Detailed information for compound 1742792

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1094.29 | Formula: C48H63N13O11S3
  • H donors: 12 H acceptors: 11 LogP: -1.55 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 4
  • SMILES: NC(=O)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCSSC[C@H](NC1=O)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N)CCCN=C(N)N)Cc1ccc(cc1)O)Cc1ccccc1)Cc1cccs1
  • InChi: 1S/C48H63N13O11S3/c49-38(63)24-35-45(70)60-36(47(72)61-18-5-11-37(61)46(71)56-31(10-4-17-53-48(51)52)41(66)54-25-39(50)64)26-75-74-20-16-40(65)55-32(22-28-12-14-29(62)15-13-28)42(67)57-33(21-27-7-2-1-3-8-27)43(68)58-34(44(69)59-35)23-30-9-6-19-73-30/h1-3,6-9,12-15,19,31-37,62H,4-5,10-11,16-18,20-26H2,(H2,49,63)(H2,50,64)(H,54,66)(H,55,65)(H,56,71)(H,57,67)(H,58,68)(H,59,69)(H,60,70)(H4,51,52,53)/t31-,32-,33-,34-,35-,36-,37-/m0/s1
  • InChiKey: CPJUVXWWADNXOK-PEAOEFARSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens oxytocin receptor Starlite/ChEMBL References
Homo sapiens arginine vasopressin receptor 1B Starlite/ChEMBL References
Homo sapiens arginine vasopressin receptor 2 Starlite/ChEMBL References
Homo sapiens arginine vasopressin receptor 1A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0056 0.0056
Echinococcus granulosus integrin linked protein kinase 0.0861 0.3917 0.3883
Brugia malayi SH2 domain containing protein 0.1284 0.592 0.592
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0861 0.3917 0.3917
Brugia malayi Protein kinase domain containing protein 0.2145 1 1
Onchocerca volvulus 0.2145 1 1
Onchocerca volvulus 0.1284 0.592 0.5638
Brugia malayi STAT protein, DNA binding domain containing protein 0.1284 0.592 0.592
Echinococcus granulosus tyrosine protein kinase csk 0.0861 0.3917 0.3883
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Trypanosoma brucei Flagellum attachment zone protein 20 0.0861 0.3917 0.5
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Brugia malayi cytokine inducible SH2-containing protein 5 0.1284 0.592 0.592
Echinococcus granulosus tyrosine protein kinase pr2 0.0861 0.3917 0.3883
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Echinococcus granulosus insulin receptor 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Schistosoma mansoni tensin-related 0.1284 0.592 0.592
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus granulosus activin receptor type 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Giardia lamblia Protein 21.1 0.0861 0.3917 0.5
Echinococcus granulosus protein kinase 0.0861 0.3917 0.3883
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2145 1 1
Loa Loa (eye worm) SH2 domain-containing protein 0.1284 0.592 0.592
Brugia malayi SH2 domain containing protein 0.1284 0.592 0.592
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0861 0.3917 0.3883
Brugia malayi Protein-tyrosine phosphatase containing protein 0.1284 0.592 0.592
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.107 0.1296
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1284 0.592 0.592
Trichomonas vaginalis STE family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis AGC family protein kinase 0.0861 0.3917 1
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0861 0.3917 0.3883
Echinococcus multilocularis activin receptor type 0.0861 0.3917 0.3883
Schistosoma mansoni GTPase activating protein 0.1284 0.592 0.592
Echinococcus multilocularis protein kinase 0.0861 0.3917 0.3883
Echinococcus granulosus hypothetical protein 0.1284 0.592 0.5897
Brugia malayi Variant SH3 domain containing protein 0.1284 0.592 0.592
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.1284 0.592 0.592
Echinococcus multilocularis receptor type guanylyl cyclase 0.0861 0.3917 0.3883
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Loa Loa (eye worm) TK/ROR protein kinase 0.0861 0.3917 0.3917
Schistosoma mansoni serine/threonine protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2145 1 1
Loa Loa (eye worm) hypothetical protein 0.2145 1 1
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus multilocularis FL cytokine receptor 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.2145 1 1
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Loa Loa (eye worm) SRC-1 0.2145 1 1
Echinococcus multilocularis kinase suppressor of Ras 1 0.0861 0.3917 0.3883
Onchocerca volvulus Tyrosine kinase homolog 0.0861 0.3917 0.3497
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0861 0.3917 0.3917
Echinococcus granulosus NCK adaptor protein 0.1284 0.592 0.5897
Loa Loa (eye worm) TK/FER protein kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.1284 0.592 0.5897
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.1284 0.592 0.5897
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.1284 0.592 0.592
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1284 0.592 0.5897
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0861 0.3917 0.3917
Onchocerca volvulus 0.2145 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0056 0.0056
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Echinococcus multilocularis protein tyrosine kinase 0.0861 0.3917 0.3883
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0861 0.3917 0.3917
