TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 380.399 | Formula: C18H27F3O5
H donors: 1 H acceptors: 1 LogP: 3.95 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: C[C@H]1[C@@H](C[C@@H](C(F)(F)F)O)O[C@H]2[C@@]34[C@H]1CC[C@H]([C@@H]4CC[C@@](O2)(OO3)C)C
InChi: 1S/C18H27F3O5/c1-9-4-5-12-10(2)13(8-14(22)18(19,20)21)23-15-17(12)11(9)6-7-16(3,24-15)25-26-17/h9-15,22H,4-8H2,1-3H3/t9-,10-,11+,12+,13-,14+,15-,16+,17-/m1/s1
InChiKey: VUTVZSWSUBSHAX-ZLPQVMMXSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0199	0.0507
Mycobacterium ulcerans	orotate phosphoribosyltransferase	0.0044	0.064	0.0723
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0044	0.064	0.0723
Echinococcus granulosus	neuropeptide s receptor	0.0025	0.0199	0.0507
Echinococcus granulosus	voltage dependent calcium channel	0.0077	0.1373	0.3498
Mycobacterium ulcerans	penicillin-binding protein PbpA	0.0074	0.1307	0.2605
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0077	0.1373	0.3151
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0189	0.3924	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0025	0.0199	0.0199
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0199	0.0507
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0199	0.0507
Trichomonas vaginalis	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0189	0.3924	0.7868
Mycobacterium tuberculosis	Amidophosphoribosyltransferase PurF (glutamine phosphoribosylpyrophosphate amidotransferase) (ATASE) (gpatase)	0.0044	0.064	0.1009
Onchocerca volvulus	Putative hydrolase PNKD	0.0033	0.0385	0.0189
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0033	0.0385	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0298	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Plasmodium falciparum	basic transcription factor 3b, putative	0.0036	0.0454	0.0198
Brugia malayi	hypothetical protein	0.0033	0.0385	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Echinococcus multilocularis	transcription factor btf3	0.0036	0.0454	0.0686
Onchocerca volvulus	Adenine phosphoribosyltransferase homolog	0.0044	0.064	0.045
Echinococcus granulosus	g-protein coupled receptor	0.0025	0.0199	0.0507
Mycobacterium tuberculosis	Conserved protein	0.0044	0.064	0.1009
Brugia malayi	orotate phosphoribosyltransferase family protein	0.0044	0.064	0.045
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0025	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Trichomonas vaginalis	ribose-phosphate pyrophosphokinase, putative	0.0044	0.064	0.0569
Mycobacterium tuberculosis	Conserved protein	0.0044	0.064	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Entamoeba histolytica	hypothetical protein	0.0037	0.0478	1
Echinococcus granulosus	uridine 5' monophosphate synthase	0.0044	0.064	0.1632
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0199	0.0507
Chlamydia trachomatis	transglycolase/transpeptidase	0.0074	0.1307	1
Schistosoma mansoni	zinc phosphodiesterase	0.0033	0.0385	0.0498
Treponema pallidum	penicillin-binding protein (pbp-3)	0.0074	0.1307	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Echinococcus multilocularis	uridine 5' monophosphate synthase	0.0044	0.064	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0457	1	1
Mycobacterium tuberculosis	Probable penicillin-binding protein PbpA	0.0074	0.1307	0.3637
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0199	0.0507
Mycobacterium ulcerans	penicillin-binding lipoprotein	0.0074	0.1307	0.2605
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0077	0.1373	0.3498
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Trypanosoma brucei	transcription factor BTF3, putative	0.0036	0.0454	0.0198
Echinococcus multilocularis	sodium channel protein	0.0032	0.0373	0.0467
Schistosoma mansoni	orotidine 5'-phosphate decarboxylase	0.0044	0.064	0.1184
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0199	0.0507
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0189	0.3924	1
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0199	0.0507
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0189	0.3924	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0385	0.0385
