0.008 0.0242
Schistosoma mansoni biogenic amine (5HT) receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis sex peptide receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) esterase D 0.0035 0.008 0.008
Brugia malayi Matrixin family protein 0.0195 0.0723 0.0723
Echinococcus multilocularis FTZ F1 alpha 0.0019 0.0015 0.0015
Loa Loa (eye worm) steroid hormone receptor 0.0019 0.0015 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0015 0.0015
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0015 0.0015
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0019 0.0015 0.0015
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1244 0.494 0.494
Mycobacterium ulcerans hypothetical protein 0.0035 0.008 0.0242
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0019 0.0015 0.0015
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0019 0.0015 0.0015
Brugia malayi gonadotropin-releasing hormone receptor 2 0.1097 0.4352 0.4352
Mycobacterium leprae Secreted antigen 85A FbpA (mycolyl transferase 85A) (fibronectin-binding protein A) (antigen 85 complex A) 0.0035 0.008 0.0242
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.1097 0.4352 0.4352
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Echinococcus multilocularis lamin dm0 0.0027 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0025 0.0038 0.0038
Loa Loa (eye worm) matrixin family protein 0.0433 0.168 0.168
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni neuropeptide receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.012 0.012
Echinococcus multilocularis allatostatin A receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0019 0.0015 0.0015
Schistosoma mansoni opsin-like receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) TYRA-2 protein 0.1097 0.4352 0.4352
Brugia malayi Tachykinin-like peptides receptor 99D 0.1097 0.4352 0.4352
Brugia malayi Steroid receptor seven-up type 2 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus 0.1097 0.4352 0.8051
Onchocerca volvulus 0.1097 0.4352 0.8051
Echinococcus multilocularis neuropeptide receptor 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus 7tm_1 domain containing protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0069 0.0215 0.0215
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0031 0.0064 0.0064
Echinococcus multilocularis carbonic anhydrase 0.0309 0.1181 0.1181
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, STE STE20 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Mycobacterium ulcerans secreted antigen 85-B FbpB 0.0035 0.008 0.0242
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0015 0.0015
Toxoplasma gondii hypothetical protein 0.0309 0.1181 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.1097 0.4352 0.4352
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0064 0.0064
Onchocerca volvulus 0.1097 0.4352 0.8051
Schistosoma mansoni RAR-like nuclear receptor 0.0019 0.0015 0.0015
Brugia malayi Zinc finger, C2H2 type family protein 0.0286 0.1087 0.1087
Mycobacterium ulcerans secreted antigen 85-A FbpA 0.0035 0.008 0.0242
Loa Loa (eye worm) hypothetical protein 0.0027 0.0045 0.0045
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.1097 0.4352 0.4352
Echinococcus granulosus GPCR family 2 0.0031 0.0064 0.0064
Echinococcus granulosus Excitatory amino acid transporter 0.1359 0.5406 0.5406
Chlamydia trachomatis neutral amino acid transporter 0.0602 0.2361 0.4368
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Echinococcus granulosus g protein coupled receptor 0.1097 0.4352 0.4352
Brugia malayi Dopamine receptor protein 2 0.1097 0.4352 0.4352
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0057 0.0057
Brugia malayi hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis dro:myosuppressin receptor 0.1097 0.4352 0.4352
Onchocerca volvulus 0.0195 0.0723 0.1338
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0019 0.0015 0.0015
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.1097 0.4352 0.4352
Brugia malayi Matrixin family protein 0.0195 0.0723 0.0723
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus neuropeptide receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.2501 1 1
Mycobacterium tuberculosis Possible conserved membrane protein 0.0035 0.008 0.0147
Schistosoma mansoni adenoreceptor 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni biogenic amine (dopamine) receptor 0.1097 0.4352 0.4352