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0075 0.0075
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Onchocerca volvulus 0.1284 0.592 0.5638
Loa Loa (eye worm) RGC/RGC protein kinase 0.0861 0.3917 0.3917
Onchocerca volvulus 0.0861 0.3917 0.3497
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Brugia malayi SH2 domain containing protein 0.1284 0.592 0.592
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) TK/CSK protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis SH2 motif 0.1284 0.592 0.5897
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Leishmania major protein kinase, putative 0.0861 0.3917 0.5
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Echinococcus granulosus activated cdc42 kinase 1 0.0861 0.3917 0.3883
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0861 0.3917 0.3883
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0861 0.3917 1
Loa Loa (eye worm) TK/FER protein kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.2145 1 1
Schistosoma mansoni tyrosine kinase 0.2145 1 1
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0861 0.3917 0.3883
Echinococcus multilocularis tensin 0.1284 0.592 0.5897
Echinococcus multilocularis epidermal growth factor receptor 0.0861 0.3917 0.3883
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Toxoplasma gondii protein kinase domain-containing protein 0.0861 0.3917 0.5
Onchocerca volvulus 0.2145 1 1
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0861 0.3917 0.3917
Echinococcus granulosus tyrosine protein kinase Fyn 0.2145 1 1
Schistosoma mansoni tensin 0.1284 0.592 0.592
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.2145 1 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.1284 0.592 0.5897
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein kinase Blk 0.2145 1 1
Brugia malayi ephrin receptor 1 precursor 0.0861 0.3917 0.3917
Schistosoma mansoni serine/threonine RGC 0.0861 0.3917 0.3917
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0861 0.3917 0.5
Echinococcus multilocularis tyrosine kinase 0.0861 0.3917 0.3883
Brugia malayi Immunoglobulin I-set domain containing protein 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Schistosoma mansoni shc transforming protein 0.1284 0.592 0.592
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Trichomonas vaginalis protein kinase atn1, putative 0.0861 0.3917 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.2145 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0056 0.0056
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.2145 1 1
Leishmania major protein kinase, putative 0.0861 0.3917 0.5
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein kinase Srms 0.2145 1 1
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Plasmodium vivax protein kinase, putative 0.0861 0.3917 0.5
Echinococcus granulosus suppressor of cytokine signaling 6 0.1284 0.592 0.5897
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0861 0.3917 0.3883
Brugia malayi protein-tyrosine kinase 0.2145 1 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.1284 0.592 0.592
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1284 0.592 0.592
Loa Loa (eye worm) protein-tyrosine phosphatase 0.1284 0.592 0.592
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.1284 0.592 0.592
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0861 0.3917 1
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Schistosoma mansoni tyrosine kinase 0.2145 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.107 0.1296
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0861 0.3917 0.3883
Brugia malayi Raf kinase 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.2145 1 1
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2145 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.107 0.1296
Echinococcus granulosus fibroblast growth factor receptor 4 0.0861 0.3917 0.3883
Giardia lamblia Kinase, NEK 0.0861 0.3917 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0861 0.3917 0.3883
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0861 0.3917 0.3883
Echinococcus multilocularis tyrosine protein kinase 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK protein kinase 0.0861 0.3917 0.3917
Echinococcus granulosus natriuretic peptide receptor 1 0.0861 0.3917 0.3883
Schistosoma mansoni ephrin receptor 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Plasmodium falciparum protein kinase, putative 0.0861 0.3917 0.5
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0861 0.3917 0.5
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) protein kinase domain-containing protein 0.0861 0.3917 0.3917
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0861 0.3917 0.3917
Brugia malayi SH2 domain containing protein 0.2145 1 1
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Trichomonas vaginalis TK family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0861 0.3917 0.3883
Echinococcus granulosus tyrosine protein kinase Blk 0.2145 1 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis c src tyrosine kinase 0.2145 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1284 0.592 0.5897