Plasmodium vivax	basic transcription factor 3b, putative	0.0036	0.0454	0.0432
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0273	0.0697
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0189	0.3924	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Schistosoma mansoni	uracil phosphoribosyltransferase	0.0044	0.064	0.1184
Leishmania major	xanthine phosphoribosyltransferase	0.0189	0.3924	1
Wolbachia endosymbiont of Brugia malayi	amidophosphoribosyltransferase	0.0044	0.064	0.2774
Echinococcus granulosus	biogenic amine 5HT receptor	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0077	0.1373	0.3151
Echinococcus multilocularis	Protein lozenge	0.0057	0.0936	0.1979
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0025	0.0199	0.0507
Mycobacterium leprae	PROBABLE OROTATE PHOSPHORIBOSYLTRANSFERASE PYRE (OPRT) (OPRTASE)	0.0044	0.064	0.1009
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Giardia lamblia	Adenine phosphoribosyltransferase	0.0044	0.064	0.0723
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0047	0.0693	0.0871
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0199	0.0199
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0298	0.0265
Loa Loa (eye worm)	ICD-1 protein	0.0036	0.0454	0.0454
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0044	0.064	0.1184
Echinococcus granulosus	fmrfamide receptor	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Mycobacterium leprae	PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE	0.0074	0.1307	0.3637
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0454	0.0156
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0199	0.0507
Schistosoma mansoni	transcription factor btf3	0.0036	0.0454	0.0686
Echinococcus granulosus	neuropeptide receptor	0.0025	0.0199	0.0507
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0033	0.0385	0.098
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0077	0.1373	0.3151
Loa Loa (eye worm)	metallo-beta-lactamase superfamily protein	0.0033	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0044	0.064	0.1184
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0077	0.1373	0.1373
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0044	0.064	0.0723
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0199	0.0507
Echinococcus multilocularis	voltage dependent calcium channel	0.0077	0.1373	0.3151
Trypanosoma brucei	Adenine phosphoribosyltransferase, putative	0.0044	0.064	0.0723
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.064	0.0723
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0199	0.0507
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0298	0.0265
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0189	0.3924	1
Echinococcus granulosus	neuropeptide FF receptor 2	0.0025	0.0199	0.0507
Trichomonas vaginalis	Ribose-phosphate pyrophosphokinase, putative	0.0044	0.064	0.0569
Trichomonas vaginalis	conserved hypothetical protein	0.0074	0.1307	0.205
Loa Loa (eye worm)	G-protein coupled receptor	0.0025	0.0199	0.0199
Echinococcus multilocularis	ETHE1 protein	0.0033	0.0385	0.0498
Brugia malayi	ethe1-prov protein	0.0033	0.0385	0.0189
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Mycobacterium tuberculosis	Hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (imp pyrophosphor	0.0145	0.292	1
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0298	0.0265
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0298	0.0265
Echinococcus granulosus	serotonin receptor	0.0025	0.0199	0.0507
Echinococcus multilocularis	hydroxyacylglutathione hydrolase	0.0033	0.0385	0.0498
Echinococcus multilocularis	hypoxanthine guanine phosphoribosyltransferase	0.0189	0.3924	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0077	0.1373	0.3151
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0298	0.0265
Toxoplasma gondii	hypoxanthine-xanthine-guanine phosphoribosyl transferase HXGPRT	0.0189	0.3924	1
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.4884	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0025	0.0199	0.0199
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0454	0.0156
Brugia malayi	hypothetical protein	0.0037	0.0478	0.0285
