Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0104 | 0.1655 | 0.1438 |
Loa Loa (eye worm) | hypoxia-induced factor 1 | 0.0157 | 0.2984 | 0.2801 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3476 | 0.3306 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 0.3476 | 0.3306 |
Trichomonas vaginalis | conserved hypothetical protein | 0.005 | 0.0296 | 0.5 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0104 | 0.1655 | 0.1401 |
Echinococcus multilocularis | geminin | 0.0177 | 0.3476 | 0.3476 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0439 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.0254 | 0.0254 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.3313 | 0.3139 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0254 | 0.0254 |
Brugia malayi | hypothetical protein | 0.005 | 0.0296 | 0.0296 |
Mycobacterium ulcerans | thymidylate synthase | 0.0104 | 0.1655 | 0.1655 |
Echinococcus granulosus | thymidylate synthase | 0.0104 | 0.1655 | 0.1655 |
Brugia malayi | thymidylate synthase | 0.0104 | 0.1655 | 0.1655 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0051 | 0.0329 | 0.0078 |
Echinococcus multilocularis | thymidylate synthase | 0.0104 | 0.1655 | 0.1655 |
Brugia malayi | hypoxia-induced factor 1 | 0.0157 | 0.2984 | 0.2984 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0439 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0171 | 0.3313 | 0.3313 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0254 | 0.0254 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.0254 | 0.0254 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0439 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0439 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0439 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.0254 | 0.0254 |
Schistosoma mansoni | dihydrofolate reductase | 0.0439 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0439 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0439 | 1 | 1 |
Brugia malayi | PAS domain containing protein | 0.0051 | 0.0329 | 0.0329 |
Echinococcus granulosus | geminin | 0.0177 | 0.3476 | 0.3476 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.0104 | 0.1655 | 0.1438 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0338 | 0.7469 | 0.5 |
Onchocerca volvulus | 0.0104 | 0.1655 | 1 | |
Chlamydia trachomatis | dihydrofolate reductase | 0.0439 | 1 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0338 | 0.7469 | 0.5 |
Schistosoma mansoni | single-minded | 0.0051 | 0.0329 | 0.0078 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.