Schistosoma mansoni vav2 0.1284 0.592 0.592
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.107 0.1296
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK/ALK protein kinase 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis CAMK family protein kinase 0.0861 0.3917 1
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0861 0.3917 0.3917
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Onchocerca volvulus 0.2145 1 1
Echinococcus granulosus tyrosine kinase 0.2145 1 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.2145 1 1
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Leishmania major hypothetical protein, conserved 0.0861 0.3917 0.5
Echinococcus granulosus ephrin type A receptor 4 A 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK/EPH protein kinase 0.0861 0.3917 0.3917
Trypanosoma cruzi protein kinase, putative 0.0861 0.3917 0.5
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus tyrosine protein kinase ABL1 0.2145 1 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1284 0.592 0.5897
Toxoplasma gondii protein kinase 0.0861 0.3917 0.5
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Schistosoma mansoni signal transduction protein lnk-related 0.1284 0.592 0.592
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Brugia malayi SRC-1 0.2145 1 1
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis NCK adaptor protein 0.1284 0.592 0.5897
Loa Loa (eye worm) SH2 domain-containing protein 0.1284 0.592 0.592
Brugia malayi Variant SH3 domain containing protein 0.1284 0.592 0.592
Echinococcus multilocularis heat shock protein 70 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK/EGFR protein kinase 0.0861 0.3917 0.3917
Echinococcus granulosus tyrosine protein kinase Srms 0.2145 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0075 0.0075
Echinococcus granulosus tensin C1 domain containing phosphatase 0.1284 0.592 0.5897
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Brugia malayi Protein kinase domain containing protein 0.2145 1 1
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.1284 0.592 0.5897
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Plasmodium vivax tyrosine kinase-like protein, putative 0.0861 0.3917 0.5
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Echinococcus multilocularis suppressor of cytokine signaling 7 0.1284 0.592 0.5897
Schistosoma mansoni growth factor receptor-bound protein 0.1284 0.592 0.592
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Echinococcus granulosus growth factor receptor bound protein 2 0.1284 0.592 0.5897
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Echinococcus multilocularis tyrosine kinase 0.2145 1 1
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0861 0.3917 0.3917
Echinococcus granulosus tyrosine protein kinase Lyn 0.2145 1 1
Onchocerca volvulus 0.1284 0.592 0.5638
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0075 0.0075
Echinococcus granulosus SHC transforming protein 3 0.1284 0.592 0.5897
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis SH2 motif 0.1284 0.592 0.5897
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Onchocerca volvulus 0.0861 0.3917 0.3497
Echinococcus multilocularis tyrosine protein kinase pr2 0.0861 0.3917 0.3883
Echinococcus granulosus raf serine:threonine protein kinase 0.0861 0.3917 0.3883
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus tyrosine protein kinase shark 0.2145 1 1
Echinococcus granulosus tyrosine protein kinase csk 0.0861 0.3917 0.3883
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein kinase Fgr 0.2145 1 1
Trypanosoma brucei Pseudokinase, putative 0.0861 0.3917 0.5
Brugia malayi RhoGAP domain containing protein 0.1284 0.592 0.592
Schistosoma mansoni tyrosine-protein kinase zap-70 0.1284 0.592 0.592
Trichomonas vaginalis conserved hypothetical protein 0.0861 0.3917 1
Echinococcus granulosus tyrosine kinase 0.2145 1 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.026 0.107 0.107
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0817 0.3709 0.3673
Echinococcus granulosus tyrosine protein kinase Fyn 0.2145 1 1
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Brugia malayi SH2 domain containing protein 0.2145 1 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0861 0.3917 0.3883
Echinococcus granulosus signal transduction protein lnk realted 0.1284 0.592 0.5897
Echinococcus multilocularis tyrosine protein kinase HCK 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Schistosoma mansoni serine/threonine protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.1284 0.592 0.5897
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Plasmodium vivax tyrosine kinase-like protein, putative 0.0861 0.3917 0.5
Loa Loa (eye worm) TK protein kinase 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Plasmodium falciparum protein kinase, putative 0.0861 0.3917 0.5
Schistosoma mansoni tensin-related 0.1284 0.592 0.592
Brugia malayi integrin-linked kinase 0.0861 0.3917 0.3917
Brugia malayi Guanylyl cyclase protein 23 0.0861 0.3917 0.3917
Schistosoma mansoni protein tyrosine kinase 0.0861 0.3917 0.3917
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0861 0.3917 0.5