Mycobacterium ulcerans	bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2	0.0074	0.1307	0.2605
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Schistosoma mansoni	hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II)	0.0033	0.0385	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Mycobacterium ulcerans	hypoxanthine-guanine phosphoribosyltransferase Hpt	0.0189	0.3924	1
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0077	0.1373	0.3151
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Echinococcus granulosus	allatostatin A receptor	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase cytoplasmic	0.0033	0.0385	0.0385
Schistosoma mansoni	lozenge	0.0057	0.0936	0.1979
Treponema pallidum	penicillin-binding protein (pbp-1)	0.0074	0.1307	1
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.064	0.0723
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0025	0.0199	0.0507
Toxoplasma gondii	orotate phosphoribosyltransferase	0.0044	0.064	0.1632
Mycobacterium tuberculosis	Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen	0.0074	0.1307	0.3637
Schistosoma mansoni	voltage-gated cation channel	0.0077	0.1373	0.3151
Mycobacterium ulcerans	hypothetical protein	0.0044	0.064	0.0723
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0025	0.0199	0.0507
Onchocerca volvulus		0.0231	0.4884	0.478
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Loa Loa (eye worm)	adenine phosphoribosyltransferase	0.0044	0.064	0.064
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Mycobacterium ulcerans	penicillin-binding membrane protein PbpB	0.0074	0.1307	0.2605
Leishmania major	hypoxanthine-guanine phosphoribosyltransferase	0.0189	0.3924	1
Entamoeba histolytica	hypothetical protein	0.0037	0.0478	1
Echinococcus granulosus	neuropeptide receptor A26	0.0025	0.0199	0.0507
Toxoplasma gondii	NAC domain-containing protein	0.0036	0.0454	0.1158
Mycobacterium ulcerans	bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase	0.0044	0.064	0.0723
Plasmodium vivax	unspecified product	0.0033	0.0385	0.0239
Mycobacterium ulcerans	bifunctional penicillin-binding protein 1A/1B PonA1	0.0074	0.1307	0.2605
Schistosoma mansoni	hypothetical protein	0.0033	0.0385	0.0498
Echinococcus granulosus	orexin receptor type 2	0.0025	0.0199	0.0507
Onchocerca volvulus		0.0033	0.0385	0.0189
Echinococcus granulosus	G protein coupled receptor 139	0.0025	0.0199	0.0507
Mycobacterium tuberculosis	Probable pyrimidine operon regulatory protein PyrR	0.0044	0.064	0.1009
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0025	0.0199	0.0199
Echinococcus granulosus	sex peptide receptor	0.0025	0.0199	0.0507
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0077	0.1373	0.3498
Echinococcus granulosus	transcription factor btf3	0.0036	0.0454	0.1158
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0077	0.1373	0.3498
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0298	0.0265
Onchocerca volvulus		0.0033	0.0385	0.0189
Trypanosoma cruzi	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0044	0.064	0.0723
Mycobacterium ulcerans	amidophosphoribosyltransferase	0.0044	0.064	0.0723
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.4247	0.4247
Plasmodium falciparum	hypoxanthine-guanine phosphoribosyltransferase	0.0189	0.3924	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Treponema pallidum	penicillin-binding protein (pbp-2)	0.0074	0.1307	1
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0454	0.0156
Mycobacterium tuberculosis	Possible penicillin-binding lipoprotein	0.0074	0.1307	0.3637
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Onchocerca volvulus	Hydroxyacylglutathione hydrolase, mitochondrial homolog	0.0033	0.0385	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0033	0.0385	0.0189
Plasmodium vivax	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0189	0.3924	1
Mycobacterium leprae	AMIDOPHOSPHORIBOSYLTRANSFERASE PURF (GLUTAMINE PHOSPHORIBOSYLPYROPHOSPHATE AMIDOTRANSFERASE) (ATASE) (GPATASE)	0.0044	0.064	0.1009
Leishmania major	basic transcription factor 3a, putative	0.0036	0.0454	0.0198
