Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | HMG-CoA reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.4168 | 0.4168 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0078 | 0.1851 | 0.5 |
Echinococcus multilocularis | potassium voltage gated channel subfamily A | 0.0087 | 0.2111 | 0.2111 |
Schistosoma mansoni | patched 1 | 0.0068 | 0.16 | 0.16 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.4168 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.4168 | 0.4168 |
Echinococcus granulosus | potassium voltage gated channel protein | 0.0091 | 0.2217 | 0.2217 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1851 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.16 | 0.16 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.2217 | 0.2217 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0386 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1851 | 1 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0165 | 0.4168 | 0.4168 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0068 | 0.16 | 0.16 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.2217 | 0.2217 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0386 | 1 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0068 | 0.16 | 0.16 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0091 | 0.2217 | 0.2217 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0068 | 0.16 | 0.16 |
Brugia malayi | CHE-14 protein | 0.0068 | 0.16 | 0.16 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0078 | 0.1851 | 1 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0386 | 1 | 1 |
Echinococcus multilocularis | protein patched | 0.0068 | 0.16 | 0.16 |
Echinococcus multilocularis | potassium voltage gated channel protein | 0.0091 | 0.2217 | 0.2217 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0386 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0068 | 0.16 | 0.16 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.4168 | 0.5 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0386 | 1 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0386 | 1 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily A | 0.0091 | 0.2217 | 0.2217 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0386 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit | 0.0091 | 0.2217 | 0.2217 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0165 | 0.4168 | 0.4168 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0165 | 0.4168 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0068 | 0.16 | 0.16 |
Echinococcus multilocularis | protein dispatched 1 | 0.0068 | 0.16 | 0.16 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0165 | 0.4168 | 0.5 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0165 | 0.4168 | 0.4168 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0165 | 0.4168 | 0.5 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0068 | 0.16 | 0.16 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0068 | 0.16 | 0.16 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.1 uM | Inhibition of solubilized, partially purified rat liver HMG-CoA reductase | ChEMBL. | 3950901 |
Relative potency (binding) | = 1.4 | Relative potency to inhibit solubilized, partially purified rat liver HMG-CoA reductase compared with that of compactin. | ChEMBL. | 3950901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.