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Loa Loa (eye worm) TK protein kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) STAT protein 0.1284 0.592 0.592
Echinococcus multilocularis tyrosine protein kinase ABL1 0.2145 1 1
Onchocerca volvulus 0.1284 0.592 0.5638
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0861 0.3917 0.3883
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Loa Loa (eye worm) TK/FER protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis signal transduction protein lnk realted 0.1284 0.592 0.5897
Brugia malayi Variant SH3 domain containing protein 0.1284 0.592 0.592
Onchocerca volvulus 0.1284 0.592 0.5638
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.2145 1 1
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.1284 0.592 0.5897
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0861 0.3917 0.3917
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.069 0.0133
Loa Loa (eye worm) TK/FER protein kinase 0.0861 0.3917 0.3917
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus granulosus tensin 0.1284 0.592 0.5897
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Schistosoma mansoni suppressor of cytokine signaling 0.1284 0.592 0.592
Onchocerca volvulus 0.0861 0.3917 0.3497
Plasmodium falciparum tyrosine kinase-like protein 0.0861 0.3917 0.5
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Loa Loa (eye worm) RGC/RGC protein kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) TK/FER protein kinase 0.0861 0.3917 0.3917
Echinococcus granulosus kinase suppressor of Ras 1 0.0861 0.3917 0.3883
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0861 0.3917 0.5
Echinococcus multilocularis activated cdc42 kinase 1 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0861 0.3917 0.3917
Brugia malayi bone morphogenetic protein type 1 receptor 0.0861 0.3917 0.3917
Onchocerca volvulus 0.0861 0.3917 0.3497
Brugia malayi Receptor family ligand binding region containing protein 0.0861 0.3917 0.3917
Schistosoma mansoni serine/threonine protein kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.1284 0.592 0.5897
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus multilocularis growth factor receptor bound protein 2 0.1284 0.592 0.5897
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK protein kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) serine/threonine protein kinase 0.0861 0.3917 0.3917
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus granulosus SH2 motif 0.1284 0.592 0.5897
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.2145 1 1
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Loa Loa (eye worm) TK protein kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Loa Loa (eye worm) variant SH3 domain-containing protein 0.1284 0.592 0.592
Brugia malayi Protein kinase domain containing protein 0.2145 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Echinococcus multilocularis transfer RNA-Thr 0.0861 0.3917 0.3883
Trichomonas vaginalis conserved hypothetical protein 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Schistosoma mansoni adapter molecule crk 0.1284 0.592 0.592
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Echinococcus granulosus tyrosine protein kinase Fyn 0.2145 1 1
Echinococcus multilocularis integrin linked protein kinase 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.069 0.0133
Loa Loa (eye worm) RGC/RGC protein kinase 0.0861 0.3917 0.3917
Echinococcus granulosus tyrosine protein kinase Fps85D 0.2145 1 1
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0861 0.3917 0.3917
Brugia malayi tRNA modification GTPase TrmE family protein 0.1284 0.592 0.592
Echinococcus granulosus retinal guanylyl cyclase 2 0.0861 0.3917 0.3883
Echinococcus multilocularis N chimaerin 0.1284 0.592 0.5897
Trichomonas vaginalis conserved hypothetical protein 0.0861 0.3917 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.2145 1 1
Loa Loa (eye worm) TK protein kinase 0.0861 0.3917 0.3917
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0861 0.3917 0.3883
Loa Loa (eye worm) RGC/RGC protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.2145 1 1
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0861 0.3917 0.3883
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Brugia malayi SH2 domain containing protein 0.1284 0.592 0.592
Loa Loa (eye worm) SH2 domain-containing protein 0.1284 0.592 0.592
Trichomonas vaginalis protein tyrosine kinase, putative 0.0861 0.3917 1
Echinococcus multilocularis tensin 0.1284 0.592 0.5897
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Schistosoma mansoni tyrosine kinase 0.2145 1 1
Loa Loa (eye worm) TK/DDR protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis ephrin type A receptor 4 A 0.0861 0.3917 0.3883
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0075 0.0075
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Entamoeba histolytica protein kinase, putative 0.1284 0.592 0.3293
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.2145 1 1
Giardia lamblia Kinase 0.0861 0.3917 0.5
Echinococcus granulosus tyrosine protein kinase Btk29A 0.2145 1 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus SH2 domain containing protein 7 0.1284 0.592 0.5897