Brugia malayi	beta-NAC-like protein	0.0036	0.0454	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Plasmodium vivax	orotate phosphoribosyltransferase, putative	0.0044	0.064	0.0945
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0199	0.0507
Plasmodium vivax	hydroxyacyl glutathione hydrolase, putative	0.0033	0.0385	0.0239
Echinococcus granulosus	dro:myosuppressin receptor	0.0025	0.0199	0.0507
Brugia malayi	Phosphoribosyl transferase domain containing protein	0.0189	0.3924	0.3801
Toxoplasma gondii	metallo-beta-lactamase domain-containing protein	0.0033	0.0385	0.098
Loa Loa (eye worm)	calcium channel	0.0077	0.1373	0.1373
Leishmania major	adenine phosphoribosyltransferase	0.0044	0.064	0.0723
Echinococcus granulosus	hypothetical protein	0.0025	0.0199	0.0507
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0025	0.0199	0.0507
Chlamydia trachomatis	transglycolase/transpeptidase	0.0074	0.1307	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0025	0.0199	0.0507
Echinococcus multilocularis	metallo beta lactamase domain containing protein	0.0033	0.0385	0.0498
Loa Loa (eye worm)	orotate phosphoribosyltransferase	0.0044	0.064	0.064
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Brugia malayi	Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site.	0.0033	0.0385	0.0189
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0189	0.3924	1
Mycobacterium ulcerans	adenine phosphoribosyltransferase	0.0044	0.064	0.0723
Mycobacterium leprae	PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN	0.0074	0.1307	0.3637
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0385	0.0385
Echinococcus granulosus	metallo beta lactamase domain containing protein	0.0033	0.0385	0.098
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0189	0.3924	1
Echinococcus granulosus	neuropeptide Y receptor	0.0025	0.0199	0.0507
Echinococcus granulosus	neuropeptides capa receptor	0.0025	0.0199	0.0507
Echinococcus granulosus	7tm_1 domain containing protein	0.0025	0.0199	0.0507
Echinococcus granulosus	hydroxyacylglutathione hydrolase	0.0033	0.0385	0.098
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0077	0.1373	0.1198
Schistosoma mansoni	Adenine phosphoribosyltransferase	0.0044	0.064	0.1184
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Schistosoma mansoni	hypothetical protein	0.0033	0.0385	0.0498
Trypanosoma brucei	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative	0.0044	0.064	0.0723
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0025	0.0199	0.0199
Mycobacterium leprae	Probable penicillin-binding protein PbpA	0.0074	0.1307	0.3637
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0047	0.0693	0.0871
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0454	0.0198
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0199	0.0507
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0189	0.3924	1
Brugia malayi	Pre-SET motif family protein	0.0029	0.0298	0.0101
Brugia malayi	Adenine phosphoribosyltransferase	0.0044	0.064	0.045
Schistosoma mansoni	hypoxanthine-guanine phosphoribosyltransferase	0.0044	0.064	0.1184
Mycobacterium leprae	Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP pho	0.0145	0.292	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0478	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Entamoeba histolytica	transcription factor BTF3, putative	0.0036	0.0454	0.7467
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Echinococcus granulosus	ETHE1 protein	0.0033	0.0385	0.098
Wolbachia endosymbiont of Brugia malayi	orotate phosphoribosyltransferase	0.0044	0.064	0.2774
Echinococcus granulosus	somatostatin receptor	0.0025	0.0199	0.0507
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0037	0.0478	0.1219
Onchocerca volvulus		0.0189	0.3924	0.3801
Loa Loa (eye worm)	melatonin receptor type 1A	0.0025	0.0199	0.0199
Onchocerca volvulus		0.0457	1	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0044	0.064	0.1009
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Treponema pallidum	phosphoribosylpyrophosphate synthetase	0.0044	0.064	0.2774
Onchocerca volvulus		0.0029	0.0298	0.0101
Loa Loa (eye worm)	hydroxyacylglutathione hydrolase	0.0033	0.0385	0.0385