Echinococcus granulosus fmrfamide receptor 0.1097 0.4352 0.4352
Echinococcus granulosus rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Mycobacterium tuberculosis Secreted MPT51/MPB51 antigen protein FbpD (MPT51/MPB51 antigen 85 complex C) (AG58C) (mycolyl transferase 85C) (fibronectin-bind 0.0035 0.008 0.0147
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0019 0.0015 0.0015
Schistosoma mansoni biogenic amine (5HT) receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Loa Loa (eye worm) matrixin family protein 0.0472 0.1838 0.1838
Loa Loa (eye worm) hypothetical protein 0.0019 0.0015 0.0015
Schistosoma mansoni neuropeptide f receptor 76f 0.1097 0.4352 0.4352
Brugia malayi neuropeptide F receptor 0.1097 0.4352 0.4352
Brugia malayi hypothetical protein 0.0025 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis carbonic anhydrase II 0.1244 0.494 0.494
Echinococcus granulosus g-protein coupled receptor 0.1097 0.4352 0.4352
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0195 0.0723 0.0723
Schistosoma mansoni rhodopsin-like orphan GPCR 0.1097 0.4352 0.4352
Echinococcus granulosus carbonic anhydrase 0.0309 0.1181 0.1181
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1244 0.494 0.494
Loa Loa (eye worm) hypothetical protein 0.0309 0.1181 0.1181
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni hypothetical protein 0.1097 0.4352 0.4352
Onchocerca volvulus 0.1097 0.4352 0.8051
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni hypothetical protein 0.0031 0.0064 0.0064
Echinococcus multilocularis excitatory amino acid transporter 3 0.1359 0.5406 0.5406
Entamoeba histolytica endo-1,4-beta-xylanase, putative 0.0035 0.008 0.3699
Plasmodium vivax SET domain protein, putative 0.003 0.0057 0.9577
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.1097 0.4352 0.4352
Schistosoma mansoni retinoic acid receptor RXR 0.0019 0.0015 0.0015
Onchocerca volvulus 0.1097 0.4352 0.8051
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Schistosoma mansoni lamin 0.0027 0.0045 0.0045
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis neuropeptide Y receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0019 0.0015 0.0015
Echinococcus multilocularis serotonin receptor 0.1097 0.4352 0.4352
Trichomonas vaginalis harmonin-interacting ankyrin-repeat containing protein (harp), sans, putative 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0019 0.0015 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0019 0.0015 0.0015
Echinococcus multilocularis ecdysone induced protein 78C 0.0019 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0069 0.0215 0.0215
Brugia malayi G-protein coupled receptor 0.1097 0.4352 0.4352
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0064 0.0064
Onchocerca volvulus 0.1097 0.4352 0.8051
Mycobacterium ulcerans secreted antigen 85-C FbpC 0.0831 0.3281 1
Echinococcus multilocularis neutral amino acid transporter A 0.1359 0.5406 0.5406
Brugia malayi isocitrate dehydrogenase 0.003 0.0059 0.0059
Giardia lamblia Kinase, NEK-GL-like 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) neuropeptide F receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0309 0.1181 0.1181
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni hypothetical protein 0.0068 0.021 0.021
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus Bile acid receptor homolog 0.0019 0.0015 0.0029
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Loa Loa (eye worm) melatonin receptor type 1A 0.1097 0.4352 0.4352
Schistosoma mansoni neuropeptide F-like receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis g-protein coupled receptor 0.1097 0.4352 0.4352
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0019 0.0015 0.0015
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.2501 1 1
Brugia malayi putative neuropeptide receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.0122 0.0427 0.0427
Echinococcus multilocularis biogenic amine (5HT) receptor 0.1097 0.4352 0.4352
Echinococcus multilocularis neuropeptide s receptor 0.1522 0.6062 0.6062
Schistosoma mansoni lamin 0.0027 0.0045 0.0045
Echinococcus granulosus intermediate filament protein 0.0027 0.0045 0.0045
Echinococcus granulosus tm gpcr rhodopsin 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Dopamine receptor protein 1 0.1097 0.4352 0.4352