Echinococcus multilocularis protein KINase family member (kin 25) 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Echinococcus granulosus SH2 domain containing adapter protein F 0.1284 0.592 0.5897
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0056 0.0056
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) TK/ACK protein kinase 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Onchocerca volvulus 0.0861 0.3917 0.3497
Schistosoma mansoni tensin 0.1284 0.592 0.592
Onchocerca volvulus 0.1284 0.592 0.5638
Loa Loa (eye worm) TK/FER protein kinase 0.0861 0.3917 0.3917
Echinococcus granulosus retinal guanylyl cyclase 2 0.0861 0.3917 0.3883
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Echinococcus granulosus suppressor of cytokine signaling 7 0.1284 0.592 0.5897
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.2145 1 1
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0861 0.3917 0.3917
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0861 0.3917 0.5
Echinococcus granulosus activated cdc42 kinase 1 0.0861 0.3917 0.3883
Echinococcus granulosus retinal guanylyl cyclase 2 0.0861 0.3917 0.3883
Brugia malayi Furin-like cysteine rich region family protein 0.0861 0.3917 0.3917
Loa Loa (eye worm) TK/RYK protein kinase 0.0861 0.3917 0.3917
Schistosoma mansoni tyrosine protein kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis conserved hypothetical protein 0.0861 0.3917 1
Toxoplasma gondii STE kinase 0.0861 0.3917 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.107 0.1296
Brugia malayi SH2 domain containing protein 0.1284 0.592 0.592
Echinococcus multilocularis tyrosine protein kinase csk 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Brugia malayi hypothetical protein 0.1284 0.592 0.592
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0861 0.3917 0.3883
Brugia malayi Protein kinase domain containing protein 0.2145 1 1
Brugia malayi hypothetical protein 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein kinase csk 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis conserved hypothetical protein 0.0861 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0861 0.3917 0.3497
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Plasmodium falciparum tyrosine kinase-like protein 0.0861 0.3917 0.5
Loa Loa (eye worm) TK/INSR protein kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0861 0.3917 0.3883
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0861 0.3917 0.3917
Schistosoma mansoni nck2/grb4 0.1284 0.592 0.592
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.107 0.1296
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0861 0.3917 0.5
Schistosoma mansoni hypothetical protein 0.1284 0.592 0.592
Trypanosoma cruzi protein kinase, putative 0.0861 0.3917 0.5
Loa Loa (eye worm) TK/ABL protein kinase 0.2145 1 1
Echinococcus multilocularis protein kinase 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK protein kinase 0.2145 1 1
Echinococcus multilocularis raf serine:threonine protein kinase 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK/Met protein kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0861 0.3917 1
Echinococcus granulosus tyrosine protein kinase Src64B 0.2145 1 1
Onchocerca volvulus 0.0861 0.3917 0.3497
Echinococcus multilocularis tyrosine protein kinase Fyn 0.2145 1 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0861 0.3917 0.3883
Loa Loa (eye worm) TK/FER protein kinase 0.2145 1 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.1284 0.592 0.592
Onchocerca volvulus 0.2145 1 1
Echinococcus multilocularis tyrosine protein kinase shark 0.2145 1 1
Brugia malayi SH2 domain containing protein 0.1284 0.592 0.592
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0861 0.3917 0.3917
Entamoeba histolytica SH2-protein kinase domain containing protein 0.1284 0.592 0.3293
Echinococcus multilocularis insulin receptor 0.0861 0.3917 0.3883
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Schistosoma mansoni hypothetical protein 0.1284 0.592 0.592
Echinococcus granulosus expressed conserved protein 0.1284 0.592 0.5897
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0861 0.3917 0.3883
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Entamoeba histolytica SH2-protein kinase domain containing protein 0.2145 1 1
Brugia malayi SH2 domain containing protein 0.1284 0.592 0.592
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0861 0.3917 0.3883
Echinococcus granulosus c src tyrosine kinase 0.2145 1 1
Brugia malayi Tensin 0.1284 0.592 0.592
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0861 0.3917 0.3497
Echinococcus granulosus tyrosine protein kinase 0.0861 0.3917 0.3883
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0861 0.3917 0.3883
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Echinococcus granulosus tyrosine protein kinase Src42A 0.2145 1 1
Trypanosoma brucei protein kinase, putative 0.0861 0.3917 0.5
Schistosoma mansoni suppressor of cytokine signaling 0.1284 0.592 0.592
Giardia lamblia Kinase, NEK 0.0861 0.3917 0.5
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0861 0.3917 0.3883