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0189	0.3924	1
Giardia lamblia	Guanine phosphoribosyltransferase	0.0189	0.3924	1
Echinococcus granulosus	hypoxanthine guanine phosphoribosyltransferase	0.0189	0.3924	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0385	0.0385
Echinococcus granulosus	7TM GPCR rhodopsin	0.0025	0.0199	0.0507
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0029	0.0298	0.0759
Entamoeba histolytica	hypothetical protein	0.0036	0.0454	0.7467
Brugia malayi	Pre-SET motif family protein	0.0203	0.4247	0.413
Echinococcus granulosus	adenine phosphoribosyltransferase	0.0044	0.064	0.1632
Echinococcus granulosus	g protein coupled receptor	0.0025	0.0199	0.0507
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsI	0.0074	0.1307	1
Trypanosoma cruzi	hypoxanthine-guanine phosphoribosyltransferase, putative	0.0189	0.3924	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0298	0.0759
Loa Loa (eye worm)	TYRA-2 protein	0.0025	0.0199	0.0199
Plasmodium falciparum	orotate phosphoribosyltransferase	0.0044	0.064	0.0723
Mycobacterium tuberculosis	Probable orotate phosphoribosyltransferase PyrE (OPRT) (oprtase)	0.0044	0.064	0.1009
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.064	0.0723
Echinococcus granulosus	rhodopsin orphan GPCR	0.0025	0.0199	0.0507
Echinococcus multilocularis	zinc phosphodiesterase	0.0033	0.0385	0.0498
Trypanosoma cruzi	transcription factor btf3, putative	0.0036	0.0454	0.0198
Treponema pallidum	hypothetical protein	0.0044	0.064	0.2774
Loa Loa (eye worm)	neuropeptide F receptor	0.0025	0.0199	0.0199
Entamoeba histolytica	hypothetical protein	0.0037	0.0478	1
Echinococcus multilocularis	voltage dependent calcium channel	0.0077	0.1373	0.3151
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0077	0.1373	0.3151
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Leishmania major	orotidine-5-phosphate decarboxylase/orotate phosphoribosyltransferase, putative,OMPDCase-OPRTase, putative	0.0044	0.064	0.0723
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Trypanosoma brucei	hypoxanthine-guanine phosphoribosyltransferase	0.0189	0.3924	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Mycobacterium tuberculosis	Adenine phosphoribosyltransferase Apt (APRT) (AMP diphosphorylase) (AMP pyrophosphorylase) (transphosphoribosidase)	0.0044	0.064	0.1009
Schistosoma mansoni	transcription factor LCR-F1	0.0037	0.0478	0.0749
Entamoeba histolytica	hypothetical protein	0.0037	0.0478	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Echinococcus multilocularis	adenine phosphoribosyltransferase	0.0044	0.064	0.1184
Treponema pallidum	adenine phosphoribosyltransferase	0.0044	0.064	0.2774
Mycobacterium leprae	POSSIBLE PENICILLIN-BINDING LIPOPROTEIN	0.0074	0.1307	0.3637
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0199	0.0199
Brugia malayi	metallo-beta-lactamase superfamily protein	0.0033	0.0385	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0385	0.0385
Schistosoma mansoni	zinc phosphodiesterase	0.0033	0.0385	0.0498
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0032	0.0373	0.0951
Schistosoma mansoni	hypothetical protein	0.0033	0.0385	0.0498
Loa Loa (eye worm)	runx1	0.0057	0.0936	0.0936
Toxoplasma gondii	hydroxyacylglutathione hydrolase	0.0033	0.0385	0.098
Echinococcus granulosus	zinc phosphodiesterase	0.0033	0.0385	0.098
Loa Loa (eye worm)	hypothetical protein	0.0457	1	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0037	0.0478	0.0749
Trypanosoma cruzi	Adenine phosphoribosyltransferase, putative	0.0044	0.064	0.0723

Activities

Activity type	Activity value	Assay description	Source	Reference
Relative activity (functional)	= 2.5	In Vitro relative activity against Plasmodium falciparum D-6 clone (chloroquine-sensitive and mefloquine -resistant).	ChEMBL.	11063619
Relative activity (functional)	= 3.1	In Vitro relative activity against Plasmodium falciparum W-2 clone (chloroquine-resistant and mefloquine-sensitive).	ChEMBL.	11063619

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2367749

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1742688