Onchocerca volvulus Excitatory amino acid transporter homolog 0.1359 0.5406 1
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Mycobacterium leprae PROBABLE HYDROLASE 0.0238 0.0895 0.2726
Brugia malayi follicle stimulating hormone receptor 0.1097 0.4352 0.4352
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.1097 0.4352 0.4352
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1097 0.4352 0.4352
Echinococcus granulosus neuropeptide Y receptor 0.1097 0.4352 0.4352
Onchocerca volvulus 0.0277 0.1052 0.1946
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Mycobacterium ulcerans hydrolase 0.0238 0.0895 0.2726
Giardia lamblia Kinase, NEK-like 0.0016 0.0000000050008 0.0000000050008
Onchocerca volvulus 0.0019 0.0015 0.0029
Echinococcus granulosus excitatory amino acid transporter 3 0.1359 0.5406 0.5406
Brugia malayi Hemopexin family protein 0.0277 0.1052 0.1052
Echinococcus multilocularis rhodopsin orphan GPCR 0.1097 0.4352 0.4352
Mycobacterium ulcerans hypothetical protein 0.0035 0.008 0.0242
Entamoeba histolytica hypothetical protein 0.0069 0.0215 1
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Schistosoma mansoni hypothetical protein 0.0309 0.1181 0.1181
Brugia malayi Matrixin family protein 0.0195 0.0723 0.0723
Schistosoma mansoni hypothetical protein 0.0031 0.0064 0.0064
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0064 0.0064
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0019 0.0015 0.0015
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis orexin receptor type 2 0.1097 0.4352 0.4352
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0602 0.2361 0.2361
Echinococcus multilocularis Excitatory amino acid transporter 0.1359 0.5406 0.5406
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus granulosus FTZ F1 alpha 0.0019 0.0015 0.0015
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.1097 0.4352 0.4352
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.1097 0.4352 0.4352
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.021 0.021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni neuropeptide receptor 0.1097 0.4352 0.4352
Brugia malayi Protein kinase domain containing protein 0.0016 0.0000000050008 0.0000000050008
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Schistosoma mansoni amine GPCR 0.1097 0.4352 0.4352
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.003 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Brugia malayi ecdysteroid receptor 0.0019 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Entamoeba histolytica hypothetical protein 0.0069 0.0215 1
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.1097 0.4352 0.4352
Loa Loa (eye worm) hypothetical protein 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.1097 0.4352 0.4352
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0069 0.0215 0.0215
Brugia malayi G-protein coupled receptor 0.1097 0.4352 0.4352
Echinococcus granulosus tm gpcr rhodopsin 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK 0.0016 0.0000000050008 0.0000000050008
Echinococcus multilocularis neuropeptide FF receptor 2 0.1097 0.4352 0.4352
Giardia lamblia Kinase, NEK-frag 0.0016 0.0000000050008 0.0000000050008

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 745 nM Concentration of compound to inhibit 50% (IC50) electrically evoked contractions was tested in Mouse vas deferens (MVD) assay. ChEMBL. 2537427
Ke (functional) = 2.02 nM Ke value for naloxone as antagonist(compound) was measured by using Mouse vas deferens (MVD) assay. ChEMBL. 2537427
Ki (binding) = 23.6 nM Binding affinity against mu opioid receptor by displacement of radioligand [3H]-DAGO in rat brain membrane ChEMBL. 2537427
Ki (binding) = 1880 nM Binding affinity against delta opioid receptor by displacement of radioligand [3H]-DSLET in rat brain membrane ChEMBL. 2537427
Relative potency (binding) = 0.00135 The relative potency of compound was measured against delta opioid receptor to that of [Leu]enkephalin in [3H]-DSLET binding assay. ChEMBL. 2537427
Relative potency (binding) = 0.399 The relative potency of compound was measured against mu opioid receptor to that of [Leu]enkephalin in [3H]-DAGO binding assay. ChEMBL. 2537427

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 2537427

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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