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0861 0.3917 0.3883
Schistosoma mansoni SH2A 0.1284 0.592 0.592
Echinococcus multilocularis tyrosine protein kinase csk 0.0861 0.3917 0.3883
Echinococcus granulosus receptor type guanylyl cyclase 0.0861 0.3917 0.3883
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Brugia malayi Sex muscle abnormal protein 5 0.1284 0.592 0.592
Loa Loa (eye worm) TK/FER protein kinase 0.0861 0.3917 0.3917
Brugia malayi Tyrosine-protein kinase PR2 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Brugia malayi hypothetical protein 0.0861 0.3917 0.3917
Schistosoma mansoni ephrin receptor 0.0861 0.3917 0.3917
Loa Loa (eye worm) TK protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis SHC transforming protein 3 0.1284 0.592 0.5897
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.1284 0.592 0.592
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0861 0.3917 0.5
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus protein tyrosine kinase 0.0861 0.3917 0.3883
Brugia malayi Tyrosine-protein kinase abl-1 0.2145 1 1
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.1284 0.592 0.5638
Echinococcus granulosus tyrosine protein kinase csk 0.0861 0.3917 0.3883
Schistosoma mansoni hypothetical protein 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis conserved hypothetical protein 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Plasmodium falciparum protein kinase, putative 0.0861 0.3917 0.5
Onchocerca volvulus 0.0861 0.3917 0.3497
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis suppressor of cytokine signaling 6 0.1284 0.592 0.5897
Onchocerca volvulus 0.2145 1 1
Brugia malayi C-terminal src kinase protein 1 0.0861 0.3917 0.3917
Echinococcus multilocularis SH2 domain containing adapter protein F 0.1284 0.592 0.5897
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.2145 1 1
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.1284 0.592 0.5638
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Loa Loa (eye worm) hypothetical protein 0.0861 0.3917 0.3917
Loa Loa (eye worm) TK/FAK protein kinase 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Schistosoma mansoni tyrosine kinase 0.0861 0.3917 0.3917
Echinococcus granulosus tyrosine protein kinase HCK 0.0861 0.3917 0.3883
Echinococcus multilocularis SH2 motif 0.1284 0.592 0.5897
Echinococcus multilocularis natriuretic peptide receptor 1 0.0861 0.3917 0.3883
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis 0.1284 0.592 0.5897
Loa Loa (eye worm) TK protein kinase 0.0861 0.3917 0.3917
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus granulosus tyrosine kinase 0.0861 0.3917 0.3883
Schistosoma mansoni growth factor receptor-bound protein 0.1284 0.592 0.592
Schistosoma mansoni protein kinase 0.0861 0.3917 0.3917
Echinococcus multilocularis tyrosine protein kinase Src64B 0.2145 1 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis epidermal growth factor receptor 0.0861 0.3917 0.3883
Entamoeba histolytica SH2 domain containing protein 0.1284 0.592 0.3293
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0861 0.3917 0.3883
Echinococcus granulosus SH2 motif 0.1284 0.592 0.5897
Brugia malayi Variant SH3 domain containing protein 0.1284 0.592 0.592
Brugia malayi Protein kinase domain containing protein 0.0861 0.3917 0.3917
Echinococcus granulosus N chimaerin 0.1284 0.592 0.5897
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus multilocularis SH2 domain containing protein 7 0.1284 0.592 0.5897
Brugia malayi hypothetical protein 0.2145 1 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.026 0.107 0.107
Loa Loa (eye worm) TK protein kinase 0.0861 0.3917 0.3917
Brugia malayi Immunoglobulin I-set domain containing protein 0.0861 0.3917 0.3917
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0861 0.3917 0.3883
Loa Loa (eye worm) hypothetical protein 0.1284 0.592 0.592
Echinococcus granulosus epidermal growth factor receptor 0.0861 0.3917 0.3883
Schistosoma mansoni tensin 0.1284 0.592 0.592
Onchocerca volvulus 0.0861 0.3917 0.3497
Trichomonas vaginalis conserved hypothetical protein 0.0861 0.3917 1
Trichomonas vaginalis TKL family protein kinase 0.0861 0.3917 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.1284 0.592 0.5897
Onchocerca volvulus 0.0861 0.3917 0.3497

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 4.8 nM Binding affinity against human vasopressin V1b receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors ChEMBL. 15084136
Ki (binding) = 63.3 nM Binding affinity against human vasopressin V1a receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors ChEMBL. 15084136
Ki (binding) = 369 nM Binding affinity against human oxytocin receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors ChEMBL. 15084136
Ki (binding) = 4416 nM Binding affinity against human vasopressin V2 receptor was determined by using plasma membranes from CHO cells stably transfected with VP/OT receptors ChEMBL. 15084136
SI (binding) = 13 Selectivity index of human V1b receptor towards V1a receptor ChEMBL. 15084